PHILADELPHIA — A University of Pennsylvania research team has defined a possible new way to fight a disease that is currently treatable only with the most expensive drug available for sale in the United States. In a study published this month in Blood, the Penn team describes the strategy, based on the oldest part of the human immune system – called "complement" -- that could turn out to be less costly and more effective for the majority of patients with a rare blood disorder. Complement is a network of more than 50 proteins in the blood and on cell surfaces that quietly ...

College Park, Md. -- An international study of children's perceptions of cigarette package warning labels found that the majority of children are unaware that they exist. Children in countries where larger warning labels are used, and which include a compelling graphic image of the negative health impacts of smoking, were more likely to be aware of and understand the health risks of tobacco products. The study, led by Dina Borzekowski, Ed.D, in the University of Maryland School of Public Health (UMD SPH), and Joanna Cohen, PhD, Johns Hopkins Bloomberg School of Public ...

HONOLULU – Instruments strapped onto and ingested by sharks are revealing novel insights into how one of the most feared and least understood ocean predators swims, eats and lives. For the first time, researchers at the University of Hawaii and the University of Tokyo outfitted sharks with sophisticated sensors and video recorders to measure and see where they are going, how they are getting there, and what they are doing once they reach their destinations. (Go to http://www.youtube.com/watch?v=UHDOAmXRw-0&feature=youtu.be for video). Scientists are also piloting ...

Different brain regions must communicate with each other to control complex thoughts and behaviors, but relatively little is known about how these areas organize into broad neuronal networks. In a study published by Cell Press February 27th in the journal Cell, researchers developed a mouse whole-brain atlas that reveals hundreds of neuronal pathways in a brain structure called the cerebral cortex. The online, open access, interactive image database, called the Mouse Connectome Project, provides an invaluable resource for researchers interested in studying the anatomy and ...

Males are at greater risk for neurodevelopmental disorders, such as autism spectrum disorder (ASD), than females, but the underlying reasons have been unclear. A large cohort study published by Cell Press on February 27th in the American Journal of Human Genetics provides compelling evidence in support of the "female protective model," which proposes that females require more extreme genetic mutations than do males to push them over the diagnostic threshold for neurodevelopmental disorders. "This is the first study that convincingly demonstrates a difference at the molecular ...

Anyone who has ever spent time around goats knows they have a certain smell. By carefully analyzing eau de male goat, researchers reporting in the Cell Press journal Current Biology on February 27 have now identified a novel, citrus-scented ingredient that speaks directly to the females. It acts on female goats' brains to turn their reproductive systems on. The study is the first to uncover a pheromone that activates the central reproductive axis, according to the researchers. Although the work was done in goats, the researchers say there is reason to think the findings ...

Activating a protein called sirtuin 1 extends lifespan, delays the onset of age-related metabolic diseases, and improves general health in mice. The findings, which appear online February 27 in the Cell Press journal Cell Reports, point to a potentially promising strategy for improving health and longevity. Sirtuin 1, or SIRT1, is known to play an important role in maintaining metabolic balance in multiple tissues, and studies in various organisms have shown that activating the protein can lead to many health benefits. Also, drugs that increase SIRT1 activity have been ...

You might think building muscle is a good thing, but that's often not so in the case of blood vessels in adults. In fact, excess smooth muscle is a root problem in many vascular diseases, as it causes arteries to constrict and blood pressure to rise. Now, an in-depth analysis of arterioles in mice with pulmonary hypertension explains how those misplaced smooth muscle cells develop. The findings reported in the Cell Press journal Cell Reports on February 27th are important because nearly half of patients with pulmonary hypertension die within three years of diagnosis, ...

Most of us draw roughly 25,000 breaths a day without any thought. But for patients with pulmonary hypertension, a life-threatening increase in blood pressure in the lungs, even the smallest task can leave them gasping for air. A new study by researchers at Yale School of Medicine offers insight into the function of cells linked to this incurable and often fatal illness. Published Feb. 27 in Cell Reports, the study is the first to explore the cellular mechanisms behind the changes in the way cells are organized in pulmonary arteries in pulmonary hypertension, which leaves ...

The mammalian cerebral cortex, long thought to be a dense single interrelated tangle of neural networks, actually has a "logical" underlying organizational principle, reveals a study appearing Feb. 27 in the journal Cell. Researchers have identified eight distinct neural subnetworks that together form the connectivity infrastructure of the mammalian cortex, the part of the brain involved in higher-order functions such as cognition, emotion and consciousness. "This study is the first comprehensive mapping of the most developed region of the mammalian brain: the cerebral ...

Researchers at Karolinska Institutet in Sweden have identified a biological circadian clock in the hearing organ, the cochlea. This circadian clock controls how well hearing damage may heal and opens up a new way of treating people with hearing disabilities. Important body functions, such as sleep, the immune system, and hormone levels are controlled by a biological circadian clock. A team of researchers at Karolinska Institutet have now discovered that there is also a biological clock in the ear, controlled by genes known to regulate circadian rhythms. One of these ...

Immune system defenses against dangerous bacteria in the gut can be breached by turning off a single molecular switch that governs production of the protective mucus lining our intestinal walls, according to a study led by researchers at Yale, the University of British Columbia, and the Weizmann Institute of Science. "This gut microbiota has been linked to the inflammation that triggers obesity, diabetes, metabolic disease, and most of chronic health problems of the Western World," said Yale's Richard Flavell, Sterling Professor of Immunobiology, Howard Hughes Medical ...

DURHAM, NC -- A protein that controls the metamorphosis of the common fruit fly could someday play a role in reversing brain injuries, said Duke University researchers. This protein directs both the early development and regrowth of the tiny branches that relay information from neuron to neuron. Known as dendrites, these thin structures that resemble tree branches are responsible for receiving electrical impulses that flash throughout the body. Incorrect dendrite development or injury has been linked to neurodevelopmental or psychiatric diseases in humans, such as autism, ...

It has long been believed that the appearance of complex multicellular life towards the end of the Precambrian (the geologic interval lasting up until 541 million years ago) was facilitated by an increase in oxygen, as revealed in the geological record. However, it has remained a mystery as to why oxygen increased at this particular time and what its relationship was to 'Snowball Earth' – the most extreme climatic changes the Earth has ever experienced – which were also taking place around then. This new study shows that it could in fact be what was happening to nitrogen ...

What if there were a way to make chemotherapy and radiation more effective as cancer treatments than they are today, while also getting rid of debilitating side effects that patients dread? A new study led by Alexey Ryazanov, a professor of pharmacology at Rutgers Robert Wood Johnson Medical School and member of the Rutgers Cancer Institute of New Jersey, suggests the day that happens could be getting closer. Side effects such as heart damage, nausea and hair loss occur when cancer therapy kills healthy cells along with the malignant cells that are being targeted. It ...

ALEXANDRIA, Va. – February 27, 2014 – A panel of leading health, economics and policy experts today discussed the prospects for a future where cancers are rendered manageable or even eradicated and the variables affecting progress toward that goal so that cancer patients are able to lead normal, productive lives – and thus be "free from" their cancers. The forum was hosted by Research!America and the Pancreatic Cancer Action Network. The event, titled, "A World Free from Cancers: Probable, Possible, or Preposterous?" was held at the New York Academy of Sciences. Medical ...

People who feel intimidated by math may be less able to understand messages about genetically modified foods and other health-related information, according to researchers. "Math anxiety, which happens when people are worried or are concerned about using math or statistics, leads to less effort and decreases the ability to do math," said Roxanne Parrott, Distinguished Professor of Communication Arts and Sciences and Health Policy and Administration. "Math anxiety also has been found to impair working memory." The researchers found that math anxiety led to a decrease ...

The much-talked-about Google Glass — the eyewear with computer capabilities — could potentially save lives, especially in isolated or far-flung locations, say scientists. They are reporting development of a Google Glass app that takes a picture of a diagnostic test strip and sends the data to computers, which then rapidly beam back a diagnostic report to the user. The information also could help researchers track the spread of diseases around the world. The study appears in the journal ACS Nano, a publication of the American Chemical Society, the world's largest scientific ...

COLUMBIA, Mo. – Shortly following the 9/11 terror attack in 2001, letters containing anthrax spores were mailed to news outlets and government buildings killing five people and infecting 17 others. According to a 2012 report, the bioterrorism event cost $3.2 million in cleanup and decontamination. At the time, no testing system was in place that officials could use to screen the letters. Currently, first responders have tests that can provide a screen for dangerous materials in about 24-48 hours. Now, researchers at the University of Missouri have worked with a private ...

Montréal, February 27, 2014 – A team of researchers at the IRCM in Montréal led by Rémi Rabasa-Lhoret, in collaboration with Jérôme Ruzzin from the University of Bergen in Norway, found a link between a type of pollutants and certain metabolic complications of obesity. Their breakthrough, published online this week by the Journal of Clinical Endocrinology & Metabolism, could eventually help improve the prevention, diagnosis, and treatment of cardiometabolic risk associated with obesity, such as diabetes, hypertension and cardiovascular disease. Although obesity is strongly ...

Mute the song playing on your smartphone in your pocket by flicking your index finger in the air, or pause your "This American Life" podcast with a small wave of the hand. This kind of gesture control for electronics could soon become an alternative to touchscreens and sensing technologies that consume a lot of power and only work when users can see their smartphones and tablets. University of Washington computer scientists have built a low-cost gesture recognition system that runs without batteries and lets users control their electronic devices hidden from sight with ...

COLUMBIA, Mo. – Bisphenol A (BPA) is a chemical that is used in a wide variety of consumer products, such as resins used to line metal food and beverage containers, thermal paper store receipts, and dental composites. BPA exhibits hormone-like properties, and exposure of fetuses, infants, children or adults to the chemical has been shown to cause numerous abnormalities, including cancer, as well as reproductive, immune and brain-behavior problems in rodents. Now, researchers at the University of Missouri have determined that daily exposure to very low concentrations of ...

COLUMBUS, Ohio – Household wealth for Americans still has not recovered from the recession, despite last summer's optimistic report from the U.S. Federal Reserve, a new study suggests. Economists at The Ohio State University found that the mean net worth of American households in mid-2013 was still about 14 percent below the pre-recession peak in 2006. Their analysis suggested that middle-aged people took the biggest hit. In a report last June, the Federal Reserve said that net worth of Americans – which includes the value of homes, stocks and other assets minus debts ...

INDIANAPOLIS— A research team at Indiana University-Purdue University Indianapolis (IUPUI) has helped determine the science behind how canines locate explosives such as Composition C-4 (a plastic explosive used by the U.S. military). The study found the dogs react best to the actual explosive, calling into question the use of products designed to mimic the odor of C-4 for training purposes. These findings are the culmination of a four-year contract funded by the U.S. Department of Defense (DOD). "Appropriately, dogs that are trained to find real explosives are going ...

Vitamin D is known as a major regulator of calcium levels and bone metabolism. Furthermore, it also influences the immune system. Previous studies have shown that patients with recently diagnosed type 1 diabetes have significantly lower vitamin D levels. Scientists from the Institute of Diabetes Research (IDF) and the Helmholtz Zentrum München, a member of the German Center for Diabetes Research (DZD), as well as from the Diabetes Research Group at the Technische Universität München (TUM) examined whether a vitamin D deficiency occurs during an early stage of type 1 diabetes, ...