BOSTON—Aspirin therapy can extend the life of colorectal cancer patients whose tumors carry a mutation in a key gene, but has no effect on patients who lack the mutation, Dana-Farber Cancer Institute scientists report in the Oct. 25 issue of the New England Journal of Medicine. In a study involving more than 900 patients with colorectal cancer, the researchers found that, for patients whose tumors harbored a mutation in the gene PIK3CA, aspirin use produced a sharp jump in survival: five years after diagnosis, 97 percent of those taking aspirin were still alive, compared ...

An electronic nose, used to detect the presence of molecules in the breath of a patient, could be used to diagnose obstructive sleep apnoea. A new study, published online today ahead of print (25 October 2012) in the European Respiratory Journal, could make the diagnosis of the condition quick and inexpensive compared to current methods. The gold standard used to identify sleep apnoea is an overnight sleep test. This is technically demanding, time-consuming and cost-intensive. Electronic nose devices have been shown to distinguish between a number of diseases; ...

This press release is available in German. Researchers at Aarhus University, Denmark, made a sensational discovery almost three years ago when they measured electric currents in the seabed. It was unclear as to what was conducting the current, but the researchers imagined the electric currents might run between different bacteria via a joint external wiring network.The researchers have now solved the mystery. It turns out that the whole process takes place inside bacteria that are one centimetre long. They make up a kind of live electric cable that no one had ever imagined ...

We're not used to thinking of ourselves as animals. But as Jason Samson sees it, climate is as important in shaping the distribution and movement of humans as it is in other animals. The McGill-trained ecologist and fellow researchers have been using modeling techniques similar to those used to define the ecological niche for plant and animal species to explore the correlation between climate patterns and population growth in the contiguous United States between 1900-2000. And what they discovered was a pronounced population shift away from areas within the U.S. with cool ...

Could it be that dark matter "halos" — the huge, invisible cocoons of mass that envelop entire galaxies and account for most of the matter in the universe — aren't completely dark after all but contain a small number of stars? Astronomers from UCLA, UC Irvine and elsewhere make a case for that in the Oct. 25 issue of the journal Nature. Astronomers have long disagreed about why they see more light in the universe than it seems they should — that is, why the infrared light they observe exceeds the amount of light emitted from known galaxies. When looking at the cosmos, ...

Just how new species are established is still one of the most central questions in biology. In an article in the leading scientific journal Nature, researchers at Uppsala University in Sweden describe how they mapped the genomes of the European pied flycatcher and the collared flycatcher and found that it is disparate chromosome structures rather than separate adaptations in individual genes that underlies the separation of the species. "We were surprised that such a large part of the genome was nearly identical in the two species," says Hans Ellegren, professor of evolutionary ...

CHICAGO --- In an early-stage breakthrough, a team of Northwestern University scientists has developed a new family of compounds that could slow the progression of Parkinson's disease. Parkinson's, the second most common neurodegenerative disease, is caused by the death of dopamine neurons, resulting in tremors, rigidity and difficulty moving. Current treatments target the symptoms but do not slow the progression of the disease. The new compounds were developed by Richard B. Silverman, the John Evans Professor of Chemistry at the Weinberg College of Arts and Sciences ...

(Garrison, NY) As the presidential candidates clash over the fate of the Affordable Care Act, a set of seven essays by leading legal experts, economists, and scholars examines the implications of the Supreme Court's decision on the ACA and makes it clear that there is no consensus about what is economically or morally just when it comes to health care coverage in this country. The essays appear in the Hastings Center Report. While the essays provide a range of perspectives, a few common themes emerge. Foremost among them is that the individual mandate may not work as ...

A gene known to be involved in cancer and cardiovascular development may be the cause of inflammation in the most common form of aortic aneurysm and may be a key to treatment, according to research from Nationwide Children's Hospital. The study, appearing online in Arteriosclerosis, Thrombosis, and Vascular Biology on October 18, 2012, is the first to show that Notch 1 signaling is activated in abdominal aortic aneurysmal tissue in mice and humans. The aorta is the largest blood vessel in the body. Abdominal aortic aneurysm (AAA) occurs when the weakened aortic wall dilates ...

MIAMI, FL – OCTOBER 24 , 2012 – A study found that a nitinol stent performed better than balloon angioplasty alone in treating blockages of the popliteal artery, which runs through the leg behind the knee. Results of the ETAP trial were presented today at the 24th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the world's premier educational meeting specializing in interventional cardiovascular medicine. Due to its location behind the mobile knee joint, it is controversial ...

CHAMPAIGN, Ill. — Scientists report that they can predict who will improve most on an unfamiliar video game by looking at their brain waves. They describe their findings in a paper in the journal Psychophysiology. The researchers used electroencephalography (EEG) to peek at electrical activity in the brains of 39 study subjects before they trained on Space Fortress, a video game developed for cognitive research. The subjects whose brain waves oscillated most powerfully in the alpha spectrum (about 10 times per second, or 10 hertz) when measured at the front of the head ...

MIAMI, FL – OCTOBER 24, 2012 – A study has found that the anti-clotting medication prasugrel reduced cardiovascular events among patients who present with an acute coronary syndrome and are managed medically after an angiogram is performed to determine coronary anatomy. Results of the TRILOGY ACS trial, Angiographic Cohort were presented today at the 24th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the world's premier educational meeting specializing in interventional cardiovascular ...

WASHINGTON — Scaling up the production of biofuels made from algae to meet at least 5 percent -- approximately 39 billion liters -- of U.S. transportation fuel needs would place unsustainable demands on energy, water, and nutrients, says a new report from the National Research Council. However, these concerns are not a definitive barrier for future production, and innovations that would require research and development could help realize algal biofuels' full potential. Biofuels derived from algae and cyanobacteria are possible alternatives to petroleum-based fuels and ...

CHAMPAIGN, Ill. — We humans have a fairly erratic sense of time. We tend to misjudge the duration of events, particularly when they are emotional in nature. Disturbingly negative experiences, for example, seem to last much longer than they actually do. And highly positive experiences seem to pass more quickly than negative ones. Researchers say they have found a way to lessen these emotion-driven time distortions. Having a sense of control over events reduces the influence of emotions on time perception, the researchers report. This is true even for highly reactive emotional ...

MIAMI, FL – OCTOBER 24, 2012 –A strategy of up-front percutaneous coronary intervention (PCI) for lesions confirmed to be obstructive by fractional flow reserve (FFR) was shown to be cost-effective in terms of quality-adjusted life years when compared to medical therapy alone. Results of the Cost-Effectiveness sub study of the FAME 2 trial were presented today at the 24th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the world's premier educational meeting specializing in interventional ...

MIAMI, FL – OCTOBER 24, 2012 – A study found that transcatheter aortic valve replacement (TAVR) yielded lower mortality rates after three years compared with medical therapy in patients deemed to be ineligible for conventional aortic valve surgery. Results of the PARTNER Cohort B trial were presented today at the 24th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the world's premier educational meeting specializing in interventional cardiovascular medicine. TAVR is the recommended ...

MIAMI, FL – OCTOBER 24, 2012 – A study found that second-generation drug-eluting stents are safe and effective in the treatment of left main coronary artery lesions. Results of the ISAR-LEFT MAIN 2 trial were presented at the 24th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the world's premier educational meeting specializing in interventional cardiovascular medicine. Patients undergoing invasive treatment of unprotected left main coronary artery (uLMCA) lesions are often ...

CHAMPAIGN, Ill. — The bacterium Streptococcus pneumoniae – which can cause pneumonia, meningitis, bacteremia and sepsis – likes to share its antibiotic-defeating weaponry with its neighbors. Individual cells can pass resistance genes to one another through a process called horizontal gene transfer, or by "transformation," the uptake of DNA from the environment. Now researchers report that they can interrupt the cascade of cellular events that allows S. pneumoniae to swap or suck up DNA. The new findings, reported in the journal PLoS ONE, advance the effort to develop ...

TORONTO, Oct. 24, 2012--It turns out the muscle cells on the outside of blood vessels have been wrongly accused for instigating lung disease. New research shows that while these muscle cells are responsible for constricting or dilating the blood vessels, they are not responsible for sensing the amount of oxygen that gets to the lungs. That message comes from the endothelial cells – special cells that line the blood vessels – along a "signalling pathway." When a person is low on oxygen, blood vessels throughout the body expand to improve the delivery of this vital molecule ...

ANN ARBOR, Mich. — Joint research between the University of Michigan and the Argentina-based National Council of Science and Technology (CONICET) has shed light on one of the most frustrating mysteries of weight loss – why the weight inevitably comes back. A novel animal model showed that the longer mice remained overweight, the more "irreversible" obesity became, according to the new study that appeared online ahead of print Oct.24 in the Journal of Clinical Investigation. Over time, the static, obese state of the mice reset the "normal," body weight set point to ...

MIAMI, FL – OCTOBER 24, 2012 – A clinical trial found that the use of a next generation, micronet, mesh-covered stent demonstrated improved restoration of blood flow to heart tissue, compared to the use of either bare-metal or drug-eluting stents in heart attack patients undergoing angioplasty. Results of the MASTER trial were presented today at the 24th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium and will appear in the November 6th issue of the Journal of the American College of Cardiology. Sponsored by the Cardiovascular Research Foundation, ...

ROSEMONT, IL–Obese patients have a greater risk of complications following total knee replacement surgery, including post-surgical infections, according to a new literature review recently published in the Journal of Bone and Joint Surgery (JBJS). Because of complications, obese patients are more likely to require follow-up surgery (revision). Obesity is reaching epidemic proportions, particularly in the United States, and is a well-documented risk factor for the development of osteoarthritis. Arthritis is initially treated nonsurgically, but total joint replacement often ...

The fourth installment of the Paranormal Activity films topped the box office last week. Television channel SyFy's hit show Ghost Hunters scares up big ratings, and has spawned copycat series on networks ranging from Biography to Animal Planet. The omnipresence of paranormal entertainment piqued the interest of Paul Brewer, professor of communication, who wondered what makes viewers believe—or disbelieve— what they see on the screen. His resulting study, recently published in the journal Science Communication, examines the influence of media messages about paranormal ...

Part Two: Slicing through the electron beam Wim Leemans of Berkeley Lab's Accelerator and Fusion Research Division heads LOASIS, the Laser and Optical Accelerator Systems Integrated Studies, an oasis indeed for students pursuing graduate studies in laser plasma acceleration (LPA). Among the most promising applications of future table-top accelerators are new kinds of light sources, in which their electron beams power free electron lasers. "If our LPA electron bunches had good enough quality for free electron lasers – and were really only femtoseconds long – we should ...

NASA satellites are closely monitoring Tropical Storm Sandy in visible and infrared light as it approaches Jamaica. Sandy is now responsible for hurricane and tropical storm warnings and watches from Jamaica to Cuba, the Bahamas and southern Florida. Sandy is expected to become a hurricane before it reaches Jamaica and Cuba. On Oct. 23, 2012 at 1545 UTC (11:45 a.m. EDT), the Moderate Resolution Imaging Spectroradiometer (MODIS) instrument captured a visible image of Tropical Storm Sandy when its center was a couple of hundred miles south of Jamaica. Sandy's clouds filled ...