Plvap/PV1 critical to formation of the diaphragms in endothelial cells
PV1 expression in vascular endothelium is required for survival
PV1 is required for the formation of stomatal and fenestral diaphragms
Lack of diaphragms in fenestrated endothelia causes vascular leak of plasma proteins
Vascular leak results in severe hypoproteinemia and hypertriglyceridemia
Dartmouth scientists have demonstrated the importance of the gene Plvap and the structures it forms in mammalian physiology in a study published in December by the journal Developmental Cell.
"The knowledge generated and the animal models created will allow a better understanding ...


