Researchers from Clemson University have found a way to create temporary holes in the membranes of live cells using a standard inkjet printer. The method will be published in JoVE, the Journal of Visualized Experiments, on March 16. "We first had the idea for this method when we wanted to be able to visualize changes in the cytoskeleton arrangement due to applied forces on cells," said paper-author Dr. Delphine Dean. She said other researchers have been using this method to print cells onto slides, but that they have only recently discovered that printing the cells ...

The study's objective was to identify which skills and competencies are considered most critical for primary care providers (PCPs) to learn in order to effectively manage opioid risk in patients treated for chronic pain Study participants included experts in primary care, pain management, and addiction Experts in this study identified the most important skills for PCPs managing opioid risk in chronic pain patients as how to monitor opioids and how to assess for risk factors Primary care physicians are faced with treating a large proportion of chronic pain patients, ...

The European Union's Habitats Directive is now 20 years old, and its network of protected areas, known as Natura 2000, is nearing completion. After a slow start, the network now includes some 26 000 protected sites and covers approximately 18% of the EU's land surface as well as significant areas of sea. It is widely considered to be the world's largest network of protected areas based on agreed site selection criteria. The review has been published in the newly launched open-access journal Nature Conservation. Douglas Evans, seconded to the Paris-based European Topic ...

PROVIDENCE, R.I. [Brown University] — Female mouse fetuses exposed to very high doses of a common industrial chemical that makes plastics more pliable develop significant reproductive alterations and precancerous lesions as they grow up, according to a new toxicology study conducted at Brown University. The administered doses of MEHP, the chemical that results when animals metabolize the industrial phthalate DEHP, were much higher than any normal environmental exposure that people or animals would encounter, said Mary Hixon, assistant professor of pathology and laboratory ...

BUFFALO, N.Y. -- Firms that make a previously patented innovation accessible to competitors increase overall likelihood of improving upon that breakthrough while also raising profits for the original innovator and market welfare, according to a study by a University at Buffalo economist. The practice of free-licensing -- giving up patent protection -- corresponds to an evolutionary step in the study of patents and their effect on innovation, says the study's author Gilad Sorek, assistant visiting professor of economics at UB. "This research arose from the notion that ...

TAMPA, Fla. (March 16, 2012) – An international team of researchers from the United States and Australia, including researchers at Moffitt Cancer Center in Tampa, Fla., have found that the oral BRAF inhibitor vemurafenib (PLX4032) when tested in a phase II clinical trial offered a high rate of response in patients with previously treated metastatic melanoma and who had the BRAF mutation. More than 50 percent of the patients in the trial had positive, prolonged responses and a median survival of almost 16 months. The study was published in a recent issue of the New England ...

UAB researchers developed a new vehicle to release proteins with therapeutic effects. The vehicles are known as "bacteria inclusion bodies", stable insoluble nanoparticles which are found normally in recombinant bacteria. Even though these inclusion bodies traditionally have been an obstacle in the industrial production of soluble enzymes and biodrugs, they were recently recognised to have large amounts of functional proteins with direct values in industrial and biomedical applications. The research team led by Antoni Villaverde from the Institute of Biotechnology and ...

The following highlights summarize research papers that have been recently published in Geophysical Research Letters (GRL), Journal of Geophysical Research-Atmospheres (JGR-D), and Journal of Geophysical Research-Solid Earth (JGR-B). In this release: Measuring mercury in coastal fog water Early Eocene climate warming increased petroleum production Unexpected earthquakes within continental plates pose challenges Land use changes contribute to climate extremes When will warming-induced rainfall changes be perceptible? Model describes New Zealand's complex tectonic ...

The seas are creeping higher as the planet warms. But how high could they go? Projections for the year 2100 range from inches to several feet, or even more. The sub-tropical islands of Bermuda and the Bahamas are two seemingly unlikely places scientists have gone looking for answers. The cliffs and ancient reefs on Bermuda and the Bahamas have lured fossil-hunters for decades. The land on the Bahamas, for example, has a foundation of fossil coral; the stone is derived from the disintegration of age-old coral reefs and seashells. These areas are now attracting scientists ...

Despite the amazing advances in the field of medicine, many are still suffering from treatable and avoidable oral health conditions. The Center for Disease Control and Prevention's 2011 report on America's overall oral health shows that nearly a quarter of those over the age of 65 have lost all of their teeth due to trauma, gum disease, and tooth decay. This is why the leading Torrance dentist, Dr. Robert Mondavi, is now offering huge discounts to all dental implants this spring for those patients that would like to restore their smile permanently and painlessly. Dental ...

A fundamental shift in the Indian monsoon has occurred over the last few millennia, from a steady humid monsoon that favored lush vegetation to extended periods of drought, reports a new study led by researchers at the Woods Hole Oceanographic Institution (WHOI). The study has implications for our understanding of the monsoon's response to climate change. The Indian peninsula sustains over a billion people, yet it lies at the same latitude as the Sahara Desert. Without a monsoon, most of India would be dry and uninhabitable. The ability to predict the timing and amount ...

Who wouldn't pay a penny for a sports car? That's the mentality some popular online auctions take advantage of -- the opportunity to get an expensive item for very little money. In a study of hundreds of lowest unique bid auctions, Northwestern University researchers asked a different question: Who wins these auctions, the strategic gambler or the lucky one? The answer is the lucky. But, ironically, it's a lucky person using a winning strategy. The researchers found that all players intuitively use the right strategy, and that turns the auction into a game of pure ...

Le Bonheur Professor Russell Chesney, M.D. believes he knows what was ailing Tiny Tim, the iconic character from Charles Dickens' "A Christmas Carol." Based on detailed descriptions of both the symptoms and living conditions of 18th century London, Dr. Chesney hypothesizes that Tiny Tim suffered from a combination of rickets and tuberculosis (TB). His findings were published in the March 5 edition of Archives of Pediatrics and Adolescent Medicine. Dr. Chesney noted during the time the novel was written, 60 percent of children in London had rickets and nearly 50 percent ...

While there is always going to be more to an individual than their appearance, the power of a great outfit can never be underestimated. Those with a perfect look are going to exude confidence in all that they do. For some, this often means a stylish men's suit that complements their personality. This is why Megasuits.com is now offering their spring collection of men's suits at hugely discounted prices for those that would like to look and feel great in the coming months. Purchasing suits has often been a monotonous and expensive chore in the past. Storefronts charged ...

Eighty-eight percent of Americans now own a cell phone, forming a massive network that offers scientists a wealth of information and an infinite number of new applications. With the help of these phone users — and their devices' cameras, audio recorders, and other features — researchers envision endless possibilities for gathering huge amounts of data, from services that collect user data to monitor noise pollution and air quality to applications that build maps from people's cell phone snapshots. Today, user data provides some opportunities; for example, researchers ...

SAN DIEGO -- Obesity appears to significantly increase the risk of death tied to sleeping pills, nearly doubling the rate of mortality even among those prescribed 18 or fewer pills in a year, researchers reported Friday. "Obesity emerged as a marker of increased vulnerability," said Robert Langer, M.D., M.P.H., at the annual American Heart Association's Epidemiology and Prevention | Nutrition, Physical Activity and Metabolism 2012 Scientific Sessions in San Diego. "The associations between sleeping pills and increased mortality were present, and relatively stronger, ...

Northern Australia's Pilbara coast is under warnings, alerts and watches as powerful Cyclone Lua nears for a landfall. NASA's Aqua satellite has been providing infrared, visible and microwave data on Lua that have shown forecasters the storm is strengthening on its approach to land. Two of the most recent infrared images of Cyclone Lua were captured from the Atmospheric Infrared Sounder (AIRS) instrument onboard NASA's Aqua satellite. The AIRS instrument captured infrared images of Cyclone Lua on March 15 at 1741 UTC and March 16 at 0553 UTC. The later image appeared ...

There are quite a few things around the house that many take for granted, no matter how often they are used. Individuals will find themselves enjoying the features and utility of high end appliances to cook their food, clean dishes, and help to wash clothes. When these appliances begin to break down, it is going to put an immediate halt to almost everything in the household. For locals that are going to need these devices back up in working condition as quickly and affordably as possible, the leading Los Angeles appliance repair company, AM PM, is now offering specialty ...

MAYWOOD, Il. -- Loyola University Medical Center is one of the major enrollers in a landmark clinical trial that found that plugging a hole in the heart works no better than drugs in preventing strokes. The study is published in the New England Journal of Medicine. Loyola enrolled 24 patients, one of the highest patient enrolments in the multicenter trial, and more than any other Chicago-area hospital. Principal investigators at the Loyola site are stroke specialist Dr. Michael Schneck and interventional cardiologist Dr. Fred Leya. About 1 in 4 adults has a small hole ...

PHILADELPHIA -- The number of U.S. medical student seniors at medical schools choosing internal medicine residencies leveled in 2012 after two years of significant increases. According to the 2012 National Resident Matching Program, 2,941 U.S. medical school seniors matched internal medicine, nearly unchanged from 2011 when 2,940 matched internal medicine. "After seeing increases in 2010 and 2011 for the internal medicine residency match for U.S. medical students, we are disappointed that there was not a bigger increase this year," said Virginia L. Hood, MBBS, MPH, FACP, ...

As the desert Southwest becomes hotter and drier, semi-arid grasslands are slowly being replaced by a landscape dominated by mesquite trees, such as Prosopis velutina, and other woody shrubs, a team of University of Arizona researchers has found. In a "leaf-to-landscape" approach, the team combined physiological experiments on individual plants and measurements across entire ecosystems to quantify how well grasslands, compared to mesquite trees and woody shrubs, cope with heat and water stress across seasonal precipitation periods. "Our results show that even the smallest ...

Washington, D.C. -- Researchers at Georgetown University Medical Center have revealed how a mutation in a single gene is responsible for the inability of neurons to effectively pass along appetite suppressing signals from the body to the right place in the brain. What results is obesity caused by a voracious appetite. Their study, published March 18th on Nature Medicine's website, suggests there might be a way to stimulate expression of that gene to treat obesity caused by uncontrolled eating. The research team specifically found that a mutation in the brain-derived ...

Like any law-abiding train passenger, a molecule called oskar RNA carries a stamped ticket detailing its destination and form of transport, scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have found. They show that for this molecule, moving in the right direction isn't enough: speed is of the essence. Their study, published online today in Nature Structural & Molecular Biology, also provides clues as to how a single molecule could receive tickets for different destinations, depending on what type of cell it is in. For a fruit fly ...

Ferrer Shane, PL is proud to announce that one of its attorneys, Diana E. Gonzalez, is running for Miami-Dade County Court Judge. Starting her career in 2004, Diana Gonzalez was rapidly promoted up the ranks in the Public Defender's Office, first handling misdemeanor charges, then defending young people in the juvenile division, to ultimately defending clients charged with the most serious felonies - all in the span of just five years, trying everything from a traffic ticket to a murder case. Having traveled abroad with the U.S. Department of Defense and with USAID ...

LA JOLLA, Calif., March 18, 2012 – Autoimmune diseases, such as Type I diabetes and rheumatoid arthritis, are caused by an immune system gone haywire, where the body's defense system assaults and destroys healthy tissues. A mutant form of a protein called LYP has been implicated in multiple autoimmune diseases, but the precise molecular pathway involved has been unknown. Now, in a paper published March 18 in Nature Chemical Biology, researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) show how the errant form of LYP can disrupt the immune system. ...