Scientists at the University of Leicester have opened up a whole new approach to the therapeutic intervention for a family of anti-cancer drug targets, thanks to a completely new and unexpected finding. Professor Schwabe and his colleagues, Drs Watson, Fairall and Santos, have published their research this week in leading science magazine Nature detailing a new understanding of how transcriptional repression complexes work. Their work, which is based around determining atomic resolution structures of medically important bio-molecular complexes, has been ongoing for six ...

Climate change in the form of reduced snowfall in mountains is causing powerful and cascading shifts in mountainous plant and bird communities through the increased ability of elk to stay at high elevations over winter and consume plants, according to a groundbreaking study in Nature Climate Change. The U.S. Geological Survey and University of Montana study not only showed that the abundance of deciduous trees and their associated songbirds in mountainous Arizona have declined over the last 22 years as snowpack has declined, but it also experimentally demonstrated that ...

An extremely hot, massive young galaxy cluster — the largest ever seen in the distant Universe — has been studied by an international team using ESO's Very Large Telescope (VLT) in the Atacama Desert in Chile along with NASA's Chandra X-ray Observatory and the Atacama Cosmology Telescope. The new results are being announced on 10 January 2012 at the 219th meeting of the American Astronomical Society in Austin, Texas. The newly discovered galaxy cluster [1] has been nicknamed El Gordo — the "big" or "fat one" in Spanish. It consists of two separate galaxy subclusters colliding ...

Over the holidays Long Island Exchange Columnist Cognac Wellerlane attended a holiday celebration at the House of Savoia. The event was hosted by suit and costume designer Michelle Savoia and Vanity Fair editor George Wayne. It was held on Essex Street in the lower east side of Manhattan. The House of Savoia is known for its custom suits and men's apparel and Savoia is famous for designing costumes for Broadway shows. The event was sponsored by Van Gogh Vodka, and cocktail courtesy by Molinari. Among those who attended were a variety of celebrities, such as models, actors, ...

HCMWorks announced today the naming of Ted Weyn to the Sourcing Interests Group's Advisory Board. Sourcing Interests Group (SIG), www.sig.org, is a membership organization comprised of sourcing and outsourcing professionals from Fortune 500 and Global 1000 companies, as well as the service providers and advisory firms that serve them. Members of all types are focused on advancing the sourcing/procurement and outsourcing industries by sharing best practices and thought leadership in a strictly-enforced non-commercial environment. SIG is acknowledged globally for its ...

New findings by St. Michael's researchers about the way cells work could lead to a test and therapy for kidney failure caused by E. coli TORONTO, Ont., Jan. 10, 2012—Ever since the water supply in Walkerton, Ont., was contaminated by E. coli in 2000, Dr. Philip Marsden has been trying to figure out just how a toxin released by that particular strain of the bacteria causes kidney damage in children. Now Dr. Marsden and his team based at St. Michael's Hospital and the University of Toronto, led by graduate student Tania Petruzziello-Pellegrini, together with an international ...

Using the NASA/ESA Hubble Space Telescope, astronomers have uncovered a cluster of galaxies in the initial stages of development, making it the most distant such grouping ever observed in the early Universe. In a sky survey made in near-infrared light Hubble has spotted five galaxies clustered together. They are so distant that their light has taken 13.1 billion years to reach us. These galaxies are among the brightest galaxies at that early stage of the Universe's history. They are also very young: we are seeing them just 600 million years after the Universe's birth ...

Myotronics, Inc is pleased to announce its 46th Anniversary Seminar in Seattle, June 29-30, 2012 will feature Ronan Tynan of the Irish Tenors. Known for his passion and determination in surmounting various challenges throughout his life, Mr. Tynan is an inspiring motivational speaker, an accomplished athlete, an orthopedic sports medicine physician, and a celebrated tenor. Mr. Tynan will deliver the Keynote address, before the program of 20 leaders in the field of neuromuscular dentistry begins. The seminar schedule is designed to allow participants to select the presentations ...

Despite the recent good weather in the Mediterranean, which has seen an unseasonal extension of the summer luxury yacht charter season, every good thing must come to an end and as we move into 2012 the focus of the luxury yacht charter market inevitably moves west to Florida and the Caribbean. Unfortunately the good weather clearly did not manage the move west and the Fort Lauderdale International Boat Show, which took place between the 28th and 31st of October, was hit by stormy wet weather that had an inevitably negative effect on attendance. As we approach the winter ...

MANHATTAN, KAN. -- A Kansas State University graduate student sees the unpaved road ahead, and it's filled with biomaterial. Wilson Smith, master's student in civil engineering, Independence, Mo., is working with lignin, a plant-based sustainable material that can be added to improve the quality of unpaved roads throughout Kansas. More than 70 percent of the 98,000 miles of roads in Kansas are unpaved, Smith said. "One of the problems with unpaved roads is that they are made from loose granular soils with particles that are not bound to each other on the road surface," ...

Will borrowing money to buy a new car make you feel richer? It depends on your net worth, says a new study in Psychological Science, a journal published by the Association for Psychological Science. "People's perceptions of wealth vary not only as a function of their net worth, but also of the amount of assets and debt they have," says Princeton University psychology graduate student Abigail B. Sussman, who wrote the study with Princeton professor Eldar Shafir. In fact, increasing your assets by taking on debt affects perceived wealth in opposite ways for people who are ...

Troy, N.Y. – Engineering researchers at Rensselaer Polytechnic Institute have developed a new method for creating advanced nanomaterials that could lead to highly efficient refrigerators and cooling systems requiring no refrigerants and no moving parts. The key ingredients for this innovation are a dash of nanoscale sulfur and a normal, everyday microwave oven. At the heart of these solid-state cooling systems are thermoelectric materials, which can convert electricity into a range of different temperatures—from hot to cold. Thermoelectric refrigerators employing these ...

Car hire deals website eRentals.co.uk has this week warned UK tourists heading for the sunshine in the States this winter to get their skates on when booking car hire deals. The site, which is home to deals for more than 12,000 locations, has seen a recent surge in hire car bookings for Orlando and San Francisco airports. San Francisco in California is a hugely popular holiday destination for UK tourists who want to enjoy a bit of sunshine in the winter time, and this January is seeing many travellers booking up cheap rental deals there. Right now eRentals.co.uk has ...

WickerFurniture.Net, an online retailer of wicker furniture, offers a wide range of all weather wicker furniture for sale at affordable wholesale prices. Furniture dealers and distributors will be pleasantly surprised by the quality of the furniture. Why wicker furniture for home owners. Home owners are always on the look out for high quality furniture that is suitable for both indoors and outdoors. There is no lack of furniture for the indoors. But when it comes to the outdoors (e.g. gardens and patio), the choices become narrower. Design is not the only consideration ...

New Rochelle, NY, January 10, 2011—How best to ensure environmental justice for Native Americans in terms of policy, governance, and activism on tribal lands? The broad range of issues, challenges, and possibilities are explored in an insightful and thought-provoking special issue of Environmental Justice entitled "Environmental Justice in Native America." Environmental Justice is a peer-reviewed journal published by Mary Ann Liebert, Inc. The entire issue is available online at www.liebertpub.com/env This collection of timely and provocative articles draws from extensive ...

Demand for car hire Dubai is expected to rise in 2012 according to leading car hire company Rhinocarhire.com. Following a rise of nearly 10% in bookings in 2011 over 2010, Rhinocarhire.com expect the upward trend to continue into 2012 for Dubai car hire. Dubai's appeal can be attributed to its growing popularity as a year-round sun resort boasting golden sandy beaches with a state of the art cityscape backdrop and associated amenities. With more than 120 airlines operating to and from Dubai International Airport covering more than 250 destinations, Dubai is well connected ...

Outdoorfurniture.biz, an online retailer who specializes in outdoor furniture, is now offering high-quality furniture at affordable wholesale prices. Dealers and distributors are welcome to send in their enquiries. Locating high quality outdoor furniture Searching for outdoor furniture has always been a problem because the furniture will have to be exposed to the harsh environment. Most materials won't last for long when exposed to the rain and sun. Metal will rust, and most wood will rot. Only special types of wood like teak is suitable for the outdoors. Plastic ...

Los Angeles, CA (January 9, 2012) As LSU and Alabama square off for the national college football championship, even the most rabid Tiger or Tide fan might not realize the influence that the US military had in the widespread appeal of football. According to a new study in the journal Armed Forces & Society (AFS), published by SAGE, college football can credit the military for bringing the sport to the masses. Additionally, the study explores how the impact of World Wars helped bring about issues such as payment of college athletes, which are still being debated. In ...

Most individuals coming to the United States hope to make a better life for themselves and their families. Because immigration procedures can be complex, some choose to take the risk of coming here without the proper visa. Undocumented workers in Texas learn to fear the U.S. Immigration and Customs Enforcement (ICE) service from the moment they arrive. When they are injured in either a car accident or fall at work, many Hispanics are hesitant to pursue a claim against their employer. Because of misinformation in the community, even contacting a workplace injury attorney ...

Plant oils from sources such as soybean and rapeseed are promising starting materials for the production of biofuels. Microalgae are an interesting alternative to these conventional oil-containing crops. Microalgae are individual cells or short chains of cells from algae freely moving through water. They occur in nearly any pool of water and can readily be cultivated. "They have a number of advantages over oil-containing agricultural products," explains Lercher. "They grow significantly faster than land-based biomass, have a high triglyceride content, and, unlike the terrestrial ...

CORVALLIS, Ore. – A new analysis of satellite data from the late 1990s documents for the first time the "uplift" of ground above a site of underground nuclear testing, providing researchers a potential new tool for analyzing the strength of detonation. The study has just been published in Geophysical Research Letters. Lead author Paul Vincent, a geophysicist at Oregon State University, cautions that the findings won't lead to dramatic new ability to detect secret nuclear explosions because of the time lag between the test and the uplift signature, as well as geophysical ...

They know it's the most dangerous night of the year for drinking and driving, yet they do it anyway. According to a recent survey conducted by Liberty Mutual and Students Against Drunk Driving (SADD), teenagers are more likely to drink and drive on New Year's Eve despite a common belief in the extreme perils of driving on that night. The survey is especially alarming in light of an Allstate report released earlier this month, which found that more teenagers are dying in Texas auto wrecks than any other state. According to the report, 556 teens died in car accidents throughout ...

Current approaches to calculating failure probability in complex engineering structures can be inefficient and result in inconsistency, but a Wayne State University researcher is working to change that. Christopher Eamon, associate professor of civil and environmental engineering, recently received a three-year, $250,000 grant from the National Science Foundation to develop an accurate and efficient method for calculating failure probability (reliability analysis) for computationally and probabilistically complex structural engineering problems, with the goal of achieving ...

PROVIDENCE, R.I. [Brown University] -- Scientists, health officials, and manufacturers already know that a chemical preservative found in some products, including cosmetics, is harmful to people and animals in high concentrations, but a new Brown University study in tadpoles reports that it can also interrupt neurological development even in very low concentrations. In the cosmetics industry, the biocide methylisothiazolinone or MIT, is considered safe at concentrations of less than 100 parts per million. Lab studies, however, have found that lower concentrations affected ...

In a 2007 study published in Forbes.com, 56 percent of women and 36 percent of men whose wealth was at least $1 million said that they had hidden or protected assets. Those that made over $10 million were the most likely to have hidden assets. Many people admitted to using wealth preservation strategies, where they hid assets from creditors and spouses through offshore accounts and asset protection trusts. Others use other trusts, holdings, charitable foundations, family-limited partnerships, and equity reduction plans (ERPs). Still others may hide assets through their ...