Scientists at Johns Hopkins have identified a compound that could be used to starve cancers of their sugar-based building blocks. The compound, called a glutaminase inhibitor, has been tested on laboratory-cultured, sugar-hungry brain cancer cells and, the scientists say, may have the potential to be used for many types of primary brain tumors. The Johns Hopkins scientists, are inventors on patent applications related to the discovery, caution that glutaminase inhibitors have not been tested in animals or humans, but their findings may spark new interest in the glutaminase ...

PHILADELPHIA – Cells have their own version of the cut-and-paste editing function called splicing. Researchers at the University of Pennsylvania School of Medicine have documented a novel form of splicing in the cytoplasm of a nerve cell, which dictates a special form of a potassium channel protein in the outer membrane. The channel protein is found in the dendrites of hippocampus cells -- the seat of memory, learning, and spatial navigation -- and is involved in coordinating the electrical firing of nerve cells. Dendrites, which branch from the cell body of the neuron, ...

Montreal, November 18, 2010 – Schizophrenia is a mental disorder that differs between the sexes in terms of age at onset, symptomatology, response to medication, and structural brain abnormalities. Now, a new study from the Université de Montréal shows that there is gender difference between men and women's mental ability – with women performing better than men. These findings, published recently in, Schizophrenia Research, have implications for the more than 300 000 affected Canadians. "We are the first to report sex differences in brain function of schizophrenics," ...

The Soufriere Hills Volcano on Montserrat erupted in 1995, and an international team of researchers has studied this volcano from land and sea since then to understand the workings of andesite volcanos more completely. "To the extent that the Soufriere Hills Volcano is typical of andesitic dome building volcanoes, results from this research can be expected to apply more generally," said Barry Voight, professor emeritus of geosciences, Penn State. Voight and R. S. J. Sparks, the Channing Wills professor of geology, Bristol University, guest edited and introduced a special ...

People who contract gastroenteritis from drinking water contaminated with E. coli are at an increased risk of developing high blood pressure, kidney problems and heart disease in later life, finds a study published on bmj.com today. The findings underline the importance of ensuring a safe food and water supply and the need for regular monitoring for those affected. It is estimated that E. coli O157:H7 infections cause up to 120,000 gastro-enteric illnesses annually in the US alone, resulting in over 2,000 hospitalisations and 60 deaths. However, the long term health ...

Vitamin D is somewhat of an unusual "vitamin," because it can be made in the body from sunlight and most foods do not contain vitamin D unless added by fortification. Synthesis of vitamin D in the body requires exposure to ultraviolet light and can be influenced by genetics, skin color, and sun exposure. Reports of greater than expected vitamin D insufficiency coupled with emerging evidence that higher circulating concentrations of this nutrient may protect against cardiovascular disease have prompted a renewed interest in teasing out how environment, genetics, and behavior ...

DURHAM, NC – Researchers have been stymied for years over the fact that people infected with the AIDS virus do indeed produce antibodies in response to the pathogen – antibodies that turn out to be ineffective in blocking infection. Now, scientists at Duke University Medical Center can explain why: Some of the earliest and most abundant antibodies available to fight HIV can't actually "see" the virus until after it's already invaded a healthy cell. The scientists based their conclusion on the results of a series of crystallography and biochemical experiments that revealed ...

Boston, MA – A new poll from researchers at the Harvard School of Public Health (HSPH) and Knowledge Networks (KN) shows that many people with heart disease, diabetes or cancer believe the economic downturn is hurting their health and will have further negative impacts in the future. Many Americans with these illnesses face financial problems paying for medical bills in this economy. Most of these people do not believe the new national health care reform law (Patient Protection and Affordable Care Act 2010) will help them. This national poll is the first in a collaborative ...

Alcoholic drinks served in pubs should be taxed at a lower level than drinks bought from shops, says an expert in this week's BMJ. This action would deliver the health benefits associated with introducing a minimum price on alcohol, increase tax revenue for the Treasury and save pubs says Dr Nick Sheron. The author is head of clinical hepatology at the University of Southampton, a member of the Alcohol Health Alliance and an advisor for the 2010 House of Commons Select Committee Report on Alcohol. Sheron says lowering VAT for alcohol sold in pubs would solve the plight ...

New Orleans, LA – Dr. Rohan Walvekar, Assistant Professor of Otolaryngology Head and Neck Surgery, Director of Clinical Research and the Salivary Endoscopy Service at LSU Health Sciences Center New Orleans, has reported the first use of a surgical robot guided by a miniature salivary endoscope to remove a 20mm salivary stone and repair the salivary duct of a 31-year-old patient. Giant stones have traditionally required complete removal of the salivary gland. Building upon their success with the combination of salivary endoscopic guidance with surgery, Dr. Walvekar and his ...

Living in a deprived area increases the risk of violence more sharply for girls than boys, according to a Cardiff University study of former industrial areas. The new results suggest violence prevention strategies need to focus more on local inequalities, especially to protect vulnerable adolescent girls. The survey was conducted by the Violence and Society Research Group at Cardiff University. The team studied nearly 700 young people, aged 11 to 17, who attended casualty departments in South Wales with injuries from violence. The researchers matched the patients against ...

INDIANAPOLIS – A potent anti-tumor gene introduced into mice with metastatic melanoma has resulted in permanent immune reconfiguration and produced a complete remission of their cancer, according to an article to be published in the December 2010 issue of the Journal of Clinical Investigation. The online version is now available. Indiana University School of Medicine researchers used a modified lentivirus to introduce a potent anti-melanoma T cell receptor gene into the hematopoietic stem cells of mice. Hematopoietic stem cells are the bone marrow cells that produce all ...

Many studies support the assertion that moderate drinking is beneficial when it comes to cardiovascular health, and for the first time scientists have discovered that a well-known molecule, called Notch, may be behind alcohol's protective effects. Down the road, this finding could help scientists create a new treatment for heart disease that mimics the beneficial influence of modest alcohol consumption. "Any understanding of a socially acceptable, modifiable activity that many people engage in, like drinking, is useful as we continue to search for new ways to improve ...

Scientists have simulated, for the first time, the merger of two black holes of vastly different sizes, with one mass 100 times larger than the other. This extreme mass ratio of 100:1 breaks a barrier in the fields of numerical relativity and gravitational wave astronomy. Until now, the problem of simulating the merger of binary black holes with extreme size differences had remained an unexplored region of black-hole physics. "Nature doesn't collide black holes of equal masses," says Carlos Lousto, associate professor of mathematical sciences at Rochester Institute ...

YAOUNDÉ, Cameroon (19 November 2010) – A new study finds a lack of transparency and corruption are reducing the impact of an initiative in Cameroon that channels a portion of national timber levies to rural forest communities. The study highlights the challenges of using a climate change pact to do something similar in forested regions around the world. In an article published in the peer-reviewed journal International Forestry Review, scientists at the Center for International Forestry Research (CIFOR) examined how revenues from a tax paid by logging companies in Cameroon, ...

Researchers from the Department of Cell Biology, Physiology and Immunology at Universitat Autònoma de Barcelona (UAB), in collaboration with researchers from the Institute of Microelectronics of Barcelona (IMB-CNM) of the Spanish National Research Council (CSIC), have developed an identification system for oocytes and embryos in which each can be individually tagged using silicon barcodes. Researchers are now working to perfect the system and soon will test it with human oocytes and embryos. The research, published online in Human Reproduction, represents a first step ...

Successfully treating and reversing the effects of multiple sclerosis, or MS, may one day be possible using a drug originally developed to treat chronic pain, according to Distinguished Professor Linda Watkins of the University of Colorado at Boulder. Watkins and her colleagues in CU-Boulder's department of psychology and neuroscience discovered that a single injection of a compound called ATL313 -- an anti-inflammatory drug being developed to treat chronic pain -- stopped the progression of MS-caused paralysis in rats for weeks at a time. Lisa Loram, a senior research ...

(Santa Barbara, Calif.) –– In nature, it's a dog-eat-dog world, even in the realm of bacteria. Competing bacteria use "toxic darts" to disable each other, according to a new study by UC Santa Barbara biologists. Their research is published in the journal Nature. "The discovery of toxic darts could eventually lead to new ways to control disease-causing pathogens," said Stephanie K. Aoki, first author and postdoctoral fellow in UCSB's Department of Molecular, Cellular, and Developmental Biology (MCDB). "This is important because resistance to antibiotics is on the rise." Second ...

Employee wellness programs have often been viewed as a nice extra, not a strategic imperative. But the data demonstrate otherwise, according to a team of researchers led by Leonard L. Berry of Texas A&M University, Ann M. Mirabito of Baylor University and William B. Baun of the University of Texas MD Anderson Cancer Center. Their research shows that the return on investment on comprehensive, well-run employee wellness programs is impressive — sometimes as high as six to one. The findings are compiled in a comprehensive piece in the December issue of Harvard Business ...

COLLEGE PARK, Md. -- On its recent trip by comet Hartley 2, the Deep Impact spacecraft took the first pictures of, and flew through, a storm of fluffy particles of water ice being spewed out by carbon dioxide jets coming from the rough ends of the comet. The resulting images and data shed new light on the nature and composition of comets, according to the University of Maryland-led EPOXI science team, which today announced its latest findings and released the first images of this comet created snowstorm. See images at: http://epoxi.umd.edu/index.shtml "When we visited ...

WASHINGTON, Nov. 18, 2010 — The latest episode in the American Chemical Society's (ACS) award-winning podcast series, "Global Challenges/Chemistry Solutions," focuses on development and successful initial tests of an inexpensive new filtering technology that kills up to 98 percent of disease-causing bacteria in water in just seconds without clogging. The technology could aid many of the almost one billion people lacking access to clean, safe drinking water. A report on the work appears in the American Chemical Society's monthly journal Nano Letters. Most water purifiers ...

(Boston) - Five U.S. federal agencies recently cosponsored a set of expert work groups to formulate common data elements for research related to psychological adjustment and traumatic brain injury (TBI). Danny G. Kaloupek, PhD, associate professor of psychiatry and behavioral neuroscience at Boston University School of Medicine, chaired the work group on posttraumatic stress disorder (PTSD). Dr. Kaloupek's work at the National Center for PTSD at VA Boston Healthcare helped to guide identification of key PTSD-related characteristics and evidence-based measures that might ...

MAYWOOD, Ill. -- Taking time off from certain osteoporosis drugs may be beneficial to bone health, according to a study conducted at Loyola University Health System. Researchers found that bone density remained stable for three years in patients who took a drug holiday from bisphosphonates, a popular class of osteoporosis drugs that can cause fractures in the thigh bones and tissue decay in the jaw bone. "These drugs are potentially harmful when taken for long durations, yet little has been known until now about the length of time osteoporosis patients should go without ...

COLUMBUS, Ohio – Residents of the Middle East who are heavy viewers of Arab television news networks like Al Jazeera are more likely to view their primary identity as that of Muslims, rather than as citizens of their own country, a new study suggests. Because networks like Al Jazeera are transnational – focusing on events of interest across the region rather than those in any one country – they may encourage viewers to see themselves in broader terms than simply residents of a particular nation, the researchers said. "The goal of these relatively new networks is not ...

A treatment model designed to accommodate the beliefs and concerns of Chinese immigrants appears to significantly improve the recognition and treatment of major depression in this typically underserved group. In a report in the December American Journal of Public Health, a Massachusetts General Hospital (MGH) research team describes how their model for screening and assessing patients for depression in a primary care setting increased the percentage of depressed patients entering treatment nearly sevenfold. "Ours is the first study to incorporate a culturally sensitive ...