The UK's National Physical Laboratory (NPL) with the University of Edinburgh and IBM's TJ Watson Research Center have published new research about the structure of an HIV-1 protein that could help to develop new drugs to stop the virus infecting healthy cells. The research provides a new insight into how the changes in structure of a small part of an HIV protein (a membrane proximal peptide) may alter the infection of the virus into healthy cells. The team was able to observe key changes in this part of the protein implicated in the early stages of the infection by using ...

A series of denials and a failure to formally investigate allegations of misconduct in Andrew Wakefield's MMR research meant the public was misled about the credibility of the paper for six years. Dr Fiona Godlee, BMJ Editor in Chief, says the UK has consistently failed to take research misconduct seriously. She calls on the UK government to establish mandatory oversight of clinical research integrity within the NHS, as happens for publicly funded research in the USA. "This case reveals major flaws in pre and post-publication peer review," she says. "Allegations of ...

According to the World Health Organisation (WHO), an estimated 322,000 deaths globally per year are linked to severe injuries from fire and in many of these cases death could have been avoided with surgical intervention. In this type of intervention, when major burn patients have insufficient skin left to graft on the most damaged part of their body, new skin has literally to be grown from the patient's own skin cells. However, the long delay in growing the skin can expose the burns patient to increased risk of infection and dehydration; so to help those cells to multiply, ...

Travel websites, especially those that offer 'last minute' deals, should inform people about the risks of malaria and the need to take preventative medication before travelling, say experts in infectious diseases today. Their warning, in a letter to this week's BMJ, follows three recent cases of malaria in UK citizens returning from 'winter sun' holidays to the Gambia, where malaria is highly endemic. They all used the same travel website. Two had made a late booking and all failed to take preventative drugs (chemoprophylaxis). Within two weeks of returning to the UK, ...

One of the most important predictions of Einstein's theory of General Relativity is the existence of black holes. The dynamics of these systems are not yet fully understood, but researchers from Queen Mary, University of London have now provided a rigorous way of determining the evolutionary stage of a black hole by analysing the region outside where matter cannot escape, the event horizon. Dr Thomas Bäckdahl and Dr Juan A. Valiente Kroon at Queen Mary's School of Mathematical Sciences have developed a method based on properties of the Kerr solution, a time-independent ...

Adults who suffer from attention-deficit and hyperactivity disorder (ADHD) are more than three times as likely to develop a common form of degenerative dementia than those without, according to research in the January issue of the European Journal of Neurology. Researchers from Argentina confirmed the link during a study of 360 patients with degenerative dementia and 149 healthy controls, matched by age, sex and education. The dementia patients comprised 109 people with dementia with Lewy bodies (DLB) and 251 with Alzheimer's. "Our study showed that 48 per cent of ...

Sharks are unable to distinguish colors, even though their close relatives rays and chimaeras have some color vision, according to new research by Dr. Nathan Scott Hart and colleagues from the University of Western Australia and the University of Queensland in Australia. Their study shows that although the eyes of sharks function over a wide range of light levels, they only have a single long-wavelength-sensitive cone* type in the retina and therefore are potentially totally color blind. Hart and team's findings are published online in Springer's journal Naturwissenschaften ...

Philadelphia, PA, 18 January 2011 - Biological Psychiatry is proud to announce this week's publication of a special issue focusing on postmortem studies of psychosis. This special issue showcases the use of human brains postmortem to study psychiatric disorders, focusing on schizophrenia. The review articles highlight the benefits, achievements, problems, and perhaps most importantly, the future of postmortem research. Postmortem research, which allows scientists to study the brain directly via its tissue, is difficult and expensive. Hence, it is a relatively rare avenue ...

Developing new drugs is a highly costly and time-consuming process. Of 20 candidates, 19 are normally rejected because they don't work or have unwanted side effects. Now a research team led by Professor Lars Baltzer at Uppsala University has produced a tiny molecular "binder" that has the potential to change this landscape radically. The study, published today in the prestigious journal Angewandte Chemie, presents the concept of a tiny polypeptide consisting of 42 amino acids to which virtually any target-seeking organic molecule can be bound. In the body it then seeks ...

WASHINGTON -- The first global simulation study of equatorial spread F (ESF) bubble evolution using a comprehensive 3D ionosphere model, SAMI3, has been demonstrated. The model self-consistently solves for the neutral wind driven dynamo electric field and the gravity driven electric field associated with plasma bubbles. Developed by Dr. Joseph Huba and Dr. Glenn Joyce at the NRL Plasma Physics Division, SAMI3 is a fully three-dimensional model of the low- to mid-latitude ionosphere. SAMI3 has been modified recently to use a sun-fixed coordinate system to eliminate rotation ...

Nutrients, vitamins, minerals – during pregnancy a woman's body needs more of them. For most nutrients this increase in demand can be covered with a balanced diet. However, mothers-to-be should ingest some nutrients in the form of tablets. Research conducted by the Chair of Nutritional Medicine at the Technische Universitaet Muenchen (TUM) indicates there are knowledge gaps: According to this study, pregnant women often start taking sensible dietary supplements too late or not at all. At the same time, other micronutrients are unwittingly overdosed whose effects during ...

Researchers at the University of Warwick have developed the world's first complete High Dynamic Range (HDR) video system, from video capture to image display, that will help a range of users including: surveillance camera operators, surgeons using video to conduct or record surgery, and camera crews following a football being kicked from sunshine into shadow. The researchers will be premiering footage of the world's first ever showing of a short film shot using this new HDR technology in the WMG Digital Laboratory at the University of Warwick on Wednesday January 19 ...

Controlling blood pressure is not only a medical challenge, but a social one as well. Because patients are required to strictly adhere to a treatment plan that may include medication, dietary restrictions and regular doctor visits, the ideas of wellness and health are also powerful parts of the social reinforcement needed for behavioral change. This is especially true in the African American population, which is particularly susceptible to hypertension. Social and cultural barriers have been found to contribute to African American patients being far more likely than white ...

New research by a team of psychologists from Canada, Belgium, and the United States shows there is more than a literal truth to the saying that 'you never get a second chance to make a first impression'. The findings suggest that new experiences that contradict a first impression become 'bound' to the context in which they were made. As a result, the new experiences influence people's reactions only in that particular context, whereas first impressions still dominate in other contexts. "Imagine you have a new colleague at work and your impression of that person is not ...

Boston, Mass. — Following a successful Phase 1 study for safety, researchers at MassBiologics of the University of Massachusetts Medical School (UMMS) today announced the beginning of a Phase 2 clinical trial testing the ability of a human monoclonal antibody they developed to prevent hepatitis C virus (HCV) infection of a donor liver in transplant patients. The first patients were enrolled in the study in December. The primary goal of this randomized, double-blind, placebo-controlled study is to test if the monoclonal antibody, designated MBL-HCV1, prevents re-infection ...

Montreal, January 18, 2011 – Does experience give seniors an edge in reacting to sudden change or are younger people quicker to respond? A new study from Concordia University shows that when a routine task is interrupted by an unexpected event, younger adults are faster at responding. Published in the Journal of Gerontology, the findings have implications for educators and for older adults in situations where performance is crucial. "When we frequently perform a task, our reactions become automatic," says Kevin Trewartha, first author and a PhD student in Concordia's ...

Key components of the ESA-led Mercury mapper BepiColombo have been tested in a specially upgraded European space simulator. ESA's Large Space Simulator is now the most powerful in the world and the only facility capable of reproducing Mercury's hellish environment for a full-scale spacecraft. The Mercury Magnetospheric Orbiter (MMO) has survived a simulated voyage to the innermost planet. The octagonal spacecraft, which is Japan's contribution to BepiColombo, and its ESA sunshield withstood temperatures higher than 350°C. This is a taste of things to come for the ...

Montreal, January 18, 2011 – Cyndia Charfi, a Ph. D student in biology at Université du Québec à Montréal (UQAM), supported by her thesis supervisors, Professor Éric Rassart, and Adjunct Professor Elsy Edouard, UQAM, Department of Biological Sciences and BIOMED Research Centre, made a major breakthrough in research on B-cell acute lymphocytic leukemia, a disease that occurs most commonly in children. She has successfully identified a gene that may facilitate the diagnosis of this cancer, which is characterized by an abnormal proliferation of B-cells, antibody-producing ...

Privacy in the digital age is a sensitive issue for both governments and individuals, as recent news about WikiLeaks and Facebook proved. A new research project at Tel Aviv University may better educate citizens of the virtual world about their privacy -- and even help Facebook users avoid truly embarrassing moments. It's all about fine-tuning privacy settings based on user information and behavior, says Dr. Eran Toch of Tel Aviv University's Iby and Aladar Fleischman Faculty of Engineering. His software solution, Locacino, is based on better security design, and provides ...

18 January 2011 - A recent study by Merikangas and colleagues published in the January 2011 issue of the Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP) shows that only half of adolescents that are affected with severely impairing mental disorders ever receive treatment for their disorders. The researchers found that approximately one third of adolescents with any mental disorder received services for their illness (36.2%). Disorder severity was significantly associated with an increased likelihood of receiving treatment, yet only half of ...

Changes within deep regions of the brain can now be visualized at the cellular level, based on research on mice, which was funded by the National Institutes of Health. Published Sunday in Nature Medicine, the study used a groundbreaking technique to explore cellular-level changes over a period of weeks within deep brain regions, providing a level of detail not possible with previously available methods. The study was supported by the National Institute on Drug Abuse (NIDA), the National Cancer Institute, and the National Institute of Neurological Disorders and Stroke. Researchers ...

The first letter of our childhood surname determines much about our consumer behavior as grownups, according to a new study in the Journal of Consumer Research. Why are some people more likely than others to wait in line overnight to buy a just-released book or to queue up for the new iPad? "The tendency to act quickly to acquire items such as those above is related to the first letter of one's childhood surname," write authors Kurt A. Carlson (Georgetown University) and Jacqueline M. Conard (Belmont University). The authors studied how quickly adults responded to opportunities ...

When we don't feel confident about our government, we choose indirect ways of showing support, like buying U.S. based products, according to a new study in the Journal of Consumer Research. "Today, we can barely watch television for any length of time without hearing about verbal attacks on the government, or a given religion or education system," write authors Keisha M. Cutright (Duke University), Eugenia C. Wu (Cornell University), Jillian C. Banfield (University of Waterloo), Aaron C. Kay (Duke University), and Gavan J. Fitzsimons (Duke University). The results ...

At least one in five horses used for leisure are overweight or obese. It's a condition which can lead to laminitis and equine metabolic syndrome. The pilot study, carried out by The University of Nottingham's School of Veterinary Medicine and Science, showed that rates of obesity among horses are likely to be just as high as they are among people. The results are published online on Monday 17 January 2011 in the journal Veterinary Record. The study, by third year veterinary student Helen Stephenson from Lydney in Gloucestershire, assessed the prevalence of obesity among ...

Over the last few years, researchers have used a type of brain scanning, known as functional magnetic resonance imaging fMRI, to help them map changes in blood flow in the brain and to correlate this with thoughts and behavior. A new way to analyze fMRI data, which could improve is reported in the International Journal of Computational Biology and Drug Design. Scientists have known since the 1890s that changes in blood flow and blood oxygenation in the brain (hemodynamics) are correlated with activity in brain cells, neurons. When a neuron is active it needs more energy ...