An analysis of previous studies indicates that compared with chemotherapy alone, use of the cancer drug bevacizumab in combination with chemotherapy or biological therapy is associated with an increased risk of treatment-related death, according to an article in the February 2 issue of JAMA. A fatal adverse event (FAE) is defined as a death caused in all likelihood by a drug and is a major cause of fatality in the United States. Bevacizumab was approved in combination with chemotherapy for treating many types of advanced cancer, including colorectal cancer, non-small ...

An analysis of data from more than 90,000 Medicare managed care enrollees who received care for rheumatoid arthritis finds that more than one-third did not receive the recommended treatment with a disease-modifying antirheumatic drug, and that receipt varied by demographic factors, socioeconomic status, geographic location and health plan, according to a study in the February 2 issue of JAMA. Despite evidence-based guidelines recommending early and aggressive treatment of active rheumatoid arthritis (RA), recent population-based studies of disease-modifying antirheumatic ...

SALT LAKE CITY—As day-old embryos, fruit flies called Drosophila enter a stage in which their cells freely divide and proliferate as the insect grows dramatically in size. This is true for all animals, which undergo most of their growth prior to sexual maturation. Until now, researchers have known nothing about the metabolic state that occurs when cells divide during early development. But in a study published online Tuesday, Feb. 1, 2011, in Cell Metabolism, University of Utah human genetics researchers show that this cell division in Drosophila depends on a metabolic ...

PHILADELPHIA—Medical physicists at Thomas Jefferson University and Jefferson's Kimmel Cancer Center have demonstrated a new real-time tumor tracking technique that can help minimize the amount of radiation delivered to surrounding healthy tissue in a patient—up to 50 percent less in some cases—and maximize the dose the tumor receives. Respiratory and cardiac motions have been found to displace and deform tumors in the lung, pancreas, liver, breast, and other organs. Because of this, radiation oncologists must expand the margin during radiotherapy. Consequently, a large ...

BOSTON – For-profit hospice agencies had a higher percentage of patients with diagnoses associated with less skilled care and longer lengths of stay (LOS) in hospice, than their nonprofit counterparts, a difference that may leave "nonprofit hospice agencies disproportionately caring for the most costly patients," Beth Israel Deaconess Medical Center researchers report. The findings appear in the Feb.2 issue of the Journal of the American Medical Association (JAMA). "There was a big increase in the number of for-profit hospice agencies from 2000 to 2007, and previous ...

As Internet authorities prepare to announce that they have handed over all of the available addresses, a USC research group that monitors address usage has completed the latest in its series of Internet censuses. There is some good news, according to computer scientist John Heideman, who heads a team at the USC Viterbi School of Engineering Information Sciences Institute that has just released its results in the form of a detailed outline, including a 10-minute video and an interactive web browser that allows users to explore the nooks and crannies of Internet space themselves. video: ...

"Look to the ant thou sluggard and consider her ways and be wise." This proverbial wisdom was taken to heart recently by an international group of ant experts who have published the genome sequences of four ants in a series of coordinated releases in the journal Proceedings of the National Academy of Sciences (PNAS). The quartet includes the genomes of the red harvester ant Pogonomyrmex barbatus; the Argentine ant Linepithema humile; the fire ant Solenopsis invicta, and the leaf-cutter ant Atta cephalotes, whose genome will be published on Feb. 10 in Public Library of Science ...

In a global recession, most people are thankful to have a job, but a new study published in Interdisciplinary Environmental Review suggests that employees are more likely to be satisfied with their jobs if they are working for a company that is perceived to be "green", whereas the financial performance of companies fails to correlate with employee happiness. Cassandra Walsh and Adam Sulkowski, both of the Charlton College of Business at University of Massachusetts Dartmouth, wanted to know whether employee morale is typically affected when a company is perceived as taking ...

Researchers from the Institute of Biotechnology and Biomedicine and the UAB Department of Biochemistry and Molecular Biology have developed and patented a method using Saccharomyces cerevisiae yeast to detect in human proteins the formation of oligomers, small toxic aggregations of molecules which can initiate the assembly of amyloid fibres found in neurodegenerative diseases. The test allows validating the efficacy of compounds which could dissolve or inhibit these aggregates, as well as studying at basic level the therapeutic potentiality of a large number of molecules. ...

Invasive plant species present a serious environmental, economic and social problem worldwide as their abundance can lead to lost native biodiversity and ecosystem functions, such as nutrient cycling. Despite substantial research, little is known about why some species can dominate new habitats over native plants that technically should have the advantage. A common but rarely tested assumption is that these plants are more abundant in introduced versus native communities, because they are behaving in special way. If this true and introduced species are behaving in a special ...

Philadelphia, PA, 1 February 2011 - Opiate abuse is a chronic disorder and maintaining abstinence represents a major challenge for addicts. Individuals recovering from opiate dependence have long reported that while the acute withdrawal symptoms from opiates may pass relatively quickly, they do not feel quite right for several weeks or even months thereafter. Called the "protracted abstinence syndrome," this cluster of vague depressive-like symptoms can include reduced concentration, low energy level, poor sleep quality, and anhedonia. New data in animals, reported ...

Researchers funded by the Biotechnology and Biological Sciences Research Council (BBSRC) have revealed a novel molecular mechanism that triggers plant infection by Pseudomonas syringae, the bacteria responsible for bacterial speck in tomatoes. The scientists from the Department of Life Sciences at Imperial College London have revealed how two genes in the bacteria work together to launch the infection process that ultimately kills the plant's cells and causes disease, significantly reducing crop quality and yield. Pseudomonas syringae is responsible for major disease ...

Evidence is steadily mounting that genetic factors play an important role in many cases of Parkinson's disease (PD). In a study published February 2, 2011, online in the Journal of Neuroscience, researchers from the Ecole Polytechnique Fédérale de Lausanne (EPFL) in Switzerland report a new mammalian model for studying a specific gene mutation commonly found in PD sufferers, opening the door to new drugs to fight the malady. "This is a great step forward toward a more comprehensive understanding of how the disease works, and how it can be diagnosed and treated," explains ...

"Our study proves that one of the leading factors affecting progress in Spanish productivity is the high rate of temporary hiring among workers in highly technologically intense industries. These sectors are also those that most contribute to overall productivity growth (of all sectors) in the country's economy", Bienvenido Ortega, co-author of the study and a researcher at the UMA, tells SINC. The 1984 overhaul of Spain's employment legislation led to the possibility of various forms of temporary contracting, and since further reforms in 1994, 1997 and 2001, the use ...

Jerusalem, February 1, 2011-- Research carried out at the Hebrew University of Jerusalem shows that it was possible already in 2008 to predict that countries such as Egypt and Iran were headed for dangerous periods of instability because of citizens' demands for democratization. The researchers were able to make this observation on the basis of a "democratic gap" scale of measurement between the level of freedom existing and the desire of citizens for more freedom, which was analyzed in about 90 countries around the world. In their research, Prof. Tamir Sheafer ...

With the number of norovirus infection cases rising across the country, scientists from the University of Southampton have successfully crystallised a key norovirus enzyme, which could help in the development of a norovirus treatment. Noroviruses are recognised world-wide as the most important cause of epidemic nonbacterial gastroenteritis (stomach bugs) and pose a significant public health burden, with an estimated one million cases per year in the UK. In the past, noroviruses have also been called 'winter vomiting viruses'. By crystallising the key protease enzyme, ...

Amsterdam, 1 February 2011 - Elsevier announced today the publication of two further important position statements from the European Menopause and Andropause Society (EMAS) in the journal Maturitas (http://www.maturitas.org/ ) on common management problems in the post-reproductive health of women. EMAS is providing clear guidance in its position statements covering both hormone and non hormone therapy (HT) options as well as complementary and alternative therapies . The latest two position statements cover the management of the menopause in the context of Cardiovascular ...

As the team of scientists behind NASA's MESSENGER spacecraft eagerly awaits the craft's entry into Mercury's orbit on 17 March, we could soon get answers to questions about the origin, composition, interior structure and geological history of this mysterious planet. Louise Prockter, deputy project scientist on the mission, writes exclusively in February's Physics World about the challenges the craft has been designed to face, the early successes of the mission and her own triumphant voyage over the past decade's work. A journey to Mercury faces once-thought insurmountable ...

"This is no cartoon. It's a real molecule, with all the interactions taking place correctly," said Anatoly Kolomeisky as he showed an animation of atoms twisting and turning about a central hub like a carnival ride gone mad. Kolomeisky, a Rice University associate professor of chemistry, was offering a peek into a molecular midway where atoms dip, dive and soar according to a set of rules he is determined to decode. Kolomeisky and Rice graduate student Alexey Akimov have taken a large step toward defining the behavior of these molecular whirligigs with a new paper ...

The study also found that Russian speakers had a better grasp of Hebrew than Hebrew speakers themselves. "Learning a mother tongue and preserving it does not compromise the ability to learn an additional language. The opposite is true: Knowing Russian enforces Hebrew fluency and command of both languages increases skills in English," the researchers noted. Bilinguals find it easier to learn a third language, as they gain a better aptitude for languages, a new study from the University of Haifa reveals. Prof. Salim Abu-Rabia and Ekaterina Sanitsky of the Department of ...

AUGUSTA, Ga. – A new compound appears to prevent the traffic jam of cells that causes debilitating pain crises and associated mortality in sickle cell disease, Georgia Health Sciences University (formerly Medical College of Georgia) researchers report. The aptamer, developed by Archemix Corporation in Cambridge, Mass., appears to work by occupying sticky receptors lining the walls of small blood vessels where sickle-shaped red blood cells and white blood cells can pile up, according to the study published in Blood. The cell traffic jam occludes blood and oxygen flow, ...

Sustained high vaccination coverage is key to preventing deaths from measles. Despite the availability of a vaccine, measles remains an important killer of children worldwide, particularly in less-developed regions where vaccination coverage is limited. A team of researchers, led by scientists at the Johns Hopkins Bloomberg School of Public Health and the University of Colorado, developed and successfully tested a dry powder, live-attenuated measles vaccine that can be inhaled. The novel vaccine was studied in rhesus macaques. Results of the study are published in the January ...

Many plants produce toxic chemicals to protect themselves against plant-eating animals, and many flowering plants have evolved flower structures that prevent pollinators such as bees from taking too much pollen. Now ecologists have produced experimental evidence that flowering plants might also use chemical defences to protect their pollen from some bees. The results are published next week in the British Ecological Society's journal Functional Ecology. In an elegant experiment, Claudio Sedivy and colleagues from ETH Zurich in Switzerland collected pollen from four plant ...

For some plastic surgery patients, expectations are unrealistically high. Basing their hopes on the before-and-after albums offered in surgeons' offices, they expect to achieve a perfect body or to look just like a favorite celeb. But those albums only show how someone else's liposuction, breast augmentation, or Beyonce bum enhancement turned out. Now a Tel Aviv University researcher is developing software based on real clinical data to give patients a more accurate — and three-dimensional — before-and-after picture before the scalpel comes down. Tackling a very difficult ...

Scientists discovered a new way breast cancer cells dodge the immune system and promote tumor growth, providing a fresh treatment target in the fight against the disease. While comparable mechanisms to avoid the immune system have been identified in mice with breast and other cancers, the study tested human breast tumor cells, putting researchers closer to understanding how the disease progresses in real patients. The study, published in the journal Cancer Research, found high levels of the protein Hsp27 (heat shock protein 27) are released from human breast cancer cells ...