### Gold, L., et al. (2010). “Aptamer-based multiplexed proteomic technology for biomarker discovery,” PLoS One. Available online at http://dx.plos.org/10.1371/journal.pone.0015004 Ostroff, R. et al. (2010). “Unlocking biomarker discovery: Large scale application of aptamer proteomic technology for early detection of lung cancer.” PLoS One. Available online at http://dx.plos.org/10.1371/journal.pone.0015003 About SomaLogic, Inc. SomaLogic, Inc., is a privately held biomarker discovery and clinical proteomics company based in Boulder, Colorado. The company's mission ...

A UCSF research collaboration with GE Healthcare has produced the first results in humans of a new technology that promises to rapidly assess the presence and aggressiveness of prostate tumors in real time, by imaging the tumor's metabolism. This is the first time researchers have used this technology to conduct real-time metabolic imaging in human patients and represents a revolutionary approach to assessing the precise outlines of a tumor, its response to treatment and how quickly it is growing. Data on the first four patients are being presented today at the Radiology ...

AMES, Iowa – Researchers from Iowa State University and the Ames Laboratory have developed a process capable of producing a thin and uniform light-absorbing layer on textured substrates that improves the efficiency of polymer solar cells by increasing light absorption. "Our technology efficiently utilizes the light trapping scheme," said Sumit Chaudhary, an Iowa State assistant professor of electrical and computer engineering and an associate of the U.S. Department of Energy's Ames Laboratory. "And so solar cell efficiency improved by 20 percent." Details of the fabrication ...

(Santa Barbara, Calif.) –– A ballet dancer grasps her partner's hand to connect for a pas de deux. Later that night, in the dark, she reaches for her calf to massage a sore spot. Her brain is using different "maps" to plan for each of these movements, according to a new study at UC Santa Barbara. In preparing for each of these reaching movements, the same part of the dancer's brain is activated, but it uses a different map to specify the action, according to the research. Planning to hold hands is based on her visual map of space. Her second plan, to reach for her calf, ...

DENVER (December 2, 2010) – Fresh water and reusable energy. Humans are on a constant hunt for a sustainable supply of both. Water purification requires a lot of energy, while utility companies need large amounts of water for energy production. Their goal is to find a low-energy-required treatment technology. Researchers from the University of Colorado Denver College of Engineering and Applied Science may have discovered an answer. Last year, a study published in Environmental Science & Technology incorporated desalination into microbial fuel cells, a new technology ...

Madrid, 2 december 2010.- Spanish Oncology has established a new standard treatment for Breast Cancer at early stages thanks to the results of the study 9805/Target 0 funded by Spanish Breast Cancer Research Group (GEICAM) and sponsored by Sanofi Aventis. More than thousand patients and 50 hospitals participated in the study, whose findings are reported in the latest issue of The New England Journal of Medicine. Results indicate that docentaxel during quimotherapy reduces the risk of recurrence by 32% in women with high-risk but node-negative, early stage breast cancer ...

Agricultural – or Neolithic – economics replaced the Mesolithic social model of hunter-gathering in the Near East about 10,000 years ago. One of the most important socioeconomic changes in human history, this socioeconomic shift, known as the Neolithic transition, spread gradually across Europe until it slowed down when more northern latitudes were reached. Research published today, Friday, 3 December 2010, in New Journal of Physics (co-owned by the Institute of Physics and the German Physical Society), details a physical model, which can potentially explain how the spreading ...

The use of androgen suppression therapy (AST) in prostate cancer for low-risk cases declined following a decrease in physician reimbursement, according to a study published online TK in The Journal of the National Cancer Institute. However, the indicated use of AST for metastatic disease in the palliative setting did not decline in the same period. The use of AST in prostate cancer increased more than threefold between 1991 and 1999 both for patients with metastatic cancer and those with low-risk disease, but AST treatment in the latter group has not been shown to improve ...

Randomized phase III studies should be designed to find out whether a new drug or treatment makes a meaningful difference in patients' survival or quality of life, according to a commentary published online December 3rd in The Journal of the National Cancer Institute. Instead, most trials now are designed to detect a statistically significant difference between treatment and control groups, which may not be clinically meaningful, write Alberto Ocana, M.D., Ph.D. and Ian F. Tannock, M.D., Ph.D., of Princess Margaret Hospital in Toronto. Regulatory agencies such as the ...

Improved standards for outcome reporting in breast reconstruction are needed, according to a review published online December 3rd in The Journal of the National Cancer Institute. Every year in the United States up to 40% of women with breast cancer undergo a mastectomy. They say the most valuable factor in their decision-making is information from health professionals. However, that information is largely dependent on the quality, reporting, and interpretation of research data on surgical procedures. To summarize the reporting standards of surgical outcomes in breast ...

While questions persist about the best ways to detect breast cancer early, a CT imaging system developed at the University of Rochester Medical Center and first unveiled five years ago is in a better position today to enter the fray -- at least in a supporting role to conventional mammography. URMC radiologist Avice O'Connell, M.D., was invited to summarize the studies conducted thus far on the Cone Beam Computed Tomography (CBCT) scanner, at the Radiological Society of North America Annual Scientific Assembly in Chicago at 8:30 a.m. (EST) on Friday, December 3, 2010. O'Connell ...

When doctors want their patients asleep during surgery they gently turn the gas tap. But Anaesthetic gasses have a global warming potential as high as a refrigerant that is on its way to being banned in the EU. Yet there is no obligation to report anaesthetic gasses along with other greenhouse gasses such as CO2, refrigerants and laughing gas. One kilo of anaesthetic gas affects the climate as much as 1620 kilos of CO2. That has been shown by a recent study carried out by chemists from University of Copenhagen and NASA in collaboration with anaesthesiologists from the ...

Tampa, FL (Dec. 3, 2010) -- Dynamic regulation of the chaperone protein Hsp27 was required to get rid of abnormally accumulating tau in the brains of mice genetically modified to develop the memory-choking tau tangles associated with Alzheimer's disease, a University of South Florida-led study found. Researchers at the USF Health Byrd Alzheimer's Institute demonstrated that the effective switching of Hsp27 between its active and deactivated states was critical on two fronts -- to promote the recycling of the tau protein in healthy nerve cells and to clear abnormal tau ...

Could information technology and data mining techniques be used to improve the diagnosis and treatment of depression? That's the question scientists in Australia hope to have answered in a forthcoming issue of the International Journal of Functional Informatics and Personalised Medicine. Maja Hadzic, Fedja Hadzic and Tharam Dillon of the Digital Ecosystems and Business Intelligence Institute, at Curtin University of Technology, in Perth, explain how depression is rapidly emerging as one of the major health problems now facing society. They add that the World Health Organization ...

YANG Nan, MAO ZongWan and SUN HongZhe et al., at the Department of Chemistry, University of Hong Kong and Sun Yat-sen University have characterized a series of bismuth citrate complexes by X-ray crystallography and modeled the structure of ranitidine bismuth citrate, a medicine used widely for the treatment of peptic ulcer and gastric reflux disease. The polymeric framework of bismuth citrate may serve as a "drug carrier" for delivery of other drugs in the human body. This significant contribution is reported in SCIENCE CHINA Chemistry 2010, 53(10). Elements that possess ...

Scientists have discovered that the alteration of a single gene could cause some male embryos to develop as females. The breakthrough will improve diagnosis and clinical management of patients with disorders of sex development (DSD). These conditions occur when the testis or ovary does not develop properly in the embryo, causing genital abnormalities in one in 4500 babies. An international team including researchers from the Murdoch Childrens Research Institute and the University of Melbourne identified the gene alteration in a group of patients including two families ...

The Web surfing history saved in your Web browser can be accessed without your permission. JavaScript code deployed by real websites and online advertising providers use browser vulnerabilities to determine which sites you have and have not visited, according to new research from computer scientists at the University of California, San Diego. The researchers documented JavaScript code secretly collecting browsing histories of Web users through "history sniffing" and sending that information across the network. While history sniffing and its potential implications for ...

Our research at the State Key Laboratory of Palaeobiology and Stratigraphy, Nanjing Institute of Geology and Palaeontology, has shown, based on a refined division and correlation of the graptolite-bearing strata in southern Jiangxi, China, that the Kwangsian Orogeny commenced in the early Katian Age of the Late Ordovician. Because of its significant research value, this study is published in Issue 11 of Science China Earth Sciences. An angular unconformity separating the Lower-Middle Devonian and underlying strata is widespread in the Zhujiang region of South China, and ...

Mumbai, India – The International Rice Research Institute (IRRI) and the Asia Society launched a new food security report for Asia in Mumbai today, calling for increased investment in rice research. The report, Never an empty bowl: sustaining food security in Asia, emphasizes the importance of rice as the primary staple food in Asia and a major source of income for Asian farmers. Existing global efforts to combat hunger and achieve food security are evaluated in the report, which also recommends more research on: climate change mitigation for farming, farming infrastructure, ...

VIDEO: Hit it hard and it will fracture like a solid, but tilt it slowly and it will flow like a fluid. This is the intriguing property of a type of... Click here for more information. The new findings will be highly useful to the manufacturing industry because the processing and dispensing of everyday products like toothpaste, cosmetics, pharmaceuticals and foodstuffs depends on an understanding of the physical properties and behaviours of these fluids. The research ...

Scientists studying a column of Antarctic ice spanning 650 years have found evidence for fluctuations in biomass burning--the consumption of wood, peat and other materials in wildfires, cooking fires and communal fires--in the Southern Hemisphere. The record, focused primarily on carbon monoxide (CO), differs substantially from the record in the Northern Hemisphere, suggesting changes may be necessary for several leading climate models. The research appears in Science on Dec. 2, 2010, in an early online release. The scientists studied variations in stable (non-radioactive, ...

A new report recently released by the National Science Foundation, titled "Doctorate Recipients from U.S. Universities: 2009," presents a statistical overview of the U.S. doctoral education system in snapshots and long-term trends. It notes the American system of doctoral education is widely considered the world's best, as evidenced by the large number of international students who choose to pursue a doctorate at U.S. universities. But this status is subject to the many factors that shape U.S. doctoral education. "Given the increased global engagement and economic prosperity ...

Researchers at Northwestern University have created a new infrared camera based on Type-II InAs/GaSb superlattices that produces much higher resolution images than previous infrared cameras. Created by Manijeh Razeghi, Walter P. Murphy Professor of Electrical Engineering and Computer Science, and researchers in the Center for Quantum Devices in the McCormick School of Engineering and Applied Science, the long wavelength infrared focal plane array camera provides a 16-fold increase in the number of pixels in the image and can provide infrared images in the dark. Their ...

Researchers at Northwestern University have nanoengineered a new kind of fiber that could be tougher than Kevlar. Working in a multidisciplinary team that includes groups from other universities and the MER Corporation, Horacio Espinosa, James N. and Nancy J. Farley Professor in Manufacturing & Entrepreneurship at the McCormick School of Engineering and Applied Science, and his group have created a high performance fiber from carbon nanotubes and a polymer that is remarkably tough, strong, and resistant to failure. Using state-of-the-art in-situ electron microscopy testing ...

Personalized medicine centers on being able to predict the risk of disease or response to a drug based on a person's genetic makeup. But a study by scientists at Washington University School of Medicine in St. Louis suggests that, for most common diseases, genes alone only tell part of the story. That's because the environment interacts with DNA in ways that are difficult to predict, even in simple organisms like single-celled yeast, their research shows. "The effects of a person's genes – and, therefore, their risk of disease – are greatly influenced by their environment," ...