Discovery from the lab of Youyang Zhao, PhD, from Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago offers promising treatment approaches for acute respiratory distress syndrome (ARDS) in the elderly that can be caused by severe COVID-19, pneumonia, flu or sepsis. Currently there are no pharmacological or cell-based treatments for ARDS. Dr. Zhao’s research established that a gene called FOXM1 is important in the repair of blood vessel through regeneration of endothelial cells, which line the vessels of the lung. He found that aging impairs this gene’s expression, ...

Could future opioid overdoses, fatalities and other harms of opioid addiction be prevented if hospital emergency departments made better use of effective medications for opioid addiction? A team of University of Michigan researchers thinks so.  Led by Thuy Nguyen of U-M's School of Public Health, the researchers analyzed national Medicaid claims data of patients ages 12 to 64 treated at U.S. emergency departments for opioid overdoses in 2018. They focused on ED visits for opioid overdose and the rate of initiation of FDA-approved medications for opioid addiction, including buprenorphine, methadone and extended release naltrexone.  The ...

Among adults with chronic kidney disease (CKD) enrolled in the Chronic Renal Insufficiency Cohort (CRIC), young age, Black race, and low levels of education and income were associated with lower likelihood of getting an annual flu shot. Identifying risk factors for not receiving a flu vaccine (“non-vaccination”) in people living with kidney disease, who are at risk of flu and its complications, could inform strategies for improving vaccine uptake. In this study published in the American Journal of Kidney Diseases (AJKD), researchers led by Junichi Ishigami examined whether demographic factors, social ...

In recent years, cancer researchers have hailed the arrival of chimeric antigen receptor T cell (CAR T) therapy, which has delivered promising results, transforming the fight against various forms of cancer. The process involves modifying patients’ T-cells to target cancer cells, resulting in remarkable success rates for previously intractable forms of cancer. Six CAR T cell therapies have secured FDA approval, and several more are in the pipeline. However, these therapies come with severe and potentially lethal side effects, namely cytokine release syndrome (CRS) and neurotoxicity. These drawbacks manifest as a range of symptoms—from high fever and vomiting to multiple ...

EMBARGOED: September 18, 2023 4PM EST CONTACT:  Nicole Oliverio, nicole_oliverio@dfci.harvard.edu, 617-257-0454 Boston – An innovative phase 2 clinical trial led by Dana-Farber Cancer Institute in collaboration with 10 major brain tumor centers around the country and designed to find new potential treatments for glioblastoma has reported initial results in the Journal of Clinical Oncology. While none of the three therapeutics tested so far improved overall survival of patients, this adaptive platform trial, the first of its kind in neuro-oncology, has the potential to rapidly and efficiently identify therapies that ...

A new study looks at the impact of learning environments on the academic success of racialized students. Compared to their peers, these students feel they have less control in their academic environment, less confidence and self-efficacy in their academic abilities, and weaker connections to other students and professors. The University of Ottawa study underscores that higher education institutions must recognize and address the specific needs of their racialized student communities and create inclusive learning environments that better meet these needs. Failing to do so could affect the overall psychological well-being and academic performance ...

The use of cell therapy to treat COVID-19 patients can reduce the risk of death from the disease by 60%, according to a systematic review and meta-analysis conducted by researchers at the University of São Paulo (USP) in Brazil, in partnership with colleagues in Germany and the United States. Their findings are reported in an article published in the journal Frontiers in Immunology. The review covers 195 clinical trials of advanced cell therapies targeting COVID-19 that were conducted in 30 countries between January 2020 and December 2021, as well as 26 trials with outcomes published by July 2022. Cell therapy has come into increasingly frequent use in recent years ...

Climate change is causing extinctions at an increasing rate, a new study by the University of Arizona researchers shows. They surveyed populations of the Yarrow's spiny lizard in 18 mountain ranges in southeastern Arizona and analyzed the rate of climate-related extinction over time. "The magnitude of extinction we found over the past seven years was similar to that seen in other studies that spanned almost 70 years," said John J. Wiens, a professor in the Department of Ecology and Evolutionary Biology at UArizona, ...

Reston, VA—A new 225Ac-DOTA-based pre-targeted radioimmunotherapy (PRIT) system has been shown to cure a highly lethal form of advanced intraperitoneal ovarian cancer in a preclinical setting with minimal side effects. Targeting the HER2 protein, which is commonly expressed in ovarian cancer, the therapy (anti-HER2 225Ac-PRIT) is a potential treatment for the otherwise incurable disease. This research was published in the September issue of The Journal of Nuclear Medicine. Epithelial ovarian cancer is the most lethal ovarian cancer and frequently presents as advanced-stage disease, ...

EMBARGOED FOR RELEASE UNTIL September 18, 2023 at 3:00 PM U.S. Eastern time As the days get shorter and chillier in the northern hemisphere, those who choose to work out in the mornings might find it harder to get up and running. A new study in PNAS identifies a protein that, when missing, makes exercising in the cold that much harder—that is, at least in fruit flies. A team from University of Michigan Medical School and Wayne State University School of Medicine discovered the protein in flies, which they named Iditarod after the famous long distance dog sled across Alaska, while studying metabolism and the effect of stress on the body. They were particularly ...

Living things act with purpose. But where does purpose come from? How do humans make sense of their relation to the world and realize their ability to effect change? These fundamental questions of agency – acting with purpose – have perplexed some of the greatest minds in history including Sir Isaac Newton, Charles Darwin, Erwin Schrödinger and Niels Bohr. A Florida Atlantic University study reveals groundbreaking insight into the origins of agency using an unusual and largely untapped source – human babies. Since goal-directed action appears in the first months ...

The passenger pigeon. The Tasmanian tiger. The Baiji, or Yangtze river dolphin. These rank among the best-known recent victims of what many scientists have declared the sixth mass extinction, as human actions are wiping out vertebrate animal species hundreds of times faster than they would otherwise disappear. Yet, a recent analysis from Stanford University and the National Autonomous University of Mexico, published this week in the Proceedings of the National Academy of Sciences, shows the crisis may run even deeper. Each of the three species above was also the ...

CAMBRIDGE, MA -- One promising approach to treating Type 1 diabetes is implanting pancreatic islet cells that can produce insulin when needed, which can free patients from giving themselves frequent insulin injections. However, one major obstacle to this approach is that once the cells are implanted, they eventually run out of oxygen and stop producing insulin. To overcome that hurdle, MIT engineers have designed a new implantable device that not only carries hundreds of thousands of insulin-producing islet cells, but also has its own on-board oxygen factory, which generates oxygen by splitting water vapor found in the body. The researchers showed that when ...

Some 2,000 years ago in ancient Rome, glass vessels carrying wine or water, or perhaps an exotic perfumes, tumble from a table in a marketplace, and shatter to pieces on the street. As centuries passed, the fragments were covered by layers of dust and soil and exposed to a continuous cycle of changes in temperature, moisture, and surrounding minerals. Now these tiny pieces of glass are being uncovered from construction sites and archaeological digs and reveal themselves to be something extraordinary. On their surface is a mosaic of iridescent colors of blue, green and orange, with some displaying shimmering gold-colored ...

Accurate phylogenetic trees are fundamental to evolutionary and comparative biology, but the almost simultaneous emergence of major animal phyla and diverse body plans during the Cambrian Explosion poses major challenges to reconstructing deep metazoan phylogenetic relationships. This is particularly true for the second largest phylum, Mollusca, whose major lineages originated in the Cambrian period. The diverse fossil record, extreme morphological disparity among the eight living classes, and dramatic conflict among phylogenetic hypotheses due to diverse paleontological, ...

ITHACA, N.Y. – Remote workers can have a 54% lower carbon footprint compared with onsite workers, according to a new study by Cornell University and Microsoft, with lifestyle choices and work arrangements playing an essential role in determining the environmental benefits of remote and hybrid work. The study, published in the Proceedings of the National Academy of Sciences, also finds that hybrid workers who work from home two to four days per week can reduce their carbon footprint by 11% to 29%, but working from home one day per week ...

Low socioeconomic status can negatively impact children’s health in preschool, along with their ability to follow specialized health education intervention programs, Mount Sinai researchers found in an international study focused on health promotion in schools, including those in the Harlem section of New York City. The results, published September 18 in the Journal of American College of Cardiology, stress the importance of introducing a specialized health curriculum in classrooms starting in preschool. “This study shows that socioeconomic factors, including lower household income and education level, can negatively impact children’s health starting ...

CORVALLIS, Ore. – Oregon State University has received a $7.5 million National Institutes of Health grant to modernize a lab focused on using zebrafish to address pressing human health challenges. The Sinnhuber Aquatic Research Laboratory, led by Distinguished Professor Robyn Tanguay, a molecular toxicologist in the College of Agricultural Sciences, exploits the unique advantages of zebrafish to protect and improve human and environmental health. Zebrafish and humans have similar developmental processes and are similar on a genomic level, ...

BINGHAMTON, N.Y. -- Standardized and overly simplistic questionnaires are only scratching the surface of what employees think of their leaders, according to new research from Binghamton University’s School of Management (SOM), and negative behavior may be slipping through the cracks. As a result, the research finds, organizations may be missing out on critical information that could be keeping toxic leaders in positions of power. “Instead of capturing actual leader behaviors, ratings might simply reflect whether a person likes their leader,” said Mengying ...

The key to solving the Libyan political conflict lies within the country rather than with the international community, analysis says. Electoral and governance deadlock has been blamed for the devastating impact of the flooding in the country. The “contentment” of the political elite and others with the status quo - given the currently limited levels of violence and the rising global prices of energy since the outbreak of Russia’s war on Ukraine - explains the general lack of a genuine commitment to relaunch the transition and electoral roadmap, ...

Researchers at the University of Chicago Medicine Comprehensive Cancer Center established “proof-of-concept” for a new treatment approach that was able to effectively treat the most aggressive forms of prostate cancer. The treatment showed complete tumor control and long-lasting survival without side effects in a mouse model of advanced prostate cancer. These findings, which were published online September 18, 2023, in Clinical Cancer Research, warrant further investigation in human clinical trials, the researchers concluded. Strategies to overcome resistance “Prostate cancer in the metastatic ...

Philadelphia, September 18, 2023 – Very young children who attend child care and receive onsite meals and snacks were more likely to be food secure and in good health, and less likely to be admitted after a hospital emergency department visit than children in child care whose meals and snacks were provided from home, according to a new study in the Journal of the Academy of Nutrition and Dietetics, published by Elsevier. These potential benefits could extend beyond the children themselves to their families, including through possible reductions in stress, and to society as a whole through potentially significant healthcare cost savings. Lead author Stephanie ...

HOUSTON – (Sept. 18, 2023) – Two Rice University scientists have received a 3-year grant from the Department of Energy (DOE) to investigate a form of carbon storage that is as little understood as it is ubiquitous: soil. Mark Torres, an assistant professor of Earth, environmental and planetary sciences, and Evan Ramos, a postdoctoral fellow in the Torres lab, will track how key minerals form in a watershed to build a fuller picture of the processes that allow soil to store carbon as organic matter. “Soil on Earth contains three times more carbon than the atmosphere,” Ramos said. “We ...

The National Institutes of Health has awarded $54 million over a seven-year period to the CCTSI at CU Anschutz. The grant from the National Center for Advancing Translational Sciences (NCATS) will fuel biomedical research and training across the state. This is the fourth consecutive time the NIH has funded the CCTSI since 2008 through its Clinical Translational Science Award (CTSA) program. “This powerful grant will allow the University of Colorado to conduct leading-edge research that can directly impact health and patient care, reduce health disparities across our state and remain poised to respond to public ...

UNIST, in collaboration with Pusan National University Yangsan Hospital, has embarked on an exciting joint venture to research and develop advanced 3D printing medical device technology. The UNIST 3D Printing Convergence Technology Center recently signed a business agreement with the Medical Device Usability Test Center at Pusan National University Yangsan Hospital. This agreement outlines their collaborative efforts in various areas, including the research and development of 3D printing-based medical devices as well as support for the commercialization of domestically developed devices. Notably, Yangsan Pusan National University ...