A new approach to chiral α-amino acid synthesis - photo-driven nitrogen heterocyclic carbene catalyzed highly enantioselective radical α-amino esterification
Professor Jian Wang's research group at Tsinghua University reported a photocatalyzed/nitrogen heterocyclic carbene-catalyzed asymmetric radical α-alkoxycarbonylation reaction of amines. Using dibenzylaniline derivatives and readily available pyrocarbonates as starting materials, chiral α-amino acid esters can be synthesized in one step. Further deprotection reactions yield chiral α-amino acids containing primary, secondary, or tertiary amine groups. This research provides a novel method for obtaining structurally diverse chiral α-amino acid derivatives and has ...
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