Embargoed for Release  Wednesday, June 19, 2024 5:00 p.m. ET     Contact: NCI Press Office 240-760-6600 NCIPressOfficers@nih.gov  NOTE: A virtual briefing is scheduled for Tuesday, June 18, 2024, at 1:00 p.m. ET. Details below.   Researchers at the National Institutes of Health (NIH) have developed a non-chemotherapy treatment regimen that is achieving full remissions for some people with aggressive B-cell lymphoma that has come back or is no longer responding to standard treatments. The five-drug combination targets multiple molecular pathways that diffuse large B-cell lymphoma (DLBCL) tumors use to survive. In ...

EMBARGOED FOR RELEASE UNTIL 4 P.M. ET, WEDNESDAY, JUNE 19, 2024 MINNEAPOLIS – Certain drugs used to treat urinary symptoms due to an enlarged prostate may be associated with a reduced risk of dementia with Lewy bodies, according to a study published in the June 19, 2024, online issue of Neurology®, the medical journal of the American Academy of Neurology. Dementia with Lewy bodies is a progressive neurodegenerative disorder that can cause memory and thinking issues, movement problems and issues such as hallucinations. The results do not prove that these drugs reduce the risk of dementia ...

A new study suggests that certain drugs commonly used to treat enlarged prostate may also decrease the risk for dementia with Lewy bodies (DLB). This observational finding may seem surprising, but it mirrors previous work by the University of Iowa Health Care team that links the drugs to a protective effect in another neurodegenerative condition–Parkinson's disease.  The UI researchers think that a specific side effect of the drugs targets a biological flaw shared by DLB and Parkinson’s disease, as well as other neurodegenerative ...

Titan, Saturn’s largest moon, is the only other planetary body in the solar system that currently hosts active rivers, lakes, and seas. These otherworldly river systems are thought to be filled with liquid methane and ethane that flows into wide lakes and seas, some as large as the Great Lakes on Earth.  The existence of Titan’s large seas and smaller lakes was confirmed in 2007, with images taken by NASA’s Cassini spacecraft. Since then, scientists have pored over those and other images for clues to the moon’s mysterious ...

New Haven, Conn. — Children who have an older sibling with autism spectrum disorder (autism) are at greater risk of developmental vulnerabilities if they also have other relatives with neurodevelopmental or psychiatric conditions, according to a new study from the Yale Child Study Center. Researchers found that the siblings of children with autism had an increase in the severity of social and communication difficulties — which are common in autism — if they had relatives with conditions such as schizophrenia or anxiety. Family histories of anxiety and intellectual disability were also associated ...

A team led by Lawrence Berkeley National Laboratory (Berkeley Lab) has invented a technique to study electrochemical processes at the atomic level with unprecedented resolution and used it to gain new insights into a popular catalyst material. Electrochemical reactions – chemical transformations that are caused by or accompanied by the flow of electric currents – are the basis of batteries, fuel cells, electrolysis, and solar-powered fuel generation, among other technologies. They also drive biological processes such as photosynthesis ...

Researchers have created a new class of materials called “glassy gels” that are very hard and difficult to break despite containing more than 50% liquid. Coupled with the fact that glassy gels are simple to produce, the material holds promise for a variety of applications. Gels and glassy polymers are classes of materials that have historically been viewed as distinct from one another. Glassy polymers are hard, stiff and often brittle. They’re used to make things like water bottles or airplane windows. Gels – such as contact lenses – contain liquid and are soft and stretchy. “We’ve created a class of materials ...

Scientists at EPFL have achieved a significant research milestone in the field of spinal cord injuries—mapping out the cellular and molecular dynamics of paralysis in unprecedented detail with their open-source project 'Tabulae Paralytica'. Grégoire Courtine and his team have integrated cutting-edge cell and molecular mapping technologies with artificial intelligence to chart the complex molecular processes that unfold in each cell after spinal cord injuries (SCI). Published in Nature, this seminal ...

In the late 2000s, Scott Saleska noticed something strange going on in the Amazon rainforest. In 2005, a massive drought struck the region. Two years later, Saleska – a University of Arizona professor in the Department of Ecology and Evolutionary Biology – published surprising research that used satellite images to find that the drought resulted in more green growth in large swaths of the Amazon. On the other hand, field researchers saw plants brown and some die in response to the drought. Research published today in the journal Nature reveals what caused the scientific mismatch. Shuli Chen, a doctoral degree candidate in ecology and evolutionary ...

Key Takeaways   The introduction of a standardized handoff protocol substantially improved communication among OR staff, ensuring critical information was transferred consistently.   The enhanced communication reduced potential patient safety risks and highlighted the importance of standardized handoff tools in improving surgical outcomes.  CHICAGO (June 19, 2024) — A new study showcases a successful quality improvement program that significantly enhances surgical safety. By implementing a standardized handoff protocol, known as SHRIMPS, the study demonstrates how ...

Scientists have discovered novel immune responses that help explain how some individuals avoid getting COVID-19. Using single-cell sequencing, researchers from the Wellcome Sanger Institute, University College London (UCL), Imperial College London, the Netherlands Cancer Institute and their collaborators, studied immune responses against SARS-CoV-2 infection in healthy adult volunteers, as part of the world's first COVID-19 human challenge study1. Not all exposed participants went on to develop a COVID-19 infection, ...

Corvallis, OR — A study published today in the journal BioScience sheds light on the importance of gray wolves in western United States. Led by William Ripple, a scientist at Oregon State University and the Conservation Biology Institute, the research delves into the implications of large predator absence on plant and animal communities, and ecosystem functions. It calls attention to “shifting baselines” wherein increasingly degraded conditions are viewed as reflecting the historical state of a system. "By the 1930s, wolves were largely absent from the American West, including its national parks. Most published ecological ...

New research published in the journal BioScience describes how the removal large predators is often unrecognized in ecological scholarship, creating an issue of "shifting baselines," with profound implications for restoration efforts.   A team led by researchers from Oregon State University, including co-lead authors William J. Ripple and Christopher Wolf, reviewed 96 published studies from 1955 to 2021 that were conducted in 11 national parks where gray wolves had been extirpated. Their analysis found that ...

Philadelphia, June 19, 2024 – Infant feeding, involving breastfeeding, formula feeding, and the introduction of solid foods, is crucial for parenting. Pregnant and postpartum individuals with intellectual and developmental disabilities face challenges in infant feeding compared to parents without intellectual and developmental disabilities, often due to ableism and inaccessible care. The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) program, a federal nutrition initiative, can address these disparities by offering inclusive and accessible support and counseling. A recent research article in the Journal of Nutrition Education and Behavior, published ...

The Sun Corridor in Arizona in the semi-arid Southwestern U.S. is a land of seeming unlimited growth that is constantly colliding with physical constraints. It is mountainous but also home to a large valley that includes one of the fastest growing metropolitan areas in the U.S.    While experiencing explosive growth, the Phoenix metropolitan area faces an uncertain future due to prolonged drought and fluctuating seasonal water availability. Planning for the future, especially in terms of water, ...

The roots of the project formed during a CASRI conference in 2018 when experts from various organizations learned about red spruce genetic research being conducted by Keller’s lab and collaborators at University of Maryland with funding by the National Science Foundation.  The group saw an opportunity to join forces to take an on-the-ground approach to utilizing the genetic data for red spruce restoration. In 2019, funding from the Wildlife Conservation Society’s Climate Adaptation Fund enabled this group to pursue science-informed restoration at scale.  “Science-informed ...

Even though COVID-19 manifests as a mild and short-lived disease in most people, some suffer extremely severe symptoms; in the worst cases, these patients die due to complications such as respiratory failure or thromboembolism. It is well-known that factors such as age and underlying medical conditions like diabetes or immunodeficiencies increase vulnerability to severe COVID-19. However, some patients still experience severe COVID-19 without any apparent reason. One possible explanation may lie in auto-antibodies, which are antibodies that erroneously target specific proteins produced by one’s own body. In normal circumstances, type I interferons ...

Video: https://youtu.be/-7ggs6e2UXI?si=lnFqEscjJh-91n64 B-roll: https://youtu.be/pvNBa733ICw?si=DotUuQkxVgMQ0jY7 The Federal Drug Administration approved a clinical trial to test the effectiveness of an electronic grid that records brain activity during surgery, developed by engineers at the University of California San Diego. The device with nanoscale sensors records electrical signals directly from the surface of the human brain in record-breaking detail. The grid’s breakthrough resolution could provide better guidance for planning and performing surgeries to remove brain tumors and treat drug-resistant epilepsy.  The grid’s higher resolution ...

Researchers from the Institut d’Investigació en Atenció Primària Jordi Gol (IDIAPJGol) and the Barcelona Institute for Global Health (ISGlobal), a center promoted by “la Caixa” Foundation, have led a study on the effectiveness of vaccines against COVID-19 among cancer patients in Catalonia. The research, published in the journal Nature Communications, recommends administering additional doses of the vaccine among this risk population. Cancer patients are at increased risk of death from COVID-19, especially ...

Looking under the microscope, a group of cells slowly moves forward in a line, like a train on the tracks. The cells navigate through complex environments. A new approach by researchers involving the Institute of Science and Technology Austria (ISTA) now shows how they do this and how they interact with each other. The experimental observations and the following mathematical concept are published in Nature Physics. The majority of the cells in the human body cannot move. Some specific ones, however, can go to different places. For example, in wound healing, cells move through the body to repair damaged tissue. They sometimes ...

Much of the methane released into the southern Baltic Sea from the Nord Stream gas pipeline has remained in the water. This is shown by measurements taken by researchers from the University of Gothenburg. At the end of September 2022, the Nord Stream gas pipeline on the bottom of the Baltic Sea exploded east of Bornholm and one of the largest unnatural methane gas emissions ever was a fact. The methane gas from the pipeline created large bubbles at the water surface and measurements showed elevated levels of methane in the atmosphere. Expedition ...

In a new study, investigators from McLean Hospital (a member of Mass General Brigham), Harvard Medical School and the National Institute on Drug Abuse – Intramural Research Program (NIDA-IRP) discovered that the tendency of people’s arousal to wane over the course of brain scans has been distorting the brain connection maps produced by functional magnetic resonance imaging (fMRI). The team found that as people’s arousal levels dwindle during an fMRI, such as if they become more relaxed and sleepy, changes in breathing and heart rates alter blood oxygen levels in the ...

Technology from the laboratories of IOCB Prague has been given an extraordinary opportunity to succeed in the rapidly developing segment of gene therapy. The results of successful research are set to be advanced by a newly established private company called Adalid Sciences, which is being supported with a major investment from BTL Group, a leading manufacturer of medical technologies.  The story begins with the discovery of new lipid nanoparticles with a comic book name coined by Dr. Petr Cígler and Dr. Klára Grantz Šašková of IOCB Prague. Acting as a sort of imaginary courier, their XMAN is capable of safely ...

A new study published in the academic journal Environmental Research Letters, reveals that the environmental impact of the February 3, 2023, Norfolk Southern train accident in East Palestine, Ohio covered a very large geographical area. Inorganic pollutants released due to the accident were found in wet weather downfall (wet deposition) from the Midwest through the Northeast reaching as far as southern Canada and North Carolina. The findings are significant as many inorganic pollutants in rain and snow have chemical effects on - aquatic flora and fauna. According to the paper, these pollutants spread over at least portions of 16 states and an area of 1.4 million ...

A team of researchers at the University of Zurich has discovered that plants benefit from a greater variety of interactions with pollinators and herbivores. Plants that are pollinated by insects and have to defend themselves against herbivores have evolved to be better adapted to different types of soil. Plants obtain nutrients and water from the soil. Since different soil types differ in their chemical and physical composition, plants need to adapt their physiology to optimize this process on different soil types. This evolutionary ...