DURHAM, N.C. – Biomedical engineers at Duke University have developed a new technique to better understand and test treatments for a group of extremely rare muscle disorders called dysferlinopathy or limb girdle muscular dystrophies 2B (LGMD2B). The approach grows complex, functional 3D muscle tissue from stem cells in the laboratory, creating a platform that replicates patient symptoms and treatment responses. In its debut study, researchers reveal some of the biological mechanisms underlying the characteristic loss of mobility caused by LGMD2B. They also demonstrate that a combination of existing treatments may be able to alleviate some ...

“[...] PHA is a rare yet aggressive mesenchymal tumor of the liver, which requires a multi-disciplinary approach to achieve the best patient outcomes.” BUFFALO, NY- June 21, 2024 – A new editorial paper was published in Oncoscience (Volume 11) on May 20, 2024, entitled, “Primary hepatic angiosarcoma: Treatment options for a rare tumor.” In this new editorial, researchers Gregory L. Guzik and Ankit Mangla from University Hospitals Cleveland Medical Center, University Hospitals Seidman Cancer ...

SAN ANTONIO, June 21, 2024 – Research led by in part by The University of Texas Health Science Center at San Antonio (UT Health San Antonio) finds that the most common cerebral small-vessel disease feature seen in brain magnetic resonance imaging is a primary vascular factor associated with dementia risk. Results of the major international study emphasize the significance of that feature, known as white matter hyperintensity (WMH) burden, in preventive strategies for dementia. “Our findings provide converging evidence that WMH is a major vascular factor ...

As wildfires become more intense and the fire season grows longer across parts of the world, humans will need to adapt. In this collection of papers from Cell Press journals One Earth and Cell Reports Sustainability, an intersection of fire management researchers comment on what needs to change to ensure we can collaborate across stakeholders in a more fire-resistant future. The papers are publishing in advance of a Cell Press 50th Anniversary sustainabiltiy forum on the topic of “Navigating the Pyrocene: Managing fire risk in a warming world.” The virtual event, free to register, takes place Thursday, July 11, 2024 at 11:00 am ET. This ...

Inland seas around the world are drying up due to increasing human water use and accelerating climate change, and their desiccation is releasing harmful dust that pollutes the surrounding areas during acute dust storms. Using the Great Salt Lake in Utah as a case study, researchers show that dust exposure was highest among Pacific Islanders and Hispanic people and lower in white people compared to all other racial/ethnic groups, and higher for individuals without a high school diploma. Restoring the lake ...

About The Study: The findings of this cohort study suggest that cannabis use may be an independent risk factor for COVID-19–related complications, even after considering cigarette smoking, vaccination status, comorbidities, and other risk factors.  Corresponding Author: To contact the corresponding author, Li-Shiun Chen, M.D., M.P.H., Sc.D., email li-shiun@wustl.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2024.17977) Editor’s ...

About The Study: This randomized clinical trial of Chinese adults with overweight or obesity and with early type 2 diabetes found that an intermittent fasting plan consisting of two nonconsecutive fasting days and five days of habitual intake per week and meal replacement diet (5:2 MR) could improve glycemic outcomes and weight loss in the short term compared with metformin or empagliflozin, making it a promising initial intervention and early management for type 2 diabetes. Corresponding Author: To contact the corresponding author, Lixin Guo, M.D., email glx1218@163.com. To access the embargoed study: Visit ...

Scientists from the University of Copenhagen have made significant strides in understanding ancient ocean anoxia, with potential insights for today's marine environments. 500 million years ago the so-called Cambrian ‘SPICE’ event made oxygen levels in the oceans drop dramatically. Now, researchers from the University of Copenhagen have investigated how large-scale ocean anoxia, or oxygen-depleted conditions, developed during the event, and its potential consequences today. In the study, titled "Cascading oxygen loss shorewards in the oceans – insights from the Cambrian SPICE event" published in OneEarth ...

HOUSTON ― Researchers at The University of Texas MD Anderson Cancer Center have demonstrated that therapeutically restoring ‘youthful’ levels of a specific subunit of the telomerase enzyme can significantly reduce the signs and symptoms of aging in preclinical models. If these findings are confirmed in clinical studies, there may be therapeutic implications for age-related diseases such as Alzheimer’s, Parkinson’s, heart disease and cancer. The study, published today in Cell, identified a small molecule compound ...

As the deadly disease that came to be known as COVID-19 started spreading in late 2019, scientists rushed to answer a critical question: Who is most at risk? They quickly recognized that a handful of characteristics — including age, smoking history, high body mass index (BMI) and the presence of other diseases such as diabetes — made people infected with the virus much more likely to become seriously ill and even die. But one suggested risk factor remains unconfirmed more than four years later: cannabis use. Evidence has emerged over time indicating both ...

Why do some people live for longer than others? The genes in our DNA sequence are important, helping avoid disease or maintain general health, but differences in our genome sequence alone explain less than 30% of the natural variance of human life expectancy. Exploring how ageing is influenced at the molecular level could shed light on lifespan variation, but generating data at the speed, scale and quality necessary to study this in humans is unfeasible. Instead, researchers turn to worms (Caenorhabditis elegans). Humans share a lot of biology with these small creatures, who also have a large, natural variation in lifespan. Researchers ...

Small changes in our everyday actions can trigger significant, rapid societal shifts especially when it comes to climate action. A new IIASA-led study highlights the importance of analyzing these dynamics with a comprehensive framework to harness their full potential for reducing carbon emissions. Making small changes in how we live day-to-day can quickly create significant changes in society, especially in ways that benefit the environment. This idea is captured in the term social tipping points. According to the authors of a new paper just published in the journal One Earth, social tipping points are crucial for speeding up efforts to reduce carbon emissions. These points occur when ...

A pivotal study has discovered a genetic synergy between pumpkin and cucumber that fortifies the latter's resilience against salinity. The research illuminates the role of the CmoDREB2A transcription factor from pumpkin, which, when interacted with cucumber's CmoNAC1, forms a regulatory loop that enhances salt tolerance. This breakthrough could be key to developing crops that thrive in saline soils, safeguarding agricultural productivity. Soil salinity, a silent blight on global agriculture, affects an estimated 10% of the world's arable land, leading to significant crop ...

A detailed genomic study of broccoli has revealed the genetic foundations for the production of glucosinolates (GSLs), compounds celebrated for their health benefits, including anti-carcinogenic properties. By assembling a high-quality chromosome-level genome, researchers identified key genes involved in GSL biosynthesis. These findings offer critical insights for future genetic studies and the development of Brassica crops with enhanced nutritional value, paving the way for improved health benefits from these widely consumed vegetables. Broccoli is renowned for its health benefits, primarily due to its rich glucosinolate (GSL) content, which has anti-carcinogenic ...

A cutting-edge study has pinpointed the PgbHLH28 gene as a crucial catalyst in the methyl jasmonate-induced (MeJA-induced) saponin biosynthesis in Platycodon grandiflorus. This genetic insight could significantly bolster the production of saponins, which are beneficial in combating cerebrovascular diseases and COVID-19, offering a novel therapeutic avenue in medicinal plant cultivation. Platycodon grandiflorus, commonly known as balloon flower, is renowned for its medicinal properties, primarily due to its rich saponin content. Saponins are known for ...

Glomerulus, the fundamental filtering unit of the kidney, is an intricate network of capillaries — small blood vessels that regulate the movement of ions, water, and metabolites while maintaining impermeability to essential macromolecules such as proteins. The selectively permeable capillary wall, known as the glomerular filtration barrier (GFB), consists of three main components: glomerular endothelial cells (GEnCs), the glomerular basement membrane, and podocytes. GEnCs line the inner surface of the capillary wall and are covered by a thin layer of glycoproteins and other carbohydrate-based moieties. Adhesion G-protein-coupled ...

(Toronto, June 21, 2024) JMIR Publications is pleased to announce that JMIR Dermatology (JMIR Derm) has been accepted for inclusion in MEDLINE, which is the U.S. National Library of Medicine's premier bibliographic database. JMIR Dermatology was previously already indexed in PubMed, but MEDLINE is a more selective subset of PubMed, consisting of the top 5200 biomedical journals, and indexing in MEDLINE also means that articles are now also indexed with NLM Medical Subject Headings (MeSH terms) and other metadata. Selection for MEDLINE is a result of a thorough review of the ...

(WASHINGTON, June 21, 2024) – Patients with chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphomas (NHLs) who received frequent tests for immunoglobulin G (IgG) were less likely to experience severe infections compared with those who didn’t, according to a study published in Blood Advances. Moreover, only half of patients undergo such testing.  Patients with blood cancers such as CLL and NHL are at elevated risk for potentially life-threatening infections due to low blood levels of immunoglobulins — proteins ...

Earth and environmental scientists reported that as human socio-economic activities increase, greenhouse gas emissions will rise, leading to more frequent extreme weather events such as droughts and floods. However, a research team from Pohang University of Science and Technology (POSTECH) has published a study suggesting that anthropogenic greenhouse gases might actually mitigate droughts, offering a new perspective on the impact of human activities on nature.   Professor Jonghun Kam from the Division of Environmental Science and Engineering at POSTECH ...

Co-authored by Pascal François (HEC Montreal) and Georges Hubner (University of Liège), both professors of finance, The Complete Guide to Portfolio Performance: Appraise, Analyse, Act, just published by Wiley, is a comprehensive guide to all aspects of financial portfolio performance. The book explores the essential topics of portfolio performance measurement in a realistic and rigorous way, with usable content clearly illustrated by practical examples that demonstrate the application of the concepts discussed. Portfolio management is a complex field, requiring in-depth expertise ...

As a neurodegenerative disease characterized by childhood onset dementia, Sanfilippo syndrome causes immense suffering in many ways, including pain, loss of speech, extreme agitation, and distress, gastrointestinal symptoms, and profound sleep disturbance. With no approved treatment, clinical specialists have had few options to help alleviate this suffering until now. A groundbreaking clinical trial collaboration between study lead and principal investigator Lynda Polgreen, MD, MS, Investigator at The Lundquist Institute for Biomedical Innovation at Harbor-UCLA (TLI) and Associate ...

Many drug and antibody discovery pathways focus on intricately folded cell membrane proteins: when molecules of a drug candidate bind to these proteins, like a key going into a lock, they trigger chemical cascades that alter cellular behavior. But because these proteins are embedded in the lipid-containing outer layer of cells, they are tricky to access and insoluble in water-based solutions (hydrophobic), making them difficult to study. "We wanted to get these proteins out of the cell membrane, so we redesigned them as hyperstable, soluble analogues, which look like membrane proteins but are much ...

In a world striving for sustainability, understanding the hidden half of a living plant – the roots – is crucial. Roots are not just an anchor; they are a dynamic interface between the plant and soil, critical for water uptake, nutrient absorption, and, ultimately, the survival of the plant. In an investigation to boost agricultural yields and develop crops resilient to climate change, scientists from Lawrence Berkeley National Laboratory’s (Berkeley Lab’s) Applied Mathematics and Computational Research (AMCR) and Environmental Genomics and Systems Biology (EGSB) Divisions have made a significant leap. Their latest innovation, RhizoNet, harnesses the power ...

Press release under embargo: Cleveland Clinic Study Shows Weight Loss Surgery Cuts Risk of Heart Complications and Death in Patients with Obstructive Sleep Apnea and Obesity  First-of-its-kind MOSAIC study shows weight-loss surgery is associated with a 42% reduction in risk of heart complications and 37% reduction in risk of death in patients with obstructive sleep apnea   Under embargo until Friday, June 21, 2024, 9:00 AM ET, CLEVELAND: A Cleveland Clinic study shows that bariatric surgery performed in patients with obesity and moderate to severe obstructive sleep apnea is associated with a significantly lower risk of ...

Artificial intelligence continues to squirm its way into many aspects of our lives. But what about biology, the study of life itself? AI can sift through hundreds of thousands of genome data points to identify potential new therapeutic targets. While these genomic insights may appear helpful, scientists aren’t sure how today’s AI models come to their conclusions in the first place. Now, a new system named SQUID arrives on the scene armed to pry open AI’s black box of murky internal logic. SQUID, ...