Researchers at the University of Michigan Health Rogel Cancer Center have identified a mechanism that causes severe gastrointestinal problems with immune-based cancer treatment. They also found a way to deliver immunotherapy’s cancer-killing impact without the unwelcome side effect. The findings are published in Science. “This is a good example of how understanding a mechanism helps you to develop an alternative therapy that’s more beneficial. Once we identified the mechanism causing the colitis, we could then develop ways to overcome this problem and prevent colitis while preserving the anti-tumor effect,” said senior ...

Reston, VA — The Society of Nuclear Medicine and Molecular Imaging (SNMMI) and the European Association of Nuclear Medicine (EANM) have issued a new procedure standard/practice guideline for estrogen receptor imaging of breast cancer patients using FES PET. The standard/guideline, published ahead of print in The Journal of Nuclear Medicine, is intended to assist physicians in recommending, performing, interpreting, and reporting the results of 18F-FES PET studies for patients with breast cancer. More than two million women worldwide are diagnosed with breast cancer ...

About three years before he retired, David Campbell noticed something weird happening as he typed. Whenever he tried to hit a letter, say “a,” he’d get “aaa,” like the keyboard was jamming or his finger was triple-tapping the key. That wasn’t the only thing that seemed off—his sense of smell was faltering. “Little things,” he says, “that I didn’t think of as being a big deal.” A couple of weeks after he retired in fall 2020, Campbell learned the little things weren’t ...

Climate campaigners will increasingly adopt “insider activist” roles, working to change or challenge their organisations from the inside rather than the outside, a new study says. Research led by the University of Exeter identifies different types of climate activists. As well as “insiders”, there are others who seek to undermine, or even damage, climate-recalcitrant organisations they are members of in the hope of change. The study says the growing climate backlash against traditional outside climate activism and rise of corporate “greenwashing” means collaborating or ...

PRETORIA, SOUTH AFRICA – Conservation measures have successfully stopped declines in the African savanna elephant population across southern Africa, but the pattern varies locally, according to a new study. The evidence suggests that the long-term solution to elephant survival requires not only that areas are protected but that they are also connected to allow populations to stabilize naturally, an international research team says. Their study, published on January 5th in the peer-reviewed journal Science Advances, collected survey estimates and calculated growth rates for ...

Douglas Boin, Ph.D., a professor of history at Saint Louis University, made a major announcement at the annual meeting of the Archeological Institute of America, revealing he and his team discovered an ancient Roman temple that adds significant insights into the social change from pagan gods to Christianity within the Roman Empire.  “We found three walls of a monumental structure that evidence suggests belonged to a Roman temple that dates to Constantine's period,” Boin said. “It dates to the fourth century AD and it would ...

CAMBRIDGE, MA -- Using a new technology developed at MIT, diagnosing lung cancer could become as easy as inhaling nanoparticle sensors and then taking a urine test that reveals whether a tumor is present. The new diagnostic is based on nanosensors that can be delivered by an inhaler or a nebulizer. If the sensors encounter cancer-linked proteins in the lungs, they produce a signal that accumulates in the urine, where it can be detected with a simple paper test strip. This approach could potentially replace or supplement the current gold standard for diagnosing lung cancer, low-dose computed tomography (CT). It ...

(Memphis, Tenn.—January 5, 2024) Scientists at St. Jude Children’s Research Hospital are tackling Mycobacterium abscessus (Mab) antibiotic resistance. This naturally antibiotic-resistant pathogen is becoming more prevalent, highlighting the urgent need for novel therapeutics. To address this, the scientists designed new versions of the drug spectinomycin that overcome efflux, the main mechanism driving resistance. The work was published today in Proceedings of the National Academy of Science.   Mab infections are increasingly found ...

East Hanover, NJ – January 5, 2023 – Following a historic high in November, slight declines were seen in the employment-to-population ratio and the labor force participation rate in December 2023 for people with and without disabilities. However, numbers still remain near the record levels achieved the previous month, according to today’s National Trends in Disability Employment – semi-monthly update (nTIDE), issued by Kessler Foundation and the University of New Hampshire’s Institute on Disability (UNH-IOD). Month-to-Month nTIDE Numbers (comparing November 2023 to December 2023) Based on data from the U.S. Bureau of Labor Statistics (BLS) Jobs ...

Technological advancements have enabled scientists to comprehensively explore genetic control elements, unraveling the complexities of gene activation mechanisms in our genetic code. New evidence challenges the simplistic view that cis-regulatory elements (CREs) are mere on/off switches for genes, emphasizing their ability to exhibit complex behaviors, such as the simultaneous enhancement of gene activity and initiation of gene transcription, e.g., simultaneous enhancer and promoter activities. These switches aren't only important for the enhancement ...

Coastal forests in Japan had predominantly been afforested with black pine (Pinus thunbergii), a shade-tolerant tree species that can withstand dry land ecosystems and harsh coastal environments. This afforestation initiative, dating back to the Edo period (1603~1867), aimed to mitigate the deleterious effects of robust winds and sand blowing. Subsequent to the Great East Japan Earthquake in 2011, interest shifted to the potential protective effects of coastal forests in reducing the destructive power of tsunamis. The Great East Japan Earthquake tsunami damaged a total of 2,800 hectares (ha; 10,000 square meters) of ...

D'Or Institute for Research and Education (IDOR) played an important role in the phase III LIBRETTO-431 multicenter study, which evaluated the efficacy and safety of selpercatinib compared to control treatment, which consisted of platinum-based chemotherapy associated or not with pembrolizumab (immune checkpoint inhibitor) in non-small cell lung cancer (NSCLC). The research was published in the New England Journal of Medicine (NEJM), one of the most important scientific publications in the medical field, and included Dr. Milena Perez Mak, IDOR researcher and clinical oncologist at ...

Compounds that obstruct the "landing gear" of a range of harmful viruses can successfully protect against infection by the virus that causes COVID-19, a study published today and led by Dana-Farber Cancer Institute scientists shows.  Based on the findings, researchers have launched a human clinical trial of one such compound made by chemically stabilizing a key coronavirus peptide. If the compound, called a stapled lipopeptide, proves effective as a nasal spray in the trial, it could be the basis for a new drug modality to prevent or treat COVID-19, say the authors of the study, posted online today in the journal Nature ...

The Speech Accessibility Project has expanded its recruitment and is inviting U.S. and Puerto Rican adults living with amyotrophic lateral sclerosis to participate. Those interested in participating can sign up online. Funded by Big Tech companies Amazon, Apple, Google, Meta, and Microsoft, the University of Illinois Urbana-Champaign aims to train voice recognition technologies to understand people with diverse speech patterns and disabilities. The project began recruiting people with Parkinson’s disease last ...

With the start of a new year, smokers and vapers may have resolved to quit or cut back on the habit to improve their health. They may want to use caution, however, if their strategy involves switching from cigarettes to e-cigarettes, considered by some to be a less harmful alternative. A new study from the University of Louisville shows the nicotine in certain types of e-cigarettes may be more harmful than others, increasing risk for irregular heartbeat, or heart arrhythmias. A popular claim is that nicotine in ...

About The Study: This study of 620,000 children found that maternal type 1 diabetes was associated with increased risk for most types of congenital heart defects in offspring, while obesity and overweight were associated with increased risk for complex defects and outflow tract obstruction and decreased risk for ventricular septal defects. These different risk profiles of type 1 diabetes and overweight and obesity may suggest distinct underlying teratogenic mechanisms.  Authors: Riitta Turunen, M.D., Ph.D., and Emmi Helle, M.D., ...

About The Study: Sugar-sweetened beverage (SSB) taxes in Boulder, Colorado; Philadelphia, Oakland, San Francisco, and Seattle led to substantial, consistent declines in SSB purchases following price increases associated with those taxes. Scaling SSB taxes nationally could yield substantial public health benefits.  Authors: Scott Kaplan, Ph.D., of the U.S. Naval Academy in Annapolis, Maryland, is the corresponding author. To access the embargoed study: Visit our For The Media website ...

Researchers at the University of Liège (ULiège) have identified microstructures in fossil cells that are 1.75 billion years old. These structures, called thylakoid membranes, are the oldest ever discovered. They push back the fossil record of thylakoids by 1.2 billion years and provide new information on the evolution of cyanobacteria which played a crucial role in the accumulation of oxygen on the early Earth. This major discovery is presented in the journal Nature.   Catherine Demoulin, Yannick Lara, Alexandre Lambion and Emmanuelle Javaux from the Early Life Traces & Evolution laboratory of the Astrobiology Research ...

A new study in Advanced Science unlocks the secrets of how high blood pressure (hypertension) fuels the progression of arterial disease. Led by Professor Thomas Iskratsch, Professor of Cardiovascular Mechanobiology & Bioengineering at Queen Mary University of London, the research team exposes a novel mechanism by which elevated pressure transforms muscle cells in the arterial wall into "foam cells" – the building blocks of plaque buildup that cripples arteries.  The study focuses on vascular smooth muscle cells (VSMCs), the workhorses responsible for maintaining blood vessel tone and flow. Under ...

WASHINGTON  –  U.S. Naval Research Laboratory (NRL) researchers, Kevin Cronin and Drew Rodgers, receive Technology Achievement Award for Lightweight Hydrogen Fuel Cells for Unmanned Aerial Systems (UAS) research efforts at Defense Manufacturing Conference held in Nashville, Tenn., Dec. 11, 2023.   The Department of Defense (DOD) has a critical need for increased power and endurance for persistent Intelligence, Surveillance and Reconnaissance (ISR) and transmission of radio frequency (RF) sources for communications and targeting.   “It ...

The São Paulo Advanced School on Technology & Innovation Strategies and Policies for Economic Development will be held from June 24 to July 05, 2024, at the University of Campinas (UNICAMP) in São Paulo state, Brazil.  Reporters are invited to register for the scientific sessions and short courses, which will present state-of-art science and results of new research. The School provides an opportunity to learn about and debate recent developments in the economics of technological change and in science, technology and innovation (ST&I) policy studies. The programme comprises numerous seminars, intensive courses, and roundtable discussions focusing ...

A study carried out by CNRS1 scientists working with an international team has revealed that around 70 million years ago, when dinosaurs existed, the ancestors of primates most commonly lived in pairs. Only 15% of them opted for a solitary lifestyle. This discovery — that our ancestors adopted variable forms of social organization — challenges the hitherto commonly accepted hypothesis that at the time of dinosaurs, the ancestors of primates lived alone, and that pair living evolved much later. Most likely, pair living offered significant benefits, such as easier reproduction and reduced costs of thermoregulation by huddling in pairs. While several studies have already been conducted ...

What are the clouds of Venus made of? Scientists know it’s mainly made of sulfuric acid droplets, with some water, chlorine, and iron. Their concentrations vary with height in the thick and hostile Venusian atmosphere. But until now they have been unable to identify the missing component that would explain the clouds’ patches and streaks, only visible in the UV range. In a new study published in Science Advances, researchers from the University of Cambridge synthesised iron-bearing sulfate minerals that are stable under the harsh chemical conditions in the Venusian clouds. Spectroscopic analysis revealed that a combination of two minerals, rhomboclase and acid ferric ...

The Japan-led XRISM (X-ray Imaging and Spectroscopy Mission) observatory has released a first look at the unprecedented data it will collect when science operations begin later this year. The satellite’s science team released a snapshot of a cluster of hundreds of galaxies and a spectrum of stellar wreckage in a neighboring galaxy, which gives scientists a detailed look at its chemical makeup. “XRISM will provide the international science community with a new glimpse of the hidden X-ray sky,” said Richard Kelley, the ...

Air pollution significantly impacts human health, with Hainan Province in China aiming to achieve world-leading ambient air quality by 2035, despite already having relatively good air quality in China. The existing Ambient Air Quality Standards (AAQS) offer insufficient guidance for further enhancing air quality in Hainan, which stands at the forefront of China's environmental protection efforts. Consequently, it is imperative to develop Hainan's local AAQS. This initiative, responding to WHO's strengthened guidelines, aims to address unique regional challenges in air quality ...