BOSTON, March 29, 2023 — The Institute for Protein Innovation (IPI) will host IPI Surfacing, a symposium on cell surface receptor biology, on Thursday, June 15, 2023. The free, day-long event convenes biomedical scientists at the Joseph B. Martin Conference Center at Harvard Medical School. Registration opens today. As its inaugural symposium, IPI Surfacing reflects the Institute’s mission to advance protein science to accelerate research and improve human health. In addition to providing ...

Scientists at the Fralin Biomedical Research Institute at VTC are looking to uncover the “why” of the American diet. Why are people drawn to ultra-processed foods, which have been linked to obesity, Type 2 diabetes, different types of cancer, and increased risk of heart disease and death? It’s a critical question because ultra-processed foods make up about 58 percent of calories consumed in the United States. These foods have been through multiple manufacturing processes and contain many added ingredients. Examples include sweetened cereals, hot dogs, chips, and soft drinks. “We ...

INDIANAPOLIS, March 29, 2023 — Specialty coffees are gaining traction in coffeehouses around the world — and now a fermented version could bring a fruity taste to your morning cup of joe. This new kind of beverage has a raspberry-like taste and aroma, but what causes these sensations has been a mystery. Today, scientists report six compounds that contribute to the fermented coffee experience. The work could help increase production of the drink and make it more readily available for everyone to enjoy. The researchers ...

INDIANAPOLIS, March 29, 2023 — Imagine getting the benefits of gastric bypass surgery without going under the knife — a new class of compounds could do just that. In lab animals, these potential treatments reduce weight dramatically and lower blood glucose. The injectable compounds also avoid the side effects of nausea and vomiting that are common with current weight-loss and diabetes drugs. Now, scientists report that the new treatment not only reduces eating but also boosts calorie burn. The researchers will present their results today at the spring meeting of the American Chemical Society ...

Enzymes work in the cells of all living organisms, allowing specific and complex reactions to be carried out quite easily. However, few natural enzymes are effective for industrial applications, which could benefit greatly from discoveries that make targeted enzyme creation a reality. Artificial metalloenzymes can be created simply by binding metal ions or metallic compounds to proteins, so that they exhibit enzymatic activity. Currently, metalloenzymes are being studied to discover new functions or improve their reactivity ...

Lizards may be small, with only a single hearing bonelet compared to our three, and without earflaps, but their hearing is typically good. Most lizards can hear frequencies between 100 and 5,000 Hz (although they are most sensitive between 400 and 1,500 Hz), compared to between 20 and 20,000 Hz in humans. So how do lizards react to noise pollution? Here, scientists studied the impact of noise from low-flying military aircraft on the behavior and well-being of an uncommon lizard, the Colorado checkered whiptail (Aspidoscelis neotesselatus). This ...

A research group including Professors Mitsumasa Koyanagi and Akihisa Terakita of the Osaka Metropolitan University Graduate School of Science has investigated both the genetic information and structure of the photoreceptor rhodopsin, responsible for detecting dim light, of whale sharks to investigate how they can see in the dim light at extreme depths. The research group compared the whale sharks to zebra sharks, which are considered their closest relative, and brown-banded bamboo sharks, which are in the same group: the order orectolobiformes—commonly known as carpet sharks. “This research used genetic ...

In his new book Primary Health Care and Population Mortality, released next week, Professor Richard Baker draws on international evidence to show how primary health care is key to the effect of health systems on population mortality and inequality in mortality. His conclusion is that it is time to think about primary health care in a new way. He explains: “It is as if policymakers think primary health care is little more than a triage mechanism for the health system, that its purpose is to manage access to other ...

A team of astronomers has discovered one of the biggest black holes ever found, taking advantage of a phenomenon called gravitational lensing. The team, led by Durham University, UK, used gravitational lensing - where a foreground galaxy bends the light from a more distant object and magnifies it – and supercomputer simulations on the DiRAC HPC facility, which enabled the team to closely examine how light is bent by a black hole inside a galaxy hundreds of millions of light years from Earth. They found an ultramassive black hole, an object over 30 billion times the ...

Researchers from the Okinawa Institute of Science and Technology (OIST) have developed a method to measure coral biodiversity through extracting the environmental DNA (or eDNA) from a liter of surface seawater collected from above a reef. The method has been confirmed to work through observations made by scientific divers in the same areas of ocean. The research, conducted in collaboration with the Okinawa Prefecture Environmental Science Center and University of Tokyo, was published in the Proceedings of the Royal Society B: Biological Sciences. This has paved the way for large-scale comprehensive surveys of reef-building coral to take place and removes the reliance of ...

Scientists have found out how some skin cancers stop responding to treatment at the end of life. An in-depth analysis of 14 patients who died from incurable melanoma has revealed that changes to the order, structure and number of copies of tumour DNA could cause some skin cancers to resist treatment. These changes also explain how melanoma can spread to other parts of the body.  The research, published today (29th March) in the journal Cancer Discovery, was led by scientists and clinicians at the Francis Crick Institute, UCL and The Royal Marsden. It is part of the Cancer ...

Researchers found that, despite being heavily immunocompromised, haematology patients generate strong cellular immune responses against SARS-CoV-2 after vaccination, on par with that of healthy individuals. Published today in Cell Reports Medicine, the research team, led by University of Melbourne Professor Katherine Kedzierska, a Laboratory Head at the Peter Doherty Institute for Infection and Immunity (Doherty Institute), undertook the most comprehensive analysis of adaptive SARS-CoV-2 immunity to ...

The electric vehicle market has been experiencing explosive growth,  with global sales surpassing $1 trillion (approx. KRW 1,283 trillion) in 2022 and domestic sales exceeding 108,000 units. Inevitably, demand is growing for high-capacity batteries that can extend EV driving range. Recently, a joint team of researchers from POSTECH and Sogang University developed a functional polymeric binder for stable, high-capacity anode material that could increase the current EV range at least 10-fold.   A research team led by POSTECH professors Soojin Park (Department of Chemistry) and Youn Soo Kim (Department ...

Kyoto, Japan -- Lead author Yurii Victorovich Kovtun, despite being forced to evacuate the Kharkiv Institute of Physics and Technology amid the current Russia-Ukraine war, has continued to work with Kyoto University to create stable plasmas using microwaves. Getting plasma just right is one of the hurdles to harnessing the massive amounts of energy promised by nuclear fusion.  Plasmas -- soups of ions and electrons -- must be held at the right density, temperature, and duration for atomic nuclei to fuse together to achieve the desired release of energy. One recipe involves the use of large, donut-shaped devices with powerful magnets ...

The opening day of the World Conference of Science Journalists (WCSJ) 2023 in Medellín, Colombia saw hundreds of journalists from 62 countries come together in the stunning setting of the city’s Jardin Botanico.   Over 500 attendees will gather over three days to discuss science journalism, to challenge ideas and to reinforce their professional networks and friendships.    The day began with a keynote on biodiversity delivered by Brigitte Baptiste, a Colombian biologist and expert in biodiversity issues. And it closed with an opening ceremony and vibrant social event for attendees.   Both took place under open skies in the ...

One of the many ways to reduce the energy required for transportation is to make vehicles lighter. High-strength (HS) steels are perfect candidate materials for this purpose, as their higher weight-to-strength ratio allows for the use of less metal to achieve a similar structural integrity. Many automobile companies believe HS steels will be an essential component of various types of cars in the future. However, for this to become a reality, there is a glaring problem that needs to be solved. When HS steel is exposed to rainwater (H2O) or hydrogen, a phenomenon known as hydrogen embrittlement occurs. Hydrogen atoms diffuse into the lattice ...

A health impact assessment led by the Barcelona Institute for Global Health (ISGlobal), a centre supported by the ”la Caixa” Foundation, has concluded that implementing green corridors throughout the city of Barcelona would result in a “considerable reduction” in mental disorder cases in adult residents as well as in direct and indirect costs associated to said cases. The study was published in the journal Environment International. It is estimated that mental health disorders ...

A detailed analysis of consumed food showed there is a need to improve diets in long-term care (LTC) homes to make them healthier for residents. The analysis found that eating more whole grains, plant-based proteins, and plain fruits and vegetables would help residents meet government guidelines and reduce their risk of inflammation.  Researchers at the University of Waterloo developed new artificial intelligence (AI) technology to examine data on food and fluids consumed by more than 600 residents over three days at 32 LTC homes. Results were compared to recommendations in the 2019 Canada’s Food Guide on healthy eating and expert ...

UNIVERSITY PARK, Pa. — After a building failure due to natural disasters or poor structural design, safety inspectors must enter a structure to assess the damage before occupants can return. Researchers in the Penn State Department of Architectural Engineering studied how building inspectors make their safety assessments, by analyzing their gaze patterns with eye-tracking software. Eventually, the eye-tracking data could be used to code autonomous robots, like drones, to conduct building assessments in place of humans.  The researchers' results were published in Scientific Reports.   “We ...

UNIVERSITY PARK, Pa. — Measuring temperature and nitrogen levels in soil is important for agriculture systems but detecting them apart from one another is difficult to do. Huanyu “Larry” Cheng, James L. Henderson, Jr. Memorial Associate Professor of Engineering Science and Mechanics at Penn State, led researchers in the development of a multi-parameter sensor that can effectively decouple temperature and nitrogen signals so that each can be measured accurately. The results were recently published by Advanced Materials.  “For efficient fertilization, ...

A DNA editing tool adapted by Oak Ridge National Laboratory scientists makes engineering microbes for everything from bioenergy production to plastics recycling easier and faster. The Serine recombinase-Assisted Genome Engineering, or SAGE system, lets scientists quickly insert and test new DNA designs in a variety of microorganisms. Engineered microbes hold promise for making biofuels, recycling mixed plastics, aiding soil carbon storage and treating health disorders. “SAGE works in virtually all microorganisms, revolutionizing what we’re able to do with microbes,” ...

Neuroscientists from the Medical University of South Carolina (MUSC) report in Brain Connectivity that they have detected subtle differences in the way the brain functions in older adults with preclinical Alzheimer’s disease (AD). Adults with preclinical AD have the earliest signs of disease, such as buildup of amyloid-beta proteins in their brains. However, they have no noticeable symptoms of cognitive decline. The research team, led by Andreana Benitez, Ph.D., and Stephanie Fountain-Zaragoza, Ph.D., used a novel brain imaging analysis technique to construct individualized maps of brain function. They then looked to see if there were ...

Taxes on sugary drinks reduce the risk of gestational diabetes and unhealthy weight gain in pregnant women, reports a new UC San Francisco study of more than 5 million women.  Published by the American Journal of Preventive Medicine, this is the first study to examine how sugar-sweetened beverage (SSB) taxes affect the health of mothers and children immediately before and after birth. Researchers compared mothers who were living in cities that had SSB taxes in effect while they were pregnant to mothers in cities with no SSB taxes. In addition to significantly lowering the risk of diabetes and unhealthy weight gain ...

Bioactive compounds present mostly in fruit and vegetables perform different bodily functions relating to health and well-being. Their effects are considered antioxidant, antidiabetic, antiaging and anticancer, among others. Many studies are looking for ways to optimize absorption of bioactive compounds by the organism and increase their bioavailability – the proportion that enters the bloodstream after absorption. One way is to coat the compounds with another material and package them on the nanometric scale (a nanometer is a billionth of a meter). Nanoencapsulation, as this technique is known, assures slow release of the compounds so that they take longer to digest and can survive ...

WASHINGTON (March 28, 2023)— A new combination drug treatment showed promising results in patients with pan-refractory, recurrent/metastatic head and neck cancer, according to a study published today in the Journal of Clinical Oncology. Head and neck cancer is a deadly form of cancer that arises in the lining of the mouth and throat. Worldwide more than 700,000 people were diagnosed with head and neck cancer in 2021. The disease is caused by the human papillomavirus (HPV) or environmental carcinogens, including the regular use of tobacco or alcohol. When the cancer comes back after curative ...