SAN ANTONIO, March 26, 2024 – Thomas Patterson, MD, and David Gius, MD, PhD, two top physician-scientists at The University of Texas Health Science Center at San Antonio (UT Health San Antonio), have been accepted into the prestigious Association of American Physicians for the advancement of scientific and practical medicine. Patterson is professor of medicine and chief of the Division of Infectious Diseases and vice chair for clinical research for the Department of Medicine in the Joe R. and Teresa Lozano Long School of Medicine, and Gius is associate cancer director of translational research at the Mays Cancer Center and assistant dean of research and ...

When FAMU-FSU College of Engineering Professor Fang Peng was a boy, he saw the power and peril of electricity firsthand. He was in middle school when his remote Chinese hometown first received electric service. His family shared a single portable, 15-watt light bulb attached to a cable. It was his job to replace the bulb. “One night, the bulb went out and I tried to change it in total darkness,” Peng said. “I accidentally stuck my left thumb in the socket and was immediately shocked. I got knocked off balance and down to the dirt floor, trembling as the electricity seared through my body. Luckily, my right ...

Bruce A. Freeman, Irwin Fridovich Distinguished Professor and Chair at the University of Pittsburgh School of Medicine Department of Pharmacology & Chemical Biology, will introduce Redox Medicine 2024 with a key note talk titled "Small Molecule Electrophiles: Lessons from a Journey through Studying the Redox Chemistry of Nitrogen Oxides to Drug Development”. The 26th International Conference of the Redox Medicine, Redox Medicine 2024, will take place on June 27-28 at Fondation Biermans Lapôtre in Paris, France. Professor Freeman will discuss the generation and actions of nitrogen oxide-derived fatty acid nitroalkenes in the context of ...

PHILADELPHIA – Patients being treated for B-cell non-Hodgkin’s Lymphoma (NHL) who are part of minority populations may not have equal access to cutting-edge CAR T cell therapies, according to a new analysis led by researchers from the Perelman School of Medicine at the University of Pennsylvania and published today in NEJM Evidence. CAR T cell therapy is a personalized form of cancer therapy that was pioneered at Penn Medicine and has brought hope to thousands of patients who had otherwise run ...

The beautiful, gnarled, nooked-and-crannied reefs that surround tropical islands serve as a marine refuge and natural buffer against stormy seas. But as the effects of climate change bleach and break down coral reefs around the world, and extreme weather events become more common, coastal communities are left increasingly vulnerable to frequent flooding and erosion.  An MIT team is now hoping to fortify coastlines with “architected” reefs — sustainable, offshore structures engineered to mimic the wave-buffering effects of natural reefs while also providing pockets for fish and other marine ...

University of Maryland School of Medicine (UMSOM) Dean Mark T. Gladwin, MD, announced today that Martine Rothblatt PhD, JD, MBA, Chairperson and CEO of United Therapeutics, and inventor of SiriusXM Satellite Radio, will deliver the keynote address for this year’s graduating medical student class. The UMSOM MD graduation ceremony will take place at the Hippodrome Theatre on Thursday, May 16, 2024. The ceremony will begin at 1:00 pm. Details for faculty members are here. Details for students/guests are here. Dr. Rothblatt is a trailblazing pioneer of several innovations in biotechnology, pharmaceuticals, and satellite communications. After developing SiriusXM, ...

The ORIGAMI (Optimized Resource Integration and Global Architecture for Mobile Infrastructure for 6G) project is now underway. The project, funded by the European Commission under the Horizon Europe program, will spearhead architectural innovations for the next generation of 6G mobile networks, to enable innovative applications, new business models, and substantial reductions in energy consumption. By proposing and developing three critical architecture innovations – Global Services Based Architecture (GSBA), Zero Trust Exposure Layer (ZTL), and Continuous Compute ...

New research says the wide variety of skills displayed by people with conditions such as ADHD, dyslexia and autism should be celebrated to help reduce stigma and change society’s expectations. Creativity, resilience and problem-solving are just some of the strengths exhibited and a study is now calling for a change in the way we think about people with neurodevelopmental conditions. Dr Edwin Burns, senior lecturer from the School of Psychology at Swansea University, worked with academics from Edge Hill University on the study and their findings have just been published by ...

Local and state governments have a variety of tools at their disposal to attract businesses or entice them to stay. One is tax relief. Austin, for example, helped lure electric automaker Tesla in part with property tax rebates worth $14 million over 10 years. In a study released today from Texas McCombs, Dean and Accounting Professor Lillian Mills finds that another kind of government aid — cash grants — has a different kind of impact. It helps companies lighten their balance sheets by borrowing less. Corporations ...

TUCSON, Ariz., March 26, 2024 — Critical Path Institute (C-Path) is excited to announce the launch of the Critical Path for Alpha-1 Antitrypsin Deficiency (CPA-1) Consortium. The CPA-1 consortium aims to accelerate drug development for alpha-1 antitrypsin deficiency (AATD), a rare disease that affects individuals and families worldwide. This will be achieved by integrating data through C-Path’s Rare Diseases Cures Accelerator–Data Analytics Platform (RDCA-DAP®) and leveraging those data for CPA-1 to collaboratively develop regulatory-grade solutions to continuously address unmet needs in drug development for this condition, including: Generating evidence to ...

COLUMBUS, Ohio – When the skeletal remains of a giant ground sloth were first unearthed in 1796, the discovery marked one of the earliest paleontological finds in American history.  The animal, named Megalonyx by Thomas Jefferson in 1799, was the first genus of fossil named from the United States. Thought to have roamed North America during one of the last ice ages, the extinct giant ground sloth was an herbivorous mammal resembling a large bear — at full size, it likely reached nearly 10 feet tall (3 meters) and weighed about as much as a small elephant.  The report made by Jefferson, an avid fossil collector who was known to keep ...

Organisms constantly face the challenge of adapting their behavior to survive in a world full of uncertainties. This ability relies on complex neural circuits in the brain that help them find resources while avoiding danger. Scientists study how these neural circuits change over time to understand better how behaviors emerge. One powerful way to study these changes is through optical imaging techniques that allow researchers to track the activity of individual brain cells. Traditional methods rely on observing the activity of cells directly, ...

“[...] chlorogenic acid appears to be a promising candidate for the management of osteoporosis.” BUFFALO, NY- March 26, 2024 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 5, entitled, “Chlorogenic acid prevents ovariectomized-induced bone loss by facilitating osteoblast functions and suppressing osteoclast formation.” Osteoporosis is a common bone disease in ...

Researchers at Weill Cornell Medicine have discovered a protein called SEL1L that plays a critical role in clearing collagen from tissue, and which may be a therapeutic target to help prevent fibrosis, scar tissue that interferes with organ function. The paper, published on Feb. 20 in Nature Communications, provides clues that could lead to drug development for diseases like lung fibrosis which have no therapeutic options currently. Corresponding author, Dr. Michael J. Podolsky, assistant professor of medicine at Weill Cornell Medicine, has led a team that searched the human genome for genes involved in the ...

FOR IMMEDIATE RELEASE Recent historical, political and public health events, most notably the COVID-19 pandemic, have collectively contributed to increased stress and mental health challenges among many groups of people — including adolescents in racial and ethnic minorities.  In a study published Feb. 1 in Academic Pediatrics, Johns Hopkins Children’s Center researchers investigated the pandemic’s effect on preexisting mental health disparities among youth, and found rates of depression, anxiety, and suicidal thoughts and behaviors ...

By 2030, the World Health Organization (WHO), the Global Fund and UNAIDS are hoping to end the human immunodeficiency virus (HIV) and AIDS epidemic. An international team of researchers led by Eric Arts, professor at the Schulich School of Medicine & Dentistry, and Jamie Mann, senior lecturer at the University of Bristol (U.K.), has brought us another step closer to meeting this goal, by finding an effective and affordable targeted treatment strategy for an HIV cure.  In a first, the study published ...

Leuven (Belgium) 26 March 2024 - Belgian scientists have developed AI models that can predict how a particular beer will be rated by consumers, and what aroma compounds brewers can add to improve it. The research was published today in the renowned scientific journal Nature Communications and may revolutionize how the food and beverage industry develops new products.  Tricky to compare Comparing and ranking flavor profiles of different beers is a challenge. There are a multitude of guides on the market describing ...

Grapes grown to make wine are sensitive to climate conditions such as temperature and extreme drought. These effects are already visible worldwide on yields, the composition of grapes and the quality of wines, with already and soon-to-be-observed consequences on the geography of wine production. Understanding shifts in wine production potential due to climate change is a major scientific concern. Based on their expertise and a thorough analysis of the scientific literature — over 250 publications in the last 20 years – a research team has established a global map of evolving trends in the threats and potential benefits that climate change brings ...

SAN ANTONIO — March 26, 2024 —Southwest Research Institute Senior Research Scientist Dr. Rohini Giles has received the NASA Early Career Achievement Medal. The medal recognizes unusual and significant performance supporting NASA’s mission during the first 10 years of their career. Giles was cited for “significant early career achievements in the analysis of Juno data to study Jovian Transient Luminous Events and the distribution of constituents in Jupiter’s atmosphere.” “It’s ...

About The Study: In this cohort study of 64,000 low-income Americans, nearly 80% of study participants consumed sodium exceeding the current recommended daily amount, which was associated with 10% to 30% of cardiovascular disease mortality. Public health programs targeted to reduce sodium intake among this underserved population may be beneficial. Authors: Xiao-Ou Shu, M.D., Ph.D., of the Vanderbilt University School of Medicine in Nashville, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi: 10.1001/jamanetworkopen.2024.3802) Editor’s Note: Please see the ...

About The Study: In this cohort study including 309,000 Danish children, longer duration of exclusive breastfeeding was associated with reduced risk of childhood B-cell precursor-acute lymphoblastic leukemia, corroborating results of previous case-control investigations in this field. To inform future preemptive interventions, continued research should focus on the potential biologic mechanisms underlying the observed association. Authors: Signe Holst Søegaard, Ph.D., of the Danish Cancer Society in Copenhagen, is the corresponding ...

There are 40% more Hispanic/Latino kids diagnosed with acute lymphoblastic leukemia (ALL) than white non-Hispanic/Latino children; actually, Hispanic/Latino individuals have the highest risk of ALL in the United States.  However, the basis for this difference is not well understood. Researchers recently identified a genetic variant that accounts for the increased risk of B-cell ALL in Hispanic/Latino children, and using ancient DNA, they traced the mutation all the way back to the first migrants who ...

Acute lymphoblastic leukemia (ALL), the most common childhood cancer, disproportionately affects children of Hispanic/Latino origin in the United States. They are 30-40% more likely to get ALL than non-Hispanic white children, but the exact genetic basis and cause of that increased risk are unknown. Now, a study from the Keck School of Medicine of USC has revealed a key genetic variant contributing towards the increased risk, as well as details about the biological basis of ALL. The team used genetic fine-mapping analysis, a statistical method that allows researchers ...

Mammalian mitochondrial electron transport chain complexes are the most important and complicated protein machinery in mitochondria. Although this system has been studied for more than a century, its composition and molecular mechanism are still largely unknown. Here, Yang’s group report the high-resolution cryo-electron microscopy (cryo-EM) structures of porcine respiratory chain megacomplex-I2III2IV2 (MCI2III2IV2) in five different conformations, including State 1, State 2, Mid 1, Mid 2, and Mid 3. High-resolution cryo-EM imaging, combined with super-resolution gated stimulated emission depletion microscopy (gSTED), strongly supports ...

This study is led by Prof. Ying Li (Xuzhou Medical University), Prof. Zuobin Zhu (Xuzhou Medical University), and Prof. Wenqiang Chang (Shandong University). A small molecule library consisting of 40 compounds, specifically N-substituted maleimide and its derivatives were initially screened in the study. Among them, twelve maleimides, each with a distinct N-protection group, were synthesized using ring-opening and ring-closing reactions involving various amines and maleic anhydride. Additionally, a set of twenty-eight ...