Cold Spring Harbor Laboratory Associate Professor and Cancer Center member Tobias Janowitz led a COVID-19 clinical trial with Northwell Health in 2021. When he and Clinical Fellow Hassal Lee reviewed the data, a surprising trend emerged. “The patient roster was very diverse,” Janowitz explains. “We’d made no deliberate effort toward that other than conducting the trial remotely.” When it comes to cancer trials, many variables impact patient participation. One measurable factor is distance. On average, people are less likely to ...

About The Study: This analysis including 157,000 individuals from two large study cohorts found that among U.S. veterans, higher body mass index (BMI) variability was a significant risk marker associated with adverse cardiovascular events independent of mean BMI across major racial and ethnic groups. Results were consistent in the UK Biobank for the cardiovascular death end point. Further studies should investigate the phenotype of high BMI variability.  Authors: Yan V. Sun, Ph.D., M.S., ...

About The Study: In this early childhood study including 303 children, concussion was associated with more postconcussive symptoms than orthopedic injuries or typical development up to three months after injury. Given the limited verbal and cognitive abilities typical of early childhood, using developmentally appropriate manifestations and behaviors is a valuable way of tracking postconcussive symptoms and could aid in concussion diagnosis in young children.  Authors: Miriam Beauchamp, Ph.D., of the Universite de Montreal, is the corresponding author.  To access the embargoed study: Visit our For The Media website at ...

The first study of humpback whale entanglements in B.C. aquaculture facilities in PLOS One found eight over 13 years, with the curiosity of young whales a potential contributing factor. A rare occurrence Entanglements are one of several threats to humpbacks. The eight occurred from 2008 to 2021 at seven fish farms, with five animals successfully released and three deaths. The entanglements accounted for less than six per cent of all entanglements in B.C. Approximately 7,000 animals return to B.C. waters annually. Most whales became entangled between the predator and containment nets on fish farms. In five cases, experienced ...

Tokyo, Japan – Drinking milk helps your bones grow big and strong; but what if direct exposure to light could help too? Now, researchers from Japan report that lighting up bone tissue could help treat bone disease. In a study published last month in Scientific Reports, researchers from Tokyo Medical and Dental University (TMDU) have revealed that a treatment approach based on light could help activate bones to repair themselves. Bones are constantly being remodeled through the action of osteoclasts, which break down bone tissue, and osteoblasts, which create new bone tissue. ...

We are used to computers getting faster and faster, but complicated calculations involving lots of data can take a very long time, even today. This applies to calculations of chemical reactions, how proteins assume different three-dimensional forms and so-called phase transitions, where one chemical substance transitions from one state to another, such as from solid to liquid form. These types of results are often very important – for example, in the chemical industry. Down from one year to ten days These complicated calculations can take years to perform, and access to the most ...

1. A NIMS research team has developed a technique that enables the nanoscale observation of heat propagation paths and behavior within material specimens. This was achieved using a scanning transmission electron microscope (STEM) capable of emitting a pulsed electron beam and a nanosized thermocouple—a high-precision temperature measurement device developed by NIMS. 2. Public interest in energy conservation and recycling has grown considerably in recent years. This change has inspired scientists to develop next-generation materials/devices capable of controlling and utilizing heat with a high degree of precision, including thermoelectric devices able to ...

They published their work on Mar. 15th in Energy Material Advances.   "It is highly necessary to design highly conductive and high-performance materials for application in alkaline ion batteries," said paper author Xijun Xu, associate Professor at the College of Chemical Engineering and Light Industry, Guangdong University of Technology. "In recent years, with the development of large-scale power systems such as electric vehicles, the demand for secondary batteries has gradually shifted towards high power and low cost. Furthermore, in light of the increasing energy and environmental concerns, the exploration of green and renewable ...

They published their work on Mar. 15th in Energy Material Advances.   "The development of cost-effective and high-performance RP anode materials for LIBs/SIBs is imperative," said paper author Hailei Zhao, professor with the Beijing Key Lab of New Energy Materials and Technology, School of Materials Science and Engineering, University of Science and Technology Beijing, "Despite RP shows a great potential, the inherent poor electrical conductivity of RP (~10-14 S cm-1) and significant volume changes during charge/discharge processes (> 300%) compromise its cycling stability."   Zhao explained that the poor electrical conductivity ...

In a Finnish outcrop nestled between some of Northern Europe's oldest mountains, researchers have found traces of a previously hidden part of Earth's crust that points more than three billion years back in time and north towards Greenland. These traces were found in the mineral zircon, which after chemical analyses, indicated to researchers from the Department of Geosciences and Natural Resource Management that the "foundation" upon which Denmark and Scandinavia rest, was probably 'born' from Greenland approximately 3.75 billion years ago. "Our data suggest that the oldest part of Earth's crust beneath Scandinavia originates ...

Among the many confounding symptoms in patients recovering from a COVID-19 infection are memory loss and difficulty learning. Yet little is known about the mechanisms of cognitive impairments like these, commonly called brain fog.  In a new study, researchers at the University of Illinois Chicago have identified a mechanism that causes neurological problems in mice infected with SARS-CoV-2, the virus behind COVID-19. The researchers also found a treatment that helped prevent these changes. Sarah Lutz, assistant professor of anatomy and cell biology in the College of Medicine, led the research, ...

 Highlights: Legionnaires’ disease is a rare and dangerous respiratory tract infection. Diagnoses and surveillance usually require culturing isolates. A new study shows how whole genome sequencing could be used when culturing isn’t an option. The work points to new avenues for public health surveillance of infectious diseases.   Washington, D.C.—Legionnaires’ disease (LD), a rare and severe type of pneumonia, is a respiratory infection caused by species of Legionella bacteria. One of the most accurate ways to diagnose LD is to perform culture on samples from a patient’s lower respiratory tract, but those samples are difficult ...

New York, NY [March 21, 2024]—Using novel genetic and genomic tools, researchers at the Icahn School of Medicine at Mount Sinai have shed light on the role of immune cells called macrophages in lipid-rich tissues like the brain, advancing our understanding of Alzheimer’s and other diseases. The study, published in the March 6 online issue of Nature Communications [DOI: 0.1038/s41467-024-46315-7], represents a step forward in understanding immune cell regulation and its impact on disease progression. The researchers initially studied genes controlling macrophages, also referred ...

Plants-derived essential oils (EOs) find applications in various industries, such as detergents, cosmetics, pharmacology, and food additives. Moreover, EOs have an exceptional safety profile, and their numerous bioactivities greatly benefit human health. Beyond these benefits, EOs have also been found to illicit insect-repellent responses by inducing neurotoxic effects.   Terpenoids are abundant in plant EOs and have garnered widespread attention as they can regulate plant defense responses by regulating the expression of defense genes. For example, soybean and komatsuna plants, when grown near mint, experience a significant improvement in defense properties ...

Contact: Jillian McKoy, jpmckoy@bu.edu Michael Saunders, msaunder@bu.edu ## Identifying genetic variants and the role they play in predisposing people to Alzheimer’s disease can help researchers better understand how to treat the neurodegenerative condition for which there is currently no cure. A new study led by Boston University School of Public Health (BUSPH) and UTHealth Houston School of Public Health has identified several genetic variants that may influence Alzheimer’s disease risk, putting researchers one step closer to uncovering biological pathways to target for future treatment and prevention. Published in the journal Alzheimer’s ...

In order for plants to grow, they absorb water and nutrients through their roots. In doing so, they rely on tiny helpers: bacteria and fungi in particular are found in a thin layer around the roots. These microbes also ward off organisms that are harmful to the plant, just as the "microbiome" in the human gut helps determine whether we fall ill or stay healthy. An international research team led by the University of Bonn and with the participation of the IPK Leibniz Institute has now demonstrated on maize plants that the genetic make-up of the host plant has a significant influence on the composition of the root microbes. "It was shown ...

Reduced snow cover and shifting vegetation patterns in the Alps, both driven by climate change, are having major combined impacts on biodiversity and functioning of ecosystems in the high mountains, according to new research published today. Mountain ranges covering vast areas of the world are warming much faster than surrounding lowland areas, triggering huge reductions in snow cover and rapid upward movement of dwarf-shrubs, such as heather. Scientists at The University of Manchester have found that these changes are disrupting the timing of crucial alpine ecosystem functions performed by ...

Microplastics are tiny, nearly indestructible fragments shed from everyday plastic products. As we learn more about microplastics, the news keeps getting worse. Already well-documented in our oceans and soil, we’re now discovering them in the unlikeliest of places: our arteries, lungs and even placentas. Microplastics can take anywhere from 100 to 1,000 years to break down and, in the meantime, our planet and bodies are becoming more polluted with these materials every day. Finding viable alternatives to traditional petroleum-based plastics and microplastics has never been more important. New research from scientists ...

In addition to their main components, the properties of crystalline and nanoporous materials often depend crucially on guest atoms or ions that are embedded in the tiny pores of their lattice structure. This applies to high-tech materials used in sensor or separation technology as well as to natural materials. The bluish gemstone aquamarine, for example, would be colourless without such guest components. Determining the type and position of guest components is difficult, as many materials react sensitively to the radiation emissions ...

Acute myeloid leukemia (AML) is an aggressive form of blood cancer. It is caused by mutations in a large number of genes that are acquired in the course of a person’s life. One of these genes – the tumor suppressor gene TP53 – plays a key role. Normally, TP53 helps to prevent the development of tumors. Blood cancer patients in whom this gene is mutated, however, face an extremely poor prognosis, as their genes are resistant to conventional chemotherapeutic agents. Intensive research is therefore being carried out into new therapeutic approaches, ...

The worry of gaining weight is a common excuse for smokers not to quit. A new study published today in the scientific journal Addiction has found that both starting smoking and lifetime smoking may increase abdominal fat, especially visceral fat:  the unhealthy fat deep inside the abdomen that is linked to a higher risk of heart disease, diabetes, stroke, and dementia. Smokers tend to have lower body weights than non-smokers, but they also have more abdominal fat, and more abdominal visceral fat. Visceral fat is hard to see; you can have ...

A cross-disciplinary University of Waterloo team has developed a new contact lens material that could act as a bandage for corneal wounds while releasing drugs in a controlled manner to help the eye heal faster. Typically, corneal abrasion patients spend seven to 10 days wearing a clear, oxygen-permeable bandage contact lens, often instilled with eyedrops containing antibiotics. However, the one-time antibiotic application makes it difficult to ensure enough drugs stay on the eye for sustained treatment.  “It’s a targeted-release drug delivery ...

High temperatures during critical periods of the reproductive cycle of sheep result in 2.1 million fewer lambs produced in Australia each year, costing sheep farmers an estimated $97 million annually. The work, funded by Meat and Livestock Australia and conducted by a transdisciplinary team of researchers from the University of Adelaide and South Australian Research Development Institute (SARDI), found that days above 32°C during the week of mating caused the significant loss of potential lambs. Published in Nature Food, the study found annual losses of potential lambs would increase to 2.5 million if median global warming increased ...

This study was led by Professor Mingliang Xu (College of Agronomy and Biotechnology, China Agricultural University, Beijing, China). Through phylogenic analysis, the authors identified a gene encoding a calcium-dependent protein kinase, ZmCPK39, as a candidate gene for plant height regulation in maize. The function of ZmCPK39 in controlling plant height has been verified using gene editing technology. Compared to the wild-type ND101, knockout of ZmCPK39 significantly reduced plant height by 40%.   The authors further ...

Cellulose, abundantly available from plant biomass, can be converted into molecules used to make a new class of recyclable polymers, to sustainably replace some plastics. Researchers at Hokkaido University have taken a significant step forward in the drive to make recyclable yet stable plastics from plant materials. This is a key requirement to reduce the burden of plastic pollution in the environment. They developed a convenient and versatile method to make a variety of polymers from chemicals derived from plant cellulose; crucially, these polymers can be fully recycled. The method was published in the journal ACS Macro Letters. Cellulose is one of the most abundant ...