LOS ANGELES — A clinical trial from Keck Medicine of USC will test the feasibility of treating non-small cell lung cancer with immunotherapy provided at home.    Immunotherapy, medicines that use the body’s immune system to eliminate or control cancer cells, are effective for many cancer patients, but are currently only administered intravenously (into the vein) in a doctor’s office or hospital.  The study will examine if a new formulation of atezolizumab, an immunotherapy approved for treating certain types of non-small cell lung cancer, can instead be safely and effectively ...

An expert panel has published the first performance measures to identify remission and evaluate the effectiveness of lifestyle medicine treatments, which will allow more objective comparisons between lifestyle behavior interventions and other non-lifestyle treatments. The performance measures are significant because, as interest in the field of lifestyle medicine has grown, it became clear that the lack of standards to document remission or long-term progress following lifestyle medicine treatment was a barrier to the widespread integration of the ...

At a time when America needs volunteers more than ever, to tackle social problems from homelessness to disaster recovery, fewer people have been volunteering. The number of volunteers for nonprofit and community-based organizations declined recently for the first time in decades, from 30% of the population in 2019 to 23% in 2021. That’s according to AmeriCorps and the U.S Census Bureau, which have tracked rates of volunteerism since 2002. New research from Yifan Yu, assistant professor of ...

Boredom is more common at work than in any other setting, studies show, and employees are bored at work for more than 10 hours per week on average. Even astronauts and police officers get bored on the job. No occupation is immune. Boredom serves an important purpose — it signals the need to stop an action and find an alternative project. But boredom becomes problematic when it’s ignored. New research from the University of Notre Dame shows that trying to stifle boredom prolongs its effects and that alternating boring and meaningful tasks helps to prevent the effects of one boring task from ...

For oligodendrocytes—the central nervous system cells critical for brain function—age may not bring wisdom, but it does come with the power to cling to life for much, much longer than scientists knew. That's according to a new study featured on the March 27 cover of the Journal of Neuroscience. Mature oligodendrocytes took a shocking 45 days to die following a fatal trauma that killed younger cells within the expected 24 hours, Dartmouth researchers report. The findings suggest there's a new pathway for efforts to reverse or prevent the damage that aging and diseases such as multiple sclerosis cause to these important cells. In the brain, ...

There has been a redistribution in the risk of arterial disease in type 1 and 2 diabetes. The risks of heart attack and stroke have decreased significantly, while complications in more peripheral vessels have increased in relative importance, according to studies at the University of Gothenburg. It is well known that type 1 and 2 diabetes increase the risk of heart attack and stroke. Previous research has also identified the clearest cardiometabolic risk factors in this context, such as obesity, lipid disorders, and high blood pressure. How diabetes and cardiometabolic risk factors affect blood ...

Barcelona, 27 March 2024 – The EBMT proudly commemorates its 50th anniversary, marking five decades of transformative advancements in the field of hematopoietic cell transplantation (HCT) and cellular therapy. More than 5,000 healthcare professionals will gather from the 14th to the 17th of April, 2024, at the Scottish Event Campus in Glasgow for this special edition and they will immerse themselves in cutting-edge scientific content, network with their peers from across the globe, and be part of a community that is driving innovation and change. In 1974, a small group ...

What did an ancient Chinese emperor from 1,500 years ago look like? A team of researchers reconstructed the face of Chinese Emperor Wu of Northern Zhou using DNA extracted from his remains. The study, published March 28 in the journal Current Biology, suggests the emperor’s death at the age of 36 might be linked to a stroke. It also sheds light on the origin and migration patterns of a nomadic empire that once ruled parts of northeastern Asia. Emperor Wu was a ruler of the Northern Zhou dynasty in ancient China. Under his reign from AD 560 to AD 578, Emperor Wu built a strong military and unified the northern part ...

New DNA sequencing technologies have identified the historical remains of George Washington’s grandnephews, Samuel Walter Washington and George Steptoe Washington Jr., and their mother, Lucy Payne Washington, from unmarked, fragmentary bones left at the Harewood family cemetery in Charles Town, West Virginia, in the mid-1800s. In addition to enabling the remains in question to be reunited and reburied if desired, the researchers plan to apply the validated DNA analysis techniques to their ongoing efforts to identify the remains of service members lost around the world in past conflicts going back to World War II. The findings appear March 28 in the journal iScience. “The ...

Familial Alzheimer’s disease can be transferred via bone marrow transplant, researchers show March 28 in the journal Stem Cell Reports. When the team transplanted bone marrow stem cells from mice carrying a hereditary version of Alzheimer’s disease into normal lab mice, the recipients developed Alzheimer’s disease—and at an accelerated rate. The study highlights the role of amyloid that originates outside of the brain in the development of Alzheimer’s disease, which changes the paradigm of Alzheimer’s from being a disease ...

About The Study: In this survey study of 204 oncologists, few reported that patients needed to understand artificial intelligence (AI) models, but most agreed that patients should consent to their use, and many tasked patients with choosing between physician- and AI-recommended treatment regimens. These findings suggest that the implementation of AI in oncology must include rigorous assessments of its effect on care decisions as well as decisional responsibility when problems related to AI use arise.  Authors: Gregory A. Abel, M.D., M.P.H., of the Dana-Farber Cancer Institute in Boston, is the corresponding author.   To ...

About The Study: From 2013 to 2022, U.S. physicians received $12.1 billion from industry. More than half of physicians received at least one payment. Payments varied widely between specialties and between physicians within the same specialty. A small number of physicians received the largest amounts, often exceeding $1 million, while the median physician received much less, typically less than a hundred dollars.   Authors: Andrew J. Foy, M.D., of the Penn State Milton S. Hershey ...

BOSTON --  Andrew E. Place, MD, PhD, has been named as Vice President, Pediatric Chief Medical Officer (CMO) at Dana-Farber Cancer Institute (within the Department of Pediatric Oncology) and Boston Children’s Hospital (within the Division of Hematology/Oncology) for the Dana-Farber/Boston Children’s Cancer and Blood Disorders Center.  In this role, Place will work closely with institutional and departmental leaders at Boston Children’s Hospital (BCH) and Dana-Farber to help define and implement clinical strategies and operational approaches that enhance smooth and efficient running of clinical care ...

UVA Health researchers have discovered a potential explanation for some of the most perplexing mysteries of COVID-19 and long COVID. The surprising findings could lead to new treatments for the difficult acute effects of COVID-19, long COVID and possibly other viruses. Researchers led by UVA’s Steven L. Zeichner, MD, PhD, found that COVID-19 may prompt some people’s bodies to make antibodies that act like enzymes that the body naturally uses to regulate important functions – blood pressure, for example. Related enzymes also regulate ...

Just as many people battle seasonal colds and flu, native plants face their own viral threats. People have long known that plants can succumb to viruses just like humans. Now, a new study led by Michigan State University and the University of California, Riverside reveals a previously unknown threat: non-native crop viruses are infecting and jeopardizing the health of wild desert plants. “For years, the ecological field assumed wild plants were immune to invasive viruses that damage crops,” said Carolyn ...

Fukuoka, Japan—Researchers from Kyushu University have developed a hydrogen energy carrier to address some of the biggest hurdles in the path towards a sustainable hydrogen economy. As explained in a paper published in JACS Au, this novel compound can efficiently “store electrons” from hydrogen in a solid state to use in chemical reactions later. Hydrogen is a promising source of clean energy with a lot of untapped potential applications in industry and everyday life. Unlike conventional fuels, hydrogen can be used to generate electricity without producing greenhouse ...

Scientists at The Florey have developed an mRNA technology approach to target the toxic protein tau, which builds up in patients with Alzheimer’s disease and other dementias.  To date, mRNA has been predominantly used for vaccines, including those used to fight COVID-19.  New research published today in Brain Communications establishes The Florey as a key player in the mRNA field, with Dr Rebecca Nisbet taking the technology in a new direction.  “This is the first time mRNA has been explored for use in Alzheimer’s disease,” Dr Nisbet said. “Our work in cell models demonstrates that this technology ...

East Hanover, NJ – March 28, 2024 – Kessler Foundation received two grants from The New Jersey Commission on Spinal Cord Research that will fuel innovative research in the field of spinal cord injury (SCI). These grants will fund efforts aimed at improving the cognitive assessment of individuals with traumatic SCI and pilot-testing the first-of-its-kind Spinal Cord Injury Personal Assistance Services Survey (SCI-PASS). Traumatic spinal cord injury (tSCI) often leads to cognitive impairment, affecting up to 60 percent of individuals living with this condition. “The challenge lies in assessing cognitive functions in people with tSCI, as many existing tests rely on upper limb ...

Rising temperatures and disease outbreaks are decimating coral reefs throughout the tropics. Evidence suggests that higher latitude marine environments may provide crucial refuges for many at-risk, temperature-sensitive coral species. However, how coral populations expand into new areas and sustain themselves over time is constrained by the limited scope of modern observations.  What can thousands of years of history tell us about what lies ahead for coral reef communities? A lot. In a new study, Florida Atlantic University researchers and collaborators provide geological insights into coral range expansions by reconstructing the composition of a Late Holocene-aged subfossil coral ...

Fukuoka, Japan—The interaction between the oceans and the atmosphere plays a vital role in shaping the Earth’s climate. Changing sea surface temperatures can heat or cool the atmosphere, and changes in the atmosphere can do the same to the ocean surface. This exchange in energy is known as “ocean-atmosphere coupling.” Now, researchers from Kyushu University have revealed that this ocean-atmosphere coupling enhances teleconnection patterns—when climate conditions change across vast regions of the globe—in the Northern Hemisphere. In their recent ...

Low recurrence seen with cryoablation for large breast tumors Cryoablation, a minimally invasive technique used to freeze and destroy small tumors, is effective for breast cancer patients with larger tumors, according to research presented by MSK interventional radiologist Yolanda Bryce, MD, at the 2024 Society of Interventional Radiology Annual Scientific Meeting. The retrospective study assessed outcomes for 60 patients who underwent cryoablation because they were not candidates for surgery or declined surgery due to other health concerns. The average size of their tumors was 2.5 centimeters. In a follow-up after 16 months, only 10% of patients experienced a recurrence ...

MANDAN, N.D., March 28, 2024—The U.S.  Department of Agriculture (USDA) Agricultural Research Service (ARS) announces a cooperative agreement with the Nueta Hidatsa Sahnish (NHS) College to conduct research supporting Indigenous Seed Sovereignty. This collaborative effort will increase the number of traditional varieties of seeds of the Mandan, Hidatsa, and Arikara (MHA) Nation crops within NHS College's traditional seed cache. This agreement builds upon USDA’s strengthened partnerships with ...

Younger women are generally thought to have a low risk of heart disease, but new research urges clinicians to revisit that assumption, especially for women who suffer from certain mental health conditions. A new study being presented at the American College of Cardiology’s Annual Scientific Session found that having anxiety or depression could accelerate the development of cardiovascular risk factors among young and middle-aged women. The study draws new attention to the importance of cardiovascular screening and preventive care as rates of cardiovascular risk factors rise and heart attacks become more common in younger people. Anxiety and depression ...

Automated external defibrillators (AEDs) are a common resource in public buildings, yet a new analysis reveals that they are rarely used to help resuscitate people suffering cardiac arrest. Research, which will be presented at the American College of Cardiology’s Annual Scientific Session, found that AEDs were only used in 13 of nearly 1,800 cases of out-of-hospital cardiac arrest, even though many of the incidents occurred near a public AED. Cardiac arrest occurs when the heart suddenly stops beating. It is different from a heart attack, which is when a blockage prevents blood ...

Whether you like your eggs sunny-side up, hard boiled or scrambled, many hesitate to eat them amid concerns that eggs may raise cholesterol levels and be bad for heart health. However, results from a prospective, controlled trial presented at the American College of Cardiology’s Annual Scientific Session show that over a four-month period cholesterol levels were similar among people who ate fortified eggs most days of the week compared with those who didn’t eat eggs. A total of 140 patients with or at high risk for cardiovascular disease were enrolled in ...