About 1 in 10 prescription drugs — mainly brand-name and expensive drugs and those for rare diseases — has a manufacturer-sponsored patient support program, which usually includes financial, nursing and educational supports. "In an era where policy-makers are grappling with escalating drug prices and budgetary impacts globally, the pharmaceutical industry promotes patient support programs as adding complementary value to a drug through supporting medication adherence and enhancing clinical outcomes, patient experience or quality of life," ...

Health Canada increased maximum residue limits for glyphosate in some crops, such as oats and beans, in 2021 despite concerns about the health impact of glyphosate-based herbicides (GBHs). The World Health Organization's (WHO) International Agency for Research on Cancer regards these pesticides as genotoxic, meaning they can damage DNA and are likely carcinogenic. "Health Canada's PMRA considers pesticide sales and risk evaluation data in Canada to be confidential business information, and independent researchers cannot access these data, even through the Access to Information Act. Such ...

Stem cells can differentiate to replace dead and damaged cells. But how do stem cells decide which type of cell to become in a given situation? Using intestinal organoids, the group of Bon-Kyoung Koo at IMBA and the Institute for Basic Science identified a new gene, Daam1, that plays an essential role, switching on the development of secretory cells in the intestine. This finding, published on November 24 in Science Advances, opens new perspectives in cancer research.   Our bodies are, in some ways, like cars – to keep functioning, they need to be checked and repaired regularly. In the case of our bodies, ...

The Fens of eastern England, a low-lying, extremely flat landscape dominated by agricultural fields, was once a vast woodland filled with huge yew trees, according to new research. Scientists from the University of Cambridge studied hundreds of tree trunks, dug up by Fenland farmers while ploughing their fields. The team found that most of the ancient wood came from yew trees that populated the area between four and five thousand years ago. These trees, which are a nuisance when they jam farming equipment during ploughing, contain a treasure trove of perfectly preserved ...

A new study led by UCL researchers confirms that autistic people experience a reduced life expectancy, however the number of years of life lost may not be as high as previously claimed. The research, published in The Lancet Regional Health – Europe, is the first to estimate the life expectancy and years of life lost by autistic people living in the UK. The team used anonymised data from GP practices throughout the UK to study people who received an autism diagnosis between 1989 to 2019. They ...

Plants have no visual organs, so how do they know where light comes from? In an original study combining expertise in biology and engineering, the team led by Prof Christian Fankhauser at UNIL, in collaboration with colleagues at EPFL, has uncovered that a light-sensitive plant tissue uses the optical properties of the interface between air and water to generate a light gradient that is 'visible' to the plant. These results have been published in the journal Science. The majority of living organisms (micro-organisms, plants and animals) have the ability to determine the origin of a light source, even in the absence of a sight organ comparable to the eye. This information is invaluable ...

E. coli bacteria may be far more capable at evolving antibiotic resistance than scientists previously thought, according to a new study published in Science on November 24. Led by SFI External Professor Andreas Wagner, the researchers experimentally mapped more than 260,000 possible mutations of an E. coli protein that is essential for the bacteria’s survival when exposed to the antibiotic trimethoprim. Over the course of thousands of highly realistic digital simulations, the researchers then found that 75% of all possible evolutionary paths of the E. coli protein ultimately ...

Blame it on plate tectonics. The deep ocean is never preserved, but instead is lost to time as the seafloor is subducted. Geologists are mostly left with shallower rocks from closer to the shoreline to inform their studies of Earth history. “We have only a good record of the deep ocean for the last ~180 million years,” said David Fike, the Glassberg/Greensfelder Distinguished University Professor of Earth, Environmental, and Planetary Sciences in Arts & Sciences at Washington University in St. Louis. “Everything else is just shallow-water deposits. So it’s really important to understand the bias that might be present when we look ...

Addressing the long-standing “dolomite problem,” an oddity that has vexed scientists for nearly 200 years, researchers report that dolomite crystals require cycling of saturation conditions to grow. The findings provide new insights into how dolomite is formed and why modern dolomite is primarily found in natural environments with pH or salinity fluctuations. Dolomite – a calcium magnesium carbonate – is one of the major minerals in carbonate rocks, accounting for nearly 30% of the sedimentary carbonate minerality in Earth’s crust. However, despite its geological abundance, dolomite does not readily grow under laboratory conditions, ...

Using a new algorithm called FLSHclust (“flash clust”), researchers have discovered 188 rare and previously unknown CRISPR-linked gene modules – including a novel type VII CRISPR-Cas system – among billions of protein sequences. The approach and its findings provide novel opportunities for harnessing CRISPR systems and understanding the vast functional diversity of microbial proteins. CRISPR systems have been leveraged to develop a growing suite of novel biomolecular approaches, including CRISPR/Cas-mediated genome editing. The discovery ...

An extremely energetic cosmic ray – an extragalactic particle with an energy exceeding ~240 exa-electron volts (EeV) – has been detected by the Telescope Array experiment’s surface detector, researchers report. However, according to the findings, its arrival direction shows no obvious source. Ultrahigh-energy cosmic rays (UHECRs) are subatomic charged particles from space with energies greater than 1 EeV – roughly a million times as high as the energy reached by human-made particle accelerators. Although low-energy cosmic rays primarily emanate from the sun, the origins of rarer UHECRs are thought to be related to the most energetic phenomena in the Universe, ...

In 1991, the University of Utah Fly’s Eye experiment detected the highest-energy cosmic ray ever observed. Later dubbed the Oh-My-God particle, the cosmic ray’s energy shocked astrophysicists. Nothing in our galaxy had the power to produce it, and the particle had more energy than was theoretically possible for cosmic rays traveling to Earth from other galaxies. Simply put, the particle should not exist.  The Telescope Array has since observed more than 30 ultra-high-energy cosmic rays, though none approaching the Oh-My-God-level energy. No observations have yet revealed ...

Images // Video ANN ARBOR—For 200 years, scientists have failed to grow a common mineral in the laboratory under the conditions believed to have formed it naturally. Now, a team of researchers from the University of Michigan and Hokkaido University in Sapporo, Japan have finally pulled it off, thanks to a new theory developed from atomic simulations. Their success resolves a long-standing geology mystery called the "Dolomite Problem." Dolomite—a key mineral in the Dolomite mountains in Italy, Niagara Falls, the White Cliffs of Dover and Utah's Hoodoos—is very abundant in rocks older than 100 million years, but nearly absent in younger ...

Animal embryos go through a series of characteristic developmental stages on their journey from a fertilized egg cell to a functional organism. This biological process is largely genetically controlled and follows a similar pattern across different animal species. Yet, there are differences in the details – between individual species and even among embryos of the same species. For example, the tempo at which individual embryonic stages are passed through can vary. Such variations in embryonic development are considered an important driver of evolution, as they can lead to new characteristics, thus promoting evolutionary adaptations and biodiversity. Studying the embryonic ...

In a Nature Metabolism paper published today, researchers from the University of Pittsburgh detail a potential new target and a small-molecule drug candidate for treating Barth syndrome, a rare, life-threatening and currently incurable genetic disease with devastating consequences. Barth syndrome affects about 1 in every 300,000 to 400,000 babies born worldwide. Those with the condition have weak muscles and hearts and experience debilitating fatigue and recurrent infections. Pitt researchers discovered that faulty mitochondria are at least partially to blame, and identified a molecular culprit that could be targeted to potentially reverse the disease course in the future. In ...

A lot of research has been done over many decades on diseases that are widespread in large parts of the population, such as cancer and heart disease. As a result, treatment methods have improved enormously thanks to long-term research efforts on diseases that affect many people. However, there are many diseases that affect just a handful people. These diseases often fly under the radar and are far less researched. They include quite a few rare, hereditary diseases, such as DOOR syndrome, which is ...

A major breakthrough in human genetics has been achieved with the complete decoding of the human Y chromosome, opening up new avenues for research into digestive diseases. This milestone, along with advancements in third-generation sequencing technologies, is poised to revolutionize our understanding of the genetic underpinnings of digestive disorders and pave the way for more personalized and effective treatment strategies. The Y chromosome, the smallest of the human chromosomes, has long been shrouded in mystery due to its complex repetitive structure. However, recent advancements in sequencing technologies have enabled researchers to unravel the intricate details of this genetic ...

Reducing the dose of a widely used COVID-19 booster vaccine produces a similar immune response in adults to a full-dose with fewer side effects, according to a new study. The research, led by Murdoch Children's Research Institute (MCRI) and the National Centre for Communicable Diseases in Mongolia, found that a half dose of a Pfizer COVID-19 booster vaccine elicited a non-inferior immune response to a full dose in Mongolian adults who previously had AstraZeneca or Sinopharm COVID-19 shots. But it found half-dose boosting may be less effective in adults primed with the Sputnik V COVID-19 vaccine.  The research ...

Iliana Ivanova, European Commissioner for Innovation, Research, Culture, Education and Youth, said: “I extend my heartfelt congratulations to all the brilliant researchers who have been selected for ERC Consolidator Grants. I'm especially thrilled to note the significant increase in the representation of women among the winners for the third consecutive year in this prestigious grant competition. This positive trend not only reflects the outstanding contributions of women researchers but also highlights the strides we are making towards a more inclusive and diverse scientific community.”  President of the European Research Council Prof. Maria Leptin said: “The new ...

Extreme events like tropical cyclones have immediate impacts, but also long-term implications for societies. A new study published in the journal Nature Communications now finds: Accounting for the long-term impacts of these storms raises the global Social Cost of Carbon by more than 20 percent, compared to the estimates currently used for policy evaluations. This increase is mainly driven by the projected rise of tropical-cyclone damages to the major economies of India, USA, China, Taiwan, and Japan under global warming. “Intense tropical cyclones have the power to slow down the economic development of a country for more than a decade, our analysis shows. With global warming, the share ...

An estimated 50,000 shipwrecks can be found around the UK’s coastline and have been acting as a hidden refuge for fish, corals and other marine species in areas still open to destructive bottom towed fishing, a new study has shown. Many of these wrecks have been lying on the seabed for well over a century, and have served as a deterrent to fishers who use bottom towed trawling to secure their catches. As a result, while many areas of the seabed have been damaged significantly in areas of heavy fishing pressure, the ...

Rice, maize, and wheat provide more than half of the calories consumed by humans. The decrease in crop diversity poses a significant risk to global food security. Therefore, the utilization of orphan crops has become an effective approach to address food security crises. Nevertheless, in the face of rapid urban and rural modernization and the intensification of agricultural practices, the availability of wild and cultivated orphan crops is dwindling, with a noticeable disparity in their collection, preservation, ...

Paeonia ostii is a widely grown woody crop with up to 40% α-linolenic acid in its seed oil, which is beneficial to human health. Drought is a major environmental factor limiting the popularisation of P. ostii in hilly and mountainous areas, which may affect plant growth or lead to plant death.WRKY is one of the largest families of transcription factors in plants, and plays an important role in plant response to drought stress. However, the molecular mechanism by which  P. ostii WRKY transcription factors respond to drought stress is still unclear. In September 2023, Horticulture ...

Cornus wilsoniana (2n=22) is a common shrub in the northern temperate zone of China. It blooms white flowers in spring and produces purple-black berries in autumn. This tree has a unique mottled bark texture that makes it particularly eye-catching in winter, earning it the common name "ghost dogwood". Due to its peeling bark in winter, it is commonly known as "Guangpi tree" in China. The fruit of C. wilsoniana is rich in oil and can be used to extract edible oil. The oil content ...

Does patient-surgeon gender concordance lead to lower patient mortality? Mostly no, UCLA-led research suggests New research finds little evidence that post-surgical patient mortality is lower when patient and surgeon are the same gender. While gender concordance has been shown to improve patient care in other health specialties, evidence has been limited when it comes to concordance between patient and surgeon. This study shows that gender concordance was associated with lower mortality for female patients, but higher mortality for male patients—patient mortality was the lowest for ...