In C. elegans, the protein SID1 plays a crucial role in the systemic RNA interference process by facilitating the transport of exogenous double-stranded RNA into the cytoplasm. Previously, Chen-Yu Zhang's group has already demonstrated that intact plant miRNA found in dietary sources can be absorbed through the mammalian digestive system and mediate cross-kingdom gene regulation. Mammalian SID-1 transmembrane family proteins, namely SIDT1 and SIDT2, have attracted considerable attention due to their role in facilitating the uptake of regulatory exogenous small RNAs, such as small interfering RNA (siRNA) and plant-derived ...

Trans-vaccenic acid (TVA), a long-chain fatty acid found in meat and dairy products from grazing animals such as cows and sheep, improves the ability of CD8+ T cells to infiltrate tumors and kill cancer cells, according to a new study by researchers from the University of Chicago. The research, published this week in Nature, also shows that patients with higher levels of TVA circulating in the blood responded better to immunotherapy, suggesting that it could have potential as a nutritional supplement to complement clinical treatments for cancer. “There are many studies trying to decipher ...

Drug overdose deaths rose markedly between January to June 2018 and July to December 2021 among 10- to 44-year-old girls and women who were pregnant or pregnant within the previous 12 months, according to a new study by researchers at National Institute on Drug Abuse (NIDA) at the National Institutes of Health. Overdose mortality more than tripled among those aged 35 to 44 during the study period, from 4.9 deaths per 100,000 mothers aged 35 to 44 with a live birth in the 2018 period to 15.8 in the 2021 period. Over 60% of these pregnancy-associated overdose deaths occurred outside healthcare settings, ...

In Alzheimer’s disease and related dementias, cognitive decline is driven by the overaccumulation of a normal brain protein known as tau. Wherever tau builds up, nearby brain tissue starts to degenerate and die. Now, researchers at Washington University School of Medicine in St. Louis have found — in mice — that Alzheimer’s-like tau deposits in the brain lead to the accumulation of a form of cholesterol known as cholesteryl esters, and that lowering cholesteryl ester levels ...

About The Study: This study of Medicare claims data for 4,386 hospitals found that higher segregation of hospital care was associated with poorer health outcomes for both Black and white patients, with significantly greater negative health outcomes for Black populations, supporting racial segregation as a root cause of health disparities. Policymakers and clinical leaders could address this important public health issue through payment reform efforts and expansion of health insurance coverage, in addition to supporting upstream efforts to reduce racial segregation in hospital ...

About The Study: This study showed that during the Omicron-dominant period, patients with solid cancer and COVID-19 had higher mortality and hospitalization risks following COVID-19 infection versus patients without solid cancer with COVID-19, and that COVID-19 vaccination in the patients with cancer mitigated this risk.  Authors: Salomon M. Stemmer, M.D., of Beilinson Hospital in Petah Tikva, Israel, is the corresponding author.  To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/  (doi:10.1001/jamaoncol.2023.5042) Editor’s Note: Please see the article for additional ...

About The Study: Longer cumulative duration of attention-deficit/hyperactivity disorder (ADHD) medication use was associated with an increased risk of cardiovascular disease, particularly hypertension and arterial disease, compared with nonuse in this study of 278,000 individuals in Sweden ages 6 to 64 who had an incident ADHD diagnosis or ADHD medication dispensation. These findings highlight the importance of carefully weighing potential benefits and risks when making treatment decisions about ...

About The Study: In this study of 103,000 individuals with early-stage breast cancer, Black patients had a higher mortality risk compared with white patients among those with residual disease after neoadjuvant chemotherapy. This highlights the need for personalized treatment strategies for Black patients to help them attain pathologic complete response.  Authors: Shipra Gandhi, M.D., of Roswell Park Comprehensive Cancer Center in Buffalo, New York, is the corresponding author.  To access the embargoed ...

When you eagerly dig into a long-awaited dinner, signals from your stomach to your brain keep you from eating so much you’ll regret it – or so it’s been thought. That theory had never really been directly tested until a team of scientists at UC San Francisco recently took up the question.     The picture, it turns out, is a little different.    The team, led by Zachary Knight, PhD, a UCSF professor of physiology in the Kavli Institute for Fundamental ...

CHAMPAIGN, Ill. — Researchers report in the journal Nature that they have found a way to get antibacterial drugs through the nearly impenetrable outer membrane of Pseudomonas aeruginosa, a bacterium that – once it infects a person – is notoriously difficult to treat. By bombarding P. aeruginosa with hundreds of compounds and using machine learning to determine the physical and chemical traits of those molecules that accumulated inside it, the team discovered how to penetrate the bacterium’s defenses. They used this information ...

Cell and organ transplants can be lifesaving, but patients often encounter long waiting lists due to the shortage of suitable donors. According to donatelife.net, in 2021 6,000 people died in the U.S. alone while waiting for a transplant. One day, transplants generated from stem cells may alleviate the constant organ donor shortage, making transplants available to a larger group of patients. An issue with donation, whether it’s with solid tissues or cells from deceased or living donors, is immune rejection. Unless the donor material is carefully matched to the recipient’s immune system, the transplant will be rejected. However, stem cell research ...

Effective management of land, whether for agriculture, forests, or settlements, plays a crucial role in addressing climate change and achieving future climate targets. Land use strategies to mitigate climate change include stopping deforestation, along with enhancing forest management efforts. Countries have recognized the importance of the land use, land-use change, and forestry (LULUCF) sector, with 118 of 143 countries including land-based emissions reductions and removals in their Nationally Determined Contributions (NDCs), which are at the heart of the Paris Agreement and the achievement of its long-term goals. A new study, published in Nature, demonstrates that estimates of current land-based ...

The aim of the B-GOOD project (Giving Beekeeping Guidance By Computational-Assisted Decision Making) was to pave the way towards healthy and sustainable beekeeping within the European Union by following a collaborative and interdisciplinary approach. By merging data from within and around beehives, as well as wider socioeconomic conditions and by developing and testing innovative tools to perform risk assessments, B-GOOD provided guidance for beekeepers and helped them make better and more informed decisions. The communication of scientific information and the transformation of scientific ...

As the planet gets hotter, animal and plant species around the world will be faced with new, potentially unpredictable living conditions, which could alter ecosystems in unprecedented ways. A new study from McGill University researchers, in collaboration with researchers in Spain, Mexico, Portugal, Denmark, Australia, South Africa and other universities in Canada, investigates the importance of temperature in determining where animal species are currently found to better understand how a warming climate ...

Tracking unprecedented changes in land use over the past century, global land cover maps provide key insights into the impact of human settlement on the environment. Researchers from Sun Yat-sen University created a large-scale remote sensing annotation dataset to support Earth observation research and provide new insight into the dynamic monitoring of global land cover.   In their study, published Oct 16 in the Journal of Remote Sensing, the team examined how global land use/landcover (LULC) has undergone dramatic changes with the advancement of industrialization and urbanization, including deforestation and flooding.   “We ...

Oak Brook, IL – The latest issue of SLAS Discovery is a joint Special Collection between SLAS and the Society of Biomolecular Imaging and Informatics (SBI2) to celebrate the 10th Annual SBI2 High-Content Imaging and Informatics meeting. This collaboration features a curated special collection of articles that highlight the significant impact of high-content imaging in basic and translational research. Volume 28, Issue 7 features one perspective, four original research articles and one short communication. Perspective Evolution and Impact of High Content Imaging This ...

Fukuoka, Japan—Researchers at Kyushu University have developed a new tool to help clinicians and researchers assess individuals for pathological social withdrawal, known as Hikikomori. The tool, called Hikikomori Diagnostic Evaluation, or HiDE, can be a practical guide on collecting information on this globally growing pathology. Hikikomori is a condition characterized by sustained physical isolation or social withdrawal for a period exceeding six months. It was first defined in Japan in 1998, ...

Living cells compete with each other and try to adapt to the local environment. Cells that are unable to do so are eliminated eventually. This cellular competition is crucial as the surrounding normal epithelial cells use it to identify and eliminate mutant cancer cells.  Studies have reported that when activating mutants of “Ras” proteins are expressed in mammalian epithelial cells, they are pushed toward the lumen, excreted along with other bodily waste, and eliminated by competition. Epithelial cells containing Ras mutants have been reported to be removed in this manner in several organs, including the small intestine, stomach, pancreas, and lungs. ...

Quinoa and many other extremely resilient plants are covered with strange balloon-like 'bladders' that for 127 years were believed to be responsible for protecting them from drought and salt. Research results from the University of Copenhagen reveal this not to be the case. These so-called bladder cells serve a completely different though important function. The finding makes it likely that even more resilient quinoa plants will now be able to be bred, which could lead to the much wider cultivation of this sustainable ...

CHICAGO – People with long COVID exhibit patterns of changes in the brain that are different from fully recovered COVID-19 patients, according to research being presented next week at the annual meeting of the Radiological Society of North America (RSNA). “To the best of our knowledge, this is the first study comparing patients with long COVID to both a group without history of COVID-19 and a group that went through a COVID-19 infection but is subjectively unimpaired,” said one of the study’s lead authors, Alexander Rau, M.D., resident in the Departments of Neuroradiology and Diagnostic and ...

CHICAGO – Using a routine chest X-ray image, an artificial intelligence (AI) tool can identify non-smokers who are at high risk for lung cancer, according to a study being presented next week at the annual meeting of the Radiological Society of North America (RSNA). Lung cancer is the most common cause of cancer death. The American Cancer Society estimates about 238,340 new cases of lung cancer in the United States this year and 127,070 lung cancer deaths. Approximately 10-20% of lung cancers occur in “never-smokers” – people who have never smoked cigarettes ...

A research team, led by Professor Toru Miura from the University of Tokyo, shows how the expression of developmental genes in the Japanese green syllid worms, Megasyllis nipponica, helps form their swimming reproductive unit called stolon.     Life always finds ways to surprise us. The presence of a unique reproductive mechanism of some annelid worms or segmented worms is one such surprise. In a process called stolonization, the posterior body part with gonads of the syllid worm detaches from its original body. The detached part is called the stolon, and it is full of gametes (eggs or sperms). The stolon swims around by itself and spawns when it ...

Becoming a parent is a key turning point for adopted people Parenting is always challenging, but for adopted people becoming a mum or dad can be extra demanding, as well as extra special – according to research from the University of East Anglia. A new study is the first in to investigate the lived experiences of adopted people in the UK as they become parents. It finds that they are affected by issues that link back to their adoption and to difficult experiences in their past – related to loss, rejection, abuse and neglect. Because of these ...

Anti-rheumatic drugs used for rheumatoid arthritis might prevent the development of autoimmune thyroid disease, according to a new observational study by researchers from Karolinska Institutet published in the Journal of Internal Medicine.    It is well known that patients with rheumatoid arthritis are at increased risk of autoimmune thyroid diseases such as Hashimoto's disease and Graves' disease. While patients with RA are usually treated with immunomodulatory drugs that affect the immune system, such drugs are rarely used in autoimmune thyroid diseases. Instead, such patients are treated with thyroid hormone to compensate for the changes in normal ...

During missions into space, astronauts are exposed to high levels of galactic cosmic radiation and weightlessness. Simulation experiments in male rats indicated that these aspects of spaceflight can negatively affect vascular tissues relevant to erectile dysfunction, even after a period of long-term recovery. The research, which is published in The FASEB Journal, indicated that vascular alterations are induced by relatively low doses of galactic cosmic radiation and to a lesser extent simulated weightlessness, primarily through increases in oxidative stress. Treatment with different antioxidants could counter some of these ...