ARLINGTON HEIGHTS, Ill. (April 5, 2023) – Hereditary angioedema (HAE) is a disease that, due to its rare nature, can pose difficulties for both patients and medical professionals. A new survey of allergists/immunologists from the American College of Allergy, Asthma and Immunology (ACAAI) shows that diagnosing, treating and managing this condition can be challenging for patients and healthcare providers - including patients in rural areas. An article about the survey is published in Annals of Allergy, Asthma and Immunology, ACAAI’s scientific journal. HAE is caused by a genetic mutation, and there are different types. It is a hereditary disease. The symptoms of HAE ...

PALO ALTO, Calif. (April 5, 2023) – SynGAP Research Fund (SRF), a 501(c)(3) public charity whose mission is to improve the quality of life for SYNGAP1 patients through the research and development of treatments, therapies and support systems, today announced they have awarded a $130,000 collaborative grant to the lab of Xing Tang, PhD at Boston Children's Hospital & AXONIS Therapeutics to investigate the treatment effects of KCC2-enhancing small molecule compounds in SYNGAP1 haploinsufficiency.  Principal Investigator of translational neuroscience at AXONIS, Dr. Kadam, has been working with the SRF community for many years. While at Johns Hopkins, she gave a popular SRF ...

Water in California’s Central Valley contains enough manganese to cause cognitive disabilities and motor control issues in children, and Parkinson’s-like symptoms in adults. A naturally occurring metal, manganese is found in water supplies throughout the world. It is regulated as a primary contaminant in many Southeast Asian countries where the climate causes it to leach into groundwater. However, in the U.S. it is regulated only as a secondary contaminant, meaning no maximum level is enforced.   A ...

New research published in the Journal of Child Psychology and Psychiatry suggests that the microbial composition of the gut may affect a child’s susceptibility to attention-deficit/hyperactivity disorder (ADHD). The human gastrointestinal tract hosts a large population of microorganisms such as bacteria, viruses, and fungi. When investigators compared fecal samples from 35 children with ADHD and 35 healthy controls, samples from children with ADHD had higher levels of certain species of fungi and lower levels of other species.  In experiments with cells grown in the lab, one species in abundance in ...

SARS-CoV-2, the virus that causes COVID-19, attaches to a cellular receptor called angiotensin-converting enzyme 2 (ACE2), and activation of the farnesoid X receptor increases ACE2 expression. New research published in the Journal of Internal Medicine suggests that a drug that inhibits the farnesoid X receptor and is used to treat liver disease may decrease SARS-CoV-2 infections and reduce the severity of COVID-19. The study ran from March 2020 to February 2022 and included 3,214 patients with liver disease, half of whom were taking the drug, called ursodeoxycholic acid (UDCA). ...

In research published in Biotropica, investigators report that the Dwarf Reed Snake (Pseudorabdion longiceps) performs cartwheels when threatened. This is the first time such an active rolling motion has been documented in snakes, with images and a detailed description. The Dwarf Reed Snake is a nocturnal, small snake that lives in regions of Southeast Asia. Typical defense mechanisms that small snakes use against predators include fleeing, camouflage, coloration, odors, death-feigning, and intimidation. ...

In an analysis of published clinical trials, investigators found that phototherapy—or exposure to sessions of bright light—may be a promising non-pharmacological intervention for lessening symptoms of dementia. The analysis in Brain and Behavior included 12 randomized clinical trials. Results indicated that phototherapy improved cognitive function in patients with dementia, but it did not affect symptoms of depression or sleep quality. “Further well-designed studies are needed to explore the most effective clinical implementation ...

In a new study published in The FASEB Journal, investigators demonstrated the potential of a molecule that may help overcome some of the devastating symptoms of Duchenne muscular dystrophy (DMD), the most common life-limiting congenital neuromuscular disorder. The agent promotes the activity of AMP-activated protein kinase (AMPK), an important fuel-sensing enzyme that is present in all mammalian cells. Previous research has shown that stimulating AMPK can mitigate the dystrophy—or wasting—of muscles, but AMPK activators have failed to reach the clinic due to either their lack of potency or toxic off-target effects. In ...

CycPeptMPDB, a novel database—created by Tokyo Tech researchers—focused on the membrane permeability of cyclic peptides, could accelerate the development of drugs based on these promising compounds. This database was created by gathering published information on thousands of cyclic peptides and organizing it neatly in an online-accessible platform. Thanks to its search and visualization capabilities, CycPeptMPDB could pave the way to new computational and machine learning methods for screening and designing drugs with cyclic peptides. One of the ...

COLUMBUS, Ohio – A new approach to trauma-informed care developed by domestic violence survivor advocates and researchers at The Ohio State University has been found in a new study to improve support organizations’ care for survivors by better recognizing brain injury and addressing its often long-lasting repercussions. The study appears in the Journal of Head Trauma and Rehabilitation. CARE is the first trauma-informed approach that considers brain injury in the complex set of circumstances to be addressed and accommodated in order ...

Impact Journals (Aging's publisher) is proud to participate at the American Association for Cancer Research (AACR) Annual Meeting 2023, which convenes April 14-19 in Orlando, Florida. BUFFALO, NY-April 4, 2023 – Impact Journals will be participating as an exhibitor at the American Association for Cancer Research (AACR) Annual Meeting 2023 from April 14-19 at the Orange County Convention Center in Orlando, Florida. This year, the AACR meeting theme is: “Advancing the Frontiers of Cancer Science and Medicine.” Impact ...

Many animals have evolved to tolerate extreme environments, including being able to survive crushing pressures of ocean trenches, unforgiving heat of deserts, and limited oxygen high in the mountains. These animals are often highly specialized to live in these specific environments, limiting them from moving to new locations. Yet, there are rare examples of species that once lived in harsh environments but have since colonized more temperate settings. Angel Rivera-Colón, a former graduate student now postdoc in the lab of Julian Catchen (CIS/GNDP), an associate professor in the department ...

Similar to how cells within human tissues communicate and function together as a whole, bacteria are also able to communicate with each other through chemical signals, a behavior known as quorum signaling (QS). These chemical signals spread through a biofilm that colonies of bacteria form after they reach a certain density, and are used to help the colonies scavenge food, as well as defend against threats, like antibiotics.  “QS helps them to build infrastructure around them, like a city,” ...

Living organisms produce a myriad of natural products which can be used in modern medicine and therapeutics. Bacteria and other microbes have become the main source for natural products, including a growing family called ribosomally synthesized and post-translationally modified peptides, or RiPPs. The labs of Douglas Mitchell (MMG), John and Margaret Witt Professor of Chemistry, and Huimin Zhao (CABBI/BSD/GSE/MMG), Steven L. Miller Chair of Chemical and Biomolecular Engineering, at the University of Illinois Urbana-Champaign have been working in tandem to identify and analyze new RiPPs that could be good candidates ...

Peanut allergies affect 1 in 50 children, and the most severe cases lead to a potentially deadly immune reaction called anaphylactic shock. Currently, there is only one approved treatment that reduces the severity of the allergic reaction, and it takes months to kick in. A group of UCLA immunologists is aiming to change that. Taking inspiration from COVID-19 vaccines as well as their own research on the disease, they created a first-of-its-kind nanoparticle — so small it’s measured in billionths of a meter — that delivers mRNA to specific cells in the liver. Those cells, in turn, teach the body’s natural defenses to tolerate ...

Haley Marks is a project scientist for the Advanced Light Microscopy Lab (ALMS) at the CNSI at UCLA. She is a biomedical engineer with a specialty in nano-biosensor research, translational medicine, and optics education. Since joining CNSI in 2022, Haley has served as a technical expert, providing advanced light microscopy training and services to ALMS users. Here she works on developing and optimizing ALMS’s existing super-resolution and high-speed optical methods, developing strategies and imaging tools for in vivo imaging, and optimizing and disseminating computational imaging techniques. Haley has a passion for all things photonics, and enjoys 3D printing, materials ...

A new study published in the CABI journal Human-Animal Interactions reveals that young dog owners tend to cope well when their beloved pooch misbehaves. Past studies suggest that around 90% of dogs display undesired behaviours such as aggression and disobedience, but little is known about the impact of this on young people’s experiences and accompanying emotions. A team of scientists interviewed young dog owners in Canada, aged 17 to 26 years, to try and determine their experiences with their pets and their coping strategies in response to bad behaviour. This included barking occasional and persistent barking and, in extreme cases, being aggressive towards other dogs ...

Humans have a way of understandings others’ goals, desires and beliefs, a crucial skill that allows us to anticipate people’s actions. Taking bread out of the toaster? You’ll need a plate. Sweeping up leaves? I’ll grab the green trash can.   This skill, often referred to as “theory of mind,” comes easily to us as humans, but is still challenging for robots. But, if robots are to become truly collaborative helpers in manufacturing and in everyday life, they need to learn the same abilities.   In ...

How can we make wearable devices like Spiderman’s suit that are thin and soft yet also feature various electrical and optical functionalities? The answer lies in producing novel materials that go far beyond the performance of existing materials and developing technology that enables the precise control of the physical properties of such materials.   Separating transition metal dichalcogenide (TMD) into a single layer just like graphene makes it transform into a thin, two-dimensional (2D) film material that exhibits the characteristics of highly performing semiconductors. By stacking two disparate ...

Contrary to earlier research findings, people of power - think about politicians, celebrities or bullies in school - turn out to be no less concerned about their reputation, compared to those who have less influence and control within the society.  Previously, it has been assumed that since those who have the upper hand in the society - unlike the ‘powerless’ - are able to get away with commonly unacceptable behaviour (e.g. aggression and exploitation), would care less about any potential damages to their reputation.  However, a recent study by scientists at the University of Kent (United Kingdom) ...

•    Research at Aston University focuses on both creating lab-based meat and its psychological acceptance •    Dr Eirini Theodosiou and Dr Jason Thomas will be speaking at April’s Society matters LIVE event •    Lab made meat on the menu? will take place at Cafe Artum in Hockley Social Club on Thursday 27 April.   Lab made meat will be the topic of the latest Society matters LIVE event from Aston University at Café Artum at Birmingham’s Hockley ...

In a new study, North Carolina State University researchers had 28 high school students create their own machine-learning artificial intelligence (AI) models for analyzing data. The goals of the project were to help students explore the challenges, limitations and promise of AI, and to ensure a future workforce is prepared to make use of AI tools. The study was conducted in conjunction with a high school journalism class in the Northeast. Since then, researchers have expanded the program to high school classrooms in multiple states, including North Carolina. ...

EBViously, a spin-off from Helmholtz Munich (HMGU), is led by world-leading experts in Epstein-Barr virus biology, genetics, and immunity and was founded to develop a safe and highly effective preventive vaccine against a range of diseases caused by Epstein-Barr virus (EBV), including infectious mononucleosis, immune disorders, multiple sclerosis, and various cancers. The spin-off is based on a project of HMGU supported by the German Center for Infection Research (DZIF). The project leading to the spin-off was co-funded by the DZIF to enable GMP manufacturing ...

Planners have come up with many innovative ways to prevent flooding caused by heavy downpours — from planting rain gardens to installing green roofs. But in many cases, nothing works quite as well as a simple hole in the ground — a detention basin. That’s the finding of an analysis by University of Cincinnati geography students in a research collaboration with the Hamilton County Conservation District. Lead author and UC College of Arts and Sciences doctoral student Man Qi said cities are developing new ways to trap rainwater and direct it where it’s most wanted, especially during droughts. They call these low-impact development practices, which ...

Prostate cancer tumors harboring BRCA1/2 mutations are exceptionally sensitive to PARP inhibitors, while genomic alterations in other DNA damage response (DDR) genes are less responsive. To identify previously unknown genes whose loss has a profound impact on PARP inhibitor response, researchers from Dana-Farber Brigham Cancer Center led a multinational effort to perform genome-wide CRISPR-Cas9 knockout screens. The study goal was to inform the use of PARP inhibitors beyond BRCA1/2-deficient tumors and support reevaluation ...