Patients with autoimmune rheumatic diseases, which include rheumatoid arthritis and other chronic disorders that cause inflammation, are at increased risk of SARS-CoV-2 infection, as well as death due to severe COVID-19. Many patients receive disease-modifying antirheumatic drugs (DMARDs) to treat these conditions, but this treatment has been associated with a blunted response to COVID-19 vaccines. The U.S. Centers for Disease Control and Prevention recommends that patients receiving DMARDs receive a fourth ...

HOUSTON ― The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. Recent developments at MD Anderson include insights into the role of RNA-binding proteins in DNA damage repair, the functional role of a hidden microprotein in regulating colorectal cancer gene expression, immunotherapy combinations in gynecologic cancers, the benefits of preventive exercise in protecting ...

From invisible wafts of diesel exhaust to sun-choking plumes of orange smoke, air pollution is known to damage respiratory well-being. Now, research from Rutgers suggests another reason to hold our breath: Polluted air also may hurt reproductive health.   In a study of air pollution data in relation to markers of reproductive development in infancy, Rutgers researchers found certain pollutants may negatively alter anogenital distance, a measure of prenatal exposure to hormones.   “These findings suggest air ...

Iron storage “spheres” inside the bacterium C. diff — the leading cause of hospital-acquired infections — could offer new targets for antibacterial drugs to combat the pathogen.  A team of Vanderbilt researchers discovered that C. diff (Clostridioides difficile) produces the spheres, called ferrosomes, and that these structures are important for infection in an animal model. The findings, reported Nov. 15 in the journal Nature, are also a rare demonstration of a membrane-bound structure inside a pathogenic bacterium.  Bacteria have long been thought not to contain organelles ...

A nationwide programme to reduce the risk of developing diabetes in the UK is proven beyond reasonable doubt to work, a new study reveals.   The positive effects observed in the NHS Diabetes Prevention Programme – the largest such project in the world helping people across the UK to lose weight and control their blood sugar levels – may have relevance globally for tackling the diabetes epidemic.   The Diabetes Prevention Programme (NHS DPP) in England referred adults with high risk of developing diabetes to lifestyle counselling for losing weight, encouraging physical activity, and other ...

A team of European astronomers, co-led by researchers from the Institute of Astronomy, KU Leuven, used recent observations made with the James Webb Space Telescope to study the atmosphere of the nearby exoplanet WASP-107b. Peering deep into the fluffy atmosphere of WASP-107b they discovered not only water vapour and sulfur dioxide, but even silicate sand clouds. These particles reside within a dynamic atmosphere that exhibits vigorous transport of material. Astronomers worldwide are harnessing the advanced capabilities of the Mid-Infrared Instrument (MIRI) aboard the James Webb Space Telescope (JWST) to conduct groundbreaking observations of exoplanets – planets orbiting stars ...

Metamaterials are products of engineering wizardry. They are made from everyday polymers, ceramics, and metals. And when constructed precisely at the microscale, in intricate architectures, these ordinary materials can take on extraordinary properties.  With the help of computer simulations, engineers can play with any combination of microstructures to see how certain materials can transform, for instance, into sound-focusing acoustic lenses or lightweight, bulletproof films. But simulations can only take a design so far. To know for sure whether a metamaterial will stand up to expectation, physically testing them is a must. But there’s been no reliable way to push and pull ...

Cerebral edema, the dangerous brain swelling that occurs after traumatic brain injury (TBI), can increase risk of death tenfold and significantly worsen prospects for recovery in brain function.  In extreme cases, surgeons will remove a portion of the skull to relieve pressure, but this has significant risks and is not viable for the vast majority of TBI cases. Physicians have very few tools at their disposal that are effective in treating cerebral edema, which is one of the leading causes of in-hospital deaths, and is associated with long-term neurological disability. New ...

About The Study: The findings of this study suggest that rates of completion for 4,133 diagnostic tests and referrals (colonoscopies, cardiac stress tests, and dermatology referrals) were low for all visit types but worse when ordered during telehealth visits. Failure to close diagnostic loops presents a patient safety challenge in primary care that may be of particular concern during telehealth encounters.  Authors: Maelys J. Amat, M.D., M.B.A., of Beth Israel Deaconess Medical Center in Boston, is the corresponding author.   To ...

About The Study: Children residing in more disadvantaged neighborhoods at birth had higher likelihood of autism spectrum disorder (ASD) diagnosis in a study that included 318,000 children with health insurance. Future research is warranted to investigate the mechanisms behind the neighborhood-related disparities in ASD diagnosis, alongside efforts to provide resources for early intervention and family support in communities with a higher likelihood of ASD. Authors: Daniel A. Hackman, Ph.D., of the University of Southern California in Los Angeles, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (10.1001/jamapsychiatry.2023.4347) Editor’s ...

Seabirds roam far and wide in the Indian Ocean – so they need ocean-wide protection, new research shows. All other oceans are known to contain “hotspots” where predators including seabirds feast on prey. But the new study – by a team including Exeter, Heriot-Watt and Réunion universities, and ZSL – found no such concentrations in the Indian Ocean. With seabirds facing numerous threats due to human activity, their survival depends on protecting the open ocean. “Efforts are being made to protect key breeding colonies, but until now little was known about where Indian Ocean seabirds ...

Researchers from the University of B.C. and the BC Provincial Toxicology Centre (BCPTC) have developed a more efficient way to find out which new ‘designer drugs’ are circulating in the community. In a study published today in Analytical Chemistry, they showed how high-resolution mass spectrometry can be used to analyze urine samples at scale and uncover molecules from emerging designer drugs that have been missed by conventional testing. The approach can support public health and safety by enabling swift identification of new substances, potentially saving lives and guiding timely clinical responses to drug-related ...

With 3D inkjet printing systems, engineers can fabricate hybrid structures that have soft and rigid components, like robotic grippers that are strong enough to grasp heavy objects but soft enough to interact safely with humans.  These multimaterial 3D printing systems utilize thousands of nozzles to deposit tiny droplets of resin, which are smoothed with a scraper or roller and cured with UV light. But the smoothing process could squish or smear resins that cure slowly, limiting the types of materials that can be used.   Researchers from MIT, the MIT spinout Inkbit, and ETH Zurich have developed a new 3D inkjet printing system that works ...

For a magnet to stick to a fridge door, inside of it several physical effects need to work together perfectly. The magnetic moments of its electrons all point in the same direction, even if no external magnetic field forces them to do so. This happens because of the so-called exchange interaction, a combination of electrostatic repulsion between electrons and quantum mechanical effects of the electron spins, which, in turn, are responsible for the magnetic moments. This is common explanation for the fact that certain materials like ...

A research team, led by Tokyo Medical and Dental University（TMDU）, identifies disease-associated variants in a rare case of RAD50 deficiency/Nijmegen breakage syndrome-like disorder Tokyo, Japan – Many disorders are caused by genetic variants; to make matters worse, the genetic origin of most disorders remains unknown. Now, in a study recently published in the Journal of Clinical Immunology, researchers have shed light on the specific variants responsible for one rare and serious disorder: ‘RAD50 deficiency/Nijmegen breakage syndrome-like ...

In China, there is an old saying: "Don't let your children lose on the starting line." It highlights parents' desire to jumpstart their child's early development. Especially in recent years, parents have become increasingly anxious about their children's education, making it a trend to encourage children to participate in extracurricular activities from an early age. But is participating in extracurricular classes always advantageous for young children? Recently, a study published in the Journal of School Psychology found that extracurricular activities don't always improve a child's skills or behaviour. The ...

University of Virginia School of Medicine public health researchers, together with colleagues at the University of South Carolina, have received a $3.37 million grant from the National Institutes of Health to determine if online behavioral weight-management programs for rural residents can be improved by adding a human touch. Online obesity programs have typically failed to yield the same benefits as in-person programs, the researchers note, so they will test three approaches to add human involvement. More than 600 volunteer participants will be enrolled in a core online 24-week weight-loss ...

The American Pediatric Society (APS) is pleased to announce Rachel Katzenellenbogen, MD, as the 2024 Norman J. Siegel New Member Outstanding Science Award recipient for her considerable contributions to pediatric science. The award will be presented to Dr. Katzenellenbogen during the APS Presidential Plenary at the Pediatric Academic Societies 2024 Meeting. The award was created in honor of one of the world’s leading nephrologists, Norman J. Siegel, MD, FASN. Dr. Siegel was an outstanding teacher and mentor, nurturing the early careers of numerous fellows and residents. He was a leader within the medical community and educated the ...

Scattering sunlight-reflecting particles in the atmosphere could slow rapid melting in West Antarctica and reduce the risk of catastrophic sea-level rise, according to a study led by Indiana University researchers. The study, one of the first to look at how climate engineering might impact Antarctica, comes as scientists sound the alarm over the increasing likelihood of accelerated ice loss in West Antarctica this century. The work appears in the Journal of Geophysical Research: Atmospheres. “Even if the world meets the ambitious target of limiting global warming to 1.5 degrees Celsius above pre-industrial levels — which we are not on track ...

Washington, D.C.—The American Academy of Microbiology, the scientific think tank and honorific leadership group at the American Society for Microbiology (ASM), has released a new report, The Role of Microbes in Mediating Methane Emissions. The report highlights recommendations to further the scientific community’s understanding of microbial processes of methane production and consumption to mitigate methane emissions and address climate change. Microbes can influence climate change through biogeochemical cycles that ...

NYU Tandon School of Engineering is poised to become one of an extremely select group of American universities offering an undergraduate program in quantum technology, situating it at the forefront of a fast-growing field in which high employer demand significantly outpaces available talent.  Beginning in the spring 2024 semester, NYU Tandon students can start earning credits towards the new quantum tech minor, offered through the Department of Applied Physics.  In the past decade, quantum technology – the use of ...

LOS ANGELES – Nov. 15, 2023 – Stand Up To Cancer® (SU2C) today announced three Research Teams focused on bringing new therapies to clinical trials for the treatment of gastroesophageal cancer (GEC). The Research Teams, a part of a Dream Team Collective supported by the Torrey Coast Foundation, will unite top researchers from 11 institutions to address critical problems in GEC prevention, diagnosis and treatment. The Dream Team Collective aims to foster new and inclusive cancer research on the causes and treatments of GEC, mentor a new generation of scientists focused on GEC, bring ...

Researchers from Indiana University and Texas Christian University published a new Journal of Marketing study that examines the impact of a hospital’s portfolio strategy on patient demand. The study, forthcoming in the Journal of Marketing, is titled “Hospital Portfolio Strategy and Patient Choice” and is authored by Sarang Sunder and Sriram Thirumalai. Structural changes in the healthcare industry (e.g., the institution of the Affordable ...

Recently, morning omelets and holiday dinners have gotten more expensive. One likely cause is bird flu, outbreaks of which led to the deaths of millions of chickens and turkeys from infection or culling in 2022, according to the U.S. Department of Agriculture, and which still demands rigorous monitoring of wild populations. Now, reporting in Environmental Science & Technology Letters, researchers have developed a method that detected infectious bird flu virus in wetlands frequented by waterfowl. Wild birds represent a significant reservoir of avian influenza ...

From the depths of the seas to snow on mountains and even the air above cities, microplastics are turning up increasingly often. Now, in ACS’ Environmental Science & Technology Letters, researchers have analyzed microplastics in clouds above mountains. They suggest that these tiny particles could play a role in cloud formation and, in turn, affect weather. Microplastics — plastic fragments smaller than five millimeters — originate from a myriad of items used daily, such as clothing, packaging and car tires. As research in the field evolves, scientists are not only detecting microplastics in the atmosphere but also investigating how they may play a role in cloud formation. ...