H bond promoted hydride transfer
The precise catalytic conversion of chemical bonds is a paramount goal in catalysis. Enzymes, as efficient biocatalysts, are well known for their high catalytic activity, selectivity, and substrate specificity under mild reaction conditions, which can be attributed to the synergistic catalysis of multiple active sites. Inspired by the catalytic mechanism of enzymes, the rational design of catalysts with multiple active sites to stabilize TS and accelerate the rate-determining step is a promising strategy for achieving high activity and selectivity.
However, integrating multiple active sites into a single catalyst without interference during the catalytic process remains an enormous ...












