A new study led by researchers at Washington State University has identified a protein that could be the key to improving treatment outcomes after a heart attack. Published in the Journal of Biological Chemistry, the research suggests that protein kinase A (PKA) plays a role in heart muscle cell necrosis, a major type of cell death that commonly occurs after reperfusion therapy, the treatment used to unblock arteries and restore blood flow after a heart attack. "Our study has found that turning off a gene that controls this protein activity increased necrotic cell death and led to more heart injury and worse heart function following heart attack in a rodent model," said study author Zhaokang Cheng, an assistant professor in the WSU College ...

As early as the Neolithic period (circa 3900 BC), the domestication of animals likely led to the development of diseases including measles and smallpox. Since then, zoonotic disease has led to other major transnational outbreaks including HIV, Ebola, SARS, MERS, and H1N1 swine flu, among others. Currently, more than half of all existing human pathogens, and almost three-quarters of emerging infectious diseases, are zoonotic in nature. COVID-19 is the latest and most impactful zoonotic event of the modern era, but it will certainly not be the last. Given the breadth of these impacts and the fact that other zoonotic pandemics are highly likely - a matter of when and not if - the key public health ethics question that emerges is about whether it is ethically appropriate for governments ...

Doctors have hoped that antibiotics could benefit patients with chronic lung diseases, but a new study has found no benefit for patients with life-threatening idiopathic pulmonary fibrosis in preventing hospitalization or death. While there were no statistical benefits for patients with the lung-scarring disease, the new research will prevent unnecessary antibiotic use that could contribute to the growing problem of antibiotic resistance. The nationwide clinical trial - believed to be the largest idiopathic pulmonary fibrosis trial ever conducted - also collected biological samples that will advance the understanding and treatment of the mysterious and ultimately fatal illness. "We were certainly disappointed in the results. But we remain hopeful that in further downstream ...

(Carlisle, Pa.) -- A new study published in the American Journal of Lifestyle Medicine finds critical links between job loss and physical inactivity in young adults during the U.S. Great Recession of 2008-09 that can be crucial to understanding the role of adverse economic shocks on physical activity during the COVID-19 pandemic. It is the first study to examine how job losses during the Great Recession affected the physical activity of young adults in the United States. The study by Dickinson College economist Shamma Alam and Harvard T. H. Chan School of Public Health economist Bijetri Bose looked at Panel Study of Income Dynamics (PSID) data for young adults age 18 to 27--a phase of development associated with maturation and significant ...

Professor Tetsuo Endoh's Group at Tohoku University's Center for Innovative Integrated Electronics has announced a new magnetic tunnel junction (MTJ) quad-technology that provides better endurance and reliable data retention - over 10 years - beyond the 1X nm generation. This novel Quad technology meets the design requirements for the state-of-the-art X nm complementary metal-oxide semiconductor (CMOS) node and will pave the way for ultra-low-power consumption for Internet of Things (IoT) edge-devices in mobile communication, the automotive industry, consumer electronics, ...

Researchers from Telethon Kids Institute and Curtin University in Perth and Tulane University in New Orleans have developed sophisticated data modelling that could help eradicate malaria in Haiti. Haiti is the poorest country in the Caribbean - beset by natural disasters - and is one of the few countries in the region that have not mostly wiped out the mosquito-borne disease. Telethon Kids Institute researcher Associate Professor Ewan Cameron led the team, using a range of different health data to create a complete picture of where malaria infections are taking place in Haiti. This information has been used to directly inform Haiti's national response to malaria. The team's findings ...

Treating patients with acute respiratory failure is a constant challenge in intensive care medicine. In most cases, the underlying cause is lung inflammation triggered by a bacterial infection or - more rarely, despite being frequently observed at present due to the corona pandemic - a viral infection. During the inflammation, cells of the immune system - the white blood cells - migrate to the lungs and fight the pathogens. At the same time, however, they also cause "collateral damage" in the lung tissue. If the inflammatory reaction is not resolved in time, this can result in chronic inflammation with permanent impairment of lung function. Together with colleagues from London, Madrid and Munich, a research team at the University ...

Researchers at the University of Eastern Finland have uncovered potential mechanisms by which microRNAs (miRNA) drive atherogenesis in a cell-type-specific manner. Published in the Arteriosclerosis, Thrombosis, and Vascular Biology journal, the study provides novel insight into the miRNA profiles of the main cell types involved in atherosclerosis. Atherosclerosis is the underlying cause of most cardiovascular diseases and one of the leading causes of mortality in the world. During atherosclerosis, arteries become progressively narrow and thick due to the formation of plaques containing cholesterol deposits, calcium and cells, among other components. ...

Every tumour is different, every patient is different. So how do we know which treatment will work best for the patient and eradicate the cancer? In order to offer a personalised treatment that best suits the case being treated, a team of scientists led by the University of Geneva (UNIGE), Switzerland, had already developed a spheroidal reproduction of tumours that integrates the tumour cells, but also their microenvironment. However, the immune system had not yet been taken into account, even though it can either be strengthened or destroyed by the treatment given to the patient. Today, the Geneva team has succeeded in integrating two types of immune cells that come directly from the patient into the spheroidal structure, ...

The Permian Basin, located in western Texas and southeastern New Mexico, is the largest oil- and gas-producing region in the U.S. The oilfield operations emit methane, but quantifying the greenhouse gas is difficult because of the large area and the fact that many sources are intermittent emitters. Now, researchers reporting in ACS' Environmental Science & Technology Letters have conducted an extensive airborne campaign with imaging spectrometers and identified large methane sources across this area. According to the U.S. Energy Information Administration, 38% of the nation's total oil and 17% of natural gas production took place in the Permian Basin in 2020. Therefore, quantifying emissions from these operations, which continue to expand rapidly, is ...

A healthy diet around the time of conception through the second trimester may reduce the risk of several common pregnancy complications, suggests a study by researchers at the National Institutes of Health. Expectant women in the study who scored high on any of three measures of healthy eating had lower risks for gestational diabetes, pregnancy-related blood pressure disorders and preterm birth. The study was conducted by Cuilin Zhang, M.D., Ph.D., and colleagues at NIH's Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). It appears in the American Journal of Clinical Nutrition. ...

A team of students working with Jonathan Boreyko, associate professor in mechanical engineering at Virginia Tech, has discovered the method ducks use to suspend water in their feathers while diving, allowing them to shake it out when surfacing. The discovery opens the door for applications in marine technology. Findings were published in ACS Applied Materials & Interfaces. Boreyko has a well-established body of work in the area of fluid mechanics, including the invention of a fog harp and the use of contained, recirculated steam as a cooling device. As his research has progressed throughout the past decade, the mechanics of duck de-wetting has been one of his longest-running projects. "I got this idea when I was at Duke University," ...

Jack Tseng loves bone-crunching animals -- hyenas are his favorite -- so when paleontologist Joseph Peterson discovered fossilized dinosaur bones that had teeth marks from a juvenile Tyrannosaurus rex, Tseng decided to try to replicate the bite marks and measure how hard those kids could actually chomp down. Last year, he and Peterson made a metal replica of a scimitar-shaped tooth of a 13-year-old juvie T. rex, mounted it on a mechanical testing frame commonly used in engineering and materials science, and tried to crack a cow legbone with it. Based on 17 successful attempts to match the depth and shape of the bite marks on the fossils -- he had to toss out some trials because the fresh bone slid around too much -- he determined that a juvenile could have exerted ...

ALBUQUERQUE, N.M. -- Scientists at Sandia National Laboratories have built the world's smallest and best acoustic amplifier. And they did it using a concept that was all but abandoned for almost 50 years. According to a paper published May 13 in Nature Communications, the device is more than 10 times more effective than the earlier versions. The design and future research directions hold promise for smaller wireless technology. Modern cell phones are packed with radios to send and receive phone calls, text messages and high-speed data. The more radios in a device, the more it can do. While most radio components, including amplifiers, are electronic, they can potentially ...

Twice a day, at dusk and just before dawn, a faint layer of sodium and other metals begins sinking down through the atmosphere, about 90 miles high above the city of Boulder, Colorado. The movement was captured by one of the world's most sensitive "lidar" instruments and reported today in the AGU journal Geophysical Research Letters. The metals in those layers come originally from rocky material blasting into Earth's atmosphere from space, and the regularly appearing layers promise to help researchers understand better how earth's atmosphere interacts with space, even potentially how those interactions help support life. "This is an important discovery because we have never seen these dusk/dawn features before, and because these metal layers affect many things. The ...

DALLAS, June 2, 2021 -- A "prescription" to sit less and move more is the optimal first treatment choice for reducing mild to moderately elevated blood pressure and blood cholesterol in otherwise healthy adults, according to the new American Heart Association scientific statement published today in the American Heart Association's journal Hypertension. "The current American Heart Association guidelines for diagnosing high blood pressure and cholesterol recognize that otherwise healthy individuals with mildly or moderately elevated levels of these ...

A large group of iconic fossils widely believed to shed light on the origins of many of Earth's animals and the communities they lived in may be hiding a secret. Scientists, led by two from the University of Portsmouth, UK, are the first to model how exceptionally well preserved fossils that record the largest and most intense burst of evolution ever seen could have been moved by mudflows. The finding, published in Communications Earth & Environment, offers a cautionary note on how palaeontologists build a picture from the remains of the creatures they study. Until now, it has been widely accepted the fossils buried in mudflows in the Burgess Shale in Canada that show the result of the Cambrian ...

CRISPR-based technologies offer enormous potential to benefit human health and safety, from disease eradication to fortified food supplies. As one example, CRISPR-based gene drives, which are engineered to spread specific traits through targeted populations, are being developed to stop the transmission of devastating diseases such as malaria and dengue fever. But many scientists and ethicists have raised concerns over the unchecked spread of gene drives. Once deployed in the wild, how can scientists prevent gene drives from uncontrollably spreading across populations ...

CHICAGO -- Women who experience acute aortic dissection--a spontaneous and catastrophic tear in one of the body's main arteries--not only are older and have more advanced disease than men when they seek medical care, but they also are more likely to die, according to research published online today in The Annals of Thoracic Surgery. "Data over the course of the last few decades demonstrate differences in both presentation and outcomes between males and females who have acute aortic dissection, with greater mortality among females," said Thomas G. Gleason, MD, from Brigham and Women's Hospital in Boston, Massachusetts. "This study underscores ...

Can you trust the map on your smartphone, or the satellite image on your computer screen? So far, yes, but it may only be a matter of time until the growing problem of "deep fakes" converges with geographical information science (GIS). Researchers such as Associate Professor of Geography Chengbin Deng are doing what they can to get ahead of the problem. Deng and four colleagues -- Bo Zhao and Yifan Sun at the University of Washington, and Shaozeng Zhang and Chunxue Xu at Oregon State University -- co-authored a recent article in Cartography and Geographic Information Science that explores the problem. In "Deep ...

Popcorn. What would movies and sporting events without this salty, buttery snack? America's love for this snack goes beyond these events. We consume 15 billion quarts of popped popcorn each year. When it comes to popcorn, consumers want a seed-to-snack treat that leaves more snacks than seeds when popped. This means when they pop the corn, there shouldn't be many unpopped kernels left in the bowl. Maria Fernanda Maioli set out to determine the properties affecting popping expansion in popcorn. The team's research was recently published in Agronomy Journal, a publication of the American Society of Agronomy. "The way kernels expand is a basic, ...

BEER-SHEVA, Israel...June 2, 2021 - As drones become more ubiquitous in public spaces, researchers at Ben-Gurion University of the Negev (BGU) have conducted the first studies examining how people respond to various emotional facial expressions depicted on a drone, with the goal of fostering greater social acceptance of these flying robots. The research, which was presented recently at the virtual ACM Conference on Human Factors in Computing Systems, reveals how people react to common facial expressions superimposed on drones. "There is a lack of research on how drones are perceived and understood by humans, which is vastly different than ground robots." says Prof. Jessica Cauchard together with Viviane Herdel of BGU's Magic Lab, in the BGU Department of Industrial ...

New research from the Georgia Institute of Technology finds that elephants dilate their nostrils in order to create more space in their trunks, allowing them to store up to nine liters of water. They can also suck up three liters per second -- a speed 50 times faster than a human sneeze (150 meters per second/330 mph). The Georgia Tech College of Engineering study sought to better understand the physics of how elephants use their trunks to move and manipulate air, water, food and other objects. They also sought to learn if the mechanics could inspire the creation of more efficient robots that use air motion to hold and move things. While octopus use jets of water to move and archer fish shoot water above the surface to catch insects, the Georgia Tech researchers found that elephants ...

Boulder, Colo., USA: Article topics include Zealandia, Earth's newly recognized continent; the topography of Scandinavia; an interfacial energy penalty; major disruptions in North Atlantic circulation; the Great Bahama Bank; Pityusa Patera, Mars; the end-Permian extinction; and Tongariro and Ruapehu volcanoes, New Zealand. These Geology articles are online at https://geology.geoscienceworld.org/content/early/recent. Mass balance controls on sediment scour and bedrock erosion in waterfall plunge pools Joel S. Scheingross; Michael P. Lamb Abstract: Waterfall plunge pools experience cycles of sediment aggradation and scour that modulate ...

CHAPEL HILL, NC - Research published by JAMA Network Open shows how non-pharmaceutical interventions (NPIs) like mask wearing and physical distancing can help prevent spikes in COVID-19 cases as populations continue to get vaccinated. The study, led by Mehul Patel, PhD, a clinical and population health researcher in the department of Emergency Medicine at the UNC School of Medicine, focuses on the state of North Carolina. Similar modeling studies have been used in different states, and can serve as guidance to leaders as they make decisions to relax restrictions and safety protocols. "The computer simulation modeling allows us to look at multiple factors that play a role in decreasing the spread of COVID-19 as vaccines are ...