Cabozantinib, which targets tumor cell growth and tumor blood vessel growth, sharply improved progression-free survival over placebo in patients with extra-pancreatic and pancreatic neuroendocrine tumors Boston - A drug that simultaneously strikes cancer cells' growth circuits and pipeline to the bloodstream produced encouraging results in a clinical trial involving patients with advanced neuroendocrine tumors, according to a study led by Dana-Farber Cancer Institute investigators. Jennifer Chan, MD, MPH, director of the Program ...

The Alliance for Clinical Trials in Oncology today announced detailed results will be presented at ESMO 2023 from CABINET (A021602), a phase III pivotal trial evaluating cabozantinib compared with placebo in two cohorts of patients with previously treated neuroendocrine tumors: one cohort of patients with advanced pancreatic neuroendocrine tumors (pNET) and a second cohort of patients with advanced extra-pancreatic NET (epNET). The study met the primary objective for each cohort, demonstrating that cabozantinib provided dramatic improvements in median progression-free survival (PFS) for the patients in the pNET and epNET cohorts. ...

MADRID ― Compared with pre-surgical (neoadjuvant) chemotherapy alone, adding perioperative immunotherapy – given before and after surgery – significantly improved event-free survival (EFS) in patients with resectable early-stage non-small cell lung cancer (NSCLC). Results from the Phase III CheckMate 77T study were presented today at the 2023 European Society for Medical Oncology (ESMO) Congress by researchers from The University of Texas MD Anderson Cancer Center. At a median follow-up of 25.4 months, the median EFS with chemotherapy alone was 18.4 months, while the median had not yet been reached for patients receiving perioperative nivolumab, meaning EFS was prolonged ...

Boston – Belzutifan significantly reduced the risk of progression of clear cell renal cell carcinoma (ccRCC), the most common type of kidney cancer, in patients previously treated with immune checkpoint inhibitors and anti-angiogenic therapies compared with everolimus in a phase 3 clinical trial. The trial, led by Toni K. Choueiri, MD, Director of the Lank Center for Genitourinary Cancer at Dana-Farber Cancer Institute, showed the risk of progression was reduced by 25-26%. The results were presented at the annual European Society for Medical Oncology (ESMO) Congress on October ...

The following Lancet papers will be presented at the European Society for Medical Oncology Congress 2023 (#ESMO 2023). The conference will take place between Friday 20th – Tuesday 24th October 2023.  Contact details for corresponding authors are provided should you wish to arrange an interview with the authors. Funding information is listed on the first page of each Article. **Embargo: 13.00 [BST] / 14.00 [CEST] Friday 20th October 2023** The Lancet: Pembrolizumab plus trastuzumab and chemotherapy for HER2-positive gastric or gastro-oesophageal junction adenocarcinoma: interim analyses from the phase ...

A secondary analysis from the SWOG S0931 EVEREST trial has found that in the subgroup of patients with clear-cell renal cell carcinoma (RCC) who were at very-high risk of recurrence, those who were treated with everolimus after surgery had a statistically significant improvement in recurrence-free survival compared to patients getting placebo after surgery. The results will be presented at the European Society of Medical Oncology (ESMO) Congress 2023 in Madrid, Spain, on Oct. 23, 2023 (poster 1887P) by Primo N. Lara, Jr., MD, lead author on the abstract. ...

  Media contacts: Lisa Black, lblack@aap.org; or Adam Alexander, aalexander@aap.org     The parent’s universal cry in response to loud music-- “Turn that thing down!” -- is well-founded, as evidence shows that children and teens risk hearing loss by cranking up their personal listening devices. What families may not realize is that children are exposed to potentially harmful noise from infancy and that the effects are cumulative over a lifetime.   The American Academy of Pediatrics discusses the common sources and effects of noise, from infant sleep ...

Four senior bioengineering students at The University of Texas at Arlington have won the Biomedical Engineering Society (BMES) Coulter College for Healthcare Innovation competition for their work on an early detection device for atrial fibrillation. Brady Killham, Juan Ramirez, Jeannette Santos and Michael Ikefuna, all seniors in UTA’s Bioengineering Department, earned the Best Overall award for their plan to develop FibGuard, a wearable, non-invasive atrial fibrillation early detection device. UTA competed against teams from Vanderbilt, Purdue, Virginia Tech, Wake Forest, Texas A&M, the University of Oklahoma and Rensselaer Polytechnic ...

BIRMINGHAM, Ala. – Lung development in the fetus occurs at low oxygen tension in the womb, but after a very premature birth, the partly developed lungs of the tiny infants experience far greater oxygen tensions even without the prolonged supplemental oxygen that is often required. This can produce well-known disastrous effects on the structure and function of the neonatal lung, causing the serious lung condition of bronchopulmonary dysplasia in high-risk premature infants. Using a neonatal mouse model, researchers ...

“The majority of wound infections often manifest themselves immediately postoperatively, so close followup should take place [...]” BUFFALO, NY- October 20, 2023 – A new research perspective was published in Oncoscience (Volume 10) on October 4, 2023, entitled, “Diagnosis and management of postoperative wound infections in the head and neck region.” In everyday clinical practice at a department for oral and maxillofacial surgery, a large number of surgical procedures in the head and neck region take place under both outpatient and inpatient conditions. The basis ...

The Brain & Behavior Research Foundation announced it is awarding $10.2 million in Young Investigator Grants to 150 promising early career scientists who are working to identify causes, improve treatments, and develop methods of prevention for psychiatric illnesses that impact millions of people in the United States and around the world. The 2023 Young Investigators are focused on a broad range of psychiatric illnesses. More than half of the projects are relevant to the study or treatment of depression and schizophrenia. Addiction/substance-use disorders, anxiety, and ...

Cannabis use, even for medical purposes, could make some people sick due to harmful fungi that contaminate the plants. That is the finding of a recently published peer-reviewed journal article, whose authors recommend further study and consideration of changes to regulations to protect consumers, especially those who are immunocompromised. They examined data, previous studies, and U.S. and international regulations related to the cannabis and hemp industry. The article was published in Frontiers in Microbiology. It was researched and written by Kimberly Gwinn, professor of entomology and plant pathology at the University of Tennessee Institute ...

Since 2011, California has significantly reformed its criminal justice system, reducing the size of its prison population, with no effect on violent crime and only marginal impacts on property crime statewide. The COVID-19 pandemic furthered decarceration as the state reduced state prison and jail populations to slow the spread of the virus. Concerns emerged that releases under the auspices of COVID mitigation harmed public safety. A new study explored this notion and found no consistent relation between COVID-19-related jail decarceration and violent or property ...

It’s a familiar story to many of us: In prehistoric times, men were hunters and women were gatherers. Women were not physically capable of hunting because their anatomy was different from men. And because men were hunters, they drove human evolution. But that story’s not true, according to research by University of Delaware anthropology professor Sarah Lacy, which was recently published in Scientific American and in two papers in the journal American Anthropologist.  Lacy and her colleague Cara Ocobock from the University of Notre Dame examined the division of labor according to sex during the Paleolithic era, approximately 2.5 million to 12,000 ...

Felix Parra Diaz, the head of the Theory Department at the U.S. Department of Energy’s (DOE) Princeton Plasma Physics Laboratory (PPPL), has been elected a 2023 Fellow of the American Physical Society (APS). This honor recognizes scientists who have helped advance physics by contributing original research, showing how to apply physics to the worlds of science and technology, or exhibiting excellence in physics teaching. Parra Diaz was cited for “transformational contributions to the theory ...

ESMO announces Public Policy Manifesto on key issues for oncology to bring to European institutions after 2024 elections.   Studies presented at the ESMO Congress 2023 set new standards of care across a wide range of tumour types.    Madrid, Spain, 20 October 2023 – Evidence is building up that strong political action has the potential to tackle two of our era’s biggest challenges: climate change and the increasing burden of cancer on society. At the opening press conference of the ESMO Congress 2023 taking place 20-24 October in Madrid, Spain, a slew of studies marking meaningful ...

WOODS HOLE, Mass.—The Massachusetts Life Sciences Center (MLSC) has awarded $4.3 million to the Marine Biological Laboratory (MBL) to expand its imaging capabilities to serve the Massachusetts life sciences community. The grant, which will be used to procure two state-of-the art microscopes capable of increased resolution and advanced technology, such as milling for the reconstruction of samples in 3D, was announced at a press conference on October 18 at the grand opening of a new incubator, the Massachusetts Biomedical Initiatives (MBI). MBL Director of Research Anne Sylvester ...

Urbanization and human activities have transformed a significant proportion of the land on Earth, resulting in the formation of urban environments. These urban environments are man-made habitats that often impose several selective pressures on their inhabitants. A key characteristic of such environments is the presence of impermeable, heat-retaining surfaces created using brick, stone, asphalt, and concrete. Notably, these surfaces form urban heat islands, i.e., regions with elevated surface temperatures. An unexpected result of heat stress ...

KANSAS CITY, MO—October 20, 2023—Millions of couples worldwide experience infertility with half of the cases originating in men. For 10% of infertile males, little or no sperm are produced. Now, new research from the Stowers Institute for Medical Research, in collaboration with the Wellcome Centre for Cell Biology at the University of Edinburgh, is shedding light on what may be going wrong in the process of sperm formation, leading to potential theories on possible treatments.   “A ...

Women faculty are more likely to leave academia than men faculty throughout all career stages in U.S. universities, University of Colorado Boulder researchers revealed in the most comprehensive analysis of retention in academia to date.  The team published the findings Oct. 20 in the journal “Science Advances.” The researchers found that a harsh workplace climate, which can include harassment and feelings of not belonging, was the most common reason women left academia. This attrition affects not only early-career professionals, ...

It's said that a dog is a man’s best friend, but the wild dingo is much maligned in Australia. This may not always have been the case though, with new research led by experts at The Australian National University and The University of Western Australia suggesting that dingoes were buried – and even domesticated – by First Nations people prior to European colonisation.  The researchers examined remains at the Curracurrang archaeological site, south of Sydney, where radiocarbon dating of dingo bones revealed the animals were buried alongside humans as far back as 2,000 years ago.  The care taken to bury the animals ...

A team of researchers led by the University of California San Diego has developed soft yet durable materials that glow in response to mechanical stress, such as compression, stretching or twisting. The materials derive their luminescence from single-celled algae known as dinoflagellates. The work, inspired by the bioluminescent waves observed during red tide events at San Diego’s beaches, was published Oct. 20 in Science Advances. “An exciting feature of these materials is their inherent simplicity—they need no electronics, no external ...

LA JOLLA, CA—Scientists from La Jolla Institute for Immunology (LJI) and The University of Southampton, UK, have uncovered a group of immune cells that may drive severe asthma. These cells, called cytotoxic CD4+ tissue-resident memory T cells, gather in the lungs and appear to possess the molecular weaponry to cause the most harm in men who developed asthma later in life. "If you are male and you develop asthma after age 40, there's a high chance this T cell population is in your lungs," says LJI Research Assistant Professor Gregory Seumois, Ph.D., who co-led the study with LJI Professor Pandurangan ...

Key Takeaways  A cancer survival calculator prototype developed with machine learning showed that for each of three cancer types tested, more factors than cancer stage significantly influenced patients’ survival.  Preliminary research on the calculator found high accuracy of this individualized survival estimator.  BOSTON (October 20, 2023): Researchers have developed an artificial intelligence (AI)–based tool for estimating a newly diagnosed cancer patient’s chances for surviving long term, according ...

Key takeaways  This is the first study to examine the impact of school redistricting on firearm violence in urban communities, examining data from 63,000 urban census tracts.  Any school redistricting event was associated with a 10.6% higher firearm incidence rate compared with communities that had no redistricting, and school boundary adjustments were associated with a 21.3% increase.  In areas that had a school redistricting event, firearm violence increased 14% in the year the redistricting occurred over the previous year.  BOSTON (October 20, ...