Study lead, Research Associate of the Neurobiology Lab Marat Minlebaev explains, "Our brain is a complex mechanism, and it's important to understand how it works. If we understand how our brain functions, we can put forth new treatment methodologies or prevent pathologies, both congenital and acquired." A number of techniques were used to undertake the research, so, apart from biologists, other scientists were also invited to partake. "Fourth year students Viktoria Shumkova and Violetta Sitdikova conducted experiments and analyzed their results," says Minlebaev. "To implement the idea, new software was ...

Researchers from Russia and Germany have created a genome-wide atlas of developmental alternative splicing changes of seven organs in six mammal species and chicken. The research was published in the journal Nature Genetics. As the protein encoding RNA matures in eukaryotes, it gets spliced, with some parts cut out and the remaining fragments stitched together. Alternative splicing means that the same RNA fragment can either be cut out from or kept within the mature RNA. In this case, one gene can encode several RNAs and, therefore, several proteins. Although alternative splicing is known to be essential for many tissues to develop and function properly and its various disorders may cause health problems, ...

It is ingrained in parents to curtail the hours their children spend in front of the television. Anecdotal evidence suggests that prolonged viewing of television and use of smart gadgets during early years can adversely affect a child's eyesight and behavioral development. However, there is little scientific evidence to support such observations on the effects of excessive television exposure on children's visual acuity. Now, Professor MATSUO Toshihiko (M.D., Ph.D.) and Professor YORIFUJI Takashi (M.D., Ph.D.) from Okayama University describe how such exposure can indeed have detrimental effects on children's eyesight during later years. The researchers used a national database of the Japan Government, based on the annual survey of all children born in the certain period of the ...

Nerves release a protein at the injury site that attracts growing nerve fibers and thus keeps them entrapped there. This prevents them from growing in the right direction to bridge the injury. The research team headed by Professor Dietmar Fischer reports in the journal Proceedings of the National Academy of Sciences (PNAS) from 25. May 2021. There must be another cause Three main causes for the inability of injured nerves of the central nervous system, or CNS, to regenerate have been known to date: the insufficient activation of a regeneration program in injured nerve cells that stimulates the growth of fibers, so-called axons; the formation of a scar at the site ...

TROY, N.Y. -- Heart disease and cancer are the leading causes of death in the United States, and it's increasingly understood that they share common risk factors, including tobacco use, diet, blood pressure, and obesity. Thus, a diagnostic tool that could screen for cardiovascular disease while a patient is already being screened for cancer, has the potential to expedite a diagnosis, accelerate treatment, and improve patient outcomes. In research published today in Nature Communications, a team of engineers from Rensselaer Polytechnic Institute and clinicians from Massachusetts General Hospital developed a deep learning algorithm that can help assess a patient's risk of cardiovascular disease ...

Herndon, Va. (May 20, 2021) - The international journal Risk Analysis has published a timely special issue for May 2021, "Global Systemic Risk and Resilience for Novel Coronavirus and COVID-19." Featuring 11 papers written for this issue over the past year, the collection represents a sampling of insights and viewpoints from scholars across risk sciences and resilience analytics to guide decision-making and operations related to the COVID-19 pandemic. The 11 papers address the breadth of risk sciences represented by the Society for Risk Analysis (SRA), including risk perception, risk and resilience, human health and ...

A University of Otago study has revealed how earthquake upheaval has affected New Zealand's coastal species. Lead author Dr Felix Vaux, of the Department of Zoology, says earthquakes are typically considered devastating events for people and the environment, but the positive opportunities that they can create for wildlife are often overlooked. For the Marsden-funded study, published in Journal of Phycology, the researchers sequenced DNA from 288 rimurapa/bull-kelp plants from 28 places across central New Zealand. "All specimens from the North Island were expected to be the species Durvillaea antarctica, but unexpectedly 10 samples from four sites were ...

WASHINGTON--Yellowstone National Park is famous for harsh winters but a new study shows summers are also getting harsher, with August 2016 ranking as one of the hottest summers in the last 1,250 years. The new study drew upon samples of living and dead Engelmann spruce trees collected at high elevations in and around Yellowstone National Park to extend the record of maximum summer temperatures back centuries beyond instrumental records. The findings were published in Geophysical Research Letters, AGU's journal for high-impact, short-format reports with immediate implications spanning all Earth and space sciences. The ...

Palo Alto, CA--In a new study, researchers found that recreational boats and high-speed ferries contribute significant underwater noise in San Francisco Bay, a highly urbanized coastline that is increasingly becoming a stop along the migratory routes of gray and humpback whales and home to bottlenose dolphins and harbor porpoises. The study is the first of its kind to use radar to track boats not broadcasting information through the Automatic Identification System (AIS), a navigation safety system required onboard large commercial ships. The findings add to the growing evidence that smaller vessels, ...

Durham, NC -- Bone marrow failure due to acute myeloid leukemia (AML) is a significant factor behind the disease's high rate of morbidity and mortality. Previous studies in mice suggest that AML cells inhibit healthy hematopoietic (blood) stem and progenitor cells (HSPC). A study released in STEM CELLS adds to this extent of knowledge by showing how secreted cell factors, in particular a protein called transforming growth factor beta 1 (TGFβ1), leads to a breakdown in the production of healthy blood cells (a process called hematopoiesis) in humans. The study's findings indicate that blocking TGFβ1 could improve ...

WASHINGTON, DC - MAY 20, 2021 - As Congress considers legislation to reform prescription drug pricing, a new analysis conducted by the West Health Policy Center and released by its Council for Informed Drug Spending Analysis (CIDSA) estimates that the Elijah E. Cummings Lower Drug Costs Now Act (H.R. 3) could result in hundreds of billions of dollars in lower commercial health insurance costs by 2030.These savings would come from a $195 billion reduction in employer costs and $98 billion in savings for workers. The non-profit, non-partisan West Health Policy Center engaged the actuarial firm Milliman, to analyze the impact of the legislation on stakeholders. Using Milliman's analysis and other data sources West Health ...

In spite of decades of research, cancer remains an enigma. Conventional wisdom holds that cancer is driven by random mutations that create aberrant cells that run amok in the body. In a new paper published this week in the journal BioEssays, Arizona and Australian researchers challenge this model by proposing that cancer is a type of genetic throwback, that progresses via a series of reversions to ancestral forms of life. In contrast with the conventional model, the distinctive capabilities of cancer cells are not primarily generated by mutations, the researchers claim, but ...

Protective immune memory--through B cells, which make antibodies, and/or T cells, which in the case of CD8+ T cells can kill virus-infected cells--can be induced by identical but also by related viruses. Related to the COVID-19 virus SARS-CoV-2, there are four common cold coronaviruses (CCCoVs) that together cause ~20% of common cold infections: OC43, HKU1, 229E, and NL63. Most adults have been infected with CCCoVs multiple times in their lives. Whether or not meaningful CCCoV-induced anti-SARS-CoV-2 neutralizing antibodies exist remains a matter of debate. Meanwhile, the generation of T cell memory should depend ...

Syracuse, N.Y. - The COVID-19 death rate for people with intellectual and developmental disabilities (IDD) is higher than the general population in several states across the U.S., according to a new study published in Disability and Health Journal. The research team that conducted the study analyzed data from 12 U.S. jurisdictions: Arizona, California, Connecticut, Illinois, Louisiana, Maryland, New Jersey, Oregon, Pennsylvania, Virginia, Washington and Washington, D.C. The death rates were higher in all jurisdictions for those with IDD who live in congregate settings such as residential group homes. The results for ...

RESEARCH TRIANGLE PARK, N.C. -- A new study by the International Food Policy Research Institute (IFPRI), the USDA's Agricultural Research Service (USDA-ARS) and RTI International (RTI) projects that global chronic and hidden hunger will increase the overall years of life lost due to premature mortality and years lived with disability, also known as disability-adjusted life years (DALYs), globally by over 30 million by 2050 relative to 2010. Expected impacts of climate change on the availability and access to nutritious food will exacerbate this change in DALYs by almost 10 percent. Researchers published the findings in an article in The American Journal of Clinical Nutrition, ...

Data will support BLA filing for afamitresgene autoleucel next year - Responses observed across a broad range of antigen expression - Initial safety and durability are encouraging - PHILADELPHIA, PA., and OXFORDSHIRE, U.K., May 20, 2021 -- Adaptimmune Therapeutics plc (Nasdaq:ADAP), a leader in cell therapy to treat cancer, will report initial data from its Phase 2 SPEARHEAD-1 trial, with afamitresgene autoleucel (afami-cel, formerly ADP-A2M4), at the American Society of Clinical Oncology (ASCO) congress. Full abstracts were released online today. Data will be presented in an oral presentation by Dr. Sandra D'Angelo of the Memorial Sloan Kettering Cancer Center (Abstract #11504) on June 4th. "Patients are seeing substantial ...

Normally, mountain forests are among the most diverse habitats in alpine regions. Yet, as a team from the Alfred Wegener Institute discovered in the Tibetan Plateau, the higher, treeless areas are home to far more species. Their findings, which were just published in the journal Nature Communications, can help to predict how the biodiversity of alpine regions will decline in response to global warming - when the mountain forests spread to higher elevations. As anyone who has ever hiked in the mountains knows, the landscape changes with the elevation. At first, for a long time, you trek uphill through forests, until they open up into the first meadows and pastures, where a wide range of plant species bloom in the spring. Farther up, the landscape becomes more barren. ...

Planned missions to return humans to the Moon need to hurry up to avoid hitting one of the busiest periods for extreme space weather, according to scientists conducting the most in-depth ever look at solar storm timing. Scientists at the University of Reading studied 150 years of space weather data to investigate patterns in the timing of the most extreme events, which can be extremely dangerous to astronauts and satellites, and even disrupt power grids if they arrive at Earth. The researchers found for the first time that extreme space weather events are more likely to occur early in even-numbered solar cycles, and late in odd-numbered cycles - such as the one just starting. They are also ...

A new paper in JNCI Cancer Spectrum, published by Oxford University Press, indicates that several non-genetic factors--including greater red meat intake, lower educational attainment, and heavier alcohol use--are associated with an increase in colorectal cancer in people under 50. In the United States, incidence rates of early-onset colorectal cancer have nearly doubled between 1992 and 2013 (from 8.6 to 13.1 per 100,000), with most of this increase due to early-onset cancers of the rectum. Approximately 1 in 10 diagnoses of colorectal cancer in this country occur in people under 50. Researchers ...

Philadelphia, May 20, 2021 - Research has shown empathy gives healthcare workers the ability to provide appropriate supports and make fewer mistakes. This helps increase patient satisfaction and enhance patient outcomes, resulting in better overall care. In an upcoming issue of the END ...

A newly developed tool will allow scientists to better gauge how centuries of fossil fuel emissions could be skewing the data they collect from marine environments. Researchers at the University of Alaska Fairbanks led the effort, which created a way for marine scientists to factor into their results the vast amounts of anthropogenic carbon dioxide that are being absorbed by oceans. Those human-caused carbon sources can muddy research results -- a problem known as the Suess effect -- leading to flawed conclusions about the health and productivity of marine ecosystems. "The ...

Oncotarget published "Analytic validation and clinical utilization of the comprehensive genomic profiling test, GEM ExTra®" which reported that the authors developed and analytically validated a comprehensive genomic profiling assay, GEM ExTra, for patients with advanced solid tumors that uses Next Generation Sequencing to characterize whole exomes employing a paired tumor-normal subtraction methodology. The assay detects single nucleotide variants, indels, focal copy number alterations, TERT promoter region, as well as tumor mutation burden and microsatellite instability status. Additionally, the assay incorporates ...

Scientists have made a major breakthrough in the study of embryonic development and how it can be impacted by external factors such as climate change. Researchers at the University of Plymouth have developed a cutting edge technique which enables them to instantly examine the biological traits and behaviours of developing embryos as an energy signature, rather than focusing on individual characteristics. The method, outlined in a study published in BMC Bioinformatics, is built around timelapse video captured by the researchers of aquatic animals - specifically, the embryos of a freshwater pond snail Radix ...

Using the Five-hundred-meter Aperture Spherical radio Telescope (FAST), a research team led by Prof. HAN Jinlin from National Astronomical Observatories of Chinese Academy of Sciences (NAOC) has discovered 201 pulsars, including many very faint pulsars, 40 millisecond pulsars (MSPs), and 16 pulsars in binaries. These discoveries were published in Research in Astronomy and Astrophysics. Pulsars are compact remnants of the death of bright, massive stars. They have the strongest magnetic field, highest density and fastest rotation of any celestial body in the Universe, and show significant ...

Nearly two thirds (61%) expressed concern about their worsening mood in Lockdown and associated restrictions1. 34% said they felt more anxious and 28% felt more depressed during Lockdown and associated restrictions1. Coffee helped lift nearly half (44%) of adult's negative moods in Lockdown and associated restrictions1. A new pan-European survey funded by the Institute for Scientific Information on Coffee exploring the impact of COVID-19 Lockdowns and associated restrictions (in those countries where there has been no Lockdown), has found that nearly two thirds of adults (61%) expressed concern about their worsening mood; two times higher than those concerned about physical inactivity (24%)1. Understanding the effects of COVID-19 restrictions ...