“This is the first report that showed the efficacy of methionine restriction to reverse old-age-induced obesity.” BUFFALO, NY- June 27, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 11, entitled, “Old-age-induced obesity reversed by a methionine-deficient diet or oral administration of recombinant methioninase-producing Escherichia coli in C57BL/6 mice.” Obesity increases with aging. Methionine restriction ...

SAN FRANCISCO, CA—Magdalena Zernicka-Goetz, PhD, was announced today as the recipient of the 2023 Ogawa-Yamanaka Stem Cell Prize by Gladstone Institutes. Zernicka-Goetz is a professor of mammalian development and stem cell biology in the Department of Physiology, Development, and Neuroscience at the University of Cambridge, as well as the Bren Professor of Biology and Biological Engineering at the California Institute of Technology. A pioneering stem cell scientist, Zernicka-Goetz was selected for the prize because of her work uncovering fundamental mechanisms that drive the development of mammalian embryos, which led to the ...

Nearly half of parents who relied on formula to feed their babies during the infant formula shortage last year resorted to potentially harmful feeding methods, according to a survey from researchers at the University of California, Davis. The study was published in the journal BMC Pediatrics. In an online anonymous survey of U.S. parents, the number of individuals that used at least one unsafe feeding practice increased from 8% before the formula shortage to nearly 50% during the shortage. Unsafe practices included watering down formula, using expired or homemade formula, or using human milk from informal sharing. The percentage of parents who shared human milk ...

URBANA, Ill. – In its simplest form, popcorn is pretty uncomplicated. Most supermarket varieties offer the choice of two kernel colors, yellow or white, and two kernel shapes, pointed or pearl. When popped, the flake typically expands into one of two shapes: mushroom or butterfly. But there’s more to popcorn than meets the eye. New research from the University of Illinois Urbana-Champaign reveals a wealth of untapped diversity lurking in popcorn’s genetic code. Analyzing 320 publicly available popcorn lines, crop sciences researchers found variation at more ...

Irvine, Calif., June 27, 2023 — As human-driven climate change amplifies natural disasters, hurricanes and typhoons stand to increase in intensity. Until now, there existed very few freely available computer models designed to estimate the economic costs of such events, but a team of researchers led by Jane W. Baldwin at the University of California, Irvine recently announced the completion of an open-source model that stands to help countries with high tropical cyclone risks better calculate just how much those storms will impact their people and their economies. “Tropical cyclones are some of the most impactful natural disasters on Earth. They pose huge risks ...

Two to three weeks after conception, an embryo faces a critical point in its development. In the stage known as gastrulation, the transformation of embryonic cells into specialized cells begins. This initiates an explosion of cellular diversity in which the embryonic cells later become the precursors of future blood, tissue, muscle, and more types of cells, and the primitive body axes start to form. Studying this process in the human-specific context has posed significant challenges to biologists, but new research offers an unprecedented window into this point in time in ...

Researchers at Johns Hopkins University, US, led by Calvin Kersbergen report that mice with the most common form of human congenital deafness develop normal auditory circuitry – until the ear canal opens and hearing begins. Publishing June 27th in the open access journal PLOS Biology, the study suggests that this is possible because spontaneous activity of support cells in the inner ear remains present during the first weeks of life. Mutations to the protein connexin 26 are the most common cause of hearing loss at birth, accounting for more than 25% of genetic hearing loss worldwide. To understand how these mutations lead to deafness ...

**EMBARGOED TILL TUESDAY, JUNE 27, AT 2 P.M. ET** For the first two weeks of life, mice with a hereditary form of deafness have nearly normal neural activity in the auditory system, according to a new study by Johns Hopkins Medicine scientists. Their previous studies indicate that this early auditory activity — before the onset of hearing — provides a kind of training to prepare the brain to process sound when hearing begins. The findings are published June 27 in PLOS Biology. Mutations in Gjb2 cause more than a quarter of all hereditary forms of hearing loss at birth in people, according to some estimates. The connexin 26 protein coded by ...

The universe is awash in billions of possible chemicals. But even with a bevy of high-tech instruments, scientists have determined the chemical structures of just a small fraction of those compounds, maybe 1 percent.   Scientists at the Department of Energy’s Pacific Northwest National Laboratory (PNNL) are taking aim at the other 99 percent, creating new ways to learn more about a vast sea of unknown compounds. There may be cures for disease, new approaches for tackling climate change, or new chemical or biological threats lurking in the chemical universe.   The work is part of an initiative known as m/q or “m over q”—shorthand ...

Increasing access to prescription opioid painkillers may reduce opioid overdose deaths in the United States, according to a Rutgers study. “When access to prescription opioids is heavily restricted, people will seek out opioids that are unregulated,” said Grant Victor, an assistant professor in the Rutgers School of Social Work and lead author of the study published in the Journal of Substance Use and Addiction Treatment. “The opposite may also be true; our findings suggest that restoring easier access to opioid pain medications may protect against fatal overdoses.” America’s opioid crisis has ...

Science is a collaborative effort. What we know today would have never been, had it not been generations of scientists reusing and building on the work of their predecessors. However, in modern times, academia has become increasingly competitive and indeed rather hostile to the individual researchers. This is especially true for early-career researchers yet to secure tenure and build a name in their fields. Nowadays, scholars are left to compete with each other for citations of their published work, awards and funding.  So, understandably, many scientists have grown unwilling ...

A new USC study that zeros in on the workings of individual T cells targeting the hepatitis C virus (HCV) has revealed insights that could assist in the development of an effective vaccine. Every year, hepatitis and related illnesses kill more than one million people around the world. If unaddressed, those deaths are expected to rise—and even outnumber deaths caused collectively by HIV, tuberculosis and malaria by 2040. For that reason, the World Health Organization and other leading groups have pledged to work toward eliminating viral hepatitis by 2030. While there are vaccines for two of the three most common ...

Collaborative work by teams at the Department of Medicine and Life Sciences (MELIS) ​​at Pompeu Fabra University (UPF), University of California, Irvine (UCI), and the Institute for Research in Biomedicine (IRB Barcelona) has shown that interplay between circadian clocks in liver and skeletal muscle controls glucose metabolism. The findings reveal that local clock function in each tissue is not enough for whole-body glucose metabolism but also requires signals from feeding and fasting cycles to properly maintain glucose levels in the ...

Children with disabilities, and their families, may face discrimination in in the hospitals and clinics they visit for their health care, according to a new study led by researchers at University of Utah Health. These attitudes may lead to substandard medical treatment, which could contribute to poor health outcomes, say the study’s authors. “They mistreated her and treated her like a robot. Every single time a nurse walked in the room, they treated her like she was not even there,” said one mother who was interviewed about her child’s health care encounters. The findings, published in the journal Pediatrics, ...

Chicago, Illinois (Embargoed until 10:05 a.m. CDT, Tuesday, June 27, 2023)—Molecular imaging with 18F-flubatine PET/MRI has shown that neuroreceptors in the brains of individuals with obesity respond differently to food cues than those in normal-weight individuals, making the neuroreceptors a prime target for obesity treatments and therapy. This research, presented at the Society of Nuclear Medicine and Molecular Imaging 2023 Annual Meeting, contributes to the understanding of the fundamental mechanisms underlying obesity ...

The pandemic made remote work the norm for many, but that doesn’t mean it was always a positive experience. Remote work can have many advantages: increased flexibility, inclusivity for parents and people with disabilities, and work-life balance. But it can also cause issues with collaboration, communication, and the overall work environment. New research from the Georgia Institute of Technology used data from the employee review website Glassdoor to determine what made remote work successful. Companies that catered to employees’ interests, ...

(Boston)— Intersex people’s (people whose sex characteristics do not fit within the strict binary categorizations of male or female) healthcare has received a lot of media attention recently, particularly with the uptick in anti-transgender legislation, which often also targets this community. Discrimination and mistreatment in social and medical settings, largely due to the stigma of not conforming to binary views of sex, results in many intersex individuals experiencing isolation, secrecy and shame, which can have a lasting impact on their mental health.   A new study from researchers at Boston University Chobanian & Avedisian School of Medicine highlights the need ...

UNIVERSITY PARK, Pa. — A cancerous tumor is the accumulation of cells uncontrollably dividing, some of which can invade other parts of the body. The process is difficult to predict in detail, and eradicating the cells poses even greater difficulty. Now, a Penn State-led research team has revealed how the exodus initiates, shedding light on a potential therapeutic target to halt the invasion and providing a prognostic marker to help clinicians select the best treatment option.   They published their findings on June 26 in the Proceedings of the National Academy of Sciences.   “Cancer cells don’t randomly detach from the primary tumor and disseminate ...

HOUSTON – (June 27, 2023) – Many of the drugs we use to treat cancer and infectious disease are ⎯ or derive from ⎯ natural products, but it’s difficult to know exactly how nature assembles them. Retracing nature’s steps, Rice University chemical engineer Xue Gao and her team mapped out the full series of enzyme-powered reactions a marine fungus uses to produce 21R-citrinadin A, a complex molecule with anticancer properties. In the process, Gao and her collaborators identified a new enzyme, CtdY, which is the only one ...

UNIVERSITY PARK, Pa. — A milliliter of blood contains about 15 individual drops. For a person with human immunodeficiency virus (HIV), each drop of blood could contain anywhere from fewer than 20 copies of the virus to more than 500,000 copies. Called the viral load, this is what is measured to allow clinicians to understand how patients are responding to anti-viral medications and monitor potential progression.  The time-consuming viral load testing needs to be repeated several times as a patient undergoes treatment. Now, a Penn State research team has developed a time and cost-efficient digital assay that can directly measure the presence of HIV in ...

Having a seat at the table, and voices heard, makes a world of difference when it comes to natural resources. It sounds intuitive, but experts didn’t have enough data to prove it until now. A team of researchers from across the country pored over 108 groundwater management plans in California to see how well they protect stakeholders like domestic well users, farmers and ecosystems. They found that the plans that incorporated stakeholder input offered greater protection from groundwater depletion. Unfortunately, only 9% of the sustainability plans integrated these users in a comprehensive manner. The findings have broad implications for resource management, both in California and ...

UNIVERSITY PARK, Pa. — Acoustic waves may be able to control how particles sort themselves. While researchers have been able to separate particles based on their shape — for example, bacteria from other cells — for years, the ability to control their movement has remained a largely unsolved problem, until now. Using ultrasound technology and a nozzle, Penn State researchers have separated, controlled and ejected different particles based on their shape and various properties.   They ...

WASHINGTON, June 27, 2023 – With their unique appearance, texture, and mouthfeel, fondants have intrigued bakers and physicists for years. They present an appetizing enigma in the world of confectionery, an intriguing combination of sugar, water, and heat that, when manipulated correctly, yields a delectably creamy product. Researchers from the Max Planck Institute for Polymer Research and Technische Universität Berlin studied the kinetic and thermodynamic processes of sugar crystallization in the making of fondant. In Physics of Fluids, by AIP Publishing, they combined a controlled kneading machine with light microscopy ...

About The Study: Among 12- to 21-year-old U.S. females between 2003 and 2020, iron deficiency affected almost 40% and iron deficiency anemia affected 6%, with variation by the ferritin or hemoglobin thresholds used. Menstruation was a risk factor for both, but more than one-quarter of premenarchal individuals had iron deficiency.  Authors: Angela C. Weyand, M.D., of the University of Michigan Medical School in Ann Arbor, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2023.8020) Editor’s Note: Please see the article for ...

In their paper the team discusses their novel view of euchromatin in the cell and shows how the revealed organization is relevant to genome functions. “Our ultimate goal is to reveal how genomic information is searched and read out in living cells,” said Kazuhiro Maeshima, a leading author and a professor with the National Institute of Genetics and SOKENDAI, Japan. Chromatin describes the combination of DNA and proteins in the cells of humans and other eukaryotes. According to typical textbook models, chromatin occurs in two forms— euchromatin, that is less condensed and can be transcribed, and heterochromatin, that is more condensed and usually not transcribed. ...