Scientists from Hokkaido University have developed a rapid, efficient protocol for cross-coupling reactions, vastly expanding the pool of chemicals that can be used for the synthesis of useful organic compounds. Chemical reactions are a vital process in the synthesis of products for a diversity of purposes. For the most part, these reactions are carried out in the liquid phase, by dissolving the reactants in a solvent. However, there are a significant number of chemicals that are partially or completely insoluble, and thus have not been used for synthesis. The starting materials required for the synthesis of many cutting-edge organic materials--such as organic semiconductors and luminescent materials--are often poorly soluble, leading to problems in solution-based synthesis. Therefore, ...

Vaccines are turning the tide of the pandemic, but the risk of infection is still present in some situations. If you want to visit a friend, get on a plane, or go see a movie, there is no highly accurate, instant test that can tell you right then and there whether or not you have a SARS-CoV-2 infection. But new research from Lawrence Berkeley National Laboratory (Berkeley Lab) could help get reliable instant tests on the market. A study led by Michal Hammel and Curtis D. Hodge suggests that a highly sensitive lateral flow assay - the same type of device used in home pregnancy tests - could be developed using pairs of rigid antibodies that bind to the SARS-CoV-2 nucleocapsid protein. Such a test would only require a small drop of mucus or saliva, could give results ...

The first-ever discovery of an extraterrestrial radioactive isotope on Earth has scientists rethinking the origins of the elements on our planet. The tiny traces of plutonium-244 were found in ocean crust alongside radioactive iron-60. The two isotopes are evidence of violent cosmic events in the vicinity of Earth millions of years ago. Star explosions, or supernovae create many of the heavy elements in the periodic table, including those vital for human life, such as iron, potassium and iodine. To form even heavier elements, such as gold, uranium and plutonium it was thought that a more violent event may be needed, such as two neutron stars merging. However, a study led by Professor Anton Wallner from The Australian National University (ANU) suggests ...

A rigorous meta-analysis of randomized clinical trials (RCTs) that compared the effects of medical therapies alone with medical therapies plus revascularization in patients with stable ischemic heart disease (SIHD) was presented at EuroPCR on May 18, 2021. The study concluded that adding revascularization was associated with a statistically important reduction in cardiovascular death associated with a statistically important reduction in spontaneous myocardial infarction (MI), providing a biologically plausible explanation for the observed benefit. An international group of investigators performed a meta-analysis of RCTs conducted between 1979 and 2020. Strict entry criteria were established to assure the analysis was restricted to studies involving elective, ...

When it comes sharing recipes on social media, what users post, and what they cook may be two entirely different things. That's the conclusion of a END ...

An international team of scientists from the Menzies Health Institute Queensland (MHIQ) at Griffith University and from City of Hope, a research and treatment center for cancer, diabetes and other life-threatening diseases in the U.S., have developed an experimental direct-acting antiviral therapy to treat COVID-19. Traditional antivirals reduce symptoms and help people recover earlier. Examples include Tamiflu®, zanamivir and remdesivir. This next-generation antiviral approach used gene-silencing RNA technology called siRNA (small-interfering RNA) to attack the virus' genome directly, which stops ...

ATLANTA - MAY 18, 2021 - A new study finds breast cancer survivors in general have higher risk of new cancer diagnosis compared to healthy individuals. The article, which appears in CANCER, states that compared to the general population in the United States, the risk of new cancer diagnoses among survivors was 20% higher for those with hormone receptor (HR) positive cancers and 44% higher for those with HR-negative cancers. Breast cancer is the most commonly diagnosed and prevalent cancer among women in the U.S., with over 3.9 million living breast cancer survivors as of 2019. The number of survivors is expected to increase with the aging population and advances in breast cancer treatment. Subsequent primary cancer (SPC) after breast cancer is a well-known late effect, but the ...

PULLMAN, Wash. - Alterations in the epigenetic programming of hatchery-raised steelhead trout could account for their reduced fertility, abnormal health and lower survival rates compared to wild fish, according to a new Washington State University study. The study, published May 18 in Environmental Epigenetics, establishes a link between feeding practices that promote faster growth, as well as other environmental factors in fish hatcheries, and epigenetic changes found in the sperm and red blood cells of of steelhead trout. The research was done at a national fish hatchery on the Methow River in Winthrop, Washington and at another hatchery ...

An international research team headed by Michal Hocek of the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) and Charles University and Ciara K. O'Sullivan of Universitat Rovira i Virgili (URV) in Spain have developed a novel method for labeling DNA, which in the future can be used for sequencing DNA by means of electrochemical detection. The researchers presented their results in the Journal of the American Chemical Society. A DNA molecule comprises four basic building blocks, nucleotides. The genetic information carried within the molecule is determined by the order of the nucleotides. Knowledge of the order of these building blocks, which is known ...

CHAMPAIGN, Ill. -- A new coronavirus test can get accurate results from a saliva sample in less than 30 minutes, researchers report in the journal Nature Communications. Many of the components of the hand-held device used in this technology can be 3D-printed, and the test can detect as little as one viral particle per 1-microliter drop of fluid. "We developed a rapid, highly sensitive and accurate assay, and a portable, battery-powered device for COVID-19 testing that can be used anywhere at any time," said University of Illinois Urbana-Champaign chemical and biomolecular engineering professor Huimin Zhao, who led the research. Though it is still in the ...

A new study published in Nature Communications provides an important new basis for comparing the effectiveness of different tuberculosis treatments. Tuberculosis, a disease caused by the bacterium Mycobacterium tuberculosis (Mtb), is typically the leading infectious cause of death globally, killing 1.2 million people each year. The availability of a new way to evaluate treatments can save lives. In the study, faculty at the University of Colorado School of Medicine at the University of Colorado Anschutz Medical Campus partnered with the University of California ...

Scientists at the University of Colorado Boulder have tapped into a poltergeist-like property of electrons to design devices that can capture excess heat from their environment--and turn it into usable electricity. The researchers have described their new "optical rectennas" in a paper published today in the journal Nature Communications. These devices, which are too small to see with the naked eye, are roughly 100 times more efficient than similar tools used for energy harvesting. And they achieve that feat through a mysterious process called "resonant ...

Ants are renowned in the insect world for their complex social structure and behaviors. Workers and foragers support the queen, faithfully carrying out their social roles for the overall health of the colony. This complex "superorganism" ---as scientists have dubbed it --- has become a prime model to explore the genetic and behavioral roots of social organisms. Remarkably, there are also rare instances of ants not playing well with others and shrugging off their societal duties to become free-loading parasites amongst their free-living relatives. Now, in a new study published in Nature ...

Information flows in a well-defined direction in the brain: Chemical and electrical signals are passed from one neuron to the other across the synapse, from the pre-synaptic to the post-synaptic neuron. Now, Peter Jonas and his group at the Institute of Science and Technology Austria (IST Austria) show that information also travels in the opposite direction at a key synapse in the hippocampus, the brain region responsible for learning and memory. At the so-called mossy fiber synapse, the post-synaptic CA3 neuron influences how the pre-synaptic neuron, the so-called mossy fiber neuron, fires. "We have shown, for the first time, that a retrograde information flow ...

BOSTON - In the early months of the COVID-19 pandemic, the United States experienced higher rates of heart disease and cerebrovascular disease deaths, relative to the corresponding months the previous year. While a large body of evidence has shown that Black and Hispanic communities have borne a disproportionately high burden of disease and death from COVID-19, little is known about whether the rise in cardiovascular deaths during the pandemic has been disproportionately concentrated among racial and ethnic minority populations. A new study led by clinician-researchers at the Richard A. and Susan F. Smith Center for Outcomes Research in Cardiology at Beth Israel Deaconess Medical Center (BIDMC) characterized heart disease ...

Pollinators in the tropics are less likely to thrive in intensive croplands, finds a new study led by UCL researchers suggesting bees and butterflies are at risk of major losses. Across the globe, lower levels of land use intensity are good for pollinators, finds the new Nature Communications paper which shows the importance of sustainable land management in cities and agricultural regions. As insect pollinators were found to be more than 70% less abundant in areas with intensive cropland, compared to wild sites, the researchers say that more sustainable agricultural ...

We are truly never alone, not even within our own bodies. Human beings play host to trillions of bacteria, fungi, viruses, and other microorganisms that make up the human microbiome. In recent years, the mix of these resident bacteria, and the presence of specific bacterial species, has been linked to conditions ranging from obesity to multiple sclerosis. Now, going a step farther, researchers at Harvard Medical School and Joslin Diabetes Center have gone beyond microbial species. Analyzing the genetic makeup of bacteria in the human gut, the team has successfully linked groups of bacterial genes, or "genetic signatures," to multiple diseases. The work brings scientists closer to developing ...

Optimistic predictions expect reliable autonomous vehicles to be commercially available by 2030, at a time when mobility is undergoing a profound shift away from traditional modes of transportation and towards door-to-door services. Previous analysis suggested that public transport will lose market share to autonomous vehicles, but the environmental impact of changing transport use has hardly been considered. New research shows that the convenience of autonomous vehicles would likely come at an environmental cost. A recent paper by researchers from the University of Wisconsin-Madison addresses the use-phase implications of autonomous vehicles using a stated preference ...

Transcatheter aortic valve implantation (TAVI) offers an effective, less invasive therapeutic alternative to surgical aortic valve replacement in patients with symptomatic, severe aortic stenosis. Although TAVI is demonstrated to be superior to medical therapy or surgery in patients who are at prohibitive or high risk for aortic valve surgery, less is known about TAVI in patients who are at low risk for complications or death from surgery. At EuroPCR 2021, Dr J Forrest will present the complete 2-year follow-up from the Evolut low risk trial. The Evolut Low Risk trial is a randomized noninferiority trial in which TAVI with a self-expanding supraannular bioprosthesis ...

Previous clinical trials suggested that ultra-thin strut biodegradable polymer sirolimus-eluting stent (BP-SES) may be associated with lower target lesion failure (TLF) when compared to durable polymer everolimus-eluting stents (DP-EES). However, the possible underlying mechanisms remain unclear. Therefore, the all-comers CASTLE study was designed to assess the role of imaging-guided percutaneous cardiac intervention (PCI) in the clinical outcomes difference between BP-SES vs DP-EES. BP-SES has ultra-thin struts (60μm) and a biodegradable polymer that may provide potential advantages such as reduced vessel inflammation and thrombogenicity. ...

The European Bifurcation Club Left Main (EBC MAIN) trial addressed the issue of provisional single stent versus upfront double stenting in 467 patients with true bifurcation distal left main disease. So far, only one other randomized trial, DKCRUSH-V (n=482), has addressed the same research question, showing better outcomes with an upfront two-stent strategy, more specifically the double-kissing crush (DK CRUSH) technique. In terms of methodology, two aspects need to be considered for the correct interpretation of the EBC MAIN trial results. First, both LAD and CX ostia were affected by significant disease on angiography ...

Results of the interim analyses performed after 12 months in the first 111 patients enrolled in phase II Cool AMI trial evaluating safety and effectiveness of systemic therapeutic hypothermia as an adjunctive therapy in anterior STEMI undergoing PCI as compared to PCI only. Analyses showed significant differences among treatment groups, including longer randomization-to-balloon time and total ischemic time in treatment arm, justifying premature trial discontinuation. Therapeutic mild systemic hypothermia, when achieved before reperfusion of the infarct related vessel, has shown to limit infarct size in experimental animal models. Despite ...

The ISCHEMIA trial found no significant difference between an invasive vs. a conservative strategy in patients with chronic coronary syndromes and moderate to severe ischemia at a mean of 3.2 years. However, the cumulative difference in the estimates of cardiac death between the invasive and conservative strategies tended to increase numerically over time (e.g., 0.3% in favor of the invasive strategy at 2 years and 1.3% at 5 years). Because the ISCHEMIA trial was not powered for cardiac mortality and did not focus on long-term follow-up, the rationale for a meta-analysis emerged. At EuroPCR 2021, Navarese and colleagues present the results of a new meta-analysis of revascularization plus medical therapy versus medical therapy alone. A total of 19,806 patients with chronic coronary syndromes ...

Imagine an entire twenty storey concrete building which can store energy like a giant battery. Thanks to unique research from Chalmers University of Technology, Sweden, such a vision could someday be a reality. Researchers from the Department of Architecture and Civil Engineering recently published an article outlining a new concept for rechargeable batteries - made of cement. The ever-growing need for sustainable building materials poses great challenges for researchers. Doctor Emma Zhang, formerly of Chalmers University of Technology, Sweden, joined Professor Luping Tang's research group several years ago to search for the building materials of the future. Together they have now succeeded in developing a world-first ...

Researchers have developed a tool to help governments and other organizations with limited budgets spend money on building repairs more wisely. The new tool uses artificial intelligence (AI) and text mining techniques to analyze written inspection reports and determine which work is most urgently needed. "Those assessments are now largely subjective, the opinions of people based on experience and training," said Kareem Mostafa, an engineering PhD student at the University of Waterloo who led the project. "We're using actual data on buildings to make spending decisions more objective." Researchers looked at inspection reports on the roofs of 400 schools managed by the Toronto District School Board. A computer ...