Researchers at the UAB have designed minimalist biostructures that imitate natural enzymes, capable of carrying out two differentiated and reversibly regulated activities thanks to a unique combination of structural and functional properties. The strategy used opens the door to the creation of "intelligent" nanomaterials with tailor-made combinations of catalytic functions. There is an increasing interest in synthetic systems that can execute bioinspired chemical reactions without requiring the complex structures that characterise enzymes in their components. One of the most explored approaches is the self-assembly of peptides - molecules smaller than proteins - due to their biocompatibility and how their structural and functional properties can be controlled. Researchers from the ...

Several processes in the human body are regulated by biochemical reactions involving hydrogen peroxide (H2O2). Although it can act as a 'secondary messenger', relaying or amplifying certain signals between cells, H2O2 is generally toxic because of its oxidant character. The latter means that it converts (oxidizes) biochemical molecules like proteins and DNA. The oxidizing property of H2O2 is of potential therapeutic relevance for cancer, though: deliberately causing tumor cells to increase their H2O2 concentration would be a way to destroy them. In light of this, but also for monitoring pathologies associated with H2O2 overproduction, it is crucial to have a means to reliably quantify hydrogen peroxide concentrations in the extracellular environment. Now, Leonardo Puppulin ...

A team of researchers from the CHUM Research Centre has identified new biomarkers associated with the severity of COVID-19 in infected patients. Recent scientific literature has shown that the immune response plays a central part in the severity of COVID-19 disease. Understanding the immune responses generated during the course of the disease is therefore essential to determine which patients are at highest risk for serious complications and death from the disease. In a new study published in the Journal of Clinical Investigation, scientists and clinicians led by Dr.?Catherine Larochelle, researcher at the CHUM Research Centre, have ...

Bacteria integrate genetic material from other bacterial strains more easily than previously thought, which can lead to improved fitness and accelerated evolution. This is shown in a recent study by biophysicists at the University of Cologne. The team analysed genome transfer between bacteria of different lineages. The study was published in the journal PNAS. In the experiment, the team brought one strain of bacteria into contact with DNA fragments from another strain. The uptake of foreign genetic material is known as horizontal gene transfer -- in contrast to vertical gene transfer, by which genes are inherited from a parent cell of the same lineage. The results show that ...

DES PLAINES, IL - A Boston violence intervention advocacy program is effectively engaging the client population that hospital-based violence intervention programs (HVIPs) have been designed to support. This is the conclusion of a study titled Boston Violence Intervention Advocacy Program: Challenges and Opportunities for Client Engagement and Goal Achievement, to be published in the March 2021 issue of Academic Emergency Medicine (AEM), a journal of the Society for Academic Emergency Medicine (SAEM). According to the study, HVIPs should consider which types of client needs prove most challenging to address and which novel strategies will engage vulnerable populations not typically targeted by intervention programs. ...

The sensor network MUCCnet (Munich Urban Carbon Column network) consists of five high-precision optical instruments that analyze the sun's light spectra. They measure the concentration of the gases carbon dioxide (CO2), methane (CH4) and carbon monoxide (CO). Since each gas has its own unique spectral "fingerprint", concentrations of these gases can be determined in the columns of air between the instruments and the sun. "By measuring a vertical column of the atmosphere, local disturbances, such as the disproportionate influence of neighboring stacks, can be removed. Therefore, this type of greenhouse gas balancing is considered particularly robust and accurate," says Prof. Jia Chen. Measurements at five locations in and around Munich One of MUCCnet's measurement devices is ...

A new study by the international network Women In Supramolecular Chemistry (WISC) has highlighted the equality, diversity and inclusion (EDI) issues faced by women and marginalised groups working within that field. The network has also set out a 'calling in' approach to address these issues. The study, led by Dr Jennifer Leigh and Dr Jennifer Hiscock (both University of Kent) alongside WISC's wider team of international researchers, found that both men and women in the supramolecular community wanted to see more mentoring opportunities and more visibility for women and marginalised groups. There is a desire for more guidance during the transition from postdoctoral researcher to independent Principal Investigator, to ensure women can be retained ...

(COLUMBUS, Ohio) - Concussion, a form of traumatic brain injury, is a common injury among children and teens. Concussions can have adverse effects on physical, cognitive, emotional and sleep health. Clinical guidelines for managing concussion in children and teens traditionally recommend complete physical and cognitive rest until symptom resolution, followed by a gradual return to activities like school and sports. These guidelines are often disputed and based on expert consensus as opposed to strong evidence. The challenge has been how to quantify the amount of physical and cognitive activity that children and teens should engage in during recovery. A new study by researchers at the Center for ...

While cigarette smoking continues to be the leading cause of preventable disease, disability and death in the U.S., the evidence base for cessation support has revealed that telephone call centers, or "quitlines," have been a particularly successful intervention, according to the Centers for Disease Control and Prevention (CDC), which recently published a compilation of scientific research in the American Journal of Preventive Medicine. Titled "The Role of Quitlines in Tobacco Cessation," the supplement is composed of nine peer-reviewed articles and three commentaries presenting the latest science on quitlines' effectiveness for smoking termination. The compilation demonstrates the relevance and importance of call ...

A global observation of an ongoing atmospheric drying -- known by scientists as a rise in vapor pressure deficit -- has been observed worldwide since the early 2000s. In recent years, this concerning phenomenon has been on the rise, and is predicted to amplify even more in the coming decades as climate change intensifies. In a new paper published in the journal Global Change Biology, research from the University of Minnesota and Western University in Ontario, Canada, outlines global atmospheric drying significantly reduces productivity of both crops and non-crop plants, even under well-watered conditions. The new findings were established on a large-scale analysis covering 50 years of research and 112 plant species. "When there ...

Lockdown and other restrictions imposed to control the COVID-19 pandemic have had unseen negative effects on the cognitive capacity and mental health of the population. A study led by the UOC's research group Open Evidence, in collaboration with international universities and BDI Schlseinger Group Market Research, has gauged the impact of the measures taken during the first and second waves of the virus on citizens of three European Union countries. The study concludes that the shock produced by the situation has reduced people's cognitive capacity, leading them to take more risks, ...

Astronomers have discovered new hints of a giant, scorching-hot planet orbiting Vega, one of the brightest stars in the night sky. The research, published this month in The Astrophysical Journal, was led by University of Colorado Boulder student Spencer Hurt, an undergraduate in the Department of Astrophysical and Planetary Sciences. It focuses on an iconic and relatively young star, Vega, which is part of the constellation Lyra and has a mass twice that of our own sun. This celestial body sits just 25 light-years, or about 150 trillion miles, from Earth--pretty close, astronomically speaking. Scientists can also see Vega with telescopes even when it's light out, which makes ...

Microscopic fossilized shells are helping geologists reconstruct Earth's climate during the Paleocene-Eocene Thermal Maximum (PETM), a period of abrupt global warming and ocean acidification that occurred 56 million years ago. Clues from these ancient shells can help scientists better predict future warming and ocean acidification driven by human-caused carbon dioxide emissions. Led by Northwestern University, the researchers analyzed shells from foraminifera, an ocean-dwelling unicellular organism with an external shell made of calcium carbonate. After analyzing the calcium isotope composition of the fossils, the researchers concluded that massive volcanic activity injected large amounts of carbon dioxide into the Earth system, causing global warming and ocean acidification. They ...

Artificial intelligence can already scan images of the eye to assess patients for diabetic retinopathy, a leading cause of vision loss, and to find evidence of strokes on brain CT scans. But what does the future hold for this emerging technology? How will it change how doctors diagnose disease, and how will it improve the care patients receive? A team of doctors led by UVA Health's James H. Harrison Jr., MD, PhD, has given us a glimpse of tomorrow in a new article on the current state and future use of artificial intelligence (AI) in the field of pathology. Harrison and other members of the College of American Pathologists' Machine Learning ...

In a new paper published in Light: Science & Applications, the group led by Professor Andrea Fratalocchi from Primalight Laboratory of the Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division, King Abdullah University of Science and Technology (KAUST), Saudi Arabia, introduced a new patented, scalable flat-optics technology manufactured with inexpensive semiconductors. The KAUST-designed technology leverages on a previously unrecognized aspect of optical nanoresonators, which are demonstrated to possess a physical layer that is completely equivalent to a feed-forward deep neural network. "What we have achieved," explains Fratalocchi, "is a technological process to cover ...

Women are largely being excluded from decisions about conservation and natural resources, with potentially detrimental effects on conservation efforts globally, according to research. A University of Queensland and Nature Conservancy study reviewed a swathe of published conservation science, investigating the cause and impact of gender imbalance in the field. UQ PhD candidate and Nature Conservancy Director of Conservation in Melanesia Robyn James said it was no secret that females were underrepresented in conservation science. "In fact, according to a recent analysis of 1051 individual top?publishing authors in ecology, evolution and conservation research, only 11 per cent were women," Ms James said. "We analysed more than 230 peer-reviewed articles attempting ...

One of the world's rarest tree species has been transformed into a sophisticated model that University of Queensland researchers say is the future of plant research. "Macadamia jansenii is a critically endangered species of macadamia which was only described as a new species in 1991," said Robert Henry, Professor of Innovation at the Queensland Alliance for Agriculture and Food Innovation (QAAFI). "It grows near Miriam Vale in Queensland and there are only around 100 known trees in existence." However, with funding from Hort Innovation's Tree Genomics project, and UQ's Genome Innovation Hub Macadamia jansenii has now become the world's most sophisticated plant research model. Professor Henry said ...

In a perfect world, what you see is what you get. If this were the case, the job of artificial intelligence systems would be refreshingly straightforward. Take collision avoidance systems in self-driving cars. If visual input to on-board cameras could be trusted entirely, an AI system could directly map that input to an appropriate action -- steer right, steer left, or continue straight -- to avoid hitting a pedestrian that its cameras see in the road. But what if there's a glitch in the cameras that slightly shifts an image by a few pixels? If the car blindly trusted so-called "adversarial inputs," it might take unnecessary and potentially dangerous action. A new deep-learning algorithm developed by MIT researchers is designed to help machines ...

Cancers that are resistant to radiotherapy could be rendered susceptible through treatment with immunotherapy, a new study suggests. Researchers believe that manipulating bowel cancers based on their 'immune landscape' could unlock new ways to treat resistant tumours. Cancers can evolve resistance to radiotherapy just as they do with drugs. The new study found that profiling the immune landscape of cancers before therapy could identify patients who are likely to respond to radiotherapy off the bat, and others who might benefit from priming of their tumour with immunotherapy. Scientists at The Institute of Cancer Research, London, in collaboration with the University of Leeds and The Francis Crick ...

The public doesn't need to know how Artificial Intelligence works to trust it. They just need to know that someone with the necessary skillset is examining AI and has the authority to mete out sanctions if it causes or is likely to cause harm. Dr Bran Knowles, a senior lecturer in data science at Lancaster University, says: "I'm certain that the public are incapable of determining the trustworthiness of individual AIs... but we don't need them to do this. It's not their responsibility to keep AI honest." Dr Knowles presents (March 8) a research paper 'The Sanction of Authority: Promoting Public Trust in AI' at the ACM Conference on Fairness, Accountability and Transparency (ACM FAccT). The ...

Lowering the operating temperature of solar panels by just a few degrees can dramatically increase the electricity they generate over their lifetime, KAUST researchers have shown. The hotter a panel gets, the lower its solar power conversion efficiency (PCE) and the faster it will degrade and fail. Finding ways to keep solar panels cool could significantly improve the return on investment of solar-power systems. The long-standing focus of photovoltaics (PV) research has been to improve solar modules' PCE and make solar power more cost-competitive than nonrenewable power ...

What is the origin of black holes and how is that question connected with another mystery, the nature of dark matter? Dark matter comprises the majority of matter in the Universe, but its nature remains unknown. Multiple gravitational wave detections of merging black holes have been identified within the last few years by the Laser Interferometer Gravitational-Wave Observatory (LIGO), commemorated with the 2017 physics Nobel Prize to Kip Thorne, Barry Barish, and Rainer Weiss. A definitive confirmation of the existence of black holes was celebrated with the 2020 physics Nobel Prize awarded to Andrea Ghez, Reinhard Genzel and ...

To effectively fight off SARS-CoV-2, the immune system depends on both antibodies and T cells, a type of white blood cell, which work together to eradicate the virus. However, little was known about virus-specific T cells in asymptomatic patients. "We now know that many people are getting infected with SARS-CoV-2 without realising it, as they stay healthy and don't develop any symptoms. These asymptomatic infections may provide the key to understanding how the immune system can control the virus without triggering pathological processes," explained Dr Nina Le Bert, Senior Research Fellow ...

A Korean research group has developed a technology that allows for the differentiation of stem cells into desired cell types, such as vascular mural cells or osteoblasts, without special pretreatment. This technology is expected to facilitate the production of artificial organs for preclinical studies or artificial tissues for transplants such as artificial skin and cardiac patches. The Korea Institute of Science and Technology (KIST) announced that the research group led by Dr. Youngmee Jung of the Center for Biomaterials has developed a new cell co-culture platform ...

In recent years there has been an increased focus on the circular economy and a heightened demand for products made of recyclable materials, however many materials can only be recycled so many times before they begin to wear out. This is the case with carbon fibre reinforced polymer (CFRP) composites, non-biodegradable materials which, until now, have lacked a viable recycling method. CRFP composites are present in products such as wind turbines, aeroplane parts, vehicles such as cars and ships, and everyday technology such as laptops and mobile ...