Researchers from Tokyo Medical and Dental University (TMDU) find that pre-basophil and mast cell progenitors differentiate into pre-basophils before producing mature basophils in mice   Tokyo, Japan – Big changes often happen in small steps, and it’s not always easy to see how we get from point A to point B. Now, researchers from Japan have found a new step in the process of cell differentiation that leads to the production of fully functional basophils, which are critical cells in the immune system.   In a study published this month in Nature Communications, researchers from Tokyo Medical and Dental University (TMDU) have revealed a previously unknown intermediate ...

BOSTON – A change of scenery can restore one's outlook, but for some precancerous cells, a journey from the caves of the bone marrow to the sunny climes of the skin can trigger genetic changes that are a harbinger of cancer, according to a new study by researchers at Dana-Farber Cancer Institute, Brigham and Women's Hospital, and the Broad Institute of MIT and Harvard. The study, published online today by the journal Nature, is one of the first to uncover the "genetic travelogue" ...

About The Study: This analysis of the quality of responses to public health questions found that ChatGPT consistently provided evidence-based answers, although it primarily offered advice rather than referrals. Given the same addiction questions, Amazon Alexa, Apple Siri, Google Assistant, Microsoft’s Cortana, and Samsung’s Bixby collectively recognized 5% of the questions and made one referral, compared with 91% recognition and two referrals with ChatGPT.  Authors: John W. Ayers, Ph.D., M.A., of the University of California San Diego in La Jolla, is the corresponding author.  To ...

PLYMOUTH MEETING, PA [June 7, 2023] — The National Comprehensive Cancer Network® (NCCN®)—an alliance of leading academic cancer centers—published survey results today that shed light on just how widespread the current platinum chemotherapy shortage is, and shared a statement calling on the whole oncology community to work together on solutions. “This is an unacceptable situation. We are hearing from oncologists and pharmacists across the country who have to scramble to find appropriate alternatives for treating their patients with ...

In this project volumetric bioprinting was for the first time successfully combined with melt electrowriting. This combines the speed and cell-friendliness of volumetric printing with the structural strength needed to create functional blood vessels. The study by the biofabrication lab of Regenerative Medicine Center Utrecht (RMCU) was published today in Advanced Materials. Volumetric printing is a technique that was pioneered for bioprinting by the RMCU biofabrication lab in 2019. It is a fast technique, which allows cells to survive the printing process. However, because this ...

In just 7 years, the Irish Potato Famine caused approximately one million people to starve to death and forced another estimated million to flee Ireland as refugees. A mold called Phytophthora infestans infected Ireland’s potato crop, a staple food, and spread rapidly throughout the island. The seemingly tiny fungus destroyed roughly 75% of potato crops over the duration of the great hunger. This catastrophic famine, along with several others in various parts of the world throughout history, highlighted the critical need for the study of plant diseases. Decades ...

Researchers from University of St. Gallen and Columbia Business School published a new Journal of Marketing article that examines how the perceived meaning of manual labor can help predict the adoption of autonomous products. The study, forthcoming in the Journal of Marketing, is titled “Meaning of Manual Labor Impedes Consumer Adoption of Autonomous Products” and is authored by Emanuel de Bellis, Gita Venkataramani Johar, and Nicola Poletti. Whether it is cleaning homes or mowing lawns, consumers increasingly delegate manual tasks to autonomous products. These gadgets operate without human oversight and free consumers from ...

Reston, Virginia—The SNMMI Mars Shot Research Fund is excited to announce that Paul Ellison, PhD, assistant professor at the Department of Medical Physics at the University of Wisconsin School of Medicine and Public Health in Madison, has been selected as the recipient of a $500,000 grant from the 2023 Mars Shot Fund. The grants recognize individuals who have made transformative impact in the field and elevated the value of nuclear medicine and molecular imaging. The grant is one of five awarded in the inaugural year of the new SNMMI Mars Shot Research Fund, which ...

Reston, Virginia—The SNMMI Mars Shot Research Fund is excited to announce that Amir Iravani, MD, associate professor of radiology in the Department of Radiology at the University of Washington School of Medicine in Seattle, Washington, has been selected as the recipient of a $1,000,000 SNMMI Mars Shot Fund Grant. The grants recognize individuals who have made transformative impact in the field and elevated the value of nuclear medicine and molecular imaging. The grant is one of five awarded in the inaugural year of the new SNMMI Mars Shot Research Fund, which was established to provide resources that translate visionary nuclear medicine imaging, radiopharmaceutical therapy ...

Reston, Virginia—The SNMMI Mars Shot Research Fund is excited to announce that Craig Levin, PhD, professor of radiology, physics, electrical engineering and bioengineering at Stanford University in Stanford, California, has been selected as the recipient of a $500,000 grant from the 2023 Mars Shot Fund. The grants recognize individuals who have made transformative impact in the field and elevated the value of nuclear medicine and molecular imaging. The grant is one of five awarded in the inaugural year of the new SNMMI Mars Shot Research Fund, which was established to provide ...

Reston, Virginia—The SNMMI Mars Shot Research Fund is excited to announce that Julie Sutcliffe, PhD, professor of internal medicine and biomedical engineering, University of California–Davis, has been selected as the recipient of a $500,000 grant from the 2023 Mars Shot Fund. The grants recognize individuals who have made transformative impact in the field and elevated the value of nuclear medicine and molecular imaging. The grant is one of five awarded in the inaugural year of the new SNMMI Mars Shot Research Fund, which was established to provide ...

Reston, Virginia—The SNMMI Mars Shot Research Fund is excited to announce that Randy Yeh, MD, a radiologist and nuclear medicine physician at Memorial Sloan Kettering Cancer Center and assistant professor of radiology at Weill Cornell Medical College in New York, has been selected as the recipient of a $500,000 grant from the 2023 Mars Shot Fund. The grants recognize individuals who have made transformative impact in the field and elevated the value of nuclear medicine and molecular imaging. The grant is one of five awarded in the inaugural year of the new SNMMI Mars Shot Research Fund, which ...

KANSAS CITY, MO—June 7, 2023—The placenta, critical for healthy embryo development, is a multi- purpose organ with a precise lifespan—the length of a pregnancy. New research from the Stowers Institute for Medical Research suggests that further exploration of the placenta’s roles and capabilities may one day lead to insights for positive pregnancy outcomes. The study published in Development on June 6, 2023, focuses on a unique property of many cells comprising the placenta that explains how these cells perform essential functional and physical ...

More than 5,000 people are diagnosed annually with ALS (amyotrophic lateral sclerosis), a fatal, neurodegenerative disease that attacks nerve cells in the brain and spinal cord, gradually robbing people of the ability to speak, move, eat and breathe. To date, only a handful of drugs exist to moderately slow its progression. There is no cure. But CU Boulder researchers have identified a surprising new player in the disease—an ancient, virus-like protein best known, paradoxically, for its essential role in enabling placental development. The findings ...

Research Highlights: 58% of adults with Type 2 diabetes covered by Alabama Medicaid did not receive prompt outpatient care after hospitalization for heart failure. African American and Hispanic adults with Type 2 diabetes were less likely to have post-discharge follow-up health visits, or if they did, the visits occurred nearly two to three days later compared to white adults. Embargoed until 4 a.m. CT/5 a.m. ET Wednesday, June 7, 2023 DALLAS, June 7, 2023 — More than half of Medicaid-covered adults in Alabama with Type 2 diabetes did not receive follow-up health care within the recommended two-week period following hospitalization for newly-diagnosed heart ...

The first stars illuminated the Universe during the Cosmic Dawn and put an end to the cosmic "dark ages" that followed the Big Bang. However, the distribution of their mass is one of the great unsolved mysteries of the cosmos. Numerical simulations of the formation of the first stars estimate that the mass of the first stars reached up to several hundred solar masses. Among them, the first stars with masses between 140 and 260 solar masses ended up as pair-instability supernovae (PISNe). PISNe are quite different from ordinary supernovae (i.e., Type II ...

TORONTO, CANADA –A new study followed more than 7000 middle aged and older Canadians for approximately three years to understand whether higher rates of social participation were associated with successful aging in later life. They found that those who participated in volunteer work and those participating in recreational activities were more likely to maintain excellent health across the subsequent 3-year study period and less likely to develop physical, cognitive, mental, or emotional problems. The researchers defined successful aging as freedom from any serious physical, cognitive, mental, or emotional conditions ...

Certain crops, like greenhouse tomatoes, eggplant, peppers, and blueberries, rely on bumblebees for a style of pollination that only bumblebees can perform. Among growers, the preference can be for bigger-bodied bumblebees because they’re thought to be more efficient pollinators.  Enabled by a $750,000 grant from the National Institute of Food and Agriculture, the research team will investigate factors suspected of influencing bumblebee biology and body size, including climate change, wildfires, and the ...

PHILADELPHIA – First-line ibrutinib (Imbruvica) plus venetoclax (Venclexta) led to high response and survival rates in patients with chronic lymphocytic leukemia (CLL) whether or not their cancer harbored high-risk genetic features typically associated with poor outcomes, according to results published in Clinical Cancer Research, a journal of the American Association for Cancer Research (AACR). Patients with high-risk CLL, defined by deletion of 17p, mutated TP53, and/or unmutated immunoglobulin ...

IOP Publishing (IOPP) is expanding its open access (OA) Environmental Research portfolio to address the urgent need for sustainable food solutions globally. Environmental Research: Food Systems, which supports the United Nation’s Sustainability Development Goals (SDGs), is an interdisciplinary forum for researchers working to achieve sustainable global food security. Scientific innovations are key to transforming the global food system. Efficient and effective food supply enables the world to achieve progress on all 17 of the SDGs, from eliminating poverty ...

A research team led by the Complexity Science Hub Vienna and the Medical University of Vienna has analysed the actual prevalence of Type 2 diabetes in Austria for the first time as part of a study. In addition to identifying clear regional differences, an alarming and previously unknown figure came to light: one in three people suddenly stop treatment and go without medication and/or medical check-ups for at least a year. And, as the study also showed, this group had a higher mortality rate than patients with diabetes who regularly access the care available to them. The results have ...

Cerebral Palsy has been linked to a condition called cryptorchidism in males—when one or both of the testicles are not present in the scrotum. A new study in Developmental Medicine & Child Neurology found that spasticity in the lower extremities was linked to a higher likelihood of receiving surgery for cryptorchidism in boys with cerebral palsy. The study included 44,561 male patients with cerebral palsy in the Pediatric Health Information System, a comparative administrative database involving multiple US children’s hospitals. In addition to finding an overall association between lower extremity spasticity and cryptorchidism ...

Speech and voice disorders are common in individuals with Parkinson’s disease. New research published in the International Journal of Language & Communication Disorders found that a tele-rehabilitation program that combines conventional speech therapy and singing may help improve patients’ voice problems. For the study, 33 people with Parkinson’s disease were randomly assigned to receive the combination therapy, conventional speech therapy, or a singing intervention. Each patient participated in 12 tele-rehabilitation sessions over four weeks. Voice-related ...

New research reveals that the level of fat within the body’s muscle—or muscle adiposity—may indicate a person’s likelihood of experiencing cognitive decline as they age. In the study published in the Journal of the American Geriatrics Society, 5-year increase in fat stored in the thigh muscle was a risk factor for cognitive decline. This risk was independent of total weight, other fat deposits, and muscle characteristics (such as muscle strength or mass) and also independent of traditional dementia risk factors. Investigators assessed muscle fat in 1,634 adults 69–79 years of age at years 1 and 6 and evaluated their cognitive function ...

The quality of recovery a person experiences on a given evening after work may impact their mood when they start their job again the next day, according to new research published in the Journal of Occupational and Organizational Psychology. The study, which was based on diary entries by 124 employees on 887 days, found that people who had higher quality recovery during the evening than usual had higher levels of wakefulness, calmness, and pleasantness when they started work the next day. However, people’s wakefulness and calmness tended to decline more strongly during the workday after evenings with higher ...