A University of Melbourne led study has established how plants use their metabolism to tell time and know when to grow - a discovery that could help leverage growing crops in different environments, including different seasons, different latitudes or even in artificial environments and vertical gardens. Published in the PNAS journal, Superoxide is promoted by sucrose and affects amplitude of circadian rhythms in the evening, details how plants use their metabolism to sense time at dusk and help conserve energy produced from sunlight during the day. Lead ...

DURHAM, N.C. - Anyone who has ever developed a urinary tract infection (UTI) knows that it can be painful, pesky and persistent. UTIs have a high recurrence rate and primarily afflict women -- as many as 50% of women will experience at least one UTI during their lifetime. However, what if patients could take a vaccine that would prevent future UTIs? In a March 1 study in the Proceedings of the National Academy of Sciences, Duke researchers describe a new vaccination strategy that they think could re-program the body to fight off the bacteria that cause urinary tract infections. "Although several vaccines against UTIs have been investigated in clinical trials, they have so far had limited success," said Soman Abraham, Ph.D., Grace Kerby Distinguished Professor of Pathology, Immunology ...

A new study from Boston Children's Hospital and the Massachusetts Department of Health compared one of the latest rapid antigen tests for COVID-19 -- the Abbott BinaxNOW -- with a highly accurate PCR test in a high-volume, drive-thru testing environment. They found that the rapid test detected almost all adults who tested positive by PCR if they had had symptoms lasting seven days or less. In symptomatic children with less than seven days of symptoms, the test picked up about 85 percent of true positive cases. But no matter the age, if the patient had high amounts of virus in their nose, the test caught it 99 percent of the time. It was also able to rule out COVID-19 ...

The human gut consists of a complex community of microbes that consume and secrete hundreds of small molecules--a phenomenon called cross-feeding. However, it is challenging to study these processes experimentally. A new study, published in END ...

Researchers from Skoltech and the University of Cambridge have shown that polaritons, the quirky particles that may end up running the quantum supercomputers of the future, can form structures behaving like molecules - and these "artificial molecules" can potentially be engineered on demand. The paper outlining these results was published in the journal Physical Review B Letters. Polaritons are quantum particles that consist of a photon and an exciton, another quasiparticle, marrying light and matter in a curious union that opens up a multitude of possibilities in next-generation polaritonic devices. Alexander Johnston, Kirill Kalinin and Natalia Berloff, professor at the Skoltech Center for Photonics and Quantum Materials ...

A group of researchers representing four countries summed up the results of the Supertest, a large-scale study of the academic performance of engineering students in Russia, China, India, and the United States. It is the first study to track the progress of students in computer science and electrical engineering over the course of their studies with regard to their abilities in physics, mathematics, and critical thinking and compare the results among four countries. The article about study in Nature Human Behavior. The HSE Institute of Education played a key role not only in collecting and analyzing data from Russia, ...

March 1, 2021 - Benign bone tumors may be present in nearly 20 percent of healthy children, based on a review of historical radiographs in The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer. Although that may sound frightening, non-ossifying fibromas and other common benign bone tumors in symptom-free children are harmless and may resolve over time, reports the new study by Christopher D. Collier, MD, of Indiana University School of Medicine and colleagues. "These findings provide unique evidence to answer many commonly encountered questions when counseling patients and their families on benign bone tumors," the researchers write. Study offers reassurance that benign ...

Blocking cell receptors for glucagon, the counter-hormone to insulin, cured mouse models of diabetes by converting glucagon-producing cells into insulin producers instead, a team led by UT Southwestern reports in a new study. The END ...

Boston, MA--Most pregnant women and mothers of children younger than 18 years old say they would receive a COVID-19 vaccine and vaccinate their children, according to a survey conducted by researchers at Harvard T.H. Chan School of Public Health. The research indicated that vaccine acceptance was highest in India, the Philippines, and all sampled countries in Latin America, and it was lowest in Russia, the U.S., and Australia. The results will be published online on March 1, 2021 in the European Journal of Epidemiology. Vaccines for COVID-19 are being distributed around the world, but until ...

SILVER SPRING, Md. - A recent preclinical study by U.S. Military HIV Research Program (MHRP) researchers showed that an experimental therapy combining a TLR7 agonist and two broadly neutralizing antibodies delayed viral rebound in SHIV-infected macaques after antiretroviral therapy (ART) interruption. The experimental combination therapy consisted of TLR7 agonist GS-986 and two broadly neutralizing antibodies (bnAbs), N6-LS and PGT121, targeting different regions of the HIV envelope. The rhesus macaques were initiated on viral suppressive antiretroviral therapy 14 days post infection, a timespan from infection to treatment which mirrors what is feasible in acute HIV infection. Researchers then administered the experimental combination ...

NEW YORK, NY (March 1, 2021)--By harnessing the immune system against cancer, immunotherapies have revolutionized the way some types of cancer are treated. But most patients--across cancer types--do not respond, and in most cases, scientists are at a loss as to why. Researchers at Columbia and MIT have created a new technique that can uncover nearly all of the tricks cancer cells use to evade immunotherapies, which could lead to the development of more effective treatments. The researchers tested their new technique with cancer cells and matching immune cells from melanoma patients and identified previously unknown resistance mechanisms to immune checkpoint ...

Black Americans have a high level of vaccine hesitancy and mistrust of COVID-19 vaccines, including among Black health care workers, according to a new RAND Corporation survey. Those who expressed vaccine hesitancy also showed high levels of overall mistrust in the vaccine, concerns about potential harm and side effects, and lack of confidence in vaccine effectiveness and safety. Participants in the RAND survey reported higher trust in COVID-19 information from health care providers and public health officials than from elected local and federal officials. The findings are based on a survey ...

Tissue engineering has long-depended on geometrically static scaffolds seeded with cells in the lab to create new tissues and even organs. The scaffolding material -- usually a biodegradable polymer structure -- is supplied with cells and the cells, if supplied with the right nutrients, then develop into tissue as the underlying scaffold biodegrades. But this model ignores the extraordinarily dynamic morphological processes that underlie the natural development of tissues. Now, researchers at the END ...

A team of international researchers led by a Florida State University assistant professor has analyzed reams of data from the Neolithic to Late Roman period looking at migration patterns across the Mediterranean and found that despite evidence of cultural connections, there's little evidence of massive migration across the region. "Because of the prevailing scholarly attitude of the 'connected' Mediterranean -- one with high degrees of mobility and migration that drive the archaeological patterns we see -- we'd imagined we'd see comparatively high levels of migration reflected in the strontium isotope data," said Thomas Leppard, assistant professor of anthropology at Florida State. "That instead ...

 Invasive alien species, defined as animals and plants that breed and disperse in a landscape beyond their native range, have negative environmental, social, and economic impacts. One example among many is the forage grass genus Brachiaria, originally African and introduced to Brazil to form cattle pasture. It has become a major threat to the survival of native species and biodiversity at several spatial scales.  Complete eradication of invasive species is often impracticable. Attempts to do so have had undesirable consequences and even been damaging because merely withdrawing an invasive ...

Too much activity in the hippocampus may cause navigation impairments seen in aging adults, according to new research published in JNeurosci. Spatial navigation is one of the cognitive abilities that declines sharply in old age. Older adults often have difficulty navigating new environments and will choose to stick with familiar ones. Plus, key regions in the brain's navigation circuit are some of the first affected by Alzheimer's disease. In a recent study, Diersch et al. examined the neural mechanism behind this decline in spatial learning. In the study, younger ...

A single letter difference in a single gene, inherited from both parents, spells a lifetime of anemia and pain for 20 million people, mostly of African ancestry, worldwide. Sickle cell disease (SCD) causes red blood cells to assume a sickle shape and jam in capillaries, cutting off oxygen to lungs, brain, bones and other organs. Despite the single genetic origin of SCD, each person's disease experience and even life expectancy depend upon where they live, and the social, physical and environmental factors they encounter. Now, a new review published by Wiley in the journal Advanced Genetics proposes that it is ...

The rapid loss of variation within species is a hidden biodiversity crisis, according to the authors of a new study looking at how this variation supports essential ecological functions and the benefits nature provides for people. Published March 1 in Nature Ecology and Evolution, the study highlights the need to better understand and conserve variation within species in order to safeguard nature's contributions to people. "Biodiversity means more than the number of species, and when we focus on species-level extinctions we are missing part of the story," said corresponding author Eric Palkovacs, professor of ecology and evolutionary biology at UC Santa Cruz. "Intraspecific variation is a neglected aspect of biodiversity, ...

ITHACA, N.Y. - The expansion of charter schools in the 2000s led to an increase in school segregation and a slight decline in residential segregation, according to new research from Cornell University providing the first national estimates of the diverging trends. According to the study, the average district to expand charter school enrollment between 2000 and 2010 experienced a 12% increase in white-Black school segregation and a 2% decrease in white-Black residential segregation. The patterns moved in opposite directions, the research found, because charter ...

Scientists from the Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago found that a region within the DNA of the cancer-promoting GLI1 gene is directly responsible for regulating this gene's expression. These findings, published in the journal Stem Cells, imply that this region within GLI1 could potentially be targeted as cancer treatment, since turning off GLI1 would interrupt excessive cell division characteristic of cancer. "From previous research, we know that GLI1 drives the unrelenting cell proliferation that is responsible for many cancers, and that this gene also stimulates its own expression," says co-senior author Philip Iannaccone, MD, PhD, Professor Emeritus at the Manne Research Institute at Lurie Children's and Northwestern ...

Scientists from Far Eastern Federal University (FEFU) together with Russian and German colleagues, continue studying antitumor compounds synthesized based on bioactive molecules isolated from a sea sponge. One of them fights cancer cells resistant to standard chemotherapy, and at the same time has an interesting dual mechanism of action. A related article appears in Marine Drugs. Scientists have tested the biological effect of the marine alkaloid 3,10-dibromofascaplysin on various prostate cancer cells, including those resistant to standard docetaxel-based chemotherapy. ...

CORVALLIS, Ore. - In tropical oceans, a combination of sunlight and weak winds drives up surface temperatures in the afternoon, increasing atmospheric turbulence, unprecedented new observational data collected by an Oregon State University researcher shows. The new findings could have important implications for weather forecasting and climate modeling, said Simon de Szoeke, a professor in OSU's College of Earth, Ocean, and Atmospheric Sciences and the lead author of the study. "The ocean warms in the afternoon by just a degree or two, but it is an effect that has largely been ignored," said de Szoeke. ...

HARWELL, UK (1 March 2021) Scientists based at the University of Oxford as part of the Faraday Institution CATMAT project researching next-generation cathode materials have made a significant advance in understanding oxygen-redox processes involved in lithium-rich cathode materials. The paper, published in Nature Energy, proposes strategies that offer potential routes to increase the energy density of lithium-ion batteries. "In the ever more difficult quest to make incremental improvements to Li-ion battery energy density, being able to harness the potential of oxygen-redox cathodes and the bigger improvements they offer relative to the nickel rich cathodes in commercial use today is potentially significant," Prof Peter Bruce, University ...

Childhood cancer and its treatment can result in cognitive struggles. Scientists atSt. Jude Children's Research Hospital are studying the risk factors. They looked at social and economic issues in children with brain tumors treated with radiation. These patients have the greatest risk of cognitive problems. Scientists followed a group of St. Jude patients for 10 years. The children all had conformal radiation therapy. For each patient, researchers looked at certain factors. These included the parent's job, education level, and whether it was a single parent home. The children were from different backgrounds. The findings show social and economic status is linked to IQ, academics, attention ...

Amsterdam, March 1, 2021 - Comfort is a daily human experience central to the perception of our environment and the continuous processing of sensory input. Environmental factors such as smell, temperature and light can influence comfort, as can our interaction with products, such as the design of a chair or a mattress. Increasingly, researchers investigating the science of comfort and discomfort are focusing on the role of human behavior. A special supplement to the journal WORK presents the latest advances, from optimal seat design in offices and transportation to the influence of smell on comfort and the interaction between time and comfort. "This special supplement adds unique findings to comfort knowledge. ...