The study, published April 7 in Nature Communications, analyzed electronic health records as part of the National Institutes of Health’s Researching COVID to Enhance Recovery (RECOVER) Initiative to better understand the persistence of symptoms after SARS-CoV-2 infection, also known as long COVID, among broad, diverse populations. Led by Dr. Rainu Kaushal, chair of the Department of Population Health Sciences at Weill Cornell Medicine and physician-in-chief of population health sciences at New York-Presbyterian ...

LA JOLLA, CA—Jeffery Kelly, PhD, the Lita Annenberg Hazen Professor of Chemistry at Scripps Research, has been elected to the National Academy of Sciences for his work on understanding protein shapes and controlling the ensemble of shapes with small molecules in order to develop therapeutic strategies for a range of devastating diseases. The academy awards membership in recognition of “distinguished and continuing achievements in original research.”  The election of Kelly brings the total number of memberships held by Scripps Research faculty in the National Academies of Sciences, Medicine and Engineering to 31.  “This ...

Two highly similar molecules with essential, but often contrasting, signaling roles in most life forms exert their distinct effects through subtle differences in their bindings to their signaling partners, according to a new study led by researchers at Weill Cornell Medicine. In the study, published March 27 in Nature Structural & Molecular Biology, the researchers used exquisitely sensitive measurement techniques to reveal at the single-molecule level how the signaling molecules cAMP and cGMP bind to an ion channel from the pacemaker channel family, one of the major types of proteins whose activities they regulate. Ion channels are common features of cell membranes, ...

Researchers from Karolinska Institutet and Sachs’ Children and Youth Hospital in Sweden have mapped the immune system in the gut of children with inflammatory bowel disease (IBD). The results, which were published in Cell Reports Medicine, can be used to design more targeted therapies. Today, we know relatively little about how the immune system functions in children with IBD and how this differs from adults. About 40 percent of patients, including both children and adults, do not respond to the treatments that are currently available. It is therefore very important to identify biomarkers that can both predict ...

A National Institute for Materials Science (NIMS) research team has succeeded in substantially improving the cycling performance of a lithium metal battery by developing a mechanically very strong polymeric gel electrolyte and integrating it into the battery as a layer to protect the lithium metal anode. This achievement may greatly facilitate efforts to put lithium metal anodes—a potentially very high performance anode material—into practical use.   Today’s society is rapidly transforming through the widespread use of digital technologies, the increasing popularity of electric vehicles and the growing use of renewable energy. These ...

The National Institute for Materials Science (NIMS) has achieved a tunnel magnetoresistance (TMR) ratio of 631% at room temperature, breaking the previous world record which had stood for 15 years. This was accomplished by fine-tuning the interfaces in a magnetic tunnel junction (MTJ). This MTJ exhibited very large TMR ratio oscillation effect with a peak-to-valley (PV) difference of 141%. This phenomenon may be exploitable to significantly increase the sensitivity of magnetic sensors and the capacity of magnetoresistive random access ...

CLAY CENTER, Neb., May 9, 2023 -Scientists have collaborated to produce the first gene-edited calf with resistance to bovine viral diarrhea virus (BVDV), a virus that costs the U.S. cattle sector billions of dollars annually. The recent study published in PNAS Nexus results from a collaboration between the USDA’s Agricultural Research Service (ARS), the University of Nebraska–Lincoln (UNL), the University of Kentucky, and industry partners, Acceligen and Recombinetics, Inc. BVDV is one of the most significant viruses ...

Cattle worldwide face major health threats from a highly infectious viral disease that decades of vaccinations and other precautions have failed to contain. Federal, private-sector and Husker scientists are collaborating on a new line of defense, by producing a gene-edited calf resistant to the virus. If follow-up research confirms its efficacy, the gene-editing approach offers long-term potential to reduce antimicrobial and antibiotic use in the cattle industry.   The bovine viral diarrhea virus (BVDV) devastates the bovine immune system and can cause severe respiratory and intestinal harm to infected beef and dairy cattle, said veterinary epidemiologist Brian Vander ...

A team of scientists from the University of Ottawa has developed an innovative technique to manufacture complex chemical structures from easily accessible substrates, making it one of the simplest and most practical methods for converting alcohols into their arylated equivalents. This innovative method for performing the reaction, namely the deoxygenative Suzuki-Miyaura arylation of aliphatic alcohols, uses two distinct metal catalysts. Their reaction operates under mild reaction conditions with minimal waste products and is expected to have a significant impact on the creation of new molecules. As a result, it will contribute to advances in pharmaceutical, agrochemical, ...

Cameras used in harsh environments must be designed in a way that prevents temperature swings from influencing their optical performance. New research demonstrates that accounting for the exact lens mounting structure used is a critical step in ensuring that lens systems remain robust to temperature changes. Eric M. Schiesser from Synopsys, Inc. will present the new research at the Optica Design and Fabrication Conference, which will take place 04 – 08 June 2023 in Quebec City, Canada. “Most optical systems – from the camera in your smartphone to the eyes of the Mars rover - are used over a range of temperatures.  To keep the image sharp ...

PROVIDENCE, R.I. [Brown University]—When patients receive a low-dose computed tomography screen for lung cancer, doctors can see more than just the lungs. The screening test often picks up abnormalities or potentially “significant incidental findings” (SIFS) not associated with lung cancer. A new study led by Ilana Gareen, an associate professor of epidemiology at the Brown University School of Public Health, and published in JAMA Internal Medicine, highlights the need for proper reporting and management of these findings to reduce mortality, health care costs and unnecessary ...

“In summary, single-cell transcriptomic analysis has allowed us to identify the specific populations and the dynamic transition states during senescence initiation and progression.” BUFFALO, NY- May 9, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 8, entitled, “Single-cell transcriptomic analysis uncovers diverse and dynamic senescent cell populations.” Senescence is a state of enduring growth arrest triggered by sublethal cell damage. Given that senescent cells actively ...

Researchers at Baylor College of Medicine have linked specific variants or mutations of the gene myocardin-related transcription factor B (MRTFB) with a novel neurodevelopmental disorder. The team reports in the journal Genetics in Medicine that they were able to find variants in this gene in patients whose neurodevelopment disorders had previously gone undiagnosed. The research also revealed that the mutations disrupt the way the MRTFB protein controls other genes in the cell and this cascades to affect hundreds of other genes. “We identified ...

Many middle-aged and older women get mammograms every one to two years to screen for breast cancer, as recommended by their doctors. A study by researchers at Washington University School of Medicine in St. Louis indicates that previous mammograms hold underutilized data that could help identify women at high risk of breast cancer and even reveal which breast is likely to be affected. When doctors read mammograms, they assess breast density along with signs of cancer, comparing a woman’s previous mammograms to her most recent one to look for worrisome changes. But some changes are difficult to ...

(Boston)—COVID-19, the disease resulting from SARS-CoV-2 infection, is associated with highly variable clinical outcomes that range from asymptomatic disease to death. For those with milder infections, COVID-19 can produce respiratory infection symptoms (cough, congestion, fever) and sensory phenotypes such as headache and loss of sense of smell. In more severe cases, SARS-CoV-2 infection can affect nearly every organ and result in strokes from vascular occlusion, cardiovascular damage and acute renal failure. ...

New Method Uses Engineered Bacteria and AI to Sense and Record Environmental Signals Columbia synthetic biologists first to engineer bacterial swarm patterns to visibly record environment, use deep learning to decode patterns; applications could range from monitoring environmental pollution to building living materials  New York, NY—May 9, 2023—Researchers in Biomedical Engineering Professor Tal Danino’s lab were brainstorming several years ago about how they could engineer and apply naturally-pattern-forming bacteria. There are many bacteria species, such as Proteus mirabilis (P. mirabilis), that self-organize into defined patterns on solid surfaces that are visible ...

Philadelphia, May 9, 2023 – The increase in obesity in lower-middle-income countries (LMIC) is largely thought to be affected by lifestyle transition away from traditional diets toward unhealthy Western dietary patterns that follow economic development. This study in the Journal of Nutrition Education and Behavior, published by Elsevier, collected data on eating and physical activity behaviors from families in two socioeconomically-different communities in Nairobi, Kenya. Researchers found that increasing prosperity is linked to unhealthy eating patterns in Kenyan preadolescents. "Dietary ...

The University of Ottawa’s Interdisciplinary Centre for Black Health survey reveals scope of coronavirus vaccine hesitancy in Black communities in relation to healthcare. The health care system must play a significant role in combatting COVID-19 mistrust among Black individuals in Canada according to a new University of Ottawa study that found distrust in the healthcare network was so profound that educated individuals were hesitant to receive the vaccine. Professor Jude Mary Cénat, Associate Professor in the School of Psychology at the Faculty of Social Sciences, is the Chair of the Interdisciplinary Centre ...

CHICAGO, May 9, 2023 – Millions of people now regularly communicate with AI-based devices, such as smartphones, speakers, and cars. Studying these interactions can improve AI’s ability to understand human speech and determine how talking with technology impacts language. In their talk, “Clear speech in the new digital era: Speaking and listening clearly to voice-AI systems,” Georgia Zellou and Michelle Cohn of the University of California, Davis will describe experiments to investigate how speech and comprehension change when humans communicate ...

According to a new Johns Hopkins Medicine study, low pain self-efficacy can predict daily pre-surgery prescribed opioid use among patients seeking elective spine surgery. The study defined pain self-efficacy as the “beliefs held by people with chronic pain that they can carry out certain activities, even when experiencing pain.” Previous studies showed that lower pain self-efficacy is associated with higher pain intensity and greater pain interference in day-to-day life. However, the Johns Hopkins research team believes its study is among the first to investigate ...

Vitamin D intake could reduce cancer mortality in the population by twelve percent - provided the vitamin is taken daily. This was the result of an evaluation of 14 studies of the highest quality conducted at the German Cancer Research Center with a total of almost 105,000 participants. Vitamin D deficiency is widespread worldwide and is particularly common among cancer patients. Averaged over the year, the vitamin D blood levels of about 15 percent of German adults are below the threshold for a pronounced vitamin D deficiency*. In contrast, in a study of colorectal ...

Scientists from UNSW Sydney with collaborators at Boston University have developed a tool that shows early promise in detecting Parkinson’s disease years before the first symptoms start appearing. In research published today in the journal ACS Central Science, the researchers described how they used neural networks to analyse biomarkers in patients’ bodily fluids. The researchers from UNSW School of Chemistry examined blood samples taken from healthy individuals gathered by the Spanish European ...

SAN ANTONIO — May 9, 2023 —NASA has selected Southwest Research Institute for a Phase A study to develop SwRI’s Space Weather Solar Coronagraph (SwSCOR) on behalf of the National Oceanic and Atmospheric Administration (NOAA). NOAA’s Space Weather Next Program is charged with providing critical data for its space weather prediction center. SwRI is one of five organizations developing a definition-phase study to produce the next-generation NOAA L1 Series COR instrument to detect and characterize Earth-directed coronal mass ejections (CMEs). CMEs are huge bursts of coronal plasma threaded with intense magnetic fields ...

AUGUSTA, Ga. (May 9, 2023) –  A long molecule of RNA found in abundance in the healthy smooth muscle cells that give our blood vessels strength and flexibility is also essential to the continuous contraction that moves food through our gastrointestinal tract. Without CARMN, a long, noncoding RNA, which means it doesn’t produce proteins but does help regulate cell activity, the 30-foot-long GI tract doesn’t contract as it should. That can result in a painful even lethal situation where partially undigested food gets ...

A gene-edited calf shows resistance to a common bovine virus. Bovine viral diarrhea virus (BVDV) causes gastrointestinal and respiratory symptoms as well as reproductive failure in cattle around the world. Vaccines against the virus exist but the virus evolves quickly and vaccines are not always fully protective. Aspen Workman and colleagues used the CRISPR/Cas9 system to swap out just six amino acids in the bovine CD46 receptor in one calf. The calf showed a dramatic reduction in susceptibility to the virus and ...