CLEVELAND, Ohio (May 8, 2023)—As the population continues to age, there is greater focus on bone health and minimizing fractures to maintain mobility. A new study suggests that various types of hormone therapies not only increase lumbar spine bone mineral density (BMD) in postmenopausal women but also protect against bone loss, even after hormones have been discontinued. Study results are published online in Menopause, the journal of The North American Menopause Society (NAMS). Osteoporosis is a common debilitating condition, ...

Pacemakers and other implantable devices that restore normal heart rhythms have saved millions of lives. In some patients, a pacemaker or implantable cardioverter defibrillator modified for “cardiac resynchronization therapy,” or CRT, can dramatically improve heart failure by synchronizing the heart’s pumping function. Unfortunately, many people don’t respond to CRT and of those who do, some don’t realize its full potential — including increased exercise capacity and staying out of the hospital. CRT can save or change many more lives, says Miaomiao Zhang, an assistant professor at the University of Virginia School ...

Collaborative research at the University of Cincinnati has developed a new probe to better study cells that has already led to new knowledge about certain cellular processes. UC’s Jiajie Diao, PhD, and Yujie Sun, PhD, are lead authors on new research published May 4 in ACS Sensors. Focus on endolysosomes The team’s research focused on organelles, or specialized structures that perform various jobs inside cells, called endolysosomes. Lysosomes are organelles that act as the “recycling center” of the cell, reusing ...

Researchers at North Carolina State University have developed a complex model to improve how quickly first responders – such as police and EMTs – reach the scene of vehicle accidents. In computational testing, the model outperformed the existing techniques for getting first responders to accident sites quickly. “The goal was to figure out the most efficient way to get first responders to an accident,” says Leila Hajibabai, corresponding author of a paper on the work and an assistant professor in NC State’s Edward P. Fitts Department of Industrial and Systems Engineering. “Where should first responders be based ...

Thalassemia (thal-uh-SEE-me-uh) is an inherited blood disorder that affects about 300 million people worldwide. Treatments for moderate to severe thalassemia include frequent blood transfusions, chelation therapy to remove excess iron from the blood, and hematopoietic stem cell transplantation (HSCT). In line with the theme of this year's International Thalassemia Day – "Be Aware. Share. Care: Strengthening Education to Bridge the Thalassemia Care Gap", BGI Genomics will co-host an event with the Shenzhen Municipal Health Commission for thalassemia patients and their family members on May 6, 2023, in Shenzhen, China, providing tips on ...

The University of Minnesota Twin Cities announced that it will receive a $20 million grant over five years from the National Science Foundation (NSF) and the U.S. Department of Agriculture’s (USDA) National Institute of Food and Agriculture (NIFA) to lead a new National Artificial Intelligence Research Institute.  Researchers at the AI Institute for Climate-Land Interactions, Mitigation, Adaptation, Tradeoffs and Economy (AI-CLIMATE) aim to leverage artificial intelligence (AI) to create more climate-smart practices that will absorb and store carbon while simultaneously boosting the economy in the agriculture and forestry industries. The new ...

DALLAS, May 8 2023 — Cardiovascular disease is the No. 1 killer of new moms.[1]  The American Heart Association, through the new campaign, “My health is our health”/ “Mi salud es nuestra salud” is raising awareness among Hispanic/ Latina moms, especially during pregnancy, about the importance of managing their blood pressure. On average, about one in every 16 Hispanic women aged 20 and older have coronary heart disease, the most common type of heart disease.[2] Hispanic/Latina mothers hold a special place in their homes when it comes to family decisions. They are considered the head of the family for their key role in raising children and ...

Recognizing and separating enantiomers is a difficult task for chemical engineers — one might say it gives them a bit of a headache. Enantiomers are molecules with virtually identical compositions that mirror one another, like a left and right hand. In chemistry, this property is called chirality. Despite the similarities in their makeup, so-called left- and right-handed enantiomers often exhibit very different properties. Sometimes a drug has an enantiomer that causes undesirable effects. For example, certain drugs have one enantiomer that can cause a headache, ...

HOUSTON – (May 8, 2023) – Many birth defects and spontaneous abortions occur during the embryonic development stage known as neurulation, yet we have very little insight into how this critical developmental process unfolds in humans. The Rice University lab of Aryeh Warmflash has received a five-year, $1.9 million grant from the National Institutes of Health to optimize and develop experimental cell models that can shed light on the self-organizing processes by which ectodermal ...

University of Minnesota Twin Cities researchers have developed a groundbreaking new diagnostic technique that will allow for faster and more accurate detection of neurodegenerative diseases. The method will likely open a door for earlier treatment and mitigation of various diseases that affect humans, such as Alzheimer's and Parkinson's, and similar diseases that affect animals, such as chronic wasting disease (CWD). Their new study is published in Nano Letters, a premier journal in the field of nanotechnology published by the American Chemical Society. “This paper mainly ...

HOUSTON – (May 8, 2023) – For newborns with congenital hypothyroidism, early diagnosis spells the difference between a normal, healthy life and lifelong disability. After learning about the heavy toll the disease takes on children born in parts of the world where testing is limited or absent, a team of Rice University students came together to develop a low-cost screening tool that can detect abnormally high thyroid-stimulating hormone (TSH) levels indicative of dysfunction. The point-of-care, paper-based test developed ...

Statement Highlights: Health research that considers Asian Americans as a single race and ethnic group may result in over- or under-estimating the risk of Type 2 diabetes and cardiovascular disease among people of diverse Asian American subgroups, by geographic region of descent. Together, cardiovascular disease and Type 2 diabetes are the leading causes of death and disease in Asian American adults, however, rates vary widely among subgroups. For example, the latest data on the prevalence of Type 2 diabetes in Asian American adults, ages 45-84, reveals a range of Type ...

Humans inherited genetic material from Neanderthals that affects the shape of our noses, finds a new study led by UCL researchers. The new Communications Biology study finds that a particular gene, which leads to a taller nose (from top to bottom), may have been the product of natural selection as ancient humans adapted to colder climates after leaving Africa. Co-corresponding author Dr Kaustubh Adhikari (UCL Genetics, Evolution & Environment and The Open University) said: “In the last 15 years, since the Neanderthal genome ...

A recent clinical trial showed that the drug combination of cemiplimab plus platinum chemotherapy can prolong survival in patients with advanced lung cancer when compared with placebo plus platinum chemotherapy. Now an analysis published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society, indicates that cemiplimab plus platinum chemotherapy also affects quality of life compared to chemotherapy alone. The multinational phase 3 EMPOWER-Lung 3 trial had shown that the addition ...

Chicago (May 2, 2023) — Researchers created organoids from cancer cells to reduce the need for trial and error in identifying effective cancer treatments in one of many cancer studies scheduled for presentation this week at Digestive Disease Week® (DDW) 2023. Below are summaries of three studies scheduled for DDW, their embargo times and presentation times at the meeting in Chicago May 6-9. Personalized drug screening in patient-derived organoids of biliary tract cancer and its clinical application Chemotherapy is often the only treatment option for biliary tract cancer, which is usually found at a late stage, making it one of the most lethal ...

Those with post-viral fatigue after suffering from COVID-19 benefit from cognitive behavioural therapy, resulting in less fatigue and concentration problems. Lead researcher, Hans Knoop, Professor of Medical Psychology at Amsterdam UMC found that “After behavioural therapy, patients not only had less symptoms but also functioned better both physically and socially. Those improvements were still present even after six months.” Today, research from Amsterdam UMC, RadboudUMC and three other hospitals is published in Clinical Infectious Diseases. After a COVID-19 infection, a substantial number of patients report persisting symptoms. This is often known as long-COVID or ...

The biofilm-forming bacteria E. coli adheres firmly to hydrophobic and hydrophilic protein-adsorbing self-assembling monolayers (SAMs) and weakly to hydrophilic protein-resisting SAMs, uncovered a recent study by Tokyo Tech researchers. These findings on how surface chemistry can influence the adhesion of bacterial cells and, in turn, biofilm formation could open doors to bacteria-resistant surfaces and antibiofouling coatings for biomedical and industrial devices. Bacterial biofilms are like a double-edged sword. On one hand, they have proven valuable ...

Should healthy people be screened to help reduce their risk of fragility fractures? A new interactive online Fragility Fracture Decision Aid for shared decision-making can help clinicians and patients visualize their individual risk of fracture and the potential benefits and harms of preventive treatment. The decision aid is part of a new guideline https://www.cmaj.ca/lookup/doi/10.1503/cmaj.221219 from the Canadian Task Force on Preventive Health Care on screening to prevent fragility fractures. The guideline, ...

CHICAGO (May 7, 2023) — Children and adolescents face greater risk of inflammatory bowel disease (IBD) when exposed to antibiotics or a Western diet at early ages, or when their family has higher socioeconomic status, according to a study being presented today at Digestive Disease Week® (DDW) 2023. “Pediatric IBD cases are rising globally, and approximately 1 in 4 of all IBD cases are now diagnosed before age 21,” said Nisha Thacker, the study’s lead author and a gastrointestinal dietitian. A unique concern about pediatric IBD is the impact that the inflammation has on a child’s growth and the progression of puberty, ...

Women who have suffered domestic abuse may have a higher risk of developing atopic diseases including asthma, new research has found.   Published today in the Journal of Allergy and Clinical Immunology: In Practice, the research led by the University of Birmingham found that in analysis of patient records, there were a significantly larger percentage of women who had atopic diseases and had a history of being exposed to domestic abuse and violence compared to those who hadn’t.   Dr Joht Singh Chandan from the University of Birmingham and corresponding author of the study said:   “After adjusting for possible cofounders, ...

What: Twelve people with persistent neurological symptoms after SARS-CoV-2 infection were intensely studied at the National Institutes of Health (NIH) and were found to have differences in their immune cell profiles and autonomic dysfunction. These data inform future studies to help explain persistent neurological symptoms in Long COVID. The findings, published in Neurology: Neuroimmunology & Neuroinflammation, may lead to better diagnoses and new treatments. People with post-acute sequelae of COVID-19 (PASC), which includes Long COVID, have a wide range of symptoms, including fatigue, ...

BIRMINGHAM, Ala. – The immune system has a biological telecommunications system — small proteins known as interleukins that send signals among the leukocyte white blood cells to control their defense against infections or nascent cancer. Interleukin-6, or IL-6, is one of these key mediators of inflammation, and it can, as needed, provoke the immune system into attack against pathogens. However, imbalances of IL-6 — too much or too little — can cause disease, even in the absence of infection. Excess IL-6 is central to the pathogenesis of inflammatory reactions like ...

Tokyo, Japan – Scientists from Tokyo Metropolitan University have proposed a hypothesis for why insects are so rare in marine environments. They previously showed that insects evolved a unique chemical mechanism to harden their shells which uses molecular oxygen and an enzyme called multicopper oxidase-2 (MCO2). Now, they argue that this gives them a disadvantage in the sea, while it confers advantages that help them on land, placing MCO2 at the heart of insect eco-evolution. Insects are some of the most successful organisms on the planet. ...

CHAMPAIGN, Ill. — Newly developed “smart” coatings for surgical orthopedic implants can monitor strain on the devices to provide early warning of implant failures while killing infection-causing bacteria, University of Illinois Urbana-Champaign researchers report. The coatings integrate flexible sensors with a nanostructured antibacterial surface inspired by the wings of dragonflies and cicadas. In a new study in the journal Science Advances, a multidisciplinary team of researchers found the coatings prevented infection in live mice and mapped strain in commercial implants applied to sheep spines to warn of various implant or healing failures.  “This ...

SAN CARLOS, California – A new publication in the May issue of Nature Aging by researchers from Integrated Biosciences, a biotechnology company combining synthetic biology and machine learning to target aging, demonstrates the power of artificial intelligence (AI) to discover novel senolytic compounds, a class of small molecules under intense study for their ability to suppress age-related processes such as fibrosis, inflammation and cancer. The paper, “Discovering small-molecule senolytics with deep neural networks,” authored in collaboration with ...