Below please find a summary for a new article that will be published today in Annals of Internal Medicine. The summary is not intended to substitute for the full article as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization they represent. FDA advisory panelist outlines numerous issues with aducanumab's accelerated approval for Alzheimer's disease Abstract: https://www.acpjournals.org/doi/10.7326/M21-2603 URL ...

WEST LAFAYETTE, Ind. – Surgeons may soon be able to localize critical regions in tissues and organs during a surgical operation thanks to a new, patent-pending Purdue University biosensor that can be printed in 3D using an automated printing system. Chi Hwan Lee created the biosensor, which allows for simultaneous recording and imaging of tissues and organs during a surgical operation. Lee is the Leslie A. Geddes Assistant Professor of Biomedical Engineering in the Weldon School of Biomedical Engineering and assistant professor of mechanical engineering. Lee also has a courtesy appointment in materials engineering. "Simultaneous recording and imaging could be useful during heart surgery in localizing critical regions and guiding ...

In the realm of social media, anti-science views about COVID-19 align so closely with political ideology -- especially among conservatives -- that its predictability offers a strategy to help protect public health, a new USC study shows. Resistance to science, including the efficacy of masks and vaccines, poses a challenge to conquering the coronavirus crisis. The goal of achieving herd immunity won't happen until society achieves consensus about science-based solutions. The USC study's machine-learning assisted analysis of social media communications offers policymakers and public health officials new tools to anticipate shifts in attitudes ...

A rare parasitic infection imported from Europe continues to take root in Alberta, Canada. The province is now the North American hotspot for human alveolar echinococcosis (AE), which takes the form of a growth in the liver, causing serious and potentially deadly health complications. A END ...

Only 2% of vehicles are electrified to date, but that is projected to reach 30% in 2030. A key toward improving the commercialization of electric vehicles (EVs) is to heighten their gravimetric energy density - measured in watt hours per kilogram - using safer, easily recyclable materials that are abundant. Lithium-metal in anodes are considered the "holy grail" for improving energy density in EV batteries compared to incumbent options like graphite at 240 Wh/kg in the race to reach more competitive energy density at 500 Wh/kg. Yan Yao, Cullen Professor of electrical ...

MIAMI--In a new analysis on managed retreat--the climate adaptation response of moving people and property out of harm's way--researchers explore what it would take for managed retreat to be supportive of people and their priorities. A key starting point is considering retreat alongside other responses like coastal armoring and not just as an option of last resort. In a new paper in the journal Science, University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science researcher Katharine Mach argues that managed retreat should be viewed as a proactive option that can support communities and livelihoods in the face of climate change. "Managed retreat ...

The surface of a material often has properties that are very different from the properties within the material. For example, a non-conducting crystal, which actually exhibits no magnetism, can show magnetisation restricted to its surface because of the way the atoms are arranged there. These distinct properties at interfaces and surfaces of materials often play a key role in the development of new functional components such as optoelectronic chips or sensors and are therefore subject to extensive research. An international research team from the University of Göttingen, the Max Planck Institute for Biophysical Chemistry Göttingen and the National Research Council Canada has now succeeded in investigating the surfaces of transparent crystals using ...

Understanding cellular metabolism - how a cell uses energy- could be key to treating a wide array of diseases, including vascular diseases and cancer. While many techniques can measure these processes among tens of thousands of cells, researchers have been unable to measure them at the single-cell level. Researchers at the University of Chicago's Pritzker School of Molecular Engineering and Biological Sciences Division have developed a combined imaging and machine learning technique that can, for the first time, measure a metabolic process at both the cellular and sub-cellular levels. Using a genetically encoded biosensor paired with artificial intelligence, ...

PHILADELPHIA - Sour taste does not have the nearly universal appeal that sweet taste does. Slightly sour foods or drinks such as yogurt and lemon juice are yummy to many, but such highly sour foods as spoiled milk are yucky, even dangerous. Like humans, many other animals, including insects, prefer slightly acidic over very acidic foods. Evolutionary biologists surmise that the need for sour detection to be finely tuned is a two-sided coin: slightly acidic foods can enhance digestion and stimulate saliva production; relative sour-to-sweet taste can signal optimal ripeness of fruit; and extremely sour food, as with bitter taste, is a warning to what not to ingest. However, despite this usefulness, how do animals discern different concentrations ...

The brain presents different states depending on the communication between billions of neurons, and this network is the basis of all our perceptions, memories, and behaviours. It is often considered a "black box", with difficult access for clinicians and researchers, as few limited tools are available to perform accurate and spaciotemporal studies on brain neuronal behaviour. Now, researchers from the Institute for Bioengineering of Catalonia (IBEC) in collaboration with August Pi i Sunyer Biomedical Research Institute (IDIBAPS) and have added some light to the subject: they succeeded for the first time in controlling neuronal activity in the brain using a molecule responsive to light. The study included participants ...

MADISON - In early January 2021, travelers returning to Tokyo, Japan, from Amazonas, Brazil, were screened for COVID-19 at the airport. A few days later, the National Institute of Infectious Disease of Japan announced that the travelers had returned with a new variant of the SARS-CoV-2 virus. That variant, known as gamma, or P.1, led to a deadly surge in COVID-19 cases in Brazil this spring, and has now spread across the world. More than 200 cases have been detected in Wisconsin. Whether current vaccines are as effective against the gamma variant remains unknown. In a new study using variant virus recovered from one of the original travelers, ...

University of Delaware disaster researcher A.R. Siders said it's time to put all the options on the table when it comes to discussing climate change adaptation. Managed retreat -- the purposeful movement of people, buildings and other assets from areas vulnerable to hazards -- has often been considered a last resort. But Siders said it can be a powerful tool for expanding the range of possible solutions to cope with rising sea levels, flooding and other climate change effects when used proactively or in combination with other measures. Siders, a core faculty member in UD's Disaster Research Center, and Katharine J. Mach, associate professor at the University ...

KIYATEC, Inc. announced today the publication of new peer-reviewed data that establishes clinically meaningful prediction of patient-specific responses to standard of care therapy, prior to treatment, in newly diagnosed glioblastoma (GBM) and other high-grade glioma (HGG) patients. The results, the interim data analysis of the company's 3D-PREDICT clinical study, were published June 16, 2021 in Neuro-Oncology Advances, an open access clinical journal. A goal of the study, which continues to enroll, was for the test's prospective, patient-specific response prediction to achieve statistical significance for ...

Researchers from Bentley University, in partnership with Waltham Council on Aging in Massachusetts, and as part of a study funded by the National Science Foundation, have been exploring how the elderly use smart speakers at home. Waltham, a satellite city about eight miles west of Cambridge has a population of about 60,000, with about one in six being an elderly citizen. The purpose of the study was to understand how the elderly use the smart speaker technology at home. A smart speaker is a hardware device that is always-on. When a wake-word triggers the software contained in the device, the smart speaker listens to the command to provide a response or carry out the command (accessing resources ...

When Ana K. Spalding, a Research Associate at the Smithsonian Tropical Research Institute (STRI) and Assistant Professor of Marine and Coastal Policy at Oregon State University (OSU) talks about mentorship in academia, she describes it as meaningful relationship. It goes beyond conversations about research and publications, and into shared experiences. This is just one approach--proposed by Spalding and 23 other women scientists from around the world, in a new article published in PLOS Biology--that calls for a shift in the value system of science to emphasize a more equal, diverse and inclusive academic culture. The authors came together after reading a ...

Superconductors are something like a miracle in the modern world. Their unique property of zero resistance can revolutionize power transmission and transport (e.g., Maglev train). However, most of the conventional superconductors require cooling down to extremely low temperatures that can only be achieved with liquid helium, a rather expensive coolant. Material scientists are now investigating "high-temperature superconductors" (HTSs) that can be cooled to a superconducting state by using the significantly cheaper liquid nitrogen (which has a remarkably higher temperature than liquid helium). ...

TROY, N.Y. -- Optoelectronic materials that are capable of converting the energy of light into electricity, and electricity into light, have promising applications as light-emitting, energy-harvesting, and sensing technologies. However, devices made of these materials are often plagued by inefficiency, losing significant useful energy as heat. To break the current limits of efficiency, new principles of light-electricity conversion are needed. For instance, many materials that exhibit efficient optoelectronic properties are constrained by inversion symmetry, a physical property that limits engineers' control of electrons in the material and their options for designing novel or efficient devices. In research published today in Nature ...

With sorghum poised to become an important crop grown by Pennsylvania farmers, Penn State researchers, in a new study, tested more than 150 germplasm lines of the plant for resistance to a fungus likely to hamper its production. Sorghum, a close relative to corn, is valuable for yielding human food, animal feed and biofuels. Perhaps its most notable attribute is that the grain it produces is gluten free. Drought resistant and needing a smaller amount of nutrients than corn to thrive, sorghum seems to be a crop that would do well in the Keystone State's ...

The article 'The RNA Atlas expands the catalog of human non-coding RNAs', published today in Nature Biotechnology, is the result of more than five years of hard work to further unravel the complexity of the human transcriptome. Never before such a comprehensive effort was undertaken to characterize all RNA-molecules in human cells and tissues. RNAs in all shapes and sizes Our transcriptome is - analogous to our genome - the sum of all RNA molecules that are transcribed from the DNA strands that make up our genome. However, there's no 1-on-1 relationship with the latter. Firstly, each cell and tissue hasve a unique transcriptomes, with varying RNA production and compositions, including tissue-specific RNAs. Secondly, ...

Additive manufacturing offers an unprecedented level of design flexibility and expanded functionality, but the quality and process can drastically differ across production machines, according to Hui Yang, a professor of industrial engineering at Penn State. With applications in aerospace, health care and automotive industries with potential for mass customization, additive manufacturing needs quality management. To address this concern, Yang and a team of researchers from Penn State, University of Nebraska--Lincoln and the National Institute of Standards and Technology (NIST) proposed the design, development and implementation of a new data-driven methodology for quality control in additive manufacturing. They published their work in the Proceedings ...

CAMBRIDGE, MA--Geothermal energy systems have the potential to power the world and become the leading technology for reducing greenhouse gas emissions if we can drill down far enough into the Earth to access the conditions necessary for economic viability and release the heat beneath our feet. END ...

SAN ANTONIO (June 17, 2021) -- Convalescent plasma therapy was associated with better survival in blood cancer patients hospitalized with COVID-19, especially in sicker patients. The findings by the COVID-19 and Cancer Consortium (CCC19) are newly published in the peer-reviewed journal JAMA Oncology. The Mays Cancer Center, home to UT Health San Antonio MD Anderson, is part of the CCC19. The international consortium is composed of 124 medical centers and institutions in North and South America that conduct research to learn how COVID-19 affects cancer patients. Dimpy Shah, MD, PhD, is an epidemiologist and assistant professor of population health sciences at The University of Texas Health ...

Forest fires have crept higher up mountains over the past few decades, scorching areas previously too wet to burn, according to researchers from McGill University. As wildfires advance uphill, a staggering 11% of all Western U.S. forests are now at risk. "Climate change and drought conditions in the West are drying out high-elevation forests, making them particularly susceptible to blazes," says lead author Mohammad Reza Alizadeh, a PhD student at McGill University under the supervision of Professor Jan Adamowski. "This creates new dangers for mountain communities, with impacts on downstream water supplies and the plants and wildlife that call these forests home." Climate warming has diminished 'flammability barrier' In ...

If the genome is the recipe of life, base pairs are the individual ingredients listed. These chemical structures form DNA, and every living organism on Earth has just four. The specific arrangements of these four base pairs -- A, T, C, G -- make us who and what we are. So it was a big surprise when Scripps Research scientists revealed in 2014 that they could introduce two new, unnatural base pairs (they called them X and Y for short) into the genetic code of living bacteria in the lab. It was like two never-seen-before ingredients tossed into the recipe, hypothetically expanding the variety of dishes a cell can whip up. Researchers immediately saw the potential applications: With more control and selection, they ...

In a bid to find or refine laboratory research models for cancer that better compare with what happens in living people, Johns Hopkins Medicine scientists report they have developed a new computer-based technique showing that human cancer cells grown in culture dishes are the least genetically similar to their human sources. The finding, they say, should help focus more resources on cancer research models such as genetically engineered mice and 3D balls of human tissue known as "tumoroids" to better evaluate human cancer biology and treatments, and the genetic errors ...