Kanazawa, Japan - Interluekin-1α (IL-1α) is an important part of the immune response, but until now it has been unclear how this molecule is processed from its precursor, pro-IL-1α, and exits the cell during inflammasome activation. Now, researchers from Japan have found that gasdermin D, a protein that was already known to mediate pyroptosis, a form of regulated cell death, plays a crucial role in the maturation and release of IL-1α. In a study published in March in Cell Reports, researchers from Kanazawa University report that, when the ...

COVID-19 has changed the world in unimaginable ways. Some have even been positive, with new vaccines developed in record time. Even the extraordinary lockdowns, which have had severe effects on movement and commerce, have had beneficial effects on the environment and therefore, ironically, on health. Studies from all around the world, including China, Europe and India, have found major drops in the level of air pollution. However, to fully understand the impact of anthropogenic causes, it is important to separate them from natural events in the atmosphere like wind flow. To demonstrate this point, a new study by researchers at the Research Institute for Humanity and Nature, Japan, uses satellite data and mathematical modeling to explain just ...

Identifying the causes of human neurodegenerative diseases is a global research priority, warranting frequent reviews of the accumulating knowledge. In doing just that, biologists from the Plant Physiology Laboratory at the University of Guam and neuroscientists from the Experimental Medicine Program at The University of British Columbia have published an update on the reputed environmental toxins that have been suspected of being involved in mammal neurodegeneration. Their summary was published in April in the book Spectrums of Amyotrophic Lateral Sclerosis, which is available online ...

According to a recent Finnish study, higher levels of moderate and vigorous physical activity can curb arterial stiffening already in childhood. However, sedentary time or aerobic fitness were not linked to arterial health. The results, based on the ongoing Physical Activity and Nutrition in Children (PANIC) Study conducted at the University of Eastern Finland, were published in the Journal of Sports Sciences. The study was made in collaboration among researchers from the University of Jyväskylä, University of Eastern Finland, the Norwegian School of Sport sciences, and the University of Cambridge. Arterial stiffening predisposes to heart diseases, ...

Tokyo, Japan - In Japan, thousands of homes and businesses and hundreds of lives have been lost to typhoons. But now, researchers have revealed that a new flood forecasting system could provide earlier flood warnings, giving people more time to prepare or evacuate, and potentially saving lives. In a study published this month in Scientific Reports, researchers from The University of Tokyo Institute of Industrial Science have shown that a recently developed flood forecasting system provides much earlier advance warnings of extreme flooding events than current systems. ...

Germany is a hotspot for dragonflies and damselflies (Odonata) species in Europe, owing to the range of habitats and climates that it provides. While many recent and mostly small-scale studies suggest long-term declines of insect populations in different parts of Europe, studies of freshwater insects - including dragonflies and damselflies - suggest that some species have increased in occurrence. Researchers of iDiv, FSU and UFZ have now provided a nationwide analysis of the occurrence and distribution of dragonflies and damselflies in Germany between 1980 and 2016. For this, they analysed over 1 million occurrence records on 77 species from different regional ...

The population on Earth is increasingly growing and people are expected to live longer in the future. Thus, better and more reliable therapies to treat human diseases such as Alzheimer's and cardiovascular diseases are crucial. To cope with the challenge of ensuring healthy ageing, a group of international scientists investigated the potential of biosynthesising several polyamines and polyamines analogues with already known functionalities in treating and preventing age-related diseases. One of the most interesting molecules to study was spermidine, which is a natural product already present in people's blood and an inducer of autophagy that is an essential cellular process for clearing damaged proteins, e.g., misfolded proteins ...

URBANA, Ill. - For the most accurate accounting of a product's environmental impact, scientists look at the product's entire life cycle, from cradle to grave. It's a grand calculation known as a life cycle assessment (LCA), and greenhouse gas emissions are a key component. For corn ethanol, most greenhouse gas emissions can be mapped to the fuel's production, transportation, and combustion, but a large portion of the greenhouse gas calculation can be traced right back to the farm. Because of privacy concerns, however, scientists can't access individual farm management decisions such as fertilizer type and rate. Nitrogen fertilizer data are an important piece of the calculation because a portion ...

A decade-long study of the most common forearm fracture in older adults revealed that personalized medicine catering to a patient's individual needs and environment, not age or X-rays, should guide treatment options. Led by a Michigan Medicine physician, the research team examined treatment outcomes over two years for patients who fractured their distal radius, the larger of two bones in the forearm. They found no one-size-fits all method for treating the fracture, which more than 85,000 Medicare beneficiaries sustain annually. "Traditionally, surgeons look at these broken bones on X-rays, and they have to assess various ways of fixing it based off fracture anatomy and patient age," said Kevin Chung, M.D., study lead and Charles B. G. De ...

By combining satellite data and digital models, the researchers have shown that coastal overtopping, and consequently the risk of flooding, is set to further accelerate over the 21st century, by up to 50-fold under a high emission global warming scenario, especially in the tropics. This increase is principally caused by a combination of sea level rise and ocean waves. Low-lying coastal regions host nearly 10% of the world's population. In addition to ongoing erosion and rising sea levels, these areas and their unique ecosystems are facing destructive hazards, including episodic flooding due to overtopping of natural/artificial protection, as in the case of Hurricane Katrina, ...

Scientists from the Walter Reed Army Institute of Research and Naval Medical Research Center partnered with researchers at the University of Pennsylvania and Acuitas Therapeutics to develop a novel vaccine based on mRNA technology that protects against malaria in animal models, publishing their findings in npj Vaccines. In 2019, there were an estimated 229 million cases of malaria and 409,000 deaths globally, creating an extraordinary cost in terms of human morbidity, mortality, economic burden, and regional social stability. Worldwide, Plasmodium falciparum is the parasite species which ...

A staged alert system, designed by scientists and public health officials to guide local policies, helped one city prevent hospital surges and long lockdowns, according to new research published in the journal Nature Communications. In a new study led by The University of Texas at Austin COVID-19 Modeling Consortium in collaboration with Northwestern University, researchers describe the system that has guided COVID-19 policies in Austin, Texas, for more than a year, helping to safeguard the health care system and avoid costly measures. It tracks the number of new daily COVID-19 hospital admissions and triggers changes in guidance when admissions cross specific threshold values. While using this staged alert system, the Austin metropolitan area has sustained the ...

A hydrogel that forms a barrier to keep heart tissue from adhering to surrounding tissue after surgery was developed and successfully tested in rodents by a team of University of California San Diego researchers. The team of engineers, scientists and physicians also conducted a pilot study on porcine hearts, with promising results. They describe their work in the June 18, 2021 issue of Nature Communications. In rats, the hydrogel prevented the formation of adhesions altogether. In a small pilot study, porcine hearts treated with the hydrogel experienced less severe adhesions that were easier to remove. In addition, the hydrogel did not appear to cause chronic inflammation. Adhesions--organ tissue sticking to surrounding tissue--are a relatively ...

"Any problem can be solved with a little ingenuity". While they may not be the originators of this quote, recent work from researchers at Osaka Prefecture University into understanding the molecular orientation of hybrid thin-film material is a concrete example of its central message. "We wanted everyone to have access to this knowledge," states research lead Professor Masahide Takahashi of the OPU Graduate School of Engineering. Using laboratory-grade equipment with 3D printable optical setups, his research group has established an easy, versatile, yet highly sensitive approach ...

Sophia Antipolis - 18 June 2021: A small feasibility study has suggested that tai chi has the potential to reduce depression, anxiety and stress plus improve sleep in people who have had a stroke. The research is presented today at EuroHeartCare - ACNAP Congress 2021, an online scientific congress of the European Society of Cardiology (ESC).1 Depression occurs in approximately one-third of stroke survivors and is linked with greater disability and mortality rates.2,3 Individuals with post-stroke depression frequently also report anxiety, stress, and poor sleep.4-6 Tai chi focuses on releasing tension in the body, incorporating mindfulness and imagery into movement, increasing awareness and efficiency of breathing, and promoting overall relaxation of body and mind. "Mind-body ...

While postpartum depression in new mothers is well recognized and known to increase if the newborn requires intensive care, depression in new fathers has not received much attention. A large study, published in the journal Pediatrics, found that both parents with a baby in the NICU are at risk, with depression symptoms identified in 33 percent of mothers and 17 percent of fathers. Strikingly, the probability of reporting depression symptoms declined significantly for mothers but not for fathers after the baby came home. "Our findings point to the need for increased attention to the mental health of new fathers, during their baby's NICU stay and after discharge," said lead author Craig F. ...

An incredibly light new material that can reduce aircraft engine noise and improve passenger comfort has been developed at the University of Bath. The graphene oxide-polyvinyl alcohol aerogel weighs just 2.1kg per cubic metre, making it the lightest sound insulation ever manufactured. It could be used as insulation within aircraft engines to reduce noise by up to 16 decibels - reducing the 105-decibel roar of a jet engine taking off to a sound closer to that of a hair-dryer. The aerogel's meringue-like structure makes it extremely light, meaning it could act as an insulator within aircraft engine nacelles, with almost no increase ...

Just how do spiders walk straight up -- and even upside-down across -- so many different types of surfaces? Answering this question could open up new opportunities for creating powerful, yet reversible, bioinspired adhesives. Scientists have been working to better understand spider feet for the past several decades. Now, a new study in END ...

Researchers from Colorado State University, Amazon, and Dartmouth College published a new paper in the Journal of Marketing that examines the role of physical stores for selling "deep" products. The study, forthcoming in the Journal of Marketing, is titled "How Physical Stores Enhance Customer Value: The Importance of Product Inspection Depth" and is authored by Jonathan Zhang, Chunwei Chang, and Scott Neslin. While some traditional offline retailers are struggling and are closing stores (e.g., Macy's, Walgreens), online retailers are opening them (e.g., Amazon, Warby Parker). This conflicting trend ...

June 17, 2021, Nutley, NJ - During two months at the height of the first wave of COVID-19, Hackensack Meridian Health experts helped find the best way to triage and prioritize necessary surgeries across the health network. Their work allowed the system to keep up with crucial care - and it may help point the way forward in case of future emergencies. The health network experts implemented the medically necessary time sensitive (MeNTS) surgical scoring system developed by the University of Chicago to triage the case load across the health system, the largest in New Jersey. The results are published now in The American Journal of Surgery, and the lead author is a medical student at the Hackensack Meridian School of Medicine. "This is critical work and it shows how important teamwork ...

Over the past three decades, fundamental groundwork for building quantum computers has been pioneered at the University of Innsbruck, Austria. As part of the EU Flagship Quantum Technologies, researchers at the Department of Experimental Physics in Innsbruck have now built a demonstrator for a compact ion trap quantum computer. "Our quantum computing experiments usually fill 30- to 50-square-meter laboratories," says Thomas Monz of the University of Innsbruck. "We were now looking to fit the technologies developed here in Innsbruck into the smallest possible space while meeting standards commonly used in industry." The new device aims to show that quantum computers will soon be ready for use in data centers. "We were able to show that ...

The glaciers of Nanga Parbat - one of the highest mountains in the world - have been shrinking slightly but continually since the 1930s. This loss in surface area is evidenced by a long-term study conducted by researchers from the South Asia Institute of Heidelberg University. The geographers combined historical photographs, surveys, and topographical maps with current data, which allowed them to show glacial changes for this massif in the north-western Himalaya as far back as the mid-1800s. Detailed long-term glacier studies that extend the observation period to the time before the ubiquitous ...

How much do traditional practices contribute to the protection of local biodiversity? Why and how are sacred groves locally valued and protected, and how can this be promoted and harnessed for environmental protection? Working together with the University of Kurdistan, researchers of the University of Göttingen and the University of Kassel have examined the backgrounds of this form of local environmental protection in Baneh County, Iran. "Around the world, local communities are voluntarily protecting certain parts of their surroundings due to religious ...

Researchers at the University of Texas Medical Branch have observed that SARS-CoV-2, the virus that causes COVID-19, can infect the testes of infected hamsters. The findings, published in the journal Microorganisms, could help explain symptoms some men with COVID-19 have reported and have important implications for men's health. As the pandemic goes on, clinicians continue to report their findings that COVID-19 affects more than just the lungs. Some patients have reported testicular pain and some reports have shown decreases in testosterone, a key hormone produced in the ...

Below please find a summary for a new article that will be published today in Annals of Internal Medicine. The summary is not intended to substitute for the full article as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization they represent. FDA advisory panelist outlines numerous issues with aducanumab's accelerated approval for Alzheimer's disease Abstract: https://www.acpjournals.org/doi/10.7326/M21-2603 URL ...