Neurons result from a highly complex and unique series of cell divisions. For example, in fruit flies, the process starts with stem cells that divide into mother cells (progenitor cells), that then divide into precursor cells that eventually become neurons. A team of the University of Michigan (U-M), spearheaded by Nigel Michki, a graduate student, and Assistant Professor Dawen Cai in the departments of Biophysics (LS&A) and Cell and Developmental Biology at the Medical School, identified many genes that are important in fruit flies' neuron development, and that had never been described before in that context. Since many genes are conserved across species such as between fruit flies (Drosophila), mice, and humans, what is learnt in flies can also serve as a model to better ...

DALLAS - April 27, 2021 - Researchers with the Peter O'Donnell Jr. Brain Institute at UT Southwestern have identified a new protein implicated in cell death that provides a potential therapeutic target that could prevent or delay the progress of neurodegenerative diseases following a stroke. Scientists from the departments of pathology, neurology, biochemistry, and pharmacology at UTSW have identified and named AIF3, an alternate form of the apoptosis-inducing factor (AIF), a protein that is critical for maintaining normal mitochondrial function. Once released from mitochondria, AIF triggers processes that induce a type of programmed cell death. In a END ...

Isaac Newton may have met his match. For centuries, engineers have relied on physical laws -- developed by Newton and others -- to understand the stresses and strains on the materials they work with. But solving those equations can be a computational slog, especially for complex materials. MIT researchers have developed a technique to quickly determine certain properties of a material, like stress and strain, based on an image of the material showing its internal structure. The approach could one day eliminate the need for arduous physics-based calculations, instead relying on computer vision and machine learning to generate estimates in real time. The researchers say the advance could enable faster design prototyping and material ...

Des Plaines, IL - In a randomized, double-blind trial of patients with acute undifferentiated agitation in the emergency department, droperidol was more effective for sedation and was associated with fewer episodes of respiratory depression than lorazepam or either dose of ziprasidone. This is the conclusion of END ...

COLUMBIA, Mo. -- Having grown up poor in a rural village in Zimbabwe, Wilson Majee saw firsthand as a child the lack of educational opportunities that were easily accessible and how that impacted the youth in his village. Now an associate professor in the University of Missouri School of Health Professions, Majee researches the challenges facing disadvantaged, rural youth. He found in a recent study that young people who are disengaged from their communities are much more likely to participate in risky behaviors such as substance abuse, particularly in rural areas that lack educational opportunities. For the study, Majee spoke with youth in rural South Africa about the factors contributing to drug abuse for the NEET population, which stands ...

A promising new concept published by an interdisciplinary research team in "Proceedings of the National Academy of Sciences" (PNAS) paves the way for major advances in the field of magnetic resonance imaging (MRI). Their new technique could significantly simplify hyperpolarized MRI, which developed around 20 years ago for observing metabolic processes in the body. The proposal involves the hyperpolarization of the metabolic product fumarate using parahydrogen and the subsequent purification of the metabolite. "This technique would not only be simpler, but also much cheaper than the previous procedure," said leader of the project Dr. James Eills, a member of the research team of Professor Dmitry Budker at Johannes Gutenberg ...

African waters have been contributing to the global supply of fish for years, with three of the four most productive marine ecosystems in the world near the continent. African countries' Exclusive Economic Zones (EEZs) contributed over 6 million metric tons of fish to the world's food supply, supporting food security and livelihood in the continent, while generating $15 billion to the African gross domestic product in 2011. Every sovereign state has an EEZ, an area of ocean adjacent to their shores in which they have special rights regarding the exploration and use of marine resources. Industrial fleets from countries around the world have been increasingly fishing in African waters, but with climate change ...

The risk of developing atherosclerosis - a narrowing of the arteries as cholesterol plaque builds up, leading to obstruction of blood flow - is higher for people with autoimmune rheumatic diseases than for the general population. As a result, they are more likely to have heart attacks and other cardiovascular disorders.  The good news, according to a new study published in Rheumatology, is that regular exercise is a powerful weapon against vascular dysfunction in these patients. In the article, researchers working in Brazil and the United Kingdom report the results of a systematic review of the scientific literature on the subject. The review, which ...

SAN FRANCISCO, CA--April 27, 2021--In the 40-some years since the beginning of the HIV/AIDS epidemic, scientists have learned a lot about the virus, the disease, and ways to treat it. But one thing they still don't completely understand is which exact cells are most susceptible to HIV infection. Without this knowledge, it is difficult to envision targeting these cells to protect the millions of people who encounter the virus for the first time every year, or the infected people in which infection will likely rebound if they go off therapy. Scientists have known for a long time that the virus homes in on so-called memory ...

Researchers have spent more than three decades developing and studying miniature biosensors that can identify single molecules. In five to 10 years, when such devices may become a staple in doctors' offices, they could detect molecular markers for cancer and other diseases and assess the effectiveness of drug treatment to fight those illnesses. To help make that happen and to boost the accuracy and speed of these measurements, scientists must find ways to better understand how molecules interact with these sensors. Researchers from the National Institute of Standards and Technology (NIST) and Virginia Commonwealth University (VCU) have now developed a new approach. ...

Skoltech researchers used Google Trends' Big Data ensuing from human interactions with the Internet to develop a new methodology - a tool and a data source - for analyzing and researching the growth of startups. A paper reporting these important findings was published in technology management journal, Technological Forecasting and Social Change. Startups and high-growth technology-based ventures they transform into are regarded as the key drivers of economic development, innovation, and job creation on the national and global level. However, despite their crucial importance for the economy and high interest from researchers and policy-makers, startups display growth patterns that are difficult to analyze. These fragile, early-stage private ...

New research from the University of Surrey has shown that silicon could be one of the most powerful materials for photonic informational manipulation - opening up new possibilities for the production of lasers and displays. While computer chips' extraordinary success has confirmed silicon as the prime material for electronic information control, silicon has a reputation as a poor choice for photonics; there are no commercially available silicon light-emitting diodes, lasers or displays. Now, in a paper published by Light: Science and Applications journal, a Surrey-led international team of scientists has ...

A pregnant woman's exposure to tobacco smoke and pollution from road traffic can influence the development of behavioural outcomes in early childhood. This is the conclusion of a recent study led by a team from the Barcelona Institute for Global Health (ISGlobal), a centre supported by the "la Caixa" Foundation. The study, published in Environmental International, is the first to investigate the impact of the exposome--i.e. the set of all environmental exposures, both chemical and non-chemical, during the prenatal and postnatal stages--on child behaviour. Previous research had assessed the impact of environmental ...

Irvine, Calif., April 27, 2021 -- University of California, Irvine biologists have developed a new genetically engineered mouse model that, unlike its predecessors, is based on the most common form of Alzheimer's disease. The advance holds promise for making new strides against the neurodegenerative disease as cases continue to soar. Their study appears in the journal, Nature Communications. Link to study: https://www.nature.com/articles/s41467-021-22624-z While over 170 Alzheimer's mouse models have been in use since the 1990s, those models mimic early-onset AD, also known as "familial AD," which accounts for less than 5 percent of total AD cases. Until ...

Just as humans receive the first members of their microbiomes from their mothers, seeds may harbor some of the first microorganisms plants encounter. While these initial microbes could become influential players in the plants' microbiomes, the microbial communities that colonize seeds have not received as much attention as root, shoot, or soil microbiomes. To understand how seed microbiomes are assembled, a group of researchers at the University of Saskatchewan (Canada) examined the relative effects of growth environment and plant genotype on the seed microbiome of canola, a globally important crop grown in diverse environments. In their recently published paper in Phytobiomes Journal, ...

It's easy to think that more nutrients -- the stuff life needs to grow and thrive -- would foster more vibrant ecosystems. Yet nutrient pollution has in fact wrought havoc on marine systems, contributing to harmful algae blooms, worse water quality and oxygen-poor dead zones. A team of researchers from UC Santa Barbara has proposed a novel strategy for reducing large amounts of nutrients -- specifically nitrogen and phosphorous -- after they have already been released into the environment. In a study appearing in the journal Marine Policy, the authors contend that seaweed's incredible ability to draw nutrients from the water could provide an efficient and cost-effective solution. Looking at the U.S. Gulf of Mexico, the team identified over 63,000 square kilometers suitable for seaweed aquaculture. "A ...

The discovery of a novel enzyme that releases a valuable chemical from agricultural waste could provide an important breakthrough in the upscaling of renewable fuels and chemicals, a new study shows. Researchers - led by the University of York - have discovered an enzyme in a fungus which can act as a catalyst to bring about a biochemical reaction that breaks down lignocellulose Lignocellulose is found in forestry and agricultural waste like wheat straw, which was used in this research. It has long been considered by scientists that this dry matter could ...

A team of engineering researchers at the Georgia Institute of Technology hopes to uncover new ways to diagnose and treat brain ailments, from tumors and stroke to Parkinson's disease, leveraging vibrations and ultrasound waves. The five-year, $2 million National Science Foundation (NSF) project initiated in 2019 already has resulted in several published journal articles that offer promising new methods to focus ultrasound waves through the skull, which could lead to broader use of ultrasound imaging -- considered safer and less expensive than magnetic resonance imaging (MRI) technology. Specifically, the team is researching a broad range of frequencies, spanning low frequency vibrations (audio frequency range) and moderate frequency guided waves (100 kHz to 1 MHz) to high ...

DALLAS (SMU) - An international team of paleontologists has identified a new genus and species of hadrosaur or duck-billed dinosaur, Yamatosaurus izanagii, on one of Japan's southern islands. The fossilized discovery yields new information about hadrosaur migration, suggesting that the herbivors migrated from Asia to North America instead of vice versa. The discovery also illustrates an evolutionary step as the giant creatures evolved from walking upright to walking on all fours. Most of all, the discovery provides new information and asks new questions about dinosaurs in Japan. The research, "A New Basal Hadrosaurid (Dinosauria: Ornithischia) From the latest Cretaceous Kita-ama Formation in Japan implies the origin of Hadrosaurids," ...

Researchers at the Pritzker School of Molecular Engineering (PME) at the University of Chicago have designed a completely novel potential treatment for COVID-19: nanoparticles that capture SARS-CoV-2 viruses within the body and then use the body's own immune system to destroy it. These "Nanotraps" attract the virus by mimicking the target cells the virus infects. When the virus binds to the Nanotraps, the traps then sequester the virus from other cells and target it for destruction by the immune system. In theory, these Nanotraps could also be used on variants of the virus, leading to a potential new way to inhibit the virus going forward. Though the therapy remains in early stages of testing, the researchers envision it could be administered ...

In a paper published in the journal Scientific Reports, researchers from Surrey investigated whether the daily consumption of a prebiotic food supplement could improve overall wellbeing in a group of 18 to 25 year-olds. The study found that those who received a daily dose of prebiotics improved mental wellbeing by reducing anxiety levels and had better gut health than the control group. Researchers studied a group of 64 healthy female participants with no current or previous clinical diagnoses of anxiety. Participants received either a daily dose of the prebiotic galacto-oligosaccharides (GOS) or a placebo for 28 days. All those involved in the trial completed surveys about their health experiences, including mood, anxiety and sleep quality and provided a stool sample ...

New studies from the Center for Advanced Bioenergy and Bioproducts Innovation (CABBI) shed more light on the economic and environmental costs of mandates in the Renewable Fuels Standard (RFS), a federal program to expand the nation's biofuels sector. Researchers said the studies indicate the need to adopt more targeted policies that value the environmental and ecosystem benefits of perennial bioenergy crops over cheaper options -- and provide financial incentives for farmers to grow them. The RFS was issued in 2005 and updated through the Energy Independence and Security Act of 2007 ...

MEMPHIS, Tenn. - For the first time in published literature, Le Bonheur Children's Hospital and University of Tennessee Health Science Center (UTHSC) researchers showed that a variety of white blood cells known as eosinophils modify the respiratory barrier during influenza A (IAV) infection, according to a recent paper in the journal Cells. This research could have implications in understanding SARS-CoV-2 (COVID-19) infection in asthmatic patients. The Le Bonheur/UTHSC study found that eosinophils immunomodulate airway epithelial cells during IAV infection, helping to neutralize the virus and ...

The legend of the "kraken" has captivated humans for millennia. Stories of deep-sea squid dragging sailors and even entire ships to their doom can be found in everything from ancient Greek mythology to modern-day movie blockbusters. It is therefore ironic that the species that inspired these stories, the giant squid Architeuthis dux, is camera-shy. In fact, filming this species in the wild has proven an insurmountable challenge for countless scientists, explorers, and filmmakers. To date, only one scientist, Dr. Edith Widder of the Ocean Research & Conservation Association, has repeatedly caught a live giant squid on camera. In a new study, Dr. Widder and her colleagues have finally revealed the secrets behind their success. This study, which is free to access, also ...

An Academic Analytics Research Center (AARC) study published in the journal Scientometrics found that senior faculty (scholars who earned their terminal degree 30 or more years ago) research publication activity exceeded expectations based on age cohort population for book chapters and book publications, and senior scholars largely kept pace in terms of journal article publications. "Across all disciplines, senior faculty may be uniquely positioned to invest their time in a longer-term publication effort, shifting their research focus to the review and synthesis of ideas through the publication of books and chapters," said AARC Senior Researcher and Co-Author of the study, Bill Savage, Ph.D. The study explored the publishing activity of 167,299 unique faculty members at American ...