Murat Torgutalp and colleagues investigated the longitudinal association between radiographic sacroiliitis progression and treatment with TNFi in patients with early axSpA in a long-term inception cohort. The results were shared in an oral session at the 2021 EULAR congress. Based on the availability of at least two sets of sacroiliac joint (SIJ radiographs), 166 people with non-radiographic axialspondyloarthritis (nr-axSpA), and135 with radiographic (r-axSpA), from the German Spondyloarthritis Inception Cohort (GESPIC) were included in the analysis. Two trained and calibrated ...

RA is an inflammatory autoimmune disease that causes pain, swelling and stiffness in the joints. It can also cause fatigue, and the underlying inflammation may affect other body systems. Dementia is a symptom of damage to the brain, which can be caused by a number of different diseases - for example, Alzeimer's. Symptoms include memory loss, difficulty concentrating, confusion, and mood changes. It is not known what causes all types of dementia, but it is it thought that some of the damage could be caused by other underlying diseases. Heart failure happens when ...

Uveitis occurs in up to 20% of children with JIA, although this varies depending on the specific type of JIA that each child has. Jens Klotsche and colleagues shared new data at the 2021 EULAR congress analysing the risk of uveitis events after discontinuing disease-modifying antirheumatic drugs (DMARD) in children with one of two JIA categories: extended oligoarthritis and rheumatoid factor (RF)-negative polyarthritis. The data for the analysis came from two ongoing biologic registers: the German Biologics in Pediatric Rheumatology (BiKeR) registry, and the Juvenile arthritis Methotrexate/Biologics long-term Observation (JuMBO) study. Adverse events and reports about uveitis events during treatment and after discontinuation of DMARDs were collected. ...

Fruit flies have found at least two solutions to the problem of sorting their sex chromosomes: a matter of life and death. Sex determination in animals often depends on the unequal segregation of specific chromosomes. Female cells generally possess two X chromosomes, while male cells contain one X and one Y chromosome. The latter, which is inherited from the male parent, has far fewer genes than the X. In the fruit fly Drosophila, male cells make up for the fact that they have only one X chromosome by boosting the level of expression of all of its genes by a factor of 2. This phenomenon, which is known as dosage compensation, requires that the X chromosome in males be regulated differently from all the others. A team of molecular biologists at Ludwig-Maximilians-Universitaet (LMU) ...

Professor Konstantin Arutyunov of the HSE Tikhonov Moscow Institute of Electronics and Mathematics (MIEM HSE), together with Chinese researchers, has developed a graphene-based mechanical resonator, in which coherent emission of sound energy quanta, or phonons, has been induced. Such devices, called phonon lasers, have wide potential for application in information processing, as well as classical and quantum sensing of materials. The study is published in the journal Optics Express. Using an analogy with photons, quanta of the electromagnetic spectrum, there are also particles of sound energy, phonons. In fact, these are artificially introduced objects in physics - quasi-particles, which correspond to vibrations ...

Geologic activity on Earth appears to follow a 27.5-million-year cycle, giving the planet a "pulse," according to a new study published in the journal Geoscience Frontiers. "Many geologists believe that geological events are random over time. But our study provides statistical evidence for a common cycle, suggesting that these geologic events are correlated and not random," said Michael Rampino, a geologist and professor in New York University's Department of Biology, as well as the study's lead author. Over the past five decades, researchers have proposed cycles ...

A new paper in Scientific Reports led by researchers at William & Mary's Virginia Institute of Marine Science challenges increased salinity and seawater temperatures as the established explanation for a decades-long increase in the prevalence and deadliness of a major oyster disease in the coastal waters of the mid-Atlantic. Dr. Ryan Carnegie, the paper's lead author, says "We present an entirely new lens through which we can view our last 35 years of oyster history in the Chesapeake Bay region. We now know the great intensification of Dermo disease in the 1980s wasn't simply due to drought. It was more fundamentally due to the emergence of a new and highly virulent form of Perkinsus marinus, the parasite that causes Dermo." In an unusual twist, the team's evidence ...

The Axial Spondyloarthritis International Federation (ASIF) set out to coordinate a comprehensive evidence-based global review of the factors influencing the current diagnosis delay in axSpA, and to produce a definitive report that shines a light on these barriers, as well as providing a resource that can ultimately empower a range of international stakeholders to reduce this delay. At the 2021 EULAR congress, Wendy Gerhart and colleagues report the results of a full literature review and two virtual global forum events, involving patients and patient group ...

Ben Mulhearn and colleagues estimated the incidence of GCA seen during the COVID-19 pandemic and compared it to data from 2019, before the pandemic hit. The two distinct peaks of COVID-19 reflected by UK hospital admissions of COVID-19-positive patients allowed the authors to investigate the relationship in time between COVID-19 and GCA incidence. At the Royal National Hospital for Rheumatic Diseases in Bath, UK, there were 61 probable or definite GCA diagnoses made in 2020 compared to 28 in 2019- representing an excess of 33 cases in 2020, or an increase of 118%.Taking into account the fact that41% of the ...

Arani Vivekanantham and colleagues investigated the association between RA and the risk of COVID-19 diagnosis, hospitalization with COVID-19,and COVID-19-related death. This population-based cohort study including all individuals registered in the Information System for Research in Primary Care (SIDIAP)- which covers over80% of the population of Catalonia, Spain. This information was linked to region-wide SARS-CoV-2 testing, hospital and mortality records. Outpatient diagnoses of COVID-19, hospitalizations and deaths with COVID-19 were identified between 1st March and 6th May 2020. A total of 5,586,565 ...

MINNEAPOLIS/ST. PAUL (06/18/2021) -- Two recent studies led by researchers from the University of Minnesota Medical School add new evidence to the impact of how drug price increases affect U.S. patients and the overall cost of health care. The first study, published today in the JAMA Network Open, provides new data on how dramatic increases in anti-infective drug prices altered the overall cost of outpatient health care and decreased patient access to appropriate drug treatment. The study protocol was reviewed by the U.S. Centers for Disease Control and Prevention and scanned ...

As part of the MAINSTREAM project, Favalli and colleagues conducted a seroprevalence cross-sectional study between 4th May and 16th June 2020toestimate the prevalence of anti-SARS-CoV-2 antibodies in a large cohort of people with rheumatoid arthritis (RA) or spondyloarthritis (SpA) treated with biologic or targeted synthetic disease modifying anti rheumatic drugs (b/tsDMARDs) in a COVID-19 high-endemic area (Lombardy, Italy). Over this time, 300 people were tested for IgG, IgM and IgA antibodies against three viral antigens-nucleoprotein, spike protein, and the receptor-binding domain. These data were compared with those observed in the healthy population in the same period and region. Everyone taking part also completed a questionnaire to collect information about symptoms consistent ...

A research group including Professor MATSUDA Tetsuya of Tamagawa University's Brain Science Institute (Machida City, Tokyo; Director: SAKAGAMI Masamichi) and Assistant Professor ISHIHARA Toru from Kobe University's Graduate School of Human Development and Environment has illuminated the changes in the brain's neural network and cortex structure that underlie the positive association between childhood exercise and the maintenance and promotion of cognitive function in later life. These results were published in the academic journal NeuroImage on May 23, 2021. Main Points The researchers showed that people who are physically active during childhood (up to 12 years of age) have ...

That is the conclusion of new research published in the journal Geriatrics, which examined studies on several "telehealth" applications - smartphone apps used by patients and healthcare professionals to manage their condition. Researchers found that smartphone apps and telehealth initiatives have the potential to improve the effectiveness and efficiency of healthcare systems and patients' quality of life in relation to pain management The authors also emphasise that user involvement in development and construction of smartphone apps and telehealth initiatives is ...

Graphene consists of carbon atoms arranged in a chicken-wire like pattern. This one-atom-thick material is famous for its many extraordinary properties, such as extreme strength and remarkable capability to conduct electricity. Since its discovery, researchers have looked for ways to further tailor graphene through controlled manipulation of its atomic structure. However, until now, such modifications have been only confirmed locally, because of challenges in atomic-resolution imaging of large samples and analysis of large datasets. Now a team around Jani Kotakoski at the University of ...

TheMUC5Bgene codes for mucin - a protein that is normally found in mucus secretions, and which is part of the body'snaturaldefence against infection. The promoter variantcalledrs35705950is a common variantin theMUC5Bgene, with anallele frequency of 0.1 in the Finnish population.Overexpression ofMUC5Bin lungs influences the development of pulmonary fibrosis.The promoter variant rs35705950 inMUC5Bis the strongest known genetic risk factor for rheumatoid arthritis-associated interstitial lung disease (RA-ILD). However, there are no large-scale data on the impact oftheMUC5Bpromoter varianton the long-term incidence of RA-ILD. AnttiPalomäkiand colleagues usedFinnGen- a collection of epidemiological ...

New study by the ICTA-UAB shows that residents and visitors highlight the natural and biodiversity values of the Llobregat Delta, in Barcelona. A new study undertaken by researchers at the Institute of Environmental Science and Technology of the Universitat Autònoma de Barcelona (ICTA-UAB) supports protestors' concerns about damage to the Llobregat Delta in airport expansion plans. The research, carried out in 2019, found that the well-maintained and unique natural environment of the Llobregat Delta is important or very important to 100% residents and 98.8% of visitors who responded to the survey. The recently published article in Environmental Science ...

Pioneering technology developed by UCL (University College London) and Africa Health Research Institute (AHRI) researchers could transform the ability to accurately interpret HIV test results, particularly in low- and middle-income countries. Academics from the London Centre for Nanotechnology at UCL and AHRI used deep learning (artificial intelligence/AI) algorithms to improve health workers' ability to diagnose HIV using lateral flow tests in rural South Africa. Their findings, published today in Nature Medicine, involve the first and largest study ...

Footprints from at least six different species of dinosaur - the very last dinosaurs to walk on UK soil 110 million years ago - have been found in Kent, a new report has announced. The discovery of dinosaur footprints by a curator from Hastings Museum and Art Gallery and a scientist from the University of Portsmouth is the last record of dinosaurs in Britain. The footprints were discovered in the cliffs and on the foreshore in Folkestone, Kent, where stormy conditions affect the cliff and coastal waters, and are constantly revealing new fossils. Professor of Palaeobiology, David Martill, said: "This is ...

Biologists have identified a family of algae as a living missing link in the microscopic domain. Over the course of evolutionary time, marine microorganisms have undergone an immense range of diversification. This applies in particular to the group known as dinophytes. Also known as dinoflagellates, these unicellular algae can account for a significant fraction of the phytoplankton in the oceans, and their ecological and economic significance is correspondingly high. A team of researchers led by Ludwig-Maximilians-Universitaet (LMU) in Munich biologist Professor Marc Gottschling now reports the identification of a missing link between the two major phylogenetic groups of dinophytes, ...

One in six women and one in twelve men in Austria suffers from some form of IBS - therefore around one million people in all. Using currently available techniques, it is only possible to diagnose IBS by a process of elimination. Most people suffering from irritable bowel syndrome only go to their doctor when they have severe symptoms such as constipation, diarrhoea, abdominal pain, or a change in bowel motion. Researchers from the Department of Medicine III of the Medical University of Vienna and the University of Vienna have now shown that, in most cases, IBS is associated with bacterial biofilms ...

Due to sample size limitations, previous studies of DMARD use and COVID-19 outcomes have combined several different rheumatic diseases and medications, and investigated a single outcome- for example, the risk of hospitalization. EULAR has given financial support to a global project collecting information on SARS-CoV-2 infection in people with rheumatic diseases. The COVID-19 Global Rheumatology Alliance physician-reported registry launched in March 2020 to collect data on adults with rheumatic disease and confirmed or presumptive COVID-19. This analysis from Jeffrey Sparks, Zachary Wallace, and colleagues aimed to investigate the associations between baseline use of biologic or ...

Climate warming plays a larger role than plant genes in influencing the number and identity of fungal species on oak leaves, especially in autumn. Recently published in the journal New Phytologist, this research by ecologists sheds light on how warming and tree genes affect the dynamics of fungal communities across the season. "One of our major findings was that elevated temperature decreased the number of fungal species and changed their community composition, especially in the late season" says Maria Faticov, a researcher at the Department of Ecology, Environment and Plant Sciences (DEEP) at Stockholm University. Plants host thousands of microscopic organisms and leaves are no exception. ...

In this proof-of-concept study, Maja Skov Kragsnaes and colleagues evaluated efficacy and safety of FMT in people with psoriatic arthritis (PsA). PsA is an inflammatory arthritis that causes a person's joints to become stiff and painful. It is often found people with the skin condition psoriasis, and there is also a link between PsA and inflammatory bowel disease or gastrointestinal symptoms. This double-blind, parallel-group, sham-controlled, superiority trial randomly allocated31adults with active peripheral PsAd espite ongoing treatment with methotrexate to one gastroscopic-guided FMT procedure, or sham transplantation into the duodenum. The transplants (50 g faeces) came from one of four healthy, anonymous stool ...

Massive heavy-lift crane vessels, capable of hauling thousands of tons, navigate the rough waves and strong winds offshore to construct wind turbines and oil fields in the ocean. An international team of researchers has developed a new modeling system to help improve the control, and ultimately the safety, of such vessels. They published their approach in the April issue in IEEE/CAA Journal of Automatica Sinica. "Dynamic positioning allows the ship to stay fixed in a certain location, by acting on the thruster," said paper author Simone Baldi, professor in the School of Mathematics and School of Cyber Science and Engineering, Southeast University in China, and guest with the Delft Center for System and Control, Delft University of Technology in the Netherlands. This positioning operation ...