Combining immune-boosting drugs with radiation and surgery increased the survival and anticancer immune response in mouse models of mesothelioma in preclinical research by Princess Margaret Cancer Centre researchers. In a series of exciting experiments using mouse models of mesothelioma cancer, researchers found that combining two immunotherapy drugs can amplify the anti-tumour response first triggered by a short course of radiation, conferring long-lasting control and resistance against cancer. These response rates are improved further by adding surgery to remove the remaining tumour. Better treatments are urgently needed for mesothelioma patients, as ...

INDIANAPOLIS, IN AND BERKELEY, CA (April 14, 2021) - Researchers from Indiana University School of Medicine and OMGYES have conducted the first-ever, large-scale, nationally representative study focused on women's techniques for increasing their own pleasure from vaginal penetration. The findings, published today in the scientific journal, PLOS ONE, identify and name four distinct methods: Angling, Pairing, Rocking and Shallowing. The research was led by Dr. Devon J. Hensel, Associate Professor of Research at Indiana University School of Medicine, and Dr. Christiana von Hippel, an OMGYES Research Scientist. "For the first time, we have ...

Berkeley -- Engineers at the University of California, Berkeley, have created a tiny wireless implant that can provide real-time measurements of tissue oxygen levels deep underneath the skin. The device, which is smaller than the average ladybug and powered by ultrasound waves, could help doctors monitor the health of transplanted organs or tissue and provide an early warning of potential transplant failure. The technology, created in collaboration with physicians at the University of California, San Francisco, also paves the way for the creation of a variety of miniaturized sensors that could track other key biochemical markers in the body, ...

New research published in Science Advances provides a template for how to develop directly-acting antivirals with novel modes of action, that would combat COVID-19 by suppressing the SARS-CoV-2 viral infection. The study focused on the macrodomain part of the Nsp3 gene product that SARS-CoV-2 uses to suppress the host cell's natural antiviral response. This part of the virus's machinery, also known as Mac1, is essential for its reproduction: previous studies have shown that viruses that lack it cannot replicate in human cells, suggesting that blocking ...

"Family clustering is a confirmed phenomenon associated with Covid-19, and harrowing stories of this disease ravaging families continue to be reported," a new article explains in the March-April issue of the Hastings Center Report. In one extreme example, 28 extended family members in California reportedly tested positive for Covid-19. Two of the family members who quarantined together required hospitalization, and one of them died from the infection. In family clustering cases, multiple loved ones may suffer from the symptoms of Covid-19 and be hospitalized, in quarantine, or recovering; and family ...

The slurred speech, poor coordination, and sedative effects of drinking too much alcohol may actually be caused by the breakdown of alcohol products produced in the brain, not in the liver as scientists currently think. That is the finding of a new study led by researchers from the University of Maryland School of Medicine (UMSOM) and the National Institute on Alcohol Abuse and Alcoholism. It was published recently in the journal Nature Metabolism and provides new insights into how alcohol may affect the brain and the potential for new treatments to treat alcohol misuse. It is well known that the liver is the major organ ...

One of the technical challenges the current data revolution faces is finding an efficient way to route the data. This task is usually performed by electronic switches, while the data itself is transferred using light confined in optical waveguides. For this reason, conversion from an optical to an electronic signal and back-conversion are required, which costs energy and limits the amount of transferable information. These drawbacks are avoidable with a full optical switch operation. One of the most promising approaches is based on microelectromechanical systems (MEMS), thanks ...

Most people by now have memorized the public health guidelines meant to help minimize transmission of COVID-19: wash your hands, wear a mask, keep six feet apart from others. That part is easy. What some may not realize is that upholding these guidelines in certain urban areas can present new challenges. For example, how are you supposed to stay six feet apart from other people when the standard width of a sidewalk is only four feet? What do you do when you want to cross an intersection that requires pressing a button to activate the pedestrian signal, but you are avoiding touching any surfaces? The COVID-19 pandemic has drastically altered the way individuals interact with other people and their environment, but some public health guidelines meant to protect ...

To better understand how RNA in bacteria gives rise to protein--and along the way, target these processes in the design of new antibiotics--researchers are turning their attention to the unique way this process happens in bacteria. In eukaryotic cells, transcription (the process by which information in a DNA strand is copied into messenger RNA) and translation (the process by which a protein is synthesized by the ribosome from the mRNA) are two successive steps. In bacteria, they occur simultaneously: As the RNA is being synthesized by RNA polymerase, the ribosome comes in to make the proteins. This synchronicity ...

"New evidence of the importance of the Roman/Byzantine Mons Smaragdus settlement within the emerald mining network" A new paper published in the END ...

In 2018, when Professor Laurie Santos introduced her course "Psychology and the Good Life," a class on the science of happiness, it became the most popular in the history of Yale, attracting more than 1,200 undergraduate enrollees that first semester. An online course based on those teachings became a global phenomenon. By latest count, 3.38 million people have enrolled to take the free Coursera.org course, called "The Science of Well Being." But the popularity of the course posed an interesting question. Does taking the course and participating in homework assignments -- which include nurturing social connections, compiling a gratitude list, and meditation -- really help improve a sense of well-being? The answer is yes, according to two new studies that measured the psychological impact ...

LOS ALAMOS, N.M., April 14, 2021--New research shows how to measure the super-short bursts of high-frequency light emitted from free electron lasers (FELs). By using the light-induced ionization itself to create a femtosecond optical shutter, the technique encodes the electric field of the FEL pulse in a visible light pulse so that it can be measured with a standard, slow, visible-light camera. "This work has the potential to lead to a new online diagnostic for FELs, where the exact pulse shape of each light pulse can be determined. That information can help both the end-user and the accelerator scientists," said Pamela Bowlan, Los Alamos National Laboratory's lead researcher on the project. The paper was published April 12, ...

New research has found that the most reliable indicators of willingness to be vaccinated against SARS-CoV-2, the virus that causes COVID-19, are rejection of conspiracy suspicions about COVID-19 and a positive attitude towards vaccines in general. The study by King's College London and the University of Bristol is published in the leading peer-reviewed journal Psychological Medicine. The researchers' analysis was based on a large representative sample survey carried out in November-December 2020. They looked at a range of factors that previous ...

Mathematicians and engineers at the University of Utah have teamed up to show how ultrasound waves can organize carbon particles in water into a sort of pattern that never repeats. The results, they say, could result in materials called "quasicrystals" with custom magnetic or electrical properties. The research is published in Physical Review Letters. "Quasicrystals are interesting to study because they have properties that crystals do not have," says Fernando Guevara Vasquez, associate professor of mathematics. "They have been shown to be stiffer than similar periodic or disordered materials. They can also conduct electricity, ...

UNIVERSITY PARK, Pa. -- Eating red meat may have a bad reputation for being bad for the heart, but new research found that lean beef may have a place in healthy diets, after all. In a randomized controlled study, researchers found that a Mediterranean diet combined with small portions of lean beef helped lower risk factors for developing heart disease, such as LDL cholesterol. Jennifer Fleming, assistant teaching professor of nutrition at Penn State, said the study suggests that healthy diets can include a wide variety of foods, such as red meat, and still be heart friendly. "When you create a healthy diet built on fruits, vegetables, and other plant-based foods, it leaves room for moderate amounts of other foods like lean beef," Fleming said. "There are still ...

Irvine, CA - April 14, 2021 - A new study, led by the University of California, Irvine (UCI), reveals how chronic inflammation promotes muscle fibrosis, which could inform the development of new therapies for patients suffering from Duchenne muscular dystrophy (DMD), a fatal muscle disease. Titled, "A Stromal Progenitor and ILC2 Niche Promotes Muscle Eosinophilia and Fibrosis-Associated Gene Expression," the study was published today in Cell Reports. Chronic inflammation is a major pathological process contributing to the progression and severity of several degenerative disorders, including Duchenne muscular dystrophy (DMD). Studies directed at establishing a causal link between muscular ...

What are scientists passionate about? What do they actually do, and why does it matter? Answering questions like these is often part of public outreach efforts that, through demystifying the world of science for non-scientists, can increase appreciation for science and boost support for important research initiatives. Outreach can also make the sciences attractive and accessible to a broader diversity of people, who, in turn, can bring new ideas and perspectives. "Science is having challenges in terms of getting the general public to support it and ...

BOSTON - The anti-diabetic drug phenformin may prompt stronger cancer-fighting activities than its sister compound metformin, a finding that could have major implications for current and future clinical trials investigating both agents for their anti-cancer potential, according to researchers at Massachusetts General Hospital (MGH). In a review article in Trends in Cancer, the team presented evidence that immunotherapies such as immune checkpoint inhibitors (which enable T cells to attack and kill cancer cells) in combination with phenformin may also be a promising way to repurpose this diabetic drug as an anti-cancer ...

One consequence of the coronavirus pandemic has been global restrictions on mobility. This, in turn, has had an effect on pollution levels in the atmosphere. Researchers from across the world are using this unique opportunity to take measurements, collect data, and publish studies. An international team led by Forschungszentrum Jülich's Institute of Climate and Energy Research - Troposphere has now published a comprehensive review providing an overview of results up to September 2020. The study also has its own dedicated website, where additional measurement data can be added to supplement and refine existing research results. At the same time, this collection of data allows scientifically substantiated predictions to be made about the ...

By combining the 'chassis' of an oil-producing microalgae with genes from a Cuphea plant, scientists from the Single-Cell Center, Qingdao Institute of BioEnergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences (CAS), can turn the algae into a microbial cell factory that can produce various oils with different properties. The study was published in Metabolic Engineering on April 3. Oils are composed of fatty acids, and fatty acids are composed in part of chains of carbon atoms. The length of these carbon chains can impact the physical properties of the fatty acid and thus the ...

While people may expect suicide rates to rise during a worldwide crisis such as the COVID-19 pandemic, a University of Michigan study suggests the onset of the pandemic and state of emergency executive orders likely did not increase suicide-related behavior in the early months of the outbreak. The report, led by U-M researchers Rachel Bergmans and Peter Larson, found that emergency room visits related to suicide attempt and self-harm decreased by 40% during the first eight months of Michigan's lockdown. Their results are published in the Journal of Epidemiology and Community Health. The study compared emergency room reports of suicide attempt and intentional self-harm at a hospital in Michigan's Washtenaw County during the first 8 months of the ...

The COVID-19 pandemic has cast a harsh light on the urgent need for quick and easy techniques to sanitize and disinfect everyday high-touch objects such as doorknobs, pens, pencils, and personal protective gear worn to keep infections from spreading. Now scientists at the U.S. Department of Energy's (DOE) Princeton Plasma Physics Laboratory and the New Jersey Institute of Technology (NJIT) have demonstrated the first flexible, hand-held, device based on low-temperature plasma -- a gas that consists of atoms, molecules, and free-floating electrons ...

Birds have been shaped by evolution in many ways that have made them distinct from their vertebrate cousins. Over millions of years of evolution, our feathered friends have taken to the skies, accompanied by unique changes to their skeleton, musculature, respiration, and even reproductive systems. Recent genomic analyses have identified another unique aspect of the avian lineage: streamlined genomes. Although bird genomes contain roughly the same number of protein-coding genes as other vertebrates, their genomes are smaller, containing less noncoding DNA. Scientists are still exploring the potential consequences of this genome reduction on bird biology. In a new ...

UPTON, NY--Scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory and the University of Illinois Urbana-Champaign (UIUC) have developed a new mathematical model for predicting how COVID-19 spreads. This model not only accounts for individuals' varying biological susceptibility to infection but also their levels of social activity, which naturally change over time. Using their model, the team showed that a temporary state of collective immunity--what they coined "transient collective immunity"--emerged during early, fast-paced stages of the epidemic. However, subsequent "waves," ...

An alloy is typically a metal that has a few per cent of at least one other element added. Some aluminium alloys have a seemingly strange property. "We've known that aluminium alloys can become stronger by being stored at room temperature - that's not new information," says Adrian Lervik, a physicist at the Norwegian University of Science and Technology (NTNU). The German metallurgist Alfred Wilm discovered this property way back in 1906. But why does it happen? So far the phenomenon has been poorly understood, but now Lervik and his colleagues from NTNU and SINTEF, the largest independent research institute in Scandinavia, have tackled that question. Lervik recently completed his doctorate at NTNU's Department of Physics. His work explains an important part of this ...