In the heart there are two different subtypes of beta-adrenergic receptors - beta1 and beta2 - which are activated by the stress hormones adrenaline and noradrenaline. They both trigger the strongest stimulation of the heart rate and pumping capacity that we know of. The two subtypes are highly similar biochemically, but differ substantially in terms of their functional and therapeutic relevance. Both receptor types can stimulate the heart in the short term, yet when the beta1 receptor is activated over a prolonged period of time, it has a range ...

DUBLIN, June 15, 2021 - Scientists have identified how and why some Covid-19 patients can develop life-threatening clots, which could lead to targeted therapies that prevent this from happening. The work, led by researchers from RCSI University of Medicine and Health Sciences, is published in the END ...

A new antibody testing study examining samples originally collected through the National Institutes of Health's All of Us Research Program found evidence of SARS-CoV-2 infections in five states earlier than had initially been reported. These findings were published in the journal Clinical Infectious Diseases. The results expand on findings from a Centers for Disease Control and Prevention study that suggested SARS-CoV-2, the virus that causes COVID-19, was present in the U.S. as far back as December 2019. In the All of Us study, researchers analyzed more than 24,000 stored blood samples contributed ...

Chemotherapy kills tumour cells by causing damage to them. One of the most effective ways of causing damage is to prevent the two DNA strands from separating so that the cellular machinery cannot read the instructions written in the genes. But sometimes, the cell manages to repair the damage and survive, evading the effect of chemotherapy. CNIO researchers have found out how the cell does that and plan to use this knowledge to enhance cancer treatments. The key lies in a peculiar protein called PrimPol, as explained in a publication in The EMBO Journal by the CNIO's DNA Replication Group, led by Juan Méndez. The DNA molecule harbours the genes that direct the life of the cell and, ...

The University of Ottawa has been awarded four new Canada Research Chairs (CRC) that will strengthen its expertise in artificial intelligence, health and law. The University is also proud to announce the renewal of two CRCs that will conduct leading-edge research in quantum communications and photonics. "The Canada Research Chairs Program provides invaluable support to our researchers as they forge their paths of discovery at a world-class level," said Sylvain Charbonneau, vice-president, research. "The results of this most recent competition will ...

A review of more than 9,000 U.S. patients with severe COVID-19 infection showed less than 1% contracted the illness again, with an average reinfection time of 3.5 months after an initial positive test. Those are the findings from a study conducted by researchers from the University of Missouri School of Medicine and MU Health Care. The researchers teamed up with the MU Institute for Data Science and Informatics and the Tiger Institute for Health Innovation to review data from 62 U.S. health care facilities. They found 63 of the 9,119 patients (0.7%) with severe COVID-19 infection contracted the virus a second time, with a mean reinfection period of 116 days. Of the 63 who were reinfected, two (3.2%) died. Patients categorized as ...

Plants evolve specialised defence chemicals through the combined effects of genes, geography, demography and environmental conditions, a study published today in eLife reports. The findings reveal a pattern in the types of defence chemicals plants produce across Europe, and describe some of the evolutionary processes that create them. As plants are immobile organisms, they rely on producing defence chemicals called specialised metabolites for survival. Specialised metabolites have extensive variation in their structure, such as the number of carbon molecules ...

June 15, 2021 - Canadian researchers have discovered that a bee thought to be one of the rarest in the world, as the only representative of its genus, is no more than an unusual specimen of a widespread species. Scientists with the Canadian Museum of Nature (CMN) and York University have reclassified the mystery bee, collected somewhere in Nevada in the 1870s, as Brachymelecta californica. They note that it's an aberrant individual of a species, the California digger-cuckoo bee, that is part of a group that includes five other species. All are cleptoparasitic bees, with females that lay eggs in the nests of digger bees. Brachymelecta californica itself is known to be widespread ...

A recent UCLA clinical trial has shown encouraging results in helping daily smokers who are also heavy drinkers quit smoking and cut down their alcohol intake. The study of 165 people tested two prescription drugs -- varenicline, for smoking addiction, and naltrexone, which is used to treat alcoholism. Studies have shown that varenicline, marketed under the brand name Chantix, may also be effective in reducing alcohol consumption. Participants, who ranged in age from 21 to 65, smoked at least five cigarettes a day, with male participants generally consuming more than 14 drinks a week and women more than seven per week. Over the 12-week study period, each participant received 2 milligrams of varenicline twice a day. Roughly half the group -- 83 participants -- also received a 50-milligram ...

Hippopotamus aren't the first thing that come to mind when considering epidemiology and disease ecology. And yet these amphibious megafauna offered UC Santa Barbara ecologist Keenan Stears(link is external) a window into the progression of an anthrax outbreak that struck Ruaha National Park, Tanzania, in the dry season of 2017. Through surveys and GPS monitoring, Stears and his colleagues, Wendy Turner, Doug McCauley and Melissa Schmitt, revealed that reduced dry-season flows in the Great Ruaha River indirectly spread the disease by affecting hippo movement. The results, which appear in the journal Ecosphere(link is external), present a unique perspective on disease ecology and illustrate how anthropogenic changes can impact wildlife and human health. The ...

A team of scientists at Nanyang Technological University, Singapore (NTU Singapore) has developed millimetre-sized robots that can be controlled using magnetic fields to perform highly manoeuvrable and dexterous manipulations. This could pave the way to possible future applications in biomedicine and manufacturing. The research team created the miniature robots by embedding magnetic microparticles into biocompatible polymers -- non-toxic materials that are harmless to humans. The robots are 'programmed' to execute their desired functionalities when magnetic fields are applied. The made-in-NTU robots improve on many existing small-scale robots by optimizing their ability to move ...

Is artificial intelligence the key to preventing relapse of severe mental illness? New AI software developed by researchers at Flinders University shows promise for enabling timely support ahead of relapse in patients with severe mental illness. The AI2 (Actionable Intime Insights) software, developed by a team of digital health researchers at Flinders University, has undergone an eight-month trial with psychiatric patients from the Inner North Community Health Service, located in Gawler, South Australia. The digital tool is tipped to revolutionise consumer-centric timely mental health treatment provision outside hospital, with researchers labelling it as readily available and scalable. In the trial of 304 ...

Exposure to the rhinovirus, the most frequent cause of the common cold, can protect against infection by the virus which causes COVID-19, Yale researchers have found. In a new study, the researchers found that the common respiratory virus jump-starts the activity of interferon-stimulated genes, early-response molecules in the immune system which can halt replication of the SARS-CoV-2 virus within airway tissues infected with the cold. Triggering these defenses early in the course of COVID-19 infection holds promise to prevent or treat the infection, ...

Researchers from The Australian National University (ANU) have developed new technology that allows people to see clearly in the dark, revolutionising night-vision. The first-of-its-kind thin film, described in a new article published in Advanced Photonics, is ultra-compact and one day could work on standard glasses. The researchers say the new prototype tech, based on nanoscale crystals, could be used for defence, as well as making it safer to drive at night and walking home after dark. The team also say the work of police and security guards - who regularly employ night vision - will be easier and safer, reducing chronic neck injuries from currently bulk night-vision devices. "We have made the invisible visible," lead researcher Dr Rocio Camacho Morales said. ...

Data collected for over two decades shows that rising Baltic Sea water temperature is one of the main factors in the increasingly earlier appearance and faster growth of Baltic herring larvae. Baltic herring (Clupea harengus membras) is commercially the most important fish species in Finland, and an important part of the Baltic marine ecosystem. Conditions during herring spawning may have cascading effects on the whole Baltic ecosystem. According to a recent research, both developmental stages in Baltic herring larvae, small and large, have shifted their timing to earlier dates. "This suggests that herring spawn earlier and larvae grow faster, by about 7.7 days per decade. Water ...

Rising numbers of liver cancer in Aboriginal and Torres Strait Islander communities has led experts at Flinders University to call for more programs, including mobile liver clinics and ultrasound in rural and remote Australia. The Australian study just published in international Lancet journal EClinicalMedicine reveals the survival difference was largely accounted for by factors other than Indigenous status - including rurality, comorbidity burden and lack of curative therapy. The study of liver cancer, or Hepatocellular carcinoma (HCC), included 229 Indigenous and 3587 non-Indigenous HCC cases in South Australia, Queensland and the ...

Osaka, Japan - On the outside, animals often appear bilaterally symmetrical with mirror-image left and right features. However, this balance is not always reflected internally, as several organs such as the lungs and intestines are left-right (LR) asymmetrical. Researchers at Osaka University, using an innovative technique for imaging movement of cell nuclei in living tissue, have determined the patterns of nuclear alignment responsible for LR-asymmetrical shaping of internal organs in the developing embryo. Embryogenesis involves complex genetic and molecular processes that transform a single-celled zygote into a complete, living individual with multiple functional axes, including the LR axis. A long-standing conundrum of Developmental ...

Researchers at the University of Helsinki and the Beatson Institute for Cancer Research in Glasgow have discovered how mutated cells promote their chances to form cancer. Typically, the accumulation of harmful cells is prevented by active competition between multiple stem cells in intestinal glands, called crypts. "The functioning of intestinal stem cells relies on growth factors, named Wnts, produced by the surrounding environment. Intestinal cancers typically originate from stem cells where mutations allow growth independent of these factors. When we removed a gene called Notum, which renders Wnts inactive, from mutated stem cells, the number of precancerous adenomas in the intestine was greatly reduced. We found that ...

Echoing through history by reviving fungal specimens originally preserved and described a flabbergasting quarter of a millenium ago by the "Father of Modern Taxonomy" Carl Linnaeus, this study highlights the untapped potential of museum collections in modern research programmes. The results have just been published in the renowned Cell Press journal iScience. The "desert coprinus" fungus Podaxis has fascinated scientists and explorers for centuries, still the genus has been subjected to relatively little research. These large mushrooms thrive in hostile and mostly species-free environments and while they occur seasonally ...

Hypertension is a widespread comorbidity of patients with obesity that greatly increases the risk of mortality and disability. In recent years, researchers have found that a high-calorie diet increases the density of blood vessels (hypervascularization) in the hypothalamus - an important "eating control" area in our brain. Researchers hypothesized that elevated hormone levels of leptin are associated with a higher risk of developing hypertension. However, the exact mechanisms that contribute to the condensed growth of blood vessels in the hypothalamus were unknown. New research conducted by Cristina García-Cáceres' research group at Helmholtz Zentrum ...

Solar activities, such as CME(Coronal Mass Ejection), cause geomagnetic storm that is a temporary disturbance of the Earth's magnetosphere. Geomagnetic storms can affect GPS positioning, radio communication, and power transmission system. Solar explosions also emit radiation, which can affect satellite failures, radiation exposure to aircraft crew, and space activity. Therefore, it is important to understand space weather phenomena and their impact on the Earth. Space weather research by continuous observation of cosmic rays on the ground is mainly conducted using observation data from neutron monitors and multi-directional muon detectors. Since the phenomenon of space weather is on a short-term, days-long scale, it is effective to investigate changes in the flow ...

Alkaline zinc-iron flow battery (AZIFB) is well suitable for stationary energy storage applications due to its advantages of high open-cell voltage, low cost, and environmental friendliness. However, it surfers from zinc dendrite/accumulation and relatively low operation current density. Recently, a research group led by Prof. LI Xianfeng from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Science (CAS) developed layered double hydroxide (LDH) membrane with high hydroxide conductivity and ion selectivity for alkaline-zinc iron flow battery. The ...

Light--and all waves--can bend around the corners of obstacles found along its path. Because of this phenomenon, called diffraction, it is impossible to focus light onto a spot that is smaller than half its wavelength. In other words, the highest resolution one can theoretically achieve using an optical microscope is approximately 250 nm, a barrier called the diffraction limit. Unfortunately, this resolution is not enough for observing fine cellular structures, such as those found in neurons. Over more than a century, microscopists were hamstrung by this classic barrier until the invention of super-resolution fluorescence microscopy. One particularly powerful ...

Researchers have identified two subgroups of adolescents who self-harm and have shown that it is possible to predict those individuals at greatest risk almost a decade before they begin self-harming. The team, based at the MRC Cognition and Brain Sciences Unit, University of Cambridge, found that while sleep problems and low self-esteem were common risk factors, there were two distinct profiles of young people who self-harm - one with emotional and behavioural difficulties and a second group without those difficulties, but with different risk factors. Between one in five and one in seven adolescents in England self-harms, for example by deliberately cutting themselves. While self-harm is a significant risk factor for subsequent suicide attempts, many do not intend suicide but face ...

A new study by Newcastle University shows that the risk of dolphins and porpoises being caught in small-scale (artisanal) fisheries is highest in low- and middle-income regions around the tropics and sub-tropics. Marine scientists assessed the risk posed by small-scale fisheries to all 72 species of toothed whales found throughout the world's oceans. They found that this risk was highest in the Central Indo-Pacific, Temperate Northern Pacific, Temperate South America and the Western Indo-Pacific. Publishing their findings in the journal Fish and Fisheries, the authors ...