(Philadelphia, PA) - The human heart works under high demand, constantly pumping oxygen-rich blood through the body. When faced with disease, however, fulfilling this demand can become increasingly difficult and harmful. In the case of chronic high blood pressure - a leading cardiovascular disease in the United States - the heart continuously overexerts, resulting in maladaptive growth and, ultimately, severe dysfunction of the heart muscle itself. Maladaptive growth of the heart, known as cardiac hypertrophy, is brought about in part by activation of G protein-coupled kinase ...

Researchers at Washington University in St. Louis reported the first observations of a new form of fluorine, the isotope 13F, described in the journal Physical Review Letters. They made their discovery as part of an experiment conducted at the National Superconducting Cyclotron Laboratory at Michigan State University (MSU). Fluorine is the most chemically reactive element on the periodic table. Only one isotope of fluorine occurs naturally, the stable isotope 19F. The new isotope, 13F, is four neutrons removed from the proton drip line, the boundary that delimits the zone beyond which atomic nuclei decay by the emission ...

CAMBRIDGE, MA -- More than just a sign of illness, mucus is a critical part of our body's defenses against disease. Every day, our bodies produce more than a liter of the slippery substance, covering a surface area of more than 400 square meters to trap and disarm microbial invaders. Mucus is made from mucins -- proteins that are decorated with sugar molecules. Many scientists are trying to create synthetic versions of mucins in hopes of replicating their beneficial traits. In a new study, researchers from MIT have now generated synthetic mucins with a polymer backbone that more accurately mimic the structure and function of naturally occurring mucins. The team also showed that these synthetic mucins could effectively neutralize the bacterial toxin that causes cholera. The ...

A study conducted at the University of Campinas (UNICAMP) in the state of São Paulo, Brazil, shows that compounds produced by gut microbiota (bacteria and other microorganisms) during fermentation of insoluble fiber from dietary plant matter do not affect the ability of the novel coronavirus SARS-CoV-2 to enter and replicate in cells lining the intestines. However, while in vitro treatment of cells with these molecules did not significantly influence local tissue infection, it reduced the expression of a gene that plays a key role in viral cell entry and a cytokine receptor that favors inflammation. An ...

HERSHEY, Pa. -- Stress, increased free time and feelings of boredom may have contributed to an increase in the number of cigarettes smoked per day during the early months of the COVID-19 pandemic by nearly a third of surveyed Pennsylvania smokers. Penn State College of Medicine researchers said understanding risk factors and developing new strategies for smoking cessation and harm reduction may help public health officials address concerning trends in tobacco use that may have developed as a result of the pandemic. Jessica Yingst, assistant professor of public health sciences and Penn State Cancer Institute researcher, said smokers who increased the number of cigarettes they smoked per day could be at greater risk of dependence and have a more difficult ...

March 30, 2021 - As cancer survival rates improve, more people are living with the aftereffects of cancer treatment. For some patients, these issues include chronic radiation-induced skin injury - which can lead to potentially severe cosmetic and functional problems. Recent studies suggest a promising new approach in these cases, using fat grafting procedures to unleash the healing and regenerative power of the body's natural adipose stem cells (ASCs). "Preliminary evidence suggests that fat grafting can make skin feel and look healthier, restore lost soft tissue volume, and help alleviate pain and fibrosis in patients with radiation-induced skin injury ...

Giant trees in tropical forests, witnesses to centuries of civilization, may be trapped in a dangerous feedback loop according to a new report in Nature Plants from researchers at the Smithsonian Tropical Research Institute (STRI) in Panama and the University of Birmingham, U.K. The biggest trees store half of the carbon in mature tropical forests, but they could be at risk of death as a result of climate change--releasing massive amounts of carbon back into the atmosphere. Evan Gora, STRI Tupper postdoctoral fellow, studies the role of lightning in tropical forests. Adriane Esquivel-Muelbert, lecturer at the University of Birmingham, studies the effects of climate change in the Amazon. The two teamed up ...

PULLMAN, Wash. - Washington State University researchers have discovered a protein that could be key to blocking the most common bacterial cause of human food poisoning in the United States. Chances are, if you've eaten undercooked poultry or cross contaminated food by washing raw chicken, you may be familiar with the food-borne pathogen. "Many people that get sick think, 'oh, that's probably Salmonella,' but it is even more likely it's Campylobacter," said Nick Negretti ('20 Ph.D.), a lead member of the research team in Michael Konkel's Laboratory in WSU's School of Molecular Biosciences. According to a study on the research recently published ...

PROVIDENCE, R.I. [Brown University] -- Researchers from Brown University have discovered a previously unknown type of ancient crater lake on Mars that could reveal clues about the planet's early climate. In a study published in Planetary Science Journal, a research team led by Brown Ph.D. student Ben Boatwright describes an as-yet unnamed crater with some puzzling characteristics. The crater's floor has unmistakable geologic evidence of ancient stream beds and ponds, yet there's no evidence of inlet channels where water could have entered the crater from outside, and no evidence ...

Judges don't do court stenography. CEOs don't take minutes at meetings. So why do we expect doctors and other health care providers to spend hours recording notes -- something experts know contributes to burnout? "Having them do so much clerical work doesn't make sense," said Lisa Merlo, Ph.D., an associate professor of psychiatry and director of wellness programs at the University of Florida College of Medicine. "In order to improve the health care experience for everyone, we need to help them focus more on the actual practice of medicine." Physician burnout affects patients, too. Stressed doctors are less compassionate and more likely to make mistakes. Clinicians who leave the field or cut back hours reduce patient access ...

Mount Sinai researchers have found that a widely available and inexpensive drug targeting inflammatory genes has reduced morbidity and mortality in mice infected with SARS-CoV-2, the virus that causes COVID-19. In a study published today in the journal Cell, the team reported that the drug, Topotecan (TPT), inhibited the expression of inflammatory genes in the lungs of mice as late as four days after infection, a finding with potential implications for treatment of humans. "So far, in pre-clinical models of SARS-CoV-2, there are no therapies--either antiviral, antibody, or plasma--shown to reduce the SARS-CoV-2 disease burden when administered after more than one day post-infection" says senior author Ivan Marazzi, PhD, Associate Professor of Microbiology ...

Research into the diets of a large number of the world's carnivores has been made publicly available through a free, online database created by a PhD student at the University of Sussex. From stoats in the UK to tigers in India, users are now able to search for detailed information about the diets of species in different geographical locations around the globe. Created by doctoral student Owen Middleton, CarniDIET is an open-access database which aims to catalogue the diets of the world's carnivores by bringing together past peer-reviewed research. He hopes it will be a useful resource for conservationists and researchers, as well as educators and nature-lovers alike. Owen said: "There is so much information out ...

A simple plastic water bottle isn't so simple when it comes to the traditional manufacturing process. To appear in its final form, it has to go through a multi-step journey of synthetic procedure, casting, and molding. But what if materials scientists could tap into the same biological mechanisms that create the ridges on our fingertips or the spots on a cheetah in order to manufacture something like a water bottle? A research paper titled END ...

Preclinical research from VCU Massey Cancer Center published recently in the Proceedings of the National Academy of Sciences shows that the combination of two existing drugs can exploit the metabolic "hunger" of a particularly aggressive type of neuroblastoma to kill cancer cells without inflicting too much collateral damage to healthy tissue. Neuroblastoma - a type of cancer that strikes the nervous system of very young children - is one of the deadliest pediatric cancers. And children whose neuroblastoma overexpresses the gene MYCN tend to have the worst prognosis. While medical advancements have led to high cure ...

LOWELL, Mass. - Too often, contends UMass Lowell faculty researcher Brenna Morse, children with complex chronic medical conditions spend days in the hospital undergoing tests for what could be a simple diagnosis. The challenges include, she says, some children with medical complexities, such as severe neurological conditions and functional impairments, cannot easily signal that they are in pain or point where in their body it is located. Where children not facing such a challenge might be able to have a medical issue resolved with a simple visit to their primary care doctor, others end up hospitalized and going through days of costly testing to arrive at similar diagnoses. Morse, a UMass Lowell ...

Pink Floyd's Dark Side of the Moon cover, voted the greatest classical rock album of all time, intended to portray the prism and dispersion of light into a rainbow as a certain metaphorical symbolism and a light show that was never celebrated. However, they really were not aware of the fact that this image would be used by many to help illustrate the concept of refractive index and how light changes speed and direction when it encounters a different medium. Although conceptually the drawing was not accurate, it conveyed the message that light changes its speed when it moves into another medium, and that the different speeds of different colors causes white light to disperse ...

Sausalito, Calif. (March 30, 2021) - After more than three decades of research, scientists have proven that the cancer affecting up to one in four adult California sea lions necrospied at The Marine Mammal Center in Sausalito, CA, is caused by a sexually transmitted herpesvirus. The cancer, known as sea lion urogenital carcinoma, has clear parallels to cervical cancer in humans and provides a helpful model for human cancer study. Scientists have long suspected this cancer was associated with a virus, but this is the first study to prove this theory. The study, which was published in Animals, an open-access, peer-reviewed journal, concluded that genital herpesvirus is ...

WASHINGTON, March 30, 2021 -- Emerging technologies can screen for cervical cancer better than Pap smears and, if widely used, could save lives both in developing nations and parts of countries, like the United States, where access to health care may be limited. In Biophysics Reviews, by AIP Publishing, scientists at Massachusetts General Hospital write advances in nanotechnology and computer learning are among the technologies helping develop HPV screening that take the guesswork out of the precancer tests. That could mean better screening in places that lack highly trained doctors and advanced laboratories. Cervical cancer is the world's fourth-most common cancer, with more than ...

WASHINGTON, March 30, 2021 -- As ethanol, biodiesel, and other biofuels continue to present challenges, such as competing with food security or lacking the technology for more efficient and low-cost production, microalgae are gaining momentum as a biofuel energy crop. In their paper, published in the Journal of Renewable and Sustainable Energy, by AIP Publishing, Yangzhou University researchers in China show how a combination of monochromatic red and blue LED illumination on one type of microalga can enhance its growth and increase the biosynthesis of critical components, such ...

New observations with the European Southern Observatory's Very Large Telescope (ESO's VLT) indicate that the rogue comet 2I/Borisov, which is only the second and most recently detected interstellar visitor to our Solar System, is one of the most pristine ever observed. Astronomers suspect that the comet most likely never passed close to a star, making it an undisturbed relic of the cloud of gas and dust it formed from. 2I/Borisov was discovered by amateur astronomer Gennady Borisov in August 2019 and was confirmed to have come from beyond the Solar System a few weeks ...

WASHINGTON, March 30, 2021 -- Scientists are developing tools to observe the biological machinery in in vivo animal models to be able to understand and better treat severe brain diseases like Alzheimer's disease and many other conditions. Holographic endoscopes attracted researchers' interest because of their potential to conduct minimally invasive observations inside the human body. These tools can shed light on the biological processes occurring at the macromolecular and subcellular levels, which usually remain hidden from sight as most tissue is opaque to visible radiation. In APL Photonics, by AIP Publishing, researchers from the Leibniz Institute of Photonic Technology in Germany created a particularly narrow ...

It makes evolutionary sense for long-lived animals to have complex social relationships - such as friends and enemies - researchers say. Some species and individuals focus their energy on reproduction (live fast, die young), while "slow-living" animals prioritise survival and tend to live longer lives. In the new paper, University of Exeter scientists argue that natural selection favours complex social structures among slow-living animals - meaning that knowing their friends and enemies is easier for animals with longer lifespans, and helps them live even longer. Meanwhile, fast-lived species should only bother with such social relationships if it increases ...

What The Study Did: Researchers investigated COVID-19 vaccine intentions among racially and ethnically diverse samples of health workers and the general population in the San Francisco Bay area. Authors: Kevin Grumbach, M.D., of the San Francisco General Hospital and University of California, San Francisco, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamainternmed.2021.1445) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional ...

ARLINGTON, Va., March 30, 2021 -- Doctors who oversee cancer clinics say that new patients are arriving for treatment with more advanced disease than before the COVID-19 pandemic, according to a new survey from the American Society for Radiation Oncology (ASTRO). The national survey of radiation therapy practice leaders fielded this winter also indicates that treatment postponements and deferrals that were common a year ago have largely subsided and that clinics continue to use a variety of enhanced safety measures to protect their patients and staff. "One year into the COVID-19 pandemic, we already see the consequences of pandemic-driven drops in cancer screening and diagnostics," said Thomas J. Eichler, MD, FASTRO, ...

Boston - For decades, the power of the placebo effect was thought to lie in patients' belief that they were -- or at least, could be -- receiving a pharmacologically active treatment. A new study by physician-researchers at Beth Israel Deaconess Medical Center (BIDMC) suggests that patients don't need to be deceived to receive benefit from treatment with placebo. In a randomized clinical trial published in the journal PAIN, researchers found participants with moderate to severe irritable bowel syndrome (IBS) who were knowingly treated with a pharmacologically inactive pill -- referred to as an honest or open-label placebo -- reported clinically meaningful improvements in their IBS symptoms. People who received the open-label placebo experienced improvements ...