Gustavo Aguirre and William Beltran, veterinary ophthalmologists and vision scientists at the University of Pennsylvania School of Veterinary Medicine, have studied a wide range of different retinal blinding disorders. But the one caused by mutations in the NPHP5 gene, leading to a form of Leber congenital amaurosis (LCA), is one of the most severe. "Children with this disorder are not visual," says Aguirre. "They have a wandering, searching look on their faces and are usually diagnosed at a young age." A nearly identical disease naturally occurs in dogs. In a new paper in the journal Molecular Therapy, Aguirre, Beltran, and colleagues at Penn and other institutions have demonstrated that a canine gene therapy can restore both normal structure and function to the retina's ...

University of California, Irvine, biologists have discovered that plants influence how their bacterial and fungal neighbors react to climate change. This finding contributes crucial new information to a hot topic in environmental science: in what manner will climate change alter the diversity of both plants and microbiomes on the landscape? The paper appears in Elementa: Sciences of the Anthropocene. The research took place at the Loma Ridge Global Change Experiment, a decade-long study in which scientists simulate the impacts of climate change on neighboring grasslands and coastal scrublands in Southern California. Experimental treatments there include nitrogen addition, a common result of local fossil fuel burning, ...

The human brain regions responsible for speech and communication keep our world running by allowing us to do things like talk with friends, shout for help in an emergency and present information in meetings. However, scientific understanding of just how these parts of the brain work is limited. Consequently, knowledge of how to improve challenges such as speech impediments or language acquisition is limited as well. Using an ultra-lightweight, wireless implant, a University of Arizona team is researching songbirds - one of the few species that share humans' ability to learn new vocalizations - to improve scientific ...

Cone snails aren't glamorous. They don't have svelte waistlines or jaw-dropping good looks. Yet, some of these worm-hunting gastropods are the femme fatales or lady killers of the undersea world, according to a new study conducted by an international team of researchers, including University of Utah Health scientists. The researchers say the snails use a previously undetected set of small molecules that mimic the effects of worm pheromones to drive marine worms into a sexual frenzy, making it easier to lure them out of their hiding places so the snails can gobble them up. "In essence, these cone snails have found a way to turn the natural sex drive of their prey into a lethal weapon," says Eric W. ...

Researchers from Queen Mary University of London have shown for the first time that animal DNA shed within the environment can be collected from the air. The proof-of-concept study, published in the journal PeerJ, opens up potential for new ecological, health and forensic applications of environmental DNA (eDNA), which to-date has mainly been used to survey aquatic environments. Living organisms such as plants and animals shed DNA into their surrounding environments as they interact with them. In recent years, eDNA has become an important tool to help scientists identify species found within different environments. However, whilst a range of environmental samples, including ...

Tomatoes are an important and popular crop, but the tasty ketchup, salsa and pasta sauce they yield comes at a price: overuse of chemical fertilizers. Now, researchers report in ACS' Journal of Agricultural and Food Chemistry they have recruited a fungus to bolster fertilizer efficiency, meaning tastier tomatoes can be grown with less fertilizer. Tomato plants have a long growth period and need more nutrients -- particularly nitrogen and phosphorus-- than many other crops. Supplying these nutrients through a chemical fertilizer is inefficient, because the nutrients can leach away, evaporate or get trapped in insoluble compounds in the soil, among other problems. Some farmers react by overusing ...

Key Points The PURE study is the first multinational study exploring the association between unprocessed and processed meat intakes with health outcomes in low-, middle-, and high-income countries. The consumption of unprocessed red meat and poultry was not found to be associated with mortality nor major cardiovascular disease events. In contrast, higher processed meat intake was associated with higher risks of both total mortality and major cardiovascular disease. Rockville, MD - Red meat is a major source of medium- and long-chain saturated fatty acids, which may lead to an increased risk of cardiovascular disease. Processed meat, which has been modified to improve taste or extend its shelf-life, has also been associated with an increased ...

Hamilton, ON (March 31, 2021) - A global study led by Hamilton scientists has found a link between eating processed meat and a higher risk of cardiovascular disease. The same study did not find the same link with unprocessed red meat or poultry. The information comes from the diets and health outcomes of 134,297 people from 21 countries spanning five continents, who were tracked by researchers for data on meat consumption and cardiovascular illnesses. After following the participants for almost a decade, the researchers found consumption of 150 grams or more of processed meat a week was associated with a 46 per cent higher risk of cardiovascular disease and a 51 per cent ...

Tilapias living in crowded aquaculture ponds or small freshwater reservoirs adapt so well to these stressful environments that they stop growing and reproduce at a smaller size than their stress-free counterparts. A new study by researchers at the University of Kelaniya in Sri Lanka and the University of British Columbia, explains that while most fishes die when stressed, tilapias survive in rough environments by stunting and carrying on with their lives in dwarf form. "Tilapia and other fish in the Cichlidae family do not spawn 'earlier' than other fishes, as it is commonly believed," Upali S. Amarasinghe, lead author of the study and professor at the University of Kelaniya, said. "Rather, they are uncommonly tolerant of stressful ...

DALLAS, March 31, 2021 -- Following a routine of regular physical activity combined with a diet including fruits, vegetables and other healthy foods may be key to middle-aged adults achieving optimal cardiometabolic health later in life, according to new research using data from the Framingham Heart Study published today in the Journal of the American Heart Association, an open access journal of the American Heart Association. Cardiometabolic health risk factors include the metabolic syndrome, a cluster of disorders such as excess fat around the waist, insulin resistance and high blood pressure. Presence of the metabolic syndrome may increase the risk of developing heart disease, stroke and Type 2 diabetes. Researchers noted it has been unclear ...

More research is needed on the environmental impact of sunscreen on the world's coral reefs, scientists at the University of York say. The concerns over the number of cases of cancer as a result of overexposure to UV solar radiation, has led to extensive production and use of skin protection products. The chemical compounds used in these products, however, can enter the environment at the points of manufacture as well as through use by the consumer. It is already understood that UV-filter compounds have toxic effects on marine organisms, but research in this area ...

WASHINGTON, DC - March 31, 2021 -- Nearly 20% of Americans, or more than 46 million adults, say they did not seek treatment for a health problem in the last year due to cost, and an equal number say that if they needed some form of healthcare today they would not be able to afford it, according to a new West Health-Gallup survey. The findings come as Americans struggle through a year-plus long pandemic that has claimed over 550,000 lives and put millions of people out of work. Americans who found themselves unemployed were about twice as likely ...

The era of big data has inundated nearly all scientific fields with torrents of newly available data with the power to stimulate new research and enable inquiry at scales not previously possible. This is particularly true for ecology, where rapid growth in remote sensing, monitoring, and community science initiatives has contributed to a massive surge in the quantity and kinds of environmental data that are available to researchers. Writing in BioScience, a team led by US Department of Agriculture ecologist Sarah McCord states that the volume of the data is only part of the story. Just as important, they say, is the quality of the data. According to the newly published article, "Big data has magnified both the burden and the complexity of ensuring ...

GENEVA, LAUSANNE, 31 March 2021: Cocaine is a highly addictive substance that, in the long term, can have adverse effects on health and wellbeing. There are around 18 million cocaine users globally, according to a UN report. Understanding how cocaine modifies brain networks could reveal potential targets for therapies to treat addiction and other neuropsychological disorders. A new study published today in the journal Frontiers in Synaptic Neuroscience by a team of researchers from the University of Lausanne and the Wyss Center for Bio and Neuroengineering reveals that during cocaine withdrawal, neurons in a brain area associated with depression connect ...

CLEVELAND, Ohio (March 31, 2021)--Menopause typically signals the end of a woman's ability to become pregnant. However, in a small new study, a novel approach of administering platelet-rich plasma and gonadotropins near the ovarian follicles is showing promise in restoring ovarian function. Study results are published online today in Menopause, the journal of The North American Menopause Society (NAMS). As more women look to build their careers before pursuing motherhood, the average age of conceiving a child continues to be pushed back. For some of these women, however, their hope of becoming pregnant is cut short by the onset of early menopause, which is described as the cessation of ovarian function ...

A research team of the National Institutes of Natural Sciences, National Institute for Fusion Science and Akita Prefectural University have successfully demonstrated a broadband mid-infrared (MIR) source with a simple configuration. This light source generates highly-stable broadband MIR beam at 2.5-3.7 μm wavelength range maintaining the brightness owing to its high-beam quality. Such a broadband MIR source facilitates a simplified environmental monitoring system by constructing a MIR fiber-optic sensor, which has the potential for industrial and medical applications. In the MIR wavelength region, there are many strong absorption lines of molecules ...

A*STAR's Institute of Bioengineering and Nanotechnology (IBN) has teamed up with Singapore Institute of Advanced Medicine Holdings Pte Ltd (SIAMH) to establish the first of its kind in-vitro patient-derived 3D organoid models of Nasopharyngeal Cancer (NPC). The study was published in Frontiers in Oncology on 23 February 2021. It is the first direct experimental evidence to predict optimal Radiation Treatment (RT) boost dose required to cause sufficient damage to recurrent hypoxic (low oxygen level) NPC tumour cells, which can be further used to develop dose-painting algorithms in clinical practice. Two patient-derived xenograft (PDX) ...

Researchers from Loyola Marymount University, San Diego State University, Indian Institute of Management, and Iowa State University published a new paper in the Journal of Marketing that examines how effective marketplace participation by subsistence consumers requires knowledge and skills that relate to what, how, and why to participate. The study, forthcoming in the Journal of Marketing, is titled "Marketplace Literacy as a Pathway to a Better World: Evidence from Field Experiments in Low-Access Subsistence Marketplaces" and is authored by Madhu Viswanathan, Nita Umashankar, Arun Sreekumar, and Ashley Goreczny. Success for marketers looking to emerging markets for growth is inextricably ...

COLUMBUS, Ohio - Bangladesh's floating gardens, built to grow food during flood seasons, could offer a sustainable solution for parts of the world prone to flooding because of climate change, a new study has found. The study, published recently in the Journal of Agriculture, Food and Environment, suggests that floating gardens might not only help reduce food insecurity, but could also provide income for rural households in flood-prone parts of Bangladesh. "We are focused here on adaptive change for people who are victims of climate change, but who did not cause climate ...

PULLMAN, Wash. -- Nature's strongest material now has some stiff competition. For the first time, researchers have hard evidence that human-made hexagonal diamonds are stiffer than the common cubic diamonds found in nature and often used in jewelry. Named for their six-sided crystal structure, hexagonal diamonds have been found at some meteorite impact sites, and others have been made briefly in labs, but these were either too small or had too short of an existence to be measured. Now scientists at Washington State University's Institute for Shock Physics created hexagonal diamonds large enough to measure ...

Chestnut Hill, Mass. (3/31/21) -- Spinach, a cost-efficient and environmentally friendly scaffold, provided an edible platform upon which a team of researchers led by a Boston College engineer has grown meat cells, an advance that may accelerate the development of cultured meat, according to a new report in the advance online edition of the journal Food BioScience. Stripped of all but its veiny skeleton, the circulatory network of a spinach leaf successfully served as an edible substrate upon which the researchers grew bovine animal protein, said Boston College Professor of Engineering Glenn Gaudette, the lead author of the new study. The results may help increase the production of cellular agriculture ...

Research published today in the peer-reviewed Journal of Vertebrate Paleontology describes a newly discovered species of dinosaur - named the 'one who causes fear', or Llukalkan aliocranianus. Around 80 million years ago as tyrannosaurs ruled the Northern Hemisphere, this lookalike was one of 10 currently known species of abelisaurids flourishing in the southern continents. A fearsome killer, Llukalkan was "likely among the top predators" throughout Patagonia, now in Argentina, during the Late Cretaceous due to its formidable size (up to five meters long), extremely powerful ...

Early treatment with anti-VEGF injections slowed diabetic retinopathy in a clinical study from the DRCR Retina Network (DRCR.net). However, two years into the four-year study its effect on vision was similar to standard treatment, which usually begins at the onset of late disease. The intermediate findings published today in the JAMA Ophthalmology. The study was supported by the National Eye Institute (NEI), a part of the National Institutes of Health. "While it is possible that preventive injections of anti-VEGF drugs may help protect vision in the longer-term, ...

A new mathematical model suggests that the easing of lockdown must be accompanied by wider and more effective use of control measures such as facemasks even with vaccination, in order to suppress COVID-19 more quickly and reduce the likelihood of another lockdown. The model, developed by scientists at the Universities of Cambridge and Liverpool, is published today in the Journal of the Royal Society Interface. It uses mathematical equations to provide general insights about how COVID-19 will spread under different potential control scenarios. Control measures involving facemasks, handwashing and short-scale (1-2 metre) social distancing can all limit the number of virus particles being spread between people. These are termed ...

With shark bites increasing in countries like Australia - scientists say the use of personal electronic deterrents is an effective way to prevent future deaths and injuries which could save the lives of up to 1063 Australians along the coastline over the next 50 years. The research, published in scientific journal Royal Society Open Science, shows that while shark bites are rare events, strategies to reduce shark-bite risk are also valuable because they can severely affect victims and their support groups - with one third of victims experiencing post-traumatic stress ...