Barcelona researchers at the Hospital Clínic-IDIBAPS Research Institute, the University of Barcelona and the SOLTI academic cancer research group have shown that the molecular classification of breast cancer, which divides it into four subtypes (Luminal A, Luminal B, HER2-enriched and Basal-like) is useful for predicting the benefits of treatment in patients with advanced hormone-sensitive breast cancer. This is the largest study to have shown the value of the biomarker, and the first to do so in the context of a CDK4/6 inhibitor like ribociclib. The study, published in the Journal of Clinical Oncology of the American Society of Clinical Oncology (ASCO), was coordinated by Professor Aleix Prat, head of the Medical Oncology ...

CHAPEL HILL, NC - A team led by scientists at the UNC School of Medicine discovered an important vulnerability of the AIDS-causing retrovirus HIV, and has shown in preclinical experiments that a widely used diabetes drug, metformin, seems able to exploit this vulnerability. The scientists, whose study is published in Nature Immunology, found that HIV, when it infects immune cells called CD4 T cells, helps fuel its own replication by boosting a key process in the cells' production of chemical energy. They also found that the diabetes drug metformin inhibits the same process and thereby suppresses HIV replication in these cells, in both cell-culture and mouse experiments. "These findings suggest that metformin and other drugs that reduce T cell metabolism ...

PHOENIX, Ariz. -- March 29, 2021 -- A review of more than 20 studies by researchers at Arizona State University and the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, suggests that nonalcoholic fatty-liver disease (NAFLD) is a growing dietary problem for children across the globe. "The prevalence of fatty-liver disease is escalating not only in adults, but also in children," said Johanna DiStefano, Ph.D., a Professor and head of TGen's Diabetes and Fibrotic Disease Unit, and the review's senior author. "Like type 2 diabetes, NAFLD used to be considered a disease that developed only in adulthood, ...

Younger trees take up and release less water than mature trees 10 years or older, researchers from North Carolina State University found in a new study that tracked how water moves through wetland pine forests near the North Carolina coast. Their findings, published in Agricultural and Forest Meteorology, suggest managers should time timber harvests to leave older trees alongside new growth to mitigate runoff. "The water balance, especially in coastal sites, is very important," said the study's lead author Maricar Aguilos, postdoctoral research associate in forestry and environmental resources at NC State. "We have so much water there. We wanted to understand how land-use changes impact water use and drainage in the forests, ...

Five years ago, scientists created a single-celled synthetic organism that, with only 473 genes, was the simplest living cell ever known. However, this bacteria-like organism behaved strangely when growing and dividing, producing cells with wildly different shapes and sizes. Now, scientists have identified seven genes that can be added to tame the cells' unruly nature, causing them to neatly divide into uniform orbs. This achievement, a collaboration between the J. Craig Venter Institute (JCVI), the National Institute of Standards and Technology (NIST) and the Massachusetts Institute of Technology (MIT) Center for Bits and Atoms, was described in the journal Cell. Identifying these genes is an important step toward engineering synthetic cells that do useful things. Such ...

Maternal socioeconomic status impacts babies even before birth, emphasizing the need for policy interventions to support the wellbeing of pregnant women, according to newly published END ...

PHILADELPHIA -- The U.S. government's Special Supplemental Nutrition Program for Women, Infants, and Children, usually abbreviated as WIC, saw a jump in enrollment of nearly 8 percent in states that implemented a federally mandated switch from paper vouchers to electronic benefit cards (EBTs), according to a study led by researchers at the Perelman School of Medicine at the University of Pennsylvania. The finding, published in JAMA Pediatrics, supports the rationale for the switch, which was to increase participation by making it easier and less stigmatizing to obtain and redeem WIC benefits. "The broad takeaway ...

Around one in 57 (1.76%) children in the UK is on the autistic spectrum, significantly higher than previously reported, according to a study of more than 7 million children carried out by researchers from the University of Cambridge's Department of Psychiatry in collaboration with researchers from Newcastle University and Maastricht University. Black and Chinese pupils were 26% and 38% more likely to be autistic respectively and autistic children were much more likely to face significant social disadvantage. The results are published today in JAMA Pediatrics. The team drew on data from the School Census from the National Pupil Database, collected by the Department for Education from individuals aged 2-21 years old in state-funded schools in England. Of more than 7 million ...

What The Study Did: This comparative effectiveness study investigates how the COVID-19 pandemic is associated with the benefits and risks of standard radiation therapy in simulated patients. Authors: Rifaquat Rahman, M.D., of the Dana-Farber/Brigham and Women's Cancer Center in Boston, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.3304) Editor's Note: The article includes conflict of interest disclosures. Please see the article for additional information, ...

BOSTON --Medical professionals often advise patients not to search the Internet for their symptoms before coming into the clinic, yet many people turn to "Dr. Google" when feeling sick. Concerns about "cyberchondria" -- or increased anxiety induced by the Internet -- have made the value of using Internet searches controversial. In a new study that used case vignettes, researchers from Brigham and Women's Hospital and Harvard Medical School Department of Health Care Policy explored the impact Internet searches have on patients' abilities to reach a correct diagnosis. They found that study outcomes suggest the Internet may not be so harmful after all. Participants ...

Younger age of first cannabis use or prescription drug misuse is associated with faster development of substance use disorders NIH analysis measures the prevalence of nine substance use disorders after first substance use or misuse in young people A new study shows that in the time after first trying cannabis or first misusing prescription drugs, the percentages of young people who develop the corresponding substance use disorder are higher among adolescents (ages 12-17) than young adults (ages 18-25). In addition, 30% of young adults develop a heroin use disorder and 25% develop a methamphetamine use disorder a year after first using heroin or methamphetamine. These findings, published in JAMA Pediatrics, emphasize the vulnerability ...

A hydrogel, a type of soft matter, developed at Hokkaido University successfully reverted cancer cells back to cancer stem cells within 24 hours, in six different human cancer types. This could lead to the development of anti-cancer stem cell drugs and personalized medicines. An innovative hydrogel - called a double network (DN) gel - can rapidly reprogram differentiated cancer cells into cancer stem cells, researchers at Hokkaido University and the National Cancer Center Research Institute have reported in the journal Nature Biomedical Engineering. The hydrogel can be used to help develop ...

A new black hole breaks the record -- not for being the smallest or the biggest -- but for being right in the middle. The recently discovered 'Goldilocks' black hole is part of a missing link between two populations of black holes: small black holes made from stars and supermassive giants in the nucleus of most galaxies. In a joint effort, researchers from the University of Melbourne and Monash University have uncovered a black hole approximately 55,000 times the mass of the sun, a fabled "intermediate-mass" black hole. The discovery was published today in the paper Evidence for an intermediate mass black hole from a gravitationally lensed gamma-ray burst in the journal Nature Astronomy. Lead author and University of Melbourne PhD student, ...

In the last few years, as climate changes continues to become more severe, there has been a growing push for rich countries to pay poorer ones to preserve and protect rain forests and other tropical forests. However, according to a new study in Nature Ecology & Evolution, RIHN Associate Professor Keiichiro Kanemoto and Senior Researcher Nguyen Tien Hoang show that other financial motives, namely international trade, with these same rich countries have actually encouraged poorer countries to increase their annual deforestation levels from 2001 to 2015. Every year ...

CAMBRIDGE, MA - Using an ordinary light microscope, MIT engineers have devised a technique for imaging biological samples with accuracy at the scale of 10 nanometers -- which should enable them to image viruses and potentially even single biomolecules, the researchers say. The new technique builds on expansion microscopy, an approach that involves embedding biological samples in a hydrogel and then expanding them before imaging them with a microscope. For the latest version of the technique, the researchers developed a new type of hydrogel that maintains a more uniform configuration, allowing for greater accuracy in imaging tiny structures. This degree of accuracy ...

Simulating the interactions between atoms and molecules is important for many scientific studies. However, accurate simulations can take a long time, which limits their use. To speed up simulations without sacrificing too much detail, Siewert-Jan Marrink, Professor of Molecular Dynamics at the University of Groningen, designed a set of parameters that allow fast but accurate coarse-grained simulations. In a paper that was published on 29 March in Nature Methods, Marrink and his co-workers present a third release of what is known as the Martini forcefield. 'Our Martini forcefield typically combines four heavy atoms and any attached protons into ...

New research reveals how cancer cells endure stress and survive. Publishing in Molecular Cell, an international research team identified mechanisms that human and mouse cells use to survive heat shock and resume their original function - and even pass the memory of the experience of stress down to their daughter cells. Lead author Anniina Vihervaara, Assistant Professor in Gene Technology at KTH Royal Institute of Technology, says the results provide insight into the mechanisms that coordinate transcription in cells, which potentially could make a vital contribution in disease research. The researchers examined how embryonic fibroblast ...

The permanent rise of oxygen in the Earth's atmosphere, which fundamentally changed the subsequent nature of Earth's habitability, occurred much later than thought, according to new research. And the study, from an international team led by the University of Leeds and including researchers from the University of California-Riverside, Harvard University, the University of Southern Denmark and the University of St Andrews, also provides an explanation for some of the most extreme climate episodes to have affected the Earth, when the planet was repeatedly covered with ice. The first time oxygen was significantly present in the atmosphere was about ...

A team of researchers led by Aarhus University and including experts from universities and knowledge institutions in the US, Europe, Japan and Australia has published an article in the prestigious scientific journal Joule confirming that the role of solar photovoltaic installations in future green energy systems ought to be significantly upgraded. Solar photovoltaic technology has undergone dramatic development over the past 14 years causing the technology to be cheaper already today than has otherwise been assumed in the models that the UN Intergovernmental Panel on Climate Change (IPCC) uses for its 2050 scenarios. "And ...

The B.1.1.7 and B.1.351 variants of SARS-CoV-2 were first detected in the UK and South Africa respectively, and have since spread to many other countries. Scientists from the Institut Pasteur joined forces with Orléans Regional Hospital, Tours University Hospital, Créteil Intercommunal Hospital, Strasbourg University Hospital and Georges Pompidou European Hospital to study the sensitivity of these two variants to neutralizing antibodies present in the serum samples of people who have been vaccinated or previously infected with SARS-CoV-2. They compared this sensitivity with that of the reference virus (D614G), which was until recently the most widespread strain in France. The scientists demonstrated that the UK variant is neutralized to the ...

Until now, historians have treated accounts of extreme weather events that might indicate climate change, or more specifically an increase in rainfall, with suspicion. Too many purely cultural factors, they argue, might have influenced one author or another to write about rains, droughts or floods. A new interdisciplinary study lead by researchers from the University of Pisa and the University of Warsaw, together with an international team of collaborators, links data indicating increased precipitation in northern and central Italy during the 6th century CE to historical accounts contained in contemporaneous texts about the lives and miracles of saints. The paper successfully integrates palaeoclimate proxies with historical ...

Researchers from Skoltech have developed an early prototype of a medical imaging system that uses neural networks to analyze near-infrared images of veins and project a venous pattern onto a patient's body - this may make blood draws much easier and less of a nuisance for patients with difficult access to veins. The paper was published in the proceedings of the 16th International Conference on Control, Automation, Robotics and Vision (ICARCV). According to data cited in the paper, out of approximately 20 million blood tests performed globally every day, almost 45% are estimated to involve some degree of discomfort for the patient whose ...

(Boston)--Pregnancy complications affect up to one in three pregnancies and are increasingly linked to future chronic disease. For example, preeclampsia is associated with a doubled risk of cardiovascular disease, the leading cause of death in the U.S., and gestational diabetes is associated with a seven-fold increased risk of type 2 diabetes. While guidelines recommend preventive care starting within the first postpartum year to address such pregnancy-related health risks, the connections between pregnancy health and future health are often neglected. In ...

An international team of researchers led by a University of Virginia School of Medicine professor is warning that scientists must better prepare for the next pandemic - and has developed a plan to do just that. Noting the "avalanche" of scientific data generated in response to COVID-19, UVA's Wladek Minor, PhD, and colleagues are calling for the creation of an "advanced information system" (AIS) to help scientists integrate, monitor and evaluate the vast amounts of data that will be produced as researchers reveal the molecular architecture of the next pathogen ...

URBANA, Ill. - Ever thought about buying or building a bat box to help bats? Think carefully about the design and where you put it, University of Illinois researchers say. Here's why: Bats and their pups can overheat and die in poorly designed or placed bat boxes, and in a warming climate, it could happen more often. Illinois bat ecologists Joy O'Keefe and Reed Crawford recently synthesized the available data on bat boxes, also known as bat houses or artificial roosts, to raise awareness of the issue and motivate change in bat box design, marketing, and consumer education. Their recommendations are published in Conservation Science and Practice. "Conservation ...