PHILADELPHIA - Our biological or circadian clock synchronizes all our bodily processes to the natural rhythms of light and dark. It's no wonder then that disrupting the clock can wreak havoc on our body. In fact, studies have shown that when circadian rhythms are disturbed through sleep deprivation, jet lag, or shift work, there is an increased incidence of some cancers including prostate cancer, which is the second leading cause of cancer death for men in the U.S. With an urgent need to develop novel therapeutic targets for prostate cancer, researchers at the Sidney Kimmel Cancer - ...

Oxygen levels in the ancient oceans were surprisingly resilient to climate change, new research suggests. Scientists used geological samples to estimate ocean oxygen during a period of global warming 56 million years ago - and found "limited expansion" of seafloor anoxia (absence of oxygen). Global warming - both past and present - depletes ocean oxygen, but the new study suggests warming of 5°C in the Paleocene Eocene Thermal Maximum (PETM) led to anoxia covering no more than 2% of the global seafloor. However, conditions are different today to the PETM - today's rate of carbon emissions is much faster, and we are adding nutrient pollution to the oceans - both of which could drive more rapid and expansive oxygen loss. The study was carried out by an international ...

Champaign, IL, January 15, 2021 - American dairy consumers are often influenced by a variety of factors that can affect their buying habits. These factors include taste, preference, government information, cultural background, social media, and the news. In an article appearing in JDS Communications, researchers found that households that frequently bought food for children are interested in dairy as part of their diet and purchased larger quantities of fluid milk and more fluid milk with a higher fat content. To assess the purchasing habits of households that purchase food for children versus those ...

Families are complicated. For members of the Alligatoridae family, which includes living caimans and alligators - this is especially true. They are closely related, but because of their similarity, their identification can even stump paleontologists. But after the recent discovery of a partial skull, the caimans of years past may provide some clarity into the complex, and incomplete, history of its relatives and their movements across time and space. Michelle Stocker, an assistant professor of vertebrate paleontology in Virginia Tech's Department of Geosciences in the College of Science; Chris Kirk, of the University of Texas at Austin; and Christopher Brochu, of the University of Iowa, have ...

Researchers from University of Stavanger, University of Melbourne, and University of Wisconsin-Madison published a new paper in the Journal of Marketing that examines how major projects undertaken by temporary organizations can be better managed so that cost overruns are minimized. The study forthcoming in the Journal of Marketing is titled "Mobilizing the Temporary Organization: The Governance Roles of Selection and Pricing" and is authored by Elham Ghazimatin, Erik Mooi, and Jan Heide. When consumers return to the skies again, they may do so in Boeing's 787 Dreamliner. But the project, or "temporary organization," created to make this plane ...

Just like humans trying to stick to New Year's resolutions, guppies have varying levels of self-control, a new study shows. Researchers from the University of Exeter and Ghent University studying the behaviours of Trinidadian guppies tested "inhibitory control" (suppressing unhelpful impulses or urges). The tiny fish first learned how to swim into a cylinder to get food - then a cover was removed to make the cylinder transparent. Inhibitory control was measured by whether a guppy resisted the urge to swim directly towards the food - bumping into the cylinder - or still swam around, ...

Researchers have developed a DNA test to quickly identify secondary infections in COVID-19 patients, who have double the risk of developing pneumonia while on ventilation than non-COVID-19 patients. For patients with the most severe forms of COVID-19, mechanical ventilation is often the only way to keep them alive, as doctors use anti-inflammatory therapies to treat their inflamed lungs. However, these patients are susceptible to further infections from bacteria and fungi that they may acquire while in hospital - so called 'ventilator-associated pneumonia'. Now, a team of scientists ...

Former director of public health Professor John Ashton has said that scientific scepticism may be reinforced by the UK's rush to approve COVID vaccines for public use and the apparent political desire to be the first out of the blocks in contrast to our European neighbours. Writing in the Journal of the Royal Society of Medicine, Prof Ashton says that to risk the trust of the public for the sake of a couple of weeks propaganda advantage could prove to be unforgivable should vaccine uptake fall below that required for the ubiquitous 'herd immunity' as a result of giving oxygen to the sceptics. "In this age of scientific rationality, superstition and anti-science still run deep," he writes. "When an overwhelming majority of the public welcomes the arrival of ...

BOSTON - Studies with a popular laboratory model, the nematode Caenorhabditis elegans, have revealed a possible therapeutic avenue for a rare but deadly condition in which children are born without the ability to make molybdenum cofactor (Moco) on their own. Though little known, Moco is essential for life and so far it has proven extremely difficult to stably isolate this compound in the laboratory, preventing its use as a therapeutic supplement. This new work, which appears in Genes & Development, reveals that nematodes genetically engineered to be Moco-deficient can take up Moco that is attached to several types of proteins. This suggests that such protein-Moco complexes could be used as a treatment ...

In a normal year, biologists Daniel Janzen and Winnie Hallwachs spend about six months in Costa Rica, where they conduct research and pursue conservation efforts in Área de Conservación Guanacaste (ACG), a World Heritage Site in the northwest that encompasses, a network of parks and preserves they helped establish in the 1980s and that has grown to more than 400,000 acres, including marine, dry forest, cloud forest, and rain forest environments. In 2020 that is where the married couple was when the COVID-19 pandemic took hold of the world, and compelled them to extend their stay in the virus-free forest until the fall, when they felt safe enough to travel back to their other home in Philadelphia. "With modern laptops and internet, we could watch the world go ...

Anthropologist Caleb Everett and former student Sihan Chen used a novel data analysis of thousands of languages, in addition to studying a unique subset of celebrities, to reveal how a soft food diet--contrasted with the diet of hunter-gatherers--is restructuring dentition and changing how people speak. Their findings, published in Scientific Reports, counter the longstanding belief within the field that maintains that languages are susceptible to the same pressures and so are essentially immune to external factors. "Our results represent the most compelling evidence to date that languages are very much affected by external ...

When the Thomas Fire raged through Ventura and Santa Barbara counties in December 2017, Danielle Touma, at the time an earth science researcher at Stanford, was stunned by its severity. Burning for more than a month and scorching 440 square miles, the fire was then considered the worst in California's history. Six months later the Mendocino Complex Fire upended that record and took out 717 square miles over three months. Record-setting California wildfires have since been the norm, with five of the top 10 occurring in 2020 alone. The disturbing trend sparked some questions for Touma, who is now a postdoctoral researcher at UC Santa Barbara's Bren School for Environmental ...

DARIEN, IL - Editors of the Journal of Clinical Sleep Medicine have identified some of the most significant articles in the publication's history, publishing new commentaries on them in a special 15th anniversary collection. The 15 commentaries from associate editors and members of the journal's editorial board describe the impact of the selected articles both at the time of their publication and today. "The collection highlights some of the most influential publications in clinical sleep research over the past 15 years," JCSM Editor-in-Chief Dr. Nany Collop said. "These studies underscore the remarkable ...

By feeding arctic ground squirrels special diets, researchers have found that omega-3 fatty acids, common in flax seed and fish oil, help keep the animals warmer in deep hibernation. A University of Alaska Fairbanks-led study fed ground squirrels either a diet high in omega-3s or a normal laboratory diet, and measured how the animals hibernated afterward. Researchers found that the omega-3 diet helped the animals hibernate a little warmer than normal without negatively affecting hibernation. The omega-3 diets also increased the amount of a heat-producing fat, called brown adipose tissue, the animals pack on. The discovery could add more understanding ...

DURHAM, N.H.-- Waldenström macroglobulinemia (WM), a rare form of lymphoma, does not have any known cure and only one FDA-approved treatment making it challenging to treat patients. Researchers at the University of New Hampshire took the novel approach of targeting specific cell proteins that control DNA information using inhibitors, or drugs, that were effective in reducing the growth of the cancer cells and when combined with a third drug were even more successful in killing the WM cancer cells which could lead to more treatment options. "This is the first study to report the promising results ...

Astronomers are winding back the clock on the expanding remains of a nearby, exploded star. By using NASA's Hubble Space Telescope, they retraced the speedy shrapnel from the blast to calculate a more accurate estimate of the location and time of the stellar detonation. The victim is a star that exploded long ago in the Small Magellanic Cloud, a satellite galaxy to our Milky Way. The doomed star left behind an expanding, gaseous corpse, a supernova remnant named 1E 0102.2-7219, which NASA's Einstein Observatory first discovered in X-rays. Like detectives, researchers sifted through archival images taken by Hubble, analyzing visible-light observations made 10 years apart. The research team, led by John Banovetz and Danny Milisavljevic ...

In addition to a skin rash, many eczema sufferers also experience chronic itching, but sometimes that itching can become torturous. Worse, antihistamines -- the standard treatment for itching and allergy -- often don't help. New research from Washington University School of Medicine in St. Louis indicates that allergens in the environment often are to blame for episodes of acute itch in eczema patients, and that the itching often doesn't respond to antihistamines because the itch signals are being carried to the brain along a previously unrecognized pathway that current drugs don't target. The new findings, published ...

The sun is the only star in our system. But many of the points of light in our night sky are not as lonely. By some estimates, more than three-quarters of all stars exist as binaries -- with one companion -- or in even more complex relationships. Stars in close quarters can have dramatic impacts on their neighbors. They can strip material from one another, merge or twist each other's movements through the cosmos. And sometimes those changes unfold over the course of a few generations. That is what a team of astronomers from the University of Washington, Western Washington University and the University ...

There's a 7-fold unexplained variation in rates of euthanasia across The Netherlands, reveals an analysis of health insurance claims data, published online in the journal BMJ Supportive & Palliative Care. It's not clear if these differences relate to underuse, overuse, or even misuse, say the researchers. The Netherlands was the first country in the world to legalise euthanasia and physician-assisted suicide, introducing preliminary legislation in 1994, followed by a fully fledged law in 2002. The practice has been tolerated, however, since 1985. Official data show that the number of euthanasia cases has risen more or less continuously since 2006, reaching 6361 in 2019. These cases ...

Climate change impacts, affecting primarily ecosystems' functions and consequently human sectors, have become a crucial topic. Observed and expected variations in climate conditions can in fact undermine the ecosystems' ecological equilibrium: average climate patterns, mainly represented by intra-annual (monthly to seasonal) temperature and precipitation cycle, directly influence the distribution, abundance and interactions of biological species. During the long history of scientific research on the relationships between climate and Earth's communities, ...

BIRMINGHAM, Ala. - Use of the diabetes drug metformin -- before a diagnosis of COVID-19 -- is associated with a threefold decrease in mortality in COVID-19 patients with Type 2 diabetes, according to a racially diverse study at the University of Alabama at Birmingham. Diabetes is a significant comorbidity for COVID-19. "This beneficial effect remained, even after correcting for age, sex, race, obesity, and hypertension or chronic kidney disease and heart failure," said Anath Shalev, M.D., director of UAB's Comprehensive Diabetes Center and leader of the study. "Since similar results have now been obtained in different populations from around the world -- including China, France and a UnitedHealthcare analysis -- this suggests that the ...

Ignoring a colleague's greeting or making a sarcastic comment in the workplace may actually do more harm than intended, according to West Virginia University research. Perceived low-grade forms of workplace mistreatment, such as avoiding eye contact or excluding a coworker from conversation, can amplify suicidal thoughts in employees with mood disorders, based on a study by Kayla Follmer, assistant professor of management, and Jake Follmer, assistant professor of educational psychology. "We know from prior research that minor forms of workplace mistreatment reduce employee engagement," Kayla Follmer said. "But our paper provided an explanation for ...

New York, NY (January 14, 2020) -- Girls who are emotionally neglected or severely sexually abused early in their lives report riskier sexual behaviors during adolescence, Mount Sinai researchers report. The findings highlight the need--and suggest the potential for tailored approaches--to promote healthy sexual development in vulnerable populations. The researchers identified four distinct patterns of neglect and sexual abuse in low-income, predominantly Black and/or Latina girls and young women that led to distinct trajectories of risky sexual behavior during adolescence. Their findings were published in Child Development in January. The study was the first of its kind to identify categories of maltreatment among adolescent girls of color in an urban setting that correspond with measurable ...

The COVID-19 pandemic, which claimed more than 336,000 lives in the United States in 2020, has significantly affected life expectancy, USC and Princeton researchers have found. The researchers project that, due to the pandemic deaths last year, life expectancy at birth for Americans will shorten by 1.13 years to 77.48 years, according to their study published Thursday in the Proceedings of the National Academy of Sciences. That is the largest single-year decline in life expectancy in at least 40 years and is the lowest life expectancy estimated since ...

A team of biophysicists from the University of Massachusetts Amherst and Penn State College of Medicine set out to tackle the long-standing question about the nature of force generation by myosin, the molecular motor responsible for muscle contraction and many other cellular processes. The key question they addressed - one of the most controversial topics in the field - was: how does myosin convert chemical energy, in the form of ATP, into mechanical work? The answer revealed new details into how myosin, the engine of muscle and related motor proteins, transduces energy. In the end, their unprecedented research, meticulously ...