After seven years of intense research, a research group from Aarhus University has succeeded - through an interdisciplinary collaboration - in understanding why a very extended structure is important for an essential protein from the human immune system. The new results offer new opportunities for adjusting the activity of the immune system both up and down. Stimulation is interesting in relation to cancer treatment, while inhibition of the immune system is used in treatment of autoimmune diseases. In our bloodstream and tissues, the complement system acts as one of the very first defense mechanisms against pathogenic organisms. When these are ...

People with asthma in the most deprived areas are 50% more likely to be admitted to hospital and to die from asthma compared with those in the least deprived areas, a new five-year study of over 100,000 people in Wales has revealed. Those from more deprived backgrounds were also found to have a poor balance of essential asthma medications that help prevent asthma attacks. The new research, published in the journal PLOS Medicine, was conducted by Swansea University's Wales Asthma Observatory in collaboration with Asthma UK Centre for Applied Research and Liverpool University, and found ...

SAN FRANCISCO, CA--February 16, 2021--In people with central nervous system (CNS) lymphoma, cancerous B cells--a type of white blood cell--accumulate to form tumors in the brain or spinal cord, often in close proximity to blood vessels. This disease is quite rare, but individuals who are affected have limited treatment options and often experience recurrence. Previous research has linked the severity of CNS lymphoma to abnormal leaks in the blood-brain barrier, a protective system that allows some substances to pass from the bloodstream to the brain, while blocking others. However, the specific molecular details of this link have been murky. Now, Gladstone researchers have ...

Tsukuba, Japan - It's tough out there in the sea, as the widespread loss of complex marine communities is testament to. Researchers from Japan have discovered that ocean acidification favors degraded turf algal systems over corals and other algae, thanks to the help of feedback loops. In a study published this month in Communications Biology, researchers from the University of Tsukuba have revealed that ocean acidification and feedback loops stabilize degraded turf algal systems, limiting the recruitment of coral and other algae. Oceans are undergoing widespread changes as a result of human activities. These changes take the form of regime shifts - major, sudden and persistent changes in ecosystem structure and function. An example is the replacement of coral reefs and kelp ...

An estimated 1.1 billion people were living with untreated vision impairment in 2020, but researchers say more than 90 per cent of vision loss could be prevented or treated with existing, highly cost-effective interventions. Published today in The Lancet Global Health, a new commission report on global eye health calls for eye care to be included in mainstream health services and development policies. It argues that this is essential to achieve the WHO goal of Universal Health Coverage (UHC) and the 2030 United Nations Sustainable Development Goals (SDGs). Written by 73 leading experts from 25 countries, including University of ...

FEBRUARY 15, 2021, NEW YORK - A Ludwig Cancer Research study has identified a novel mechanism by which a type of cancer immunotherapy known as CTLA-4 blockade can disable suppressive immune cells to aid the destruction of certain tumors. The tumors in question are relatively less reliant on burning sugar through a biochemical process known as glycolysis. Researchers led by Taha Merghoub and Jedd Wolchok of the Ludwig Center at Memorial Sloan Kettering Cancer Center (MSK) and former postdoc Roberta Zappasodi--now at Weill Cornell Medicine--have discovered that in a mouse model of glycolysis-deficient tumors, CTLA-4 blockade does ...

Durham, NC- Can stem cells alleviate lymphedema, a chronic debilitating condition affecting up to one in three women treated for breast cancer? Results of a phase I clinical trial released today in STEM CELLS Translational Medicine (SCTM) show there is a strong possibility that the answer is yes. Lymphedema is swelling due to a build-up of fluid in lymph nodes - vessels that help rid the body of toxins, waste, and other unwanted materials- usually occurring in an arm or leg. While it can be the result of an inherited condition, its most common cause in the Western world is the removal of or damage to the lymph nodes during the course of cancer ...

CHICAGO --- Muscle soreness and achy joints are common symptoms among COVID-19 patients. But for some people, symptoms are more severe, long lasting and even bizarre, including rheumatoid arthritis flares, autoimmune myositis or "COVID toes." A new Northwestern Medicine study has, for the first time, confirmed and illustrated the causes of these symptoms through radiological imaging. "We've realized that the COVID virus can trigger the body to attack itself in different ways, which may lead to rheumatological issues that require lifelong management," said corresponding author Dr. Swati Deshmukh. The paper will be published Feb. 17 in the journal Skeletal Radiology. The study is a retrospective review of data from patients who presented to Northwestern Memorial Hospital between ...

A woman's body shape--not only the amount of fat--is what drives stigma associated with overweight and obesity. Fat stigma is a socially acceptable form of prejudice that contributes to poor medical outcomes and negatively affects educational and economic opportunities. But a new study has found that not all overweight and obese body shapes are equally stigmatized. Scientists from Arizona State University and Oklahoma State University have shown that women with abdominal fat around their midsection are more stigmatized than those with gluteofemoral fat on the hips, buttocks and thighs. The work will be published on February 17 in Social Psychology and Personality Science. "Fat stigma is pervasive, painful and results ...

To provoke more interest and excitement for students and lecturers alike, a professor from Florida Atlantic University's College of Engineering and Computer Science is spicing up the study of complex differential mathematical equations using relevant history of algebra. In a paper published in the Journal of Humanistic Mathematics, Isaac Elishakoff, Ph.D., provides a refreshing perspective and a special "shout out" to Stephen Colbert, comedian and host of CBS's The Late Show with Stephen Colbert. His motivation? Colbert previously referred to mathematical equations as ...

Children are protected from severe COVID-19 because their innate immune system is quick to attack the virus, a new study has found. The research led by the Murdoch Children's Research Institute (MCRI) and published in Nature Communications, found that specialised cells in a child's immune system rapidly target the new coronavirus (SARS-CoV-2). MCRI's Dr Melanie Neeland said the reasons why children have mild COVID-19 disease compared to adults, and the immune mechanisms underpinning this protection, were unknown until this study. "Children are less likely to become infected with the virus and up to a third are asymptomatic, which is strikingly different to ...

A new study, published in Bioscience, considers the future of ecology, where technological advancement towards a multidimensional science will continue to fundamentally shift the way we view, explore, and conceptualize the natural world. The study, co-led by Greg Asner, Director of the Arizona State University Center for Global Discovery and Conservation Science, in collaboration with Auburn University, the Oxford Seascape Ecology Lab, and other partners, demonstrates how the integration of remotely sensed 3D information holds great potential to provide new ecological insights on land and in the oceans. Scientific research into 3D digital applications in ecology has grown in the last decade. Landscape ...

With every passing day, human technology becomes more refined and we become slightly better equipped to look deeper into biological processes and molecular and cellular structures, thereby gaining greater understanding of mechanisms underlying diseases such as cancer, Alzheimer's, and others. Today, nanoimaging, one such cutting-edge technology, is widely used to structurally characterize subcellular components and cellular molecules such as cholesterol and fatty acids. But it is not without its limitations, as Professor Dae Won Moon of Daegu Gyeongbuk Institute of Technology (DGIST), Korea, lead scientist in a recent groundbreaking study advancing the field, explains: "Most advanced nanoimaging techniques use accelerated electron or ion beams ...

Messenger RNA (mRNA) vaccines to prevent COVID-19 have made headlines around the world recently, but scientists have also been working on mRNA vaccines to treat or prevent other diseases, including some forms of cancer. Now, researchers reporting in ACS' Nano Letters have developed a hydrogel that, when injected into mice with melanoma, slowly released RNA nanovaccines that shrank tumors and kept them from metastasizing. Cancer immunotherapy vaccines work similarly to mRNA vaccines for COVID-19, except they activate the immune system to attack tumors instead of a virus. These vaccines contain mRNA that encodes proteins made specifically by tumor cells. When the mRNA enters antigen-presenting cells, they begin making the tumor protein and displaying it on their surfaces, ...

Swimming in indoor or outdoor pools is a healthy form of exercise and recreation for many people. However, studies have linked compounds that arise from chlorine disinfection of the pools to respiratory problems, including asthma, in avid swimmers. Now, researchers reporting in ACS' Environmental Science & Technology have found that using a complementary form of disinfection, known as copper-silver ionization (CSI), can decrease disinfection byproducts and cell toxicity of chlorinated swimming pool water. Disinfecting swimming pool water is necessary to inactivate harmful pathogens. Although an effective ...

Washington, February 17, 2021--As higher education institutions worldwide transition to new methods of instruction, including the use of more pre-recorded videos, in response to the COVID-19 pandemic, many observers are concerned that student learning is suffering as a result. However, a new comprehensive review of research offers some positive news for college students. The authors found that, in many cases, replacing teaching methods with pre-recorded videos leads to small improvements in learning and that supplementing existing content with videos results in strong learning benefits. The study ...

Geologists have developed a new theory about the state of Earth billions of years ago after examining the very old rocks formed in the Earth's mantle below the continents. Assistant Professor Emma Tomlinson from Trinity College Dublin and Queensland University of Technology's Professor Balz Kamber have just published their research in leading international journal, Nature Communications. The seven continents on Earth today are each built around a stable interior called a craton, and geologists believe that craton stabilisation some 2.5 - 3 billion years ago was critical to the emergence of land masses on Earth. Little is known about how cratons and their supporting ...

A pioneering study of U.S nitrogen use in agriculture has identified 20 places across the country where farmers, government, and citizens should target nitrogen reduction efforts. Nitrogen from fertilizer and manure is essential for crop growth, but in high levels can cause a host of problems, including coastal "dead zones", freshwater pollution, poor air quality, biodiversity loss, and greenhouse gas emissions. The 20 nitrogen "hotspots of opportunity" represent a whopping 63% of the total surplus nitrogen balance in U.S. croplands, but only 24% of U.S. cropland area. In total, ...

Modern medical technology is helping scholars tell a more nuanced story about the fate of an ancient king whose violent death indirectly led to the reunification of Egypt in the 16th century BC. The research was published in Frontiers in Medicine. Pharaoh Seqenenre-Taa-II, the Brave, briefly ruled over Southern Egypt during the country's occupation by the Hyksos, a foriegn dynasty that held power across the kingdom for about a century (c. 1650-1550 BCE). In his attempt to oust the Hyskos, Seqenenre-Taa-II was killed. Scholars have debated the exact nature of the pharaoh's death since his mummy was first discovered and studied in the 1880s. These and subsequent examinations -- including an X-ray study in the 1960s -- noted the dead king had suffered several severe head injuries but no ...

Although interest in studying prosocial behaviors among U.S. Latinx individuals has increased recently, there is still limited existing research with this population. Evidence shows that prosocial behaviors (actions intended to benefit others) are a marker of healthy social functioning and can both support positive development (such as academic achievement) and mitigate problematic outcomes (such as anxiety and depression). An important question is whether prosocial behavior is fostered by parents in ways that are specific to their cultural groups or through more universal aspects of parenting. A new longitudinal study in the United States examined relations among parenting, culture, and prosocial behaviors in U.S. Mexican youth. The findings were published in a Child ...

Children raised in neighborhoods with low socio-economic status are at risk for low academic achievement. A new longitudinal study followed young children from such neighborhoods from birth until age seven to explore whether children's capacity to act kindly or generously towards others (prosocial behavior) - including peers, teachers, and family - is linked to their ability to perform well in school. The study showed that prosocial behavior may mitigate academic risk across early childhood. The findings were published in a Child Development article written by researchers at Stanford University and the University of Leeds, and the Bradford Institute for Health Research. "Identifying factors that can help children achieve academic ...

A research team in Korea has developed a ceramic fuel cell that offers both stability and high performance while reducing the required amount of catalyst by a factor of 20. The application range for ceramic fuel cells, which have so far only been used for large-scale power generation due to the difficulties associated with frequent start-ups, can be expected to expand to new fields, such as electric vehicles, robots, and drones. The Korea Institute of Science and Technology (KIST) announced that a team led by Dr. Ji-Won Son at the Center for Energy Materials Research, through joint research with Professor Seung Min Han at the Korea Advanced Institute of Science and Technology (KAIST), has developed a new technology ...

Your morning cereal or oatmeal. The bread on your sandwich. The corn chips for your snack, and the cookies for dessert. Not one would be possible with the humblest of ingredients: the seed. Seeds such as wheat, rice and corn directly provide about 70% of the calories eaten by people every day. And they ultimately provide nearly every morsel of food, either by providing feed for livestock or by being grown into fruits and vegetables. It's no overstatement to say that without seeds, civilization would be impossible. But seeds need our help. They are under stress from climate change, and under pressure to feed a growing population. Scores ...

Researchers from University of Calgary, University of Montana, HEC Paris, and University of Cincinnati published a new paper in the Journal of Marketing that explores the linguistic aspects of a name that can influence brand perceptions without people even realizing it. The study, forthcoming in the Journal of Marketing, is titled "Is Nestlé a Lady? The Feminine Brand Name Advantage" and is authored by Ruth Pogacar, Justin Angle, Tina Lowrey, L. J. Shrum, and Frank Kardes. What do iconic brands Nike, Coca-Cola, and Disney have in common? They all have linguistically feminine names. In fact, the highest-ranking companies on Interbrand's Global Top Brands list for the past twenty years have, on average, more feminine names than lower-ranked companies. ...

A study recently completed in Europe and North America indicates that the composition of wintering and breeding bird communities changes in line with global warming. However, wintering bird communities are considerably faster at tracking the changing climate compared to breeding communities. Climate change is driving species' distribution towards the poles and mountaintops, resulting in changes to bird communities. As a considerable share of birds are migratory species, with the distance they travel varying by species, the rate of change in bird communities is different in the breeding season and in the winter. ...