The mechanism that keeps arterial blood pressure stable in black and white tegu lizards (Salvator merianae) even as their body temperature varies substantially is more efficient at lower than higher external temperatures, contrary to what has always been believed, and vascular regulation plays a key role in pressure adjustments, according to an article published in PLOS ONE by researchers at the Federal University of São Carlos (UFSCar) in the state of São Paulo, Brazil. The research was supported by FAPESP. The findings pave the way for more investigation of the physiology of ectothermic animals, which rely on external environmental factors to regulate body temperature, and of novel applications for the method used in ...

A new study concluding out of Lusaka, Zambia last summer has found that as many as 19% (almost 1 in 5) of recently-deceased people tested positive for COVID-19. A new Boston University School of Public Health (BUSPH) study in Lusaka, Zambia's capital, challenges the common belief that Africa somehow "dodged" the COVID-19 pandemic. The findings indicate that low numbers of reported infections and deaths across Africa may simply be from lack of testing, with the coronavirus taking a terrible but invisible toll on the continent. Published in The BMJ, the study found that at least ...

Neutralizing antibodies develop within two weeks of a SARS-CoV-2 infection, but their durability and intensity can vary by individual, prompting concerns about the prospects of long-lasting immunity and efficacy of COVID-19 vaccines. In a PLOS ONE paper, published online February 11, 2021, researchers at University of California San Diego School of Medicine report that individual immune response to SARS-CoV-2, the virus that causes COVID-19, may be limited by the major histocompatibility complex or MHC, a set of variable genes that code for cell surface proteins essential for the adaptive immune system. Specifically, ...

Dreams take us to what feels like a different reality. They also happen while we're fast asleep. So, you might not expect that a person in the midst of a vivid dream would be able to perceive questions and provide answers to them. But a new study reported in the journal Current Biology on February 18 shows that, in fact, they can. "We found that individuals in REM sleep can interact with an experimenter and engage in real-time communication," said senior author Ken Paller (@kap101) of Northwestern University. "We also showed that dreamers are capable of comprehending questions, engaging in working-memory operations, and producing answers. ...

Dogs may be able to recognize their own body as an obstacle and also understand the consequences of their own actions, according to a study involving 32 pet dogs published in Scientific Reports. Previous research has shown that dogs have complex cognitive capabilities, such as empathy and social learning, but whether they also show any form of self-awareness was not clear. Péter Pongrácz and Rita Lenkei tested dogs in a 'body as an obstacle' task, during which the dogs had to pick up and give a toy to their owner, whilst standing on a small mat to which the toy was attached. In order to lift the toy, the dogs had to leave the mat. The authors found that dogs left the mat more frequently and sooner when the ...

The simplest of organic molecules have a much more complex relationship with oxygen than previously thought. Researchers from KAUST and their international collaborators have shown that alkanes participate extensively in autoxidation reactions with oxygen molecules1. The discovery, which overturns current chemical wisdom, has implications for air quality prediction and efficient fuel combustion in engines. Autoxidation is a chemical process in which oxygen molecules rapidly and sequentially add to organic molecules in a radical chain reaction. The process is critical for ...

New research published in Nature Food warns that heat stress in animals caused by rising temperatures and humidity will occur more frequently and for longer periods, impacting milk and meat productivity for dairy cattle, beef cattle, sheep, goat, pigs and poultry across East Africa. Analysis of historical data from 1981-2010 shows that livestock have already been progressively subjected to heat stress conditions. According to projections, this is set to worsen significantly, with severe implications for livestock unable to cope with the extra heat. Authors warn that 4-19% of current meat and milk production occurs in areas where dangerous heat stress conditions are likely to increase in frequency from 2071-2100. If climate conditions ...

The gut microbiome is an integral component of the body, but its importance in the human aging process is unclear. ISB researchers and their collaborators have identified distinct signatures in the gut microbiome that are associated with either healthy or unhealthy aging trajectories, which in turn predict survival in a population of older individuals. The work is set to be published in the journal Nature Metabolism. (Once the embargo lifts, you can access the paper here.) The research team analyzed gut microbiome, phenotypic and clinical data from over 9,000 people - between the ages of 18 and 101 years old - across three independent cohorts. The team focused, ...

Shifting world views and putting nature at the heart of decision-making is key to achieving transformative change COVID-19 recovery plans are an unmissable opportunity to invest in nature and reach net zero emissions by 2050 The world can transform its relationship with nature and tackle the climate, biodiversity and pollution crises together to secure a sustainable future and prevent future pandemics, according to a new report by the UN Environment Programme (UNEP) that offers a comprehensive blueprint for addressing our triple planetary emergency. The report, ...

As obesity becomes a growing issue worldwide - nearly tripling over the last-half century - scientists are trying to gain a better understanding of the condition at the molecular level. Now, new research led by UC San Francisco scientists suggests that a single protein could play an outsize role in weight gain. As reported in Nature Metabolism on February 18, 2021, UCSF's Davide Ruggero, PhD, and colleagues found that mice in which activity of a protein called eIF4E is diminished, either genetically or pharmaceutically, gain only half the weight of other mice, even if all the mice eat a high-fat diet. "These mice ...

What The Study Did: Characteristics associated with posttraumatic stress disorder in patients after severe COVID-19 were analyzed in this observational study. Authors: Delfina Janiri, M.D., of the Fondazione Policlinico Universitario Agostino Gemelli IRCCS in Rome, Italy, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (10.1001/jamapsychiatry.2021.0109) Editor's Note:  The article includes conflict of interest disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc. INFORMATION: Media ...

What The Study Did: This study examined how lockdowns during the COVID-19 pandemic changed the spoken communication environments of children with cochlear implants by comparing the sounds they were exposed to before and during the resulting closures of schools and nonessential businesses. Authors: Karen A. Gordon, Ph.D., of the University of Toronto and The Hospital for Sick Children in Toronto, Canada, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/  (doi:10.1001/jamaoto.2020.5496) Editor's Note: The article includes conflict of interest ...

What The Study Did: This is a diagnostic study that examines the accuracy and acceptability of a 3-dimensionally printed swab for identifying SARS-CoV-2. Authors: David M. Allen, M.D., of the National University of Singapore, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamaoto.2020.5680) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support. INFORMATION: Media ...

Over 20.5 million years of life may have been lost due to COVID-19 globally, with an average of 16 years lost per death, according to a study published in Scientific Reports. Years of life lost (YLL) - the difference between an individual's age at death and their life expectancy - due to COVID-19 in heavily affected countries may be two to nine times higher than YLL due to average seasonal influenza. Héctor Pifarré i Arolas, Mikko Mÿrskyla and colleagues estimated YLL due to COVID-19 using data on over 1,279,866 deaths in 81 countries, as well as life ...

Viruses are the most numerous biological entities on the planet. Now researchers at the Wellcome Sanger Institute and EMBL's European Bioinformatics Institute (EMBL-EBI) have identified over 140,000 viral species living in the human gut, more than half of which have never been seen before. The paper, published today (18 February 2021) in Cell, contains an analysis of over 28,000 gut microbiome samples collected in different parts of the world. The number and diversity of the viruses the researchers found was surprisingly high, and the data opens up new research avenues for understanding how viruses living in the gut affect human health. The human gut is an incredibly biodiverse environment. In addition to bacteria, hundreds of thousands of viruses ...

The incidence of surgical site infections after an operation is an important quality indicator for hospitals. An overview from six European countries published in 2017 documented increased costs and, in some cases, significantly poorer surgical outcomes due to SSIs. The European Center for Disease Control (ECDC) and authorities in the U.S. have therefore defined criteria for recording and documenting the rate of surgical site infections per procedure. Swissnoso has issued binding guidelines for Switzerland based on these criteria. The study investigated to what extent surgical site ...

Positron Emission Tomography (PET) plays a major role in the early detection of various types of cancer. A research group led by Specially Appointed Professor Katsumi Kaneko of the Research Initiative for Supra-Materials (RISM), Shinshu University have discovered a method to separate oxygen-18 from oxygen-16, an essential isotope for PET diagnosis, at high speed and high efficiency. The results of this research were recently published online in the journal Nature Communications. The novel method for the rapid and efficient separation of O-18 from O2-16, which ...

Covid-19 has not made people any less concerned about climate change - despite the pandemic disrupting and dominating many aspects of their lives, a study suggests. Over a period of 14 months - including the first three months of the Covid-19 lockdown - neither concern about climate change nor belief in the severity of the problem declined in the UK, the research found. Researchers compared responses to the pandemic with the financial crisis of 2008 to better understand how worries and priorities can change in a crisis. In contrast to the economic collapse of 2008, which led to reduced concern with environmental issues, the pandemic has not decreased people's belief in the severity of climate change. The findings shed light on how a concept called the finite pool ...

A team of researchers has devised a method using smartphones in order to measure food consumption--an approach that also offers new ways to predict physical well-being. "We've harnessed the expanding presence of mobile and smartphones around the globe to measure food consumption over time with precision and with the potential to capture seasonal shifts in diet and food consumption patterns," explains Andrew Reid Bell, an assistant professor in New York University's Department of Environmental Studies and an author of the paper, which appears in the journal Environmental Research Letters. Food consumption ...

Menopause is associated with several physiological changes, including loss of skeletal muscle mass. However, the mechanisms underlying muscle wasting are not clear. A new study conducted in collaboration between the universities of Minnesota (USA) and Jyväskylä (Finland) reveals that estrogen deficiency alters the microRNA signalling in skeletal muscle, which may activate signalling cascades leading to loss of muscle mass. Menopause leads to an estrogen deficiency that is associated with decreases in skeletal muscle mass and strength. This is likely due to changes in both muscle function and the size of muscle cells commonly referred to as fibers. "The mechanistic role of estrogen in the loss of muscle mass had not been established. In our study, we focused on signaling cascades ...

PHILADELPHIA--A significant number of non-Hodgkin lymphoma (NHL) patients in a Penn Medicine-initiated clinical trial continue to be in remission five years after receiving the chimeric antigen receptor (CAR) T cell therapy Kymriah™, researchers in Penn's Abramson Cancer Center reported today in the END ...

Tsukuba, Japan - Scientists at the University of Tsukuba demonstrated the possibility of electrons moving as if they were massless when certain materials called "topological insulators" are irradiated with laser beams. This work may lead to a new class of highly efficient electronic devices and photonic crystals. Conventional electronic devices rely primarily on silicon crystals. From the point of view of electrons that make up the electrical signals coursing through these materials, the systems are so big as to be practically endless. This causes most of the electronic structures ...

A unique brain protein measured in the blood could be used to diagnose Alzheimer's disease decades before symptoms develop, according to new Edith Cowan University (ECU) research. Published in Nature journal Translational Psychiatry, the study is the first to find that people with elevated glial fibrillary acidic protein (GFAP) in the blood also have increased amyloid beta in the brain, a known indicator of Alzheimer's disease. GFAP is a protein normally found in the brain, but it is released into the blood when the brain is damaged by early Alzheimer's disease. Alzheimer's disease affects more than 340,000 Australians and more than 35 million people in the world. Current ...

Scientists at EMBL Heidelberg and at the Zentrum für Infektiologie at Heidelberg University Hospital have succeeded for the first time in imaging HIV during transport into the nucleus of an infected cell. The electron tomographic images show the protein envelope of the virus passing through one of the nuclear pores - the openings in the membrane around the nucleus that allow molecules in and out. The scientists found that the virus passes through the nuclear pore intact, only breaking apart inside the nucleus, where it releases its genetic information. This clarifies an important mechanism by which the virus's genetic material is integrated into the genome of the infected cell. The human immunodeficiency virus type 1 (HIV-1) - which was ...

A highly porous metal organic framework, assembled from molecular building blocks designed to lock together in a specific orientation, has been developed by researchers at KAUST. Metal organic frameworks (MOFs) are crystalline materials made from metal ions connected by organic linkers. Their internal structure is like a repeating array of tiny identical cages, which are ideal for hosting various molecules. MOFs have found potential uses from gas sensing to molecular separations to storage, depending on the dimensions and structure of their pores. One family of MOFs has been inspired by inorganic porous materials called zeolites. Zeolites are a special class of porous material with ...