SINGAPORE, 19 January 2021 - Duke-NUS Medical School researchers, together with collaborators in Singapore, have designed armoured immune cells that can attack recurring cancer in liver transplant patients, while temporarily evading immunosuppressant drugs patients take to avoid organ rejection. The findings were published in the journal Hepatology. Hepatocellular carcinoma is the most common type of primary liver cancer and the sixth most common cancer worldwide. It often develops in people with chronic liver disease following hepatitis B infection. A common treatment for hepatocellular carcinoma is to completely ...

Topologically tailored photonic crystals (PhC) have opened up the possibility for attaining robust unidirectional transport of classical and quantum systems. The demand for unprecedented guiding capabilities that support unhindered transport around imperfections and sharp corners at telecom wavelengths, without the need for any optimization, is fundamental for efficient distribution of information through dense on-chip photonic networks. However, transport properties of experimental realizations of such topologically non-trivial states have been inferred by transmission measurements and even though robustness ...

Overview: A team of researchers led by Assistant Professor Yuki Arakawa (Toyohashi University of Technology, Japan) has successfully developed sulfur-containing liquid crystal (LC) dimer molecules1) with oppositely directed ester bonds, which exhibit a helical liquid crystal phase, viz. twist-bend nematic (NTB) phase, 2) over a wide temperature range, including room temperature. Collaboration with a team at the Advanced Light Source research facility (Lawrence Berkeley National Laboratory, USA) revealed that the ester bond direction in the molecular structures largely impacts the pitch lengths of helical nanostructures in the NTB phase. It is expected that this molecular design ...

Overview: A research group from the Active Intelligent System Laboratory (AISL) at Toyohashi University of Technology (TUT) has proposed a new framework for training mobile robots to quickly navigate while maintaining low collision rates. The framework combines deep reinforcement learning (DRL) and curriculum learning in the training process for robots to learn a fast but safe navigation policy. Details: One of the basic requirements of autonomous mobile robots is their navigation capability. The robot must be able to navigate from its current position to the specified target position ...

CHAMPAIGN, Ill. -- The fossilized insect is tiny and its genital capsule, called a pygophore, is roughly the length of a grain of rice. It is remarkable, scientists say, because the bug's physical characteristics - from the bold banding pattern on its legs to the internal features of its genitalia - are clearly visible and well-preserved. Recovered from the Green River Formation in present-day Colorado, the fossil represents a new genus and species of predatory insects known as assassin bugs. The find is reported in the journal Papers in Palaeontology. Discovered in 2006 by breaking open ...

Simple vision tests can predict which people with Parkinson's disease will develop cognitive impairment and possible dementia 18 months later, according to a new study by UCL researchers. The study, published in Movement Disorders, adds to evidence that vision changes precede the cognitive decline that occurs in many, but not all, people with Parkinson's. In another new study published today in Communications Biology, the same research team found that structural and functional connections of brain regions become decoupled throughout the entire brain in people with Parkinson's disease, particularly among people with vision problems. The ...

There are high hopes for the next generation of high energy-density lithium metal batteries, but before they can be used in our vehicles, there are crucial problems to solve. An international research team led by Chalmers University of Technology, Sweden, has now developed concrete guidelines for how the batteries should be charged and operated, maximising efficiency while minimising the risk of short circuits. Lithium metal batteries are one of several promising concepts that could eventually replace the lithium-ion batteries which are currently widely used - particularly in various types of electric vehicles. The big advantage of this new battery type is that the energy density can be significantly ...

New research suggests a unique program called Moms2B at The Ohio State University Wexner Medical Center shows a reduction in adverse pregnancy outcomes in communities disproportionately affected by these public health issues. The study, led by researchers Courtney Lynch and Erinn Hade and published in the Journal of Maternal and Child Health, indicates that women who attended at least two Moms2B sessions may have lower rates of preterm birth, low birth weight and infant mortality compared to women who only received individual care. "When we started the program 10 years ago, ...

New study identifies a bizarre new species suggesting that giant marine lizards thrived before the asteroid wiped them out 66 million years ago. A new species of mosasaur - an ancient sea-going lizard from the age of dinosaurs - has been found with shark-like teeth that gave it a deadly slicing bite. Xenodens calminechari, from the Cretaceous of Morocco, had knifelike teeth that were packed edge to edge to make a serrated blade and resemble those of certain sharks. The cutting teeth let the small, agile mosasaur, about the size of a small porpoise, punch above its weight, cutting fish in half and taking large bites from bigger animals. Dr Nick Longrich, Senior Lecturer at the Milner Centre for Evolution at the University of Bath and lead author on ...

Clumsy kids can be as aerobically fit as their peers with better motor skills, a new Finnish study shows. The results are based on research conducted at the Faculty of Sport and Health Sciences of the University of Jyväskylä and the Institute of Biomedicine of the University of Eastern Finland, and they were published in Translational Sports Medicine. Aerobic fitness doesn't go hand in hand with motor skills According to the general perception, fit kids also have good motor skills, while low aerobic fitness has been thought to be a link ...

A group of international scientists, including an Australian astrophysicist, has used knowhow from gravitational wave astronomy (used to find black holes in space) to study ancient marine fossils as a predictor of climate change. The research, published in the journal Climate of the Past, is a unique collaboration between palaeontologists, astrophysicists and mathematicians - to improve the accuracy of a palaeo-thermometer, which can use fossil evidence of climate change to predict what is likely to happen to the Earth in coming decades. Professor Ilya Mandel, from the ARC Centre of Excellence in Gravitational Wave Discovery (OzGrav), and colleagues, studied biomarkers left behind by tiny single-cell organisms called archaea in the distant past, including the Cretaceous period ...

In the strawberry nursery industry, a nursery's reputation relies on their ability to produce disease- and insect-free plants. The best way to produce clean plants is to start with clean planting stock. Many nurseries struggle with angular leaf spot of strawberry, a serious disease that can result in severe losses either by directly damaging the plant or indirectly through a violation of quarantine standards within the industry. Angular leaf spot is caused by the bacterial pathogen Xanthomonas fragariae. Current management strategies rely primarily ...

Chemotherapy and radiation treatments are known to cause harsh side effects that patients can see or feel throughout their bodies. Yet there are additional, unseen and often undiscussed consequences of these important therapies: the impacts on their future pregnancies and hopes for healthy children. Extensive evidence shows that chemotherapy and radiation treatments are genotoxic, meaning they can mutate the DNA and damage chromosomes in patients' cancerous and noncancerous cells alike. When this occurs in a germline cell - which are egg cells in women and sperm in men - it can lead to serious fetal and birth ...

A new type of ultra-efficient, nano-thin material could advance self-powered electronics, wearable technologies and even deliver pacemakers powered by heart beats. The flexible and printable piezoelectric material, which can convert mechanical pressure into electrical energy, has been developed by an Australian research team led by RMIT University. It is 100,000 times thinner than a human hair and 800% more efficient than other piezoelectrics based on similar non-toxic materials. Importantly, researchers say it can be easily fabricated through a cost-effective and commercially scalable method, using ...

A research team led by Nagoya University in Japan has found that blood pressure, the hematocrit (the percentage of red blood cells in blood), and serum cholesterol levels change in patients with Parkinson's disease long before the onset of motor symptoms. This finding, which was recently published online in Scientific Reports, may pave the way for early diagnosis and treatment of the disease. Parkinson's disease, the second most common disease affecting the nervous system after Alzheimer's disease, is caused by a deficiency in a neurotransmitter called dopamine. It is known that more than half of all dopaminergic neurons are already lost in patients with Parkinson's disease in the stage wherein they ...

India has an energy problem. It currently relies heavily on coal and consumer demand is expected to double by 2040, making its green energy targets look out of reach. Part of the solution could come from harvesting energy from footsteps, say Hari Anand and Binod Kumar Singh from the University of Petroleum and Energy Studies in Dehradun, India. Their new study, published in the De Gruyter journal Energy Harvesting and Systems, shows that Indian attitudes towards power generated through piezoelectric tiles are overwhelmingly positive. Cities like Delhi and Mumbai are famously crowded, especially at railway stations, temples and big commercial buildings. This led researchers to wonder whether piezoelectric tiles, which produce ...

Researchers have used the world's smallest, smartphone-sized DNA sequencing device to monitor hundreds of different bacteria in a river ecosystem. Writing in the journal eLife, the interdisciplinary team from the University of Cambridge, UK, provide practical and analytical guidelines for using the device, called the MinION (from Oxford Nanopore Technologies), to monitor freshwater health. Their guidelines promise a significantly more cost-effective and simple approach to this work outside the lab, compared to existing methods. Rowers and swimmers in Cambridge are regularly affected by waterborne infections such as Weil's disease, sometimes leading to public closures of the city's iconic waterways. Monitoring the microbial species in freshwater ...

Whether consciously or unconsciously, automotive firms time their product recalls to minimize stock price penalties, resulting in unnecessary delays and clusters of subsequent recalls by other companies, according to new research from the University of Notre Dame. An initial recall by one firm prompts clusters of additional recalls in close proximity by competitor firms, according to "Hiding in the Herd: The Product Recall Clustering Phenomenon," forthcoming in Manufacturing and Service Operations Management from Kaitlin Wowak, assistant professor of IT, analytics, and operations at Notre Dame's Mendoza College of Business. According to the study, "Automobile recalls seem to be announced after inexplicable delays. Toyota's unintended acceleration recall and General ...

Nearly 78 per cent of children with autism have at least one mental health condition and nearly half have two mental health conditions or more, according to a new U.S. study from the University of British Columbia's department of psychology and the AJ Drexel Autism Institute at Drexel University (Pennsylvania). The study also found mental health conditions present in 44.8 per cent of pre-school age children with autism. The scope of the issue among that age group had not previously been established using a large, population-based sample. By contrast, the study found that only 14.1 per cent of youth without autism (ages 3-17) had mental health conditions. It is the first research since 2008 to examine the prevalence of mental health conditions among children with autism at a population ...

Malta, a sovereign microstate in the middle of the Mediterranean Sea, has no shortage of sunny beaches, honey-bricked villages and rugged countryside. Beyond its Mediterranean charm, Malta is home to a geographically and culturally isolated population whose unique genetic makeup, makes this island nation a goldmine for genetics research. Four years ago, the University of Malta set up a national ALS Registry and Biobank to identify patients with amyotrophic lateral sclerosis (ALS) and collect data on their residence, occupation, lifestyle and environmental exposures. Blood samples ...

With the global student community taking online courses as a result of the anti-Covid-19 measures, a study led by the University of Geneva (UNIGE) reveals that online courses deepen inequalities between gifted and less gifted students by 5%. The results of the study, which was based on data collected in 2016-2017 prior to the anti-Covid lockdown initiatives, are published in the Journal of the European Economic Association. They indicate that this learning gap between different student profiles is mainly due to their behaviour and motivation. The study gives higher education establishments worldwide practical ways to deal with lockdown or the chronic lack of space in lecture theatres, including via co-educational ...

Cancer cells are smart when it comes to anti-cancer drugs, evolving and becoming resistant to even the strongest chemotherapies over time. To combat this evasive behavior, researchers have developed a method named D2O-probed CANcer Susceptibility Test Ramanometry (D2O-CANST-R) to see, at single-cell/organelle level, how pharmaceuticals induce cancer cell death and how cancer cells adapt. The research, conducted by the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences (CAS), was published on Jan. 12 in Analytical Chemistry, ...

A new study by researchers from Chulalongkorn University, Tohoku University, and The George Washington University is the first to identify autism candidate genes that may be responsible for the sex-specific effects of bisphenol A (BPA) on the brain. It suggests BPA may serve as an environmental factor that contributes to the prevalence of male bias in autism spectrum disorder (ASD). The research was published in the journal Scientific Reports. BPA is widely used in many products in our daily life and abundant in micro/nanoplastics found in the environment, ...

Summary Ultra-small nanomedicines of approximately 18 nm were fabricated by dynamic ion-pairing between Y-shaped block copolymers and nucleic acid drugs, such as siRNA and antisense drugs. Chemically modified and double-stranded oligonucleotides dramatically enhanced the stability of the ultra-small nanomedicines in the blood circulation. The ultra-small size allows for high permeability in cancer tissues by slipping through the cracks in tumor vasculatures and stromal tissues. Clinical trials and preclinical studies using the developed ultra-small nanomedicines are proceeding for cancer therapy. Published in the website of Journal of Controlled Release on January 6. https://doi.org/10.1016/j.jconrel.2021.01.001 Main body January 19, 2021 - Kawasaki in ...

The survival of pesky little flies in showers and other wet areas around the house, impervious to water droplets that may be larger than they are, comes down to more than quick reflexes. The insects have evolved a unique coating of hairs that allows them to shrug off water droplets of almost any size, KAUST researchers have shown. Sigurdur Thoroddsen, who leads the high-speed fluids imaging laboratory at KAUST, couldn't help but take a professional interest in the small drain flies that made a home in his shower and never seemed to wash away. Thoroddsen's research focuses on multiphase flow and dynamics at air-liquid interfaces -- an environment where drain flies have found a niche, despite some risky physics. Insects are so small that the surface tension of ...