JACKSONVILLE, Fla. -- A marker of immune function that predicts for better outcomes in patients treated with chemotherapy for triple negative breast cancer is also linked to improved prognosis in patients treated with chemotherapy for HER2-positive breast cancer. But that marker -- the quantity of tumor-infiltrating lymphocytes (S-TILs) in a biopsy -- appears irrelevant when trastuzumab is used. And since trastuzumab, and not chemotherapy alone, is the standard of care for the HER2-positive sub-class of breast cancer, there is no need to test for these lymphocytes in ...

In patients with metastatic triple-negative breast cancer--a disease with no approved targeted therapies--infusion of pembrolizumab produced durable responses in almost one out of five patients enrolled in a phase-Ib clinical trial, according to data presented Dec. 10, at the 2014 San Antonio Breast Cancer Symposium. The multi-center, non-randomized trial was designed to evaluate the safety, tolerability and antitumor activity of bi-weekly infusions of pembrolizumab (MK-3475, marketed as Keytruda®). The researchers enrolled 27 patients, aged 29 to 72 years, who had ...

Several past studies have suggested that the magnetic fields created by phones, high-voltage power lines and other electrical equipment are harmful for humans. Research first carried out in the 1970's and again subsequently, found an association between people living near overhead power lines and an increased risk of childhood leukaemia. Although some later studies have failed to find such a link, the International Agency for Research on Cancer has categorised low frequency magnetic fields as "possibly carcinogenic." But a mechanism for this association has never been ...

While many different combinations of genetic traits can cause autism, brains affected by autism share a pattern of ramped-up immune responses, an analysis of data from autopsied human brains reveals. The study, a collaborative effort between Johns Hopkins and the University of Alabama at Birmingham, included data from 72 autism and control brains. It will be published online Dec. 10 in the journal Nature Communications. "There are many different ways of getting autism, but we found that they all have the same downstream effect," says Dan Arking, Ph.D. , an associate professor ...

HOUSTON - (Dec. 10, 2014) - Researchers at Rice University have created flexible, patterned sheets of multilayer graphene from a cheap polymer by burning it with a computer-controlled laser. The process works in air at room temperature and eliminates the need for hot furnaces and controlled environments, and it makes graphene that may be suitable for electronics or energy storage. Under a microscope, what the researchers call laser-induced graphene (LIG) doesn't look like a perfect chicken wire-like grid of atoms. Instead, it's a jumble of interconnected graphene flakes ...

Phoenix, AZ (December 10th, 2014) - The brain responds differently to two kinds of sugar, according to a report today at the American College of Neuropsychopharmacology annual meeting in Phoenix Arizona. The study suggests that fructose heightens the response of brain reward circuits to food cues, promoting feeding behavior. Currently, roughly two out of three U.S. adults are overweight and one out of three is obese. Changes in lifestyle and dietary intake during the past quarter century are thought to be the main culprits, with the increase in fructose consumption of ...

PISCATAWAY, NJ - Communities with fewer places to buy or drink alcohol also tend to have lower rates of intimate partner violence, new evidence suggests. The research, published in the January issue of the Journal of Studies on Alcohol and Drugs, suggests that laws limiting what is called "alcohol outlet density" could offer one way to address violence within intimate relationships. States and communities throughout the United States have enacted various laws to reduce excessive use of alcohol, including limiting outlet density, limiting hours and days of sale, and ...

The simple act of saving something, such as a file on a computer, may improve our memory for the information we encounter next, according to new research published in Psychological Science, a journal of the Association for Psychological Science. The research suggests that the act of saving helps to free up cognitive resources that can be used to remember new information. Our findings show that people are significantly better at learning and remembering new information when they save previous information," says psychological scientist and study author Benjamin Storm of ...

PITTSBURGH, Dec. 9, 2014 - A treatment pioneered at the University of Pittsburgh Center for Vaccine Research (CVR) is far more effective than traditional antibiotics at inhibiting the growth of drug-resistant bacteria, including so-called "superbugs" resistant to almost all existing antibiotics, which plague hospitals and nursing homes. The findings, announced online in the journal Antimicrobial Agents and Chemotherapy and funded by the National Institutes of Health, provide a needed boost to the field of antibiotic development, which has been limited in the last four ...

Berkeley -- A systematic overview of more than 100 studies comparing organic and conventional farming finds that the crop yields of organic agriculture are higher than previously thought. The study, conducted by researchers at the University of California, Berkeley, also found that certain practices could further shrink the productivity gap between organic crops and conventional farming. The study, to be published online Wednesday, Dec. 10, in the Proceedings of the Royal Society B, tackles the lingering perception that organic farming, while offering an environmentally ...

In an editorial published online today in the International Journal of Epidemiology, experts from the Departments of Psychiatry and Epidemiology at Columbia University, New York, are calling for survivors of the Ebola epidemic to be mobilised in a bid to hasten containment of the disease. We already know that the current Ebola outbreak is unique in its magnitude and for its dispersion in dense, mobile populations. Physicians and nurses face high mortality, and foreign aid in the form of medical supplies and staff continues to be unequal to the scope of the problem. With ...

In a world first study researchers have found a coral-eating fish that disguises its smell to hide from predators. "For many animals vision is less important than their sense of smell," says study lead author Dr Rohan Brooker from the ARC Centre of Excellence for Coral Reef Studies (Coral CoE) at James Cook University. "Because predators often rely on odors to find their prey, even visually camouflaged animals may stick out like a sore thumb if they smell strongly of 'food'." Dr Brooker says. The research, published in the journal Proceedings of the Royal Society B, ...

In a report published today in the journal of Diabetes, Obesity and Metabolism, researchers from Cardiff University were also able to show a correlation between patients treated with a higher dosage of insulin and a raised risk of cancer development, heart attacks and stroke. Researchers identified these trends by scrutinizing the medical history of 6,484 patients with type 2 diabetes extracted from the UK Clinical Practice Research Datalink (CPRD). Patients were on average aged 64 at the beginning of the study in 2000, and were followed for an average of 3 years from ...

Fathering offspring is more than just a race to the egg Longer sperm are better at fertilising eggs, study reveals But females also influence a male's fertilising success Research may produce clues to understanding human fertility The chance of a male fathering offspring may not be a simple race to the egg, but is influenced by the length of the male's sperm, say scientists from the University of Sheffield. Using a captive population of zebra finches, the researchers carried out sperm competition experiments between pairs of males, where one male consistently ...

Annual NHS spending on management consultancy has doubled from £313m to £640m between 2010 and 2014, despite a promise by Health Secretary Andrew Lansley to 'slash' spending after the 2010 election, reveals an article in The BMJ this week. This is enough to run three medium sized hospitals or employ about 2000 extra nurses, says David Oliver, a former clinical director at the Department of Health, who obtained the figures through a Freedom of Information request. "In times of war, arms dealers, rebuilders, and racketeers profit from the chaos," he writes. ...

Since August 2009 all UK trainee doctors have been restricted to a 48 hour week, but some say this has had negative effects on the quantity and quality of medical training. Is there any evidence to substantiate these fears? Doctors discuss the issue in The BMJ this week. Andrew Hartle and Sarah Gibb of the Association of Anaesthetists of Great Britain and Ireland find no evidence that implementation of the European Working Time Directive has led to a decline in the quality of training. They point out that several reviews on the impact of restricting working time have ...

Poor professional performance is an unlikely cause of delays in referral for suspected cancer, argue researchers in The BMJ this week. Instead, such delays largely reflect "limitations in scientific knowledge and in the organisation and delivery of healthcare." And they question government plans to rank general practices according to how promptly patients are referred to specialist services for suspected cancer. Most patients who have cancer diagnosed after the onset of symptoms are referred after one or two GP consultations (80%), but a substantial minority (20%) ...

Most exaggeration in health related science news is already present in academic press releases, finds a study published in The BMJ this week. The researchers suggest that improving the accuracy of academic press releases "could represent a key opportunity for reducing misleading health related news." Health related news has widespread potential to influence health related behaviour but often misreports the science. It is not known whether exaggerations - claims going beyond those made in the research paper - originate in the news stories themselves or in press releases ...

The analysis of 3,494 contracts awarded by 182 Clinical Commissioning Groups (CCGs) in England between April 2013 and August 2014 - disclosed to the BMJ under the Freedom of Information (FOI) Act - showed that in total, non NHS providers have secured 45% of contracts awarded since April 2013. A total of 1,149 contracts (33%) were awarded to private sector providers, 335 contracts (10%) were awarded to voluntary and social enterprise sector providers, while 100 contracts (2%) were awarded to other providers, such as joint ventures or local authorities. A further 1,910 ...

WASHINGTON, DC (December 9, 2014)--A study published today in the Journal of the American Medical Association (JAMA) shows that physicians who do residency training in regions of the country with higher health care spending patterns continue to practice in a more costly manner - even when they move to a geographic area where health care spending is lower. Immediately following residency, physicians whose residencies were in higher-spending regions spent 29 percent more on average than their peers who had trained in lower-spending areas of the country, according to the ...

The cognitive effects of poverty can be mitigated during middle school with a targeted intervention, according to researchers at the Center for BrainHealth at The University of Texas at Dallas. In a paper published today in the open-access journal Frontiers in Human Neuroscience, researchers for the first time examine the efficacy of cognitive training in a large and diverse group of 7th and 8th grade public middle school students as compared to typically developing students who received no specific training. "Previous research has shown that growing up in poverty ...

Rules don't reduce death, morbidity or adverse effects Surgeon who best knows patient should continue with critical care Restrictions may hurt patient safety CHICAGO --- Controversial restrictions on hospital residents' duty hours imposed in 2011 did not improve surgery patients' outcomes, reports a large new Northwestern Medicine study of U.S. hospitals, one of the first national evaluations of the results of the restrictions. The restrictions also did not result in any differences in surgical residents' performance on exams. "Our study suggests that these ...

An examination of the effect of resident duty hour reforms in 2011 finds no significant change in mortality or readmission rates for hospitalized patients, according to a study in the December 10 issue of JAMA, a theme issue on medical education. In 2011, the Accreditation Council for Graduate Medical Education (ACGME) implemented new duty hour reforms for all ACGME-accredited residency programs. The revisions maintain the weekly limit of 80 hours set forth by the 2003 duty hour reforms but reduced the work hour limit from 30 consecutive hours to 16 hours for first­year ...

An examination of the effect of resident duty hour reforms in 2011 finds no significant change in outcomes for general surgery patients, according to a study in the December 10 issue of JAMA, a theme issue on medical education. Ravi Rajaram, M.D., of the American College of Surgeons, Chicago, and colleagues conducted a study to determine if the 2011 Accreditation Council for Graduate Medical Education (ACGME) duty hour reform was associated with a change in general surgery patient outcomes or in resident examination performance. The study examined general surgery patient ...

Among primary care physicians, the spending patterns in the regions in which their residency program was located were associated with expenditures for subsequent care they provided as practicing physicians, with those trained in lower-spending regions continuing to practice in a less costly manner, even when they moved to higher-spending regions, and vice versa, according to a study in the December 10 issue of JAMA, a theme issue on medical education. Regional and system-level variations in Medicare spending and overall intensity of medical services delivered to patients ...