Current drugs may stop working against the most common type of brain tumor in children, medulloblastoma, but the tumor could be targeted in a new way, according to Stanford University scientists. In research to be published in the journal eLife, a team led by Prof. Matthew P. Scott at the University's School of Medicine tested a drug called Roflumilast in mice with a brain tumor that is resistant to Vismodegib, the drug in current use. Roflumilast is normally used to treat inflammatory lung diseases. It dramatically inhibited tumor growth from the first day of treatment. ...

This news release is available in French. Montreal, September 15th 2015 - It is estimated that half of all cancer patients suffer from a muscle wasting syndrome called cachexia. Cancer cachexia impairs quality of life and response to therapy, which increases morbidity and mortality of cancer patients. Currently, there is no approved treatment for muscle wasting but a new study from the Research Institute of the McGill University Health Centre (RI-MUHC) and University of Alberta could be a game changer for patients, improving both quality of life and longevity. The ...

To better inform the tradeoffs involved in land use choices around the world, experts have assessed the value of ecosystem services provided by land resources such as food, poverty reduction, clean water, climate and disease regulation and nutrients cycling. Their report today estimates the value of ecosystem services worldwide forfeited due to land degradation at a staggering US $6.3 trillion to $10.6 trillion annually, or the equivalent of 10-17% of global GDP. Furthermore, the problem threatens to force the migration of millions of people from affected areas. ...

Solar energy is abundantly available globally, but unfortunately not constantly and not everywhere. One especially interesting solution for storing this energy is artificial photosynthesis. This is what every leaf can do, namely converting sunlight to chemical energy. That can take place with artificial systems based on semiconductors as well. These use the electrical power that sunlight creates in individual semiconductor components to split water into oxygen and hydrogen. Hydrogen possesses very high energy density, can be employed in many ways and could replace fossil ...

Amsterdam, NL, September 9, 2015 - The potential benefits of dietary cocoa extract and/or its final product in the form of chocolate have been extensively investigated in regard to several aspects of human health. Cocoa extracts contain polyphenols, which are micronutrients that have many health benefits, including reducing age-related cognitive dysfunction and promoting healthy brain aging, among others. Dr. Giulio Maria Pasinetti, MD, PhD, Saunders Family Chair and Professor of Neurology at the Icahn School of Medicine at Mount Sinai, Director of Biomedical Training ...

OAK BROOK, Ill. - Imaging patients soon after traumatic brain injury (TBI) occurs can lead to better (more accurate) detection of cerebral microhemorrhages, or microbleeding on the brain, according to a study of military service members, published online in the journal Radiology. Cerebral microhemorrhages occur as a direct result of TBI and can lead to severe secondary injuries such as brain swelling or stroke. The ability to monitor the evolution of microhemorrhages could provide important information regarding disease progression or recovery. According to the Centers ...

CHARLOTTESVILLE, VA (SEPTEMBER 15, 2015). Management of Myelomeningocele Study (MOMS) investigators analyzed updated data on the effects of prenatal myelomeningocele closure on the need for placement of a cerebrospinal fluid (CSF) shunt within the first 12 months of life. These researchers reaffirm the initial MOMS finding that prenatal repair of a myelomeningocele results in less need for a shunt at 12 months and introduce the new finding that prenatal repair reduces the need for shunt revision in those infants who do require shunt placement. The researchers also found ...

In what is believed to be the largest, most detailed study of its kind in the United States, scientists at NYU Langone Medical Center and elsewhere have confirmed that tiny chemical particles in the air we breathe are linked to an overall increase in risk of death. The researchers say this kind of air pollution involves particles so small they are invisible to the human eye (at less than one ten-thousandth of an inch in diameter, or no more than 2.5 micrometers across). In a report on the findings, published in the journal Environmental Health Perspectives online Sept. ...

Amsterdam, The Netherlands, September 15, 2015 -- Prolonged sitting time as well as reduced physical activity contribute to the prevalence of non-alcoholic fatty liver disease (NAFLD) in a study of middle-aged Koreans. These findings support the importance of both reducing time spent sitting and increasing physical activity, say researchers. Their results are published in the Journal of Hepatology. Physical activity is known to reduce the incidence and mortality of various chronic diseases. However, more than one half of the average person's waking day involves sedentary ...

PHILADELPHIA -- Recent data suggest that epigenetic therapies are likely to provide additional clinical benefit to cancer patients when rationally combined with immunotherapeutic drugs, according to a review published in Clinical Cancer Research, a journal of the American Association for Cancer Research. "The term epigenetics refers to the study of cellular changes in gene expression that are heritably transmitted during cell replication," said Michele Maio, MD, PhD, chair of medical oncology and immunotherapy, Ospedale Santa Maria alle Scotte, Istituto Toscano Tumori, ...

Video games are not adequately rated for tobacco content, according to a new UC San Francisco study that found video gamers are being widely exposed to tobacco imagery. The researchers concluded that a national ratings board set up more than 20 years ago is not a reliable source for learning whether video games contain tobacco imagery. The study will be published online September 14 in Tobacco Control. "Parents should stop relying on the ratings to screen for tobacco use in buying video games for their kids," said first author Susan Forsyth, a PhD candidate at ...

Working shifts of 16 to 24 hours in length is linked to a 60% heightened risk of injury and illness among emergency services (EMS) clinicians, compared to shifts of 8-12 hours, finds research published online in Occupational & Environmental Medicine. This risk rises in tandem with shift length, the findings show. The nature of the job requires physical strength to lift and move patients, clear mental focus to deliver medical care in uniquely stressful and often chaotic situations, and sufficient alertness to drive safely, say the researchers. Yet EMS clinicians often ...

The 3M software program, increasingly used to make payments to US hospitals based on readmission rates, doesn't clearly distinguish differences in care quality--one of the key factors involved in readmission--between readmissions that are preventable and those that aren't, suggests research published online in BMJ Quality and Safety. The Centers for Medicare and Medicaid Services (CMS) posts data on 30 day readmissions for three common causes of hospital admissions: heart attack; heart failure; and pneumonia. Hospitals with high rates of readmissions are penalised ...

A study of 350,000 patients with type 2 diabetes shows that those with poor blood sugar control have 50% higher risk of being admitted to hospital in future for dementia as those with good control. The research, which suggests improving blood sugar control could prevent many cases of dementia, is by Dr Aidin Rawshani, National Diabetes Register and Institute of Medicine, Gothenburg, Sweden, and colleagues, and is presented at this year's annual meeting of the European Association for the Study of Diabetes (EASD) in Stockholm. Evidence is growing that diabetes increases ...

New research presented at this year's annual meeting of the European Association for the Study of Diabetes in Stockholm shows that diabetic women are more at risk than diabetic men of having a heart attack and other complications as they age. The study is by Dr Giuseppe Seghieri, Regional Health Agency, Florence, Italy, and colleagues. Previous research has revealed that diabetic women have a higher risk of cardiovascular events than diabetic men, when compared with the respective non-diabetic counterparts. However, it is unclear when this risk begins or how long it ...

A systematic review and meta-analysis of 19 studies containing almost 11 million patients shows that diabetic women are around 40% more likely to suffer acute coronary syndromes (heart attack or angina) than diabetic men. The study is by Dr Xue Dong, the Affiliated ZhongDa Hospital of Southeast University, Nanjing, China, and colleagues, and is presented at this year's annual meeting of the European Association for the Study of Diabetes (EASD) in Stockholm. Diabetes is a strong risk factor for acute coronary syndrome, yet whether diabetes confers the same excess risk ...

In 2013, England performed better than average on a variety of key health outcomes compared with 18 other high-income countries in the European Union [1], and Australia, Canada, Norway, and the USA (EU15+), according to new research published in The Lancet. However, the findings also reveal the impact of substantial health disparities within English regions, the significant toll of chronic disabling conditions, and the importance of tackling preventable diseases. It is likely that around 40% of NHS workload is due to potentially preventable risk factors. Using data ...

An international panel of experts applied the RAND/UCLA Appropriateness Method to develop criteria for use of peripherally inserted central catheters (PICCs). The Michigan Appropriateness Guide for Intravenous Catheters (MAGIC) is published as a supplement in Annals of Internal Medicine. Use of PICCs has become popular for venous access in hospital settings but their use can result in important complications, such as thrombosis and infection. In addition, a growing number of studies suggest substantial variation and potentially inappropriate use of PICCs in hospitalized ...

Cost of Sustaining a Patient-Centered Medical Home More than $100,000 per Full Time Physician Annually With primary care practices in the United States aggressively shifting to the patient-centered medical home model of care, researchers examine the costs to deliver PCMH functions and find even partial implementation costs approximately $105,000 per full time equivalent provider annually. Using a PCMH cost dimensions tool, researchers assessed costs associated with activities uniquely required to maintain PCMH functions at a diverse group of 20 primary care practices in ...

BOSTON--September 14, 2015--Researchers from Harvard-affiliated Hebrew SeniorLife Institute for Aging Research (IFAR), in collaboration with scientists from a number of international institutes, have identified a genetic variant regulating a gene responsible for bone mineral density and fracture risk. Findings from this study--funded in part by grants from the National Institutes of Health (NIH)--are published in the journal Nature and could lead to interventions that may prevent fractures in older adults. Osteoporosis, a word meaning "porous bone," is a disease that ...

The buildup of a substance in the pancreas during the pre-symptomatic stage of Type 1 diabetes is essential to the development of the disease, Stanford University School of Medicine researchers have shown. The investigators used a drug to block production of this substance in mouse models, staving off damage to insulin-producing cells and preventing the onset of the autoimmune disorder. The drug, which is currently used in Europe and Asia for treating gallstone-related spasms, has an excellent safety record, the researchers said. The findings, described in a study to ...

DALLAS, Sept. 14, 2015 -- Black patients and patients with low socioeconomic status have shorter life expectancies after a heart attack. However, the largest racial differences in life expectancy after a heart attack occur in patients with high socioeconomic status, according to research in the American Heart Association journal Circulation. "Race and socioeconomic status are intimately related, with black individuals bearing a disproportionate burden of the poverty and health inequalities in the U.S.," said Emily Bucholz, M.D., MPH, Ph.D., lead author of the study and ...

The processes of globalization should have contributed to reduced inequality in the world. In reality, however, the situation looks differently, with income inequality in the populations of developing economies growing. To correct this, the level of education of low-skilled workers must be increased, said Eric Maskin, Chief Research Fellow at the HSE International Laboratory of Decision Choice and Analysis and Nobel Laureate in Economics for 2007. In the last 20 years, the world has experienced unprecedented growth in global markets. Trading borders between countries ...

TV screens that roll up. Roofing tiles that double as solar panels. Sun-powered cell phone chargers woven into the fabric of backpacks. A new generation of organic semiconductors may allow these kinds of flexible electronics to be manufactured at low cost, says University of Vermont physicist and materials scientist Madalina Furis. But the basic science of how to get electrons to move quickly and easily in these organic materials remains murky. To help, Furis and a team of UVM materials scientists have invented a new way to create what they are calling "an electron ...

Free - or very inexpensive - online courses have become quite a trend in education. Massive Open Online Course (MOOC) providers currently offer thousands of courses and have enticed millions of students to enroll. The emphasis in MOOCs is often on lecture videos that students watch and learn from. However, a study published in the Proceedings of the Second (2015) ACM Conference on Learning @ Scale shows that this central approach of MOOCs - having students watch to learn - is ineffective. Instead, the emphasis on interactive activities as advocated by Carnegie Mellon ...