A new study from UC San Francisco is the first to show that while the impact of life's stressors accumulate overtime and accelerate cellular aging, these negative effects may be reduced by maintaining a healthy diet, exercising and sleeping well. "The study participants who exercised, slept well and ate well had less telomere shortening than the ones who didn't maintain healthy lifestyles, even when they had similar levels of stress," said lead author Eli Puterman, PhD, assistant professor in the department of psychiatry at UCSF. "It's very important that we promote ...

About 100 drugs already approved by the U.S. Food and Drug Administration (FDA) for other purposes can also prevent the growth of certain bacterial pathogens inside human cells, including those that cause Legionnaires' disease, brucellosis, and Mediterranean spotted fever. The findings, published in mBio®, the online open-access journal of the American Society for Microbiology, demonstrate a new way of identifying non-antibiotic drugs that could one day help curb bacterial infections. A handful of drugs on the list inhibit the growth of at least three of the four bacterial ...

Two beneficial variants of a gene controlling red blood cell development have spread from Africa into nearly all human populations across the globe, according to a new study led by King's College London. The international team studied the genomes of world populations to look for the origin of changes in a key regulator gene which stimulate fetal haemoglobin production into adulthood. Fetal haemoglobin is normally found in fetuses and infants, but some patients with inherited blood disorders who are able to keep making it as adults experience milder symptoms of their condition. Sickle ...

Cancer cells are gluttons. We have long known that they monopolize large amounts of sugar. More recently, it became clear that some tumor cells are also characterized by a series of features such as mobility or unlikeliness to join in an ordered set. Researchers are calling this behavior "mesenchymal," and they suspect it promotes metastasis. At EPFL, Etienne Meylan's research team was able to demonstrate that the two observations – appetite for sugar and mesenchymal behavior – result from the same mechanism, at least in "non-small cell lung cancer." They also showed ...

New research published in Diabetologia (the journal of the European Association for the Study of Diabetes) suggests that both higher levels of physical activity and lower levels of sitting in leisure time may be required to substantially reduce the risk of obesity. The research is by Joshua Bell and colleagues, Department of Epidemiology and Public Health, UCL (University College London), UK. Physical activity and sitting time (or 'sedentariness') are two common lifestyle-related behaviours associated with obesity and metabolic health, as well as with chronic diseases ...

Deerfield, Ill. (July 28, 2014) – An international research team today reports the first-ever clinical trial demonstrating controlled malaria infection in an African nation in the modern era. The study, published online in the American Journal of Tropical Medicine and Hygiene (AJTMH) represents a significant milestone in the search for new malaria drugs and vaccines. The study establishes that in controlled laboratory conditions in Africa, a new product containing frozen, preserved whole sporozoites, an infectious stage of the malarial parasite Plasmodium falciparum, ...

1. Early menopausal hormone therapy shows no effect on atherosclerosis progression Early initiation of menopausal hormone therapy (MHT) improves some markers of cardiovascular disease (CVD) but does not affect the progression of atherosclerosis, according to a study being published in Annals of Internal Medicine. CVD is the leading cause of death in women and incidence increases after menopause. Research suggests that cardiovascular benefits of MHT may be limited to women who begin treatment at a younger age, closer to menopause, or both. Researchers conducted a randomized ...

NEW YORK (Monday, July 28 – 5 p.m. ET): Surgical patients who are placed in contact isolation after their operations are at a particularly high risk for developing life-threatening blood clots, but ensuring they move around has helped curb the occurrence of venous thromboembolism (VTE) in one hospital. This case study on how one surgical team prevented VTEs in their patients placed in isolation was presented today by researchers from the department of surgery at Carilion Clinic Roanoke Memorial Hospital, Roanoke, VA at the American College of Surgeons National Surgical ...

Norwegian explorer Roald Amundsen reached the South Pole in 1911, but new research shows that industrial air pollution arrived long before any human. Using data from 16 ice cores collected from widely spaced locations around the Antarctic continent, including the South Pole, a group led by Joe McConnell of the Desert Research Institute (DRI) in Reno, Nevada, created the most accurate and precise reconstruction to date of lead pollution over Earth's southernmost continent. The new record, described in an article published today in the online edition of the Nature Publishing ...

An international team of researchers led by the University of Arizona has sequenced the complete genome of African rice. The genetic information will enhance scientists' and agriculturalists' understanding of the growing patterns of African rice, as well as enable the development of new rice varieties that are better able to cope with increasing environmental stressors to help solve global hunger challenges. The paper, "The genome sequence of African rice (Oryza glaberrima) and evidence for independent domestication," was published online in Nature Genetics on Sunday. The ...

Dr. Nicole R. Fowler and her fellow reserachers have found that patients with dementia were more likely to receive a pacemaker then patients without cognitive impairment. Older adults with mild cognitive impairment (MCI) and dementia can have co-existing cardiac illnesses and that makes them eligible for therapy with devices to correct rhythm abnormalities. But the risks and benefits need to be weighed carefully with patients, families and clinicians. The authors examined data from the National Alzheimer Coordinating Center Uniform Data Set gathered from 33 Alzheimer ...

Bottom Line: An electronic screening tool that starts with a single question to assess the frequency of substance misuse appears to be an easy way to screen teenagers who visited a physician for routine medical care. Author: Sharon Levy, M.D., M.P.H., of Boston Children's Hospital, and colleagues. Background: Substance use can cause illness and death in adolescents. Screening adolescents and intervening if there is substance use can reduce the burden of addiction. The American Academy of Pediatrics and other professional organizations recommend that primary care physicians ...

PITTSBURGH, July 28, 2014 -- People with dementia are more likely to get implanted pacemakers for heart rhythm irregularities, such as atrial fibrillation, than people who don't have cognitive difficulties, according to researchers at the University of Pittsburgh School of Medicine. In a research letter published online today in JAMA Internal Medicine, the researchers noted the finding runs counter to expectations that less aggressive interventions are the norm for patients with the incurable and disabling illness. To look at the relationships between cognitive status ...

A revised version of a surgical procedure to treat severe chronic migraine headaches led to significant symptom relief more than 90 percent of the time in patients treated at Massachusetts General Hospital (MGH). Physicians from the MGH Division of Plastic and Reconstructive Surgery report that more than half of 35 patients treated with the non-endoscopic procedure – all of whom had headaches associated with compression of craniofacial nerves – reported complete symptom relief a year later. The team's paper has received advance online publication in the journal Plastic ...

The study, published in the Proceedings of the National Academy of Science, investigated the extent to which improvements in living conditions and educational opportunities over a person's life affect cognitive abilities and their implications for men and women. "Our results show that there is no reason to expect all cognitive gender differences will diminish," says Daniela Weber, IIASA researcher and lead author of the study. "However, the findings from this study suggest that if women and men had equal levels of education, then we should expect a female advantage in ...

Running for only a few minutes a day or at slow speeds may significantly reduce a person's risk of death from cardiovascular disease compared to someone who does not run, according to a study published today in the Journal of the American College of Cardiology. Exercise is well-established as way to prevent heart disease and it is component of an overall healthy life, but it is unclear whether there are health benefits below the level of 75 minutes per week of vigorous-intensity activity, such as running, recommended by the U.S. government and World Health Organization. Researchers ...

Heat stroke is 10 times more likely than cardiac events to be life-threatening for runners during endurance races in warm climates, according to a study published today in the Journal of the American College of Cardiology. The authors noted the findings may play a role in the ongoing debate over pre-participation ECG screenings for preventing sudden death in athletes by offering a new perspective on the greatest health risk for runners. Two of the most recognized causes of sudden death during an endurance race are arrhythmic death, sudden death usually caused by undetected ...

ANN ARBOR, Mich. — Babies can learn what to fear in the first days of life just by smelling the odor of their distressed mothers, new research suggests. And not just "natural" fears: If a mother experienced something before pregnancy that made her fear something specific, her baby will quickly learn to fear it too -- through the odor she gives off when she feels fear. In the first direct observation of this kind of fear transmission, a team of University of Michigan Medical School and New York University studied mother rats who had learned to fear the smell of peppermint ...

MIAMI – A new study from scientists at the University of Miami Rosenstiel School of Marine and Atmospheric Science and colleagues confirms rising levels of water vapor in the upper troposphere – a key amplifier of global warming – will intensify climate change impacts over the next decades. The new study is the first to show that increased water vapor concentrations in the atmosphere are a direct result of human activities. "The study is the first to confirm that human activities have increased water vapor in the upper troposphere," said Brian Soden, professor of atmospheric ...

A new discovery of two additional coral communities showing signs of damage from the Deepwater Horizon oil spill expands the impact footprint of the 2010 spill in the Gulf of Mexico. The discovery was made by a team led by Charles Fisher, professor of biology at Penn State University. A paper describing this work and additional impacts of human activity on corals in the Gulf of Mexico will be published during the last week of July 2014 in the online Early Edition of the journal Proceedings of the National Academy of Sciences. "The footprint of the impact of the spill ...

An evolutionarily ancient and tiny part of the brain tracks expectations about nasty events, finds new UCL research. The study, published in Proceedings of the National Academy of Sciences, demonstrates for the first time that the human habenula, half the size of a pea, tracks predictions about negative events, like painful electric shocks, suggesting a role in learning from bad experiences. Brain scans from 23 healthy volunteers showed that the habenula activates in response to pictures associated with painful electric shocks, with the opposite occurring for pictures ...

Most cells do not divide unless there is enough oxygen present to support their offspring, but certain cancer cells and other cell types circumvent this rule. Researchers at The Johns Hopkins University have now identified a mechanism that overrides the cells' warning signals, enabling cancers to continue to divide even without a robust blood supply. In the process, the researchers found that lysosomes — the cell's protein "recycling centers" — help govern cell division decisions. They also uncovered new evidence that certain drugs can halt the growth of tumors that have ...

A new study by researchers in the Department of Psychology at the University of York shows that it is possible to accurately predict first impressions using measurements of physical features in everyday images of faces, such as those found on social media. When we look at a picture of a face we rapidly form judgements about a person's character, for example whether they are friendly, trustworthy or competent. Even though it is not clear how accurate they are, these first impressions can influence our subsequent behaviour (for example, judgements of competence based on ...

JUPITER, FL - July 28, 2014 – Research conducted at the Florida campus of The Scripps Research Institute (TSRI) has discovered links between a set of genes known to promote tumor growth and mucoepidermoid carcinoma, an oral cancer that affects the salivary glands. The discovery could help physicians develop new treatments that target the cancer's underlying genetic causes. The research, recently published online ahead of print by the Proceedings of the National Academy of Sciences, shows that a pair of proteins joined together by a genetic mutation—known as CRTC1/MAML2 ...

Researchers at Yale School of Medicine have pinpointed a mechanism in part of the brain that is key to sensing glucose levels in the blood, linking it to both type 1 and type 2 diabetes. The findings are published in the July 28 issue of Proceedings of the National Academies of Sciences. "We've discovered that the prolyl endopeptidase enzyme — located in a part of the hypothalamus known as the ventromedial nucleus — sets a series of steps in motion that control glucose levels in the blood," said lead author Sabrina Diano, professor in the Departments of Obstetrics, Gynecology ...