Using a simulation model, Swedish researchers have shown that the implementation of Fracture Liaison Services (FLS) could considerably reduce the human and healthcare costs associated with osteoporotic fractures. The results from the model were presented today at the World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases in Milan. FLS are coordinated, multi-disciplinary models of care which help ensure that fracture patients are assessed and treated to reduce their risk of subsequent fractures. According to expert opinion and the International Osteoporosis ...

Big data: It's a term we read and hear about often, but is hard to grasp. Computer scientists at Washington University in St. Louis' School of Engineering & Applied Science tackled some big data about an important protein and discovered its connection in human history as well as clues about its role in complex neurological diseases. Through a novel method of analyzing these big data, Sharlee Climer, PhD, research assistant professor in computer science, and Weixiong Zhang, PhD, professor of computer science and of genetics at the School of Medicine, discovered a region ...

March 27, 2015 (Las Vegas, Nevada) A new study from researchers at NYU Langone's Hospital for Joint Diseases identifies common causes of hospital readmissions following total hip and knee arthoplasty procedures. By finding these common causes, researchers believe quality can be increased and hospital costs decreased. The study will be presented Friday, March 27, 2015 at the American Academy of Orthopaedic Surgeons Annual Meeting in Las Vegas. The patients were part of the Bundled Payment for Care Initiative from the Centers for Medicare and Medicaid Services (CMS), ...

LAS VEGAS - Nearly 93 percent of National Football League (NFL) athletes who sustained traumatic injuries to the midfoot returned to competition less than 15 months after injury and with no statistically significant decrease in performance, according to new research from the Perelman School of Medicine at the University of Pennsylvania. The findings, which focus on Lisfranc injuries - characterized by fracture of the midfoot bones and/or disruption of the midfoot ligaments - between 2000-2010, were presented today at the American Academy of Orthopaedic Surgeons (AAOS) annual ...

Young adolescents' judgements on how risky a situation might be are most influenced by what other teenagers think, while most other age groups are more influenced by adults' views, finds new UCL research. For the study, published in Psychological Science, 563 visitors to the London Science Museum were asked to rate the riskiness of everyday situations such as crossing a road on a red light or taking a shortcut through a dark alley. Ratings were given on a continuous scale from low to high risk, and children (aged 8-11) generally rated situations as more risky than all ...

The official global target of a 2°C temperature rise is 'utterly inadequate' for protecting those at most risk from climate change, says a lead author on the Intergovernmental Panel on Climate Change (IPCC), writing a commentary in the open access journal Climate Change Responses. The commentary presents a rare inside-view of a two-day discussion at the Lima Conference of the Parties (COP) on the likely consequences of accepting an average global warming target of 2°C versus 1.5°C (measured from pre-industrial times until 2100). The discussions were part ...

Highlights For older patients in need of a kidney transplant, rapid transplantation from an older deceased donor is superior to delayed transplantation from a younger donor. Kidneys from older donors do not have sufficient longevity to provide younger patients with a lifetime of kidney function, but they do have sufficient longevity to provide older patients who have a shorter life expectancy with a lifetime of kidney function. More than 100,000 people in the United States are waiting for a kidney transplant. Washington, DC (March 26, 2015) -- A new study highlights ...

Honey bees use different sets of genes, regulated by two distinct mechanisms, to fight off viruses, bacteria and gut parasites, according to researchers at Penn State and the Georgia Institute of Technology. The findings may help scientists develop honey bee treatments that are tailored to specific types of infections. "Our results indicate that different sets of genes are used in immune responses to viruses versus other pathogens, and these anti-viral genes are regulated by two very distinct processes -- expression and DNA methylation," said David Galbraith, graduate ...

(Boston) - Genes appear to play a stronger role in longevity in people living to extreme older ages, according to a study of siblings led by Boston University and Boston Medical Center (BMC) researchers. The study, published online in the Journal of Gerontology: Biological Sciences, found that for people who live to 90 years old, the chance of their siblings also reaching age 90 is relatively small - about 1.7 times greater than for the average person born around the same time. But for people who survive to age 95, the chance of a sibling living to the same age is 3.5 ...

Why does it seem as if a dark band ripples through a flock of European starlings that are steering clear of a falcon or a hawk? It all lies in the birds' ability to quickly and repeatedly dip to one side to avoid being attacked. For a split second, these zigs change the view that observers on the ground have of the birds' wings to cause a so-called agitation wave. This evasive strategy is copied as quick as a flash from one neighboring bird to the next. The escape behavior underlying this was discovered in a study led by Charlotte Hemelrijk of the Centre for Ecology and ...

Rockville, Md. (March 26, 2015) -- The motion of coins in a "Penny Pusher" carnival game is similar to the movement of cells in the eye's lens, as described in a new study published in Investigative Ophthalmology & Visual Science (IOVS). This new insight may help scientists understand how the eye maintains its precise shape -- critical for clear vision -- and how cataracts develop. "If the size, shape or position of the eye is not carefully regulated, we simply will not see clearly," said author Steven Bassnett, PhD, of Washington University School of Medicine, Department ...

Life expectancy for Hispanics in the U.S. currently outpaces other ethnic groups, yet a new study finds that Mexican Americans -- especially women who were born in Mexico -- are spending a high proportion of their later years with some form of disability, a fact that suggests a growing need for community assistance and long-term care in the future. These findings are reported in a new article published online in The Journals of Gerontology, Series B: Psychological and Social Sciences titled "Longer Lives, Sicker Lives? Increased Longevity and Extended Disability Among ...

Nobody likes getting the flu, but for some people, fluids and rest aren't enough. A small number of children who catch the influenza virus fall so ill they end up in the hospital -- perhaps needing ventilators to breathe -- even while their family and friends recover easily. New research by Rockefeller University scientists, published March 26 in Science, helps explain why: a rare genetic mutation. The researchers scrutinized blood and tissue samples from a young girl who, at the age of two-and-a-half, developed acute respiratory distress syndrome after catching the flu, ...

CAMBRIDGE, Mass., March 26, 2015 - Newly published research from the Forsyth Institute details a discovery explaining why the 100 million Americans estimated to be taking prescription and over-the-counter antacid and heartburn medications may be at an increased risk of bone fractures. The new report from Forsyth, published in the March issue of the prestigious medical research journal PLOS Genetics, explains that stomach acid in the gastrointestinal tract plays an important role in helping the intestines absorb and transfer calcium to the skeletal system. While the ...

Genetic defects affecting tiny channels in human nerve cells lead to several neurological diseases that result from aberrant nerve transmission, such as episodic ataxia, absence epilepsy, and migraines. These disorders have also been associated with neurodegeneration, but it has been less clear why this should be. The transmission of nerve impulses requires the perfect orchestration of a series of complex cellular events in a matter of fractions of a second. The membrane that surrounds a nerve cell is normally electrically polarized, but a nerve impulse triggers a Mexican ...

MADISON, Wis. -- An Ebola whole virus vaccine, constructed using a novel experimental platform, has been shown to effectively protect monkeys exposed to the often fatal virus. The vaccine, described today (March 26, 2015) in the journal Science, was developed by a group led by Yoshihiro Kawaoka, a University of Wisconsin-Madison expert on avian influenza, Ebola and other viruses of medical importance. It differs from other Ebola vaccines because as an inactivated whole virus vaccine, it primes the host immune system with the full complement of Ebola viral proteins and ...

Orchestrated costume changes make it possible for certain nasty microbes to outsmart the immune system, which would otherwise recognize them by the telltale proteins they wear. By taking the first detailed look at how one such parasite periodically assumes a new protein disguise during a long-term infection, new research at Rockefeller University challenges many assumptions about one of the best-known examples of this strategy, called antigenic variation, in the parasite that causes African sleeping sickness. For research published on March 27 in Science, a team at Rockefeller ...

A new study led by Scripps Institution of Oceanography at UC San Diego researchers has revealed that the thickness of Antarctica's floating ice shelves has recently decreased by as much as 18 percent in certain areas over nearly two decades, providing new insights on how the Antarctic ice sheet is responding to climate change. Data from nearly two decades of satellite missions have shown that the ice volume decline is accelerating, according to a study published on March 26, 2015, in the journal Science and supported by NASA. Scripps graduate student Fernando Paolo, Scripps ...

HOUSTON - (March 26, 2015) - Taking out the garbage is a crucial step in housecleaning. Similarly, autophagy is the body's first-line of defense against the buildup up of toxic substances, degrading old organelles and proteins to provide new substrates and building blocks. In this way, autophagy prevents the buildup of "garbage" that can result in destruction of neurons and cause neurologic diseases. A forward genetic screen in Drosophila melanogaster (fruit flies) identified mutant copies, or alleles, of a gene called cacophony associated with defects in autophagy ...

While most of us recover from influenza after a week, it can be a very severe disease, and even fatal in rare cases, with no reason for physicians to have expected such an outcome. By analysing the genome of a little girl who contracted a severe form of influenza at the age of two and a half years, researchers at the Laboratory of Human Genetics of Infectious Diseases (a joint French-American international laboratory), which brings together researchers from Inserm, Paris Descartes University, and physicians from the Paris public hospitals (AP-HP; Necker Hospital for Sick ...

New research shows bacteria can use tiny magnetic particles to effectively create a 'natural battery.' According to work published in journal Science on 27 March, the bacteria can load electrons onto and discharge electrons from microscopic particles of magnetite. This discovery holds out the potential of using this mechanism to help clean up environmental pollution, and other bioengineering applications. The European Association of Geochemistry is highlighting this work as especially interesting. According to study leader Dr James Byrne (Tübingen): "The geochemistry ...

A study led by Cathy Spatz Widom, Distinguished Professor of Psychology at John Jay College, found that offspring of parents with histories of child abuse and neglect are themselves at risk for childhood neglect and sexual abuse but not physical abuse. Titled "Intergenerational Transmission of Child Abuse and Neglect: Real or Detection Bias?" the study's findings were reported in the March 27 issue of the journal Science. As part of a prospective longitudinal study, Widom followed a large group of children with documented cases of childhood abuse and neglect and a demographically ...

A new study, published today in the journal PloS Neglected Tropical Diseases has given new insights into the spread of rabies in the Middle East, showing that the deadly disease regularly moves between countries in the region. The international team of researchers including scientists from the University of Surrey and the Animal and Plant Health Agency, have mapped the spread of rabies in the region to help inform control methods. Previous studies have demonstrated that rabies, a fatal disease transmitted by the bite or scratch from an infected animal, still kills approximately ...

Dark matter is one of science's great mysteries. It makes up an enormous amount matter in the universe, it is invisible, and it does not correspond to anything in the realm of our experience. Different theories compete for an explanation, but so far none of them has prevailed. In a collaborative study between École Polytechnique Fédérale de Lausanne (EPFL) and the University of Edinburgh, scientists have studied how dark matter behaves when galaxy clusters collide with each other over billions of years. Published in Science, their findings challenge at least ...

Foraging bats obey their own set of 'traffic rules', chasing, turning and avoiding collisions at high speed, new research from the University of Bristol, UK has found. Dr Marc Holderied of Bristol's School of Biological Sciences studied pairs of Daubenton's bats (Myotis daubentonii) foraging low over water for stranded insects at a site near the village of Barrow Gurney in Somerset, UK. He said: "Collective movements of flocking birds or shoaling fish are amongst the most fascinating natural phenomena, and everyone has experienced the challenges of walking through ...