PHILADELPHIA – Researchers may have identified key genes linked to why some people have a higher tolerance for pain than others, according to a study released today that will be presented at the American Academy of Neurology's 66th Annual Meeting in Philadelphia, April 26 to May 3, 2014. "Our study is quite significant because it provides an objective way to understand pain and why different individuals have different pain tolerance levels," said study author Tobore Onojjighofia, MD, MPH, with Proove Biosciences and a member of the American Academy of Neurology. "Identifying ...

NEW YORK, NY (April 20, 2014) — A team of researchers from Columbia University Medical Center (CUMC), Weill Cornell Medical College, and Brandeis University has devised a wholly new approach to the treatment of Alzheimer's disease involving the so-called retromer protein complex. Retromer plays a vital role in neurons, steering amyloid precursor protein (APP) away from a region of the cell where APP is cleaved, creating the potentially toxic byproduct amyloid-beta, which is thought to contribute to the development of Alzheimer's. Using computer-based virtual screening, ...

Stem cells – the body's master cells – demonstrate a bizarre property never before seen at a cellular level, according to a study published today from scientists at the University of Cambridge. The property – known as auxeticity – is one which may have application as wide-ranging as soundproofing, super-absorbent sponges and bulletproof vests. Most materials when stretched will contract. For example, if one pulls on an elastic band, the elastic itself will get thinner. The opposite is also true: squeeze a material and it will expand – for example, if one squeezes a tennis ...

PITTSBURGH—With gene expression analysis growing in importance for both basic researchers and medical practitioners, researchers at Carnegie Mellon University and the University of Maryland have developed a new computational method that dramatically speeds up estimates of gene activity from RNA sequencing (RNA-seq) data. With the new method, dubbed Sailfish after the famously speedy fish, estimates of gene expression that previously took many hours can be completed in a few minutes, with accuracy that equals or exceeds previous methods. The researchers' report on their ...

Most drugs used to treat lung, breast and pancreatic cancers also promote drug-resistance and ultimately spur tumor growth. Researchers at the University of California, San Diego School of Medicine have discovered a molecule, or biomarker, called CD61 on the surface of drug-resistant tumors that appears responsible for inducing tumor metastasis by enhancing the stem cell-like properties of cancer cells. The findings, published in the April 20, 2014 online issue of Nature Cell Biology, may point to new therapeutic opportunities for reversing drug resistance in a range ...

Mothers give a newborn baby a gift of germs—germs that help to kick-start the infant's immune system. But antibiotics, used to fend off infection, may paradoxically interrupt a newborn's own immune responses, leaving already-vulnerable premature babies more susceptible to dangerous pathogens. A new animal study by neonatology researchers at The Children's Hospital of Philadelphia (CHOP) sheds light on immunology in newborns by revealing how gut microbes play a crucial role in fostering the rapid production of infection-fighting white blood cells, called granulocytes. "At ...

BOSTON –Although doctors have long known that people with Down syndrome have a heightened risk of developing acute lymphoblastic leukemia (ALL) during childhood, they haven't been able to explain why. Now, a team of Dana-Farber Cancer Institute investigators has uncovered a connection between the two conditions. In a study posted online today by the journal Nature Genetics, the researchers track the genetic chain of events that links a chromosomal abnormality in Down syndrome to the cellular havoc that occurs in ALL. Their findings are relevant not only to people with ...

STANFORD, Calif. — A single type of cell in the lining of the bladder is responsible for most cases of invasive bladder cancer, according to researchers at the Stanford University School of Medicine. Their study, conducted in mice, is the first to pinpoint the normal cell type that can give rise to invasive bladder cancers. It's also the first to show that most bladder cancers and their associated precancerous lesions arise from just one cell, and explains why many human bladder cancers recur after therapy. "We've learned that, at an intermediate stage during cancer ...

Lincoln, Neb., April 20, 2014 -- Using corn crop residue to make ethanol and other biofuels reduces soil carbon and can generate more greenhouse gases than gasoline, according to a study published today in the journal Nature Climate Change. The findings by a University of Nebraska-Lincoln team of researchers cast doubt on whether corn residue can be used to meet federal mandates to ramp up ethanol production and reduce greenhouse gas emissions. Corn stover -- the stalks, leaves and cobs in cornfields after harvest -- has been considered a ready resource for cellulosic ...

The Fort Lauderdale, Florida office represents a more concerted push into the U.S. market following the success of the Toronto office and continued growth worldwide", said Tom Greenberg, President. With the opening of a new office in Florida, promotional product company Score Promotions will be able to offer a number of services and logistical upgrades to its U.S. clients. The expansion comes as the Company celebrates 15 years in business, during which time it has become one of the leading promotional products suppliers in Canada. Score Promotions continually seeks ...

One thing most sports fans have in common is that they have an opinion about the game and they are willing to share that opinion with anyone who will listen. The problem is finding those like-minded listeners who will appreciate, and even discuss, that opinion. Now a young sports media company is stepping up to provide that audience for anyone who wishes to share their thoughts with the masses. Scores.fm is an online sports magazine and sports radio station that has gained international recognition. Operated by Scores Media Group, the publishing and broadcasting venture ...

Lucent is introducing dramatic new concepts in vertical architecture, with 36 of 54 homes offering all living space on a single level, surrounded on three sides by walls of windows and balconies. The other 18 homes are two-story penthouses, which feature an upstairs family room and an outdoor deck and fireplace. Lucent consists of multiple five-story buildings, with either six or 12 homes per building. Ranging from 1,457 to 1,878 square feet, homes at Lucent offer two bedrooms, two to two-and-a-half baths, and a two-car garage located on the ground floor. An interior ...

The new update from Teletherm Infrared Systems for their Thermology Certified Online Training Course provides extensively narrated presentations for three major sections in this comprehensive package of twenty modules. The full program offers a convenient way for users and novices, alike, to learn all relevant topics associated with the procedures, science, technology, health evaluations, and applications for thermal imaging. Designed specifically for the biomedical, clinical research and health care fields, subscribers are provided unlimited access to the course site. ...

The several week event, sponsored by BourbonBlog.com, puts liquor brands head-to-head in a 64-brand NCAA basketball tournament style bracket. The fans of each brand vote and brands receiving the most votes move on to the next round. "We entered both Underground Herbal Spirits and Five Wives Vodka," explained Steve Conlin, managing partner of Ogden's Own. "Both brands made it to the Final Four and had to face each other with Underground moving on to the final." "While Utah may have the lowest per capita of drinkers, when it comes to passion for local brands, Utah is ...

Alicia Isaacs Howes, Soul Connection Expert and Founder of Your Soul Story, is teaching her third-annual 21 Day Soul Attunement programme from June 2 - 22, 2014. The programme features three weeks and ten hours of daily energetic support, in which Alicia will work with participants to release recurring, negative patterns or mindsets, physical or emotional pains and illusions about their health, relationships and finances. Brenda Strong, a previous participant in the 21 Day Soul Attunement, says: "Before the Soul Attunement I felt stuck. It felt like I had been ...

Duminiak will be discussing children's abilities to talk to dead relatives, angels, Jesus and other holy beings. Duminiak is a Certified Grief Recovery Specialist, an International Spiritual Bereavement Recovery Facilitator since 1998, a member of the Association for Death Education and Counseling, co-host of the Ask the Angels Show, the founder and spiritual advisor of Prayer Wave for After-Death Communications--an internet nondenominational grief support prayer group, and message board with members from 22 countries. An Expert Consultant listed with The Learning Annex. ...

Independent record label WinCamp Music group is set to release it's debut album "337 Tapes: International Edition", on April 23rd. The album will be available for download and physical purchase via their Bandcamp page (http://wincampmusicgroup.bandcamp.com). The 337 Tapes tracklist contains fourteen songs that take a very fusion approach to hip hop, incorporating elements of world music, EDM and classic rock into their urban sounds. It's definitely "not your average hip hop album" as CEO and producer/artist Printts A would say. "We took almost a year and a half getting ...

The Bradley Beach Chamber of Commerce is excited to announce that after years of schedule and booking conflicts they have been able to sign the Pat Roddy Band to perform at the 6th annual Lobster Fest. "Pat Roddy band has always been a favorite of the Chamber, we look forward to bringing his talent to our beach front for everyone to enjoy," says Shirley Ayres - Executive Director of the Chamber. Pat Roddy, who just released his latest album "Shed my Skin" is a singer/songwriter born and raised in Belmar, NJ. Roddy has been playing all over the Garden State for 20+ years ...

Bangor Federal Credit Union is awarding 14 area food pantries with generous donation checks on Tuesday, April 22, 2014 as the result of a successful Campaign for Ending Hunger. The event will be held at 10:00 AM in the conference room of Bangor Federal's Hogan Road branch. A Representative from each food pantry will attend the ceremony to accept their share of $24,416.03 that Bangor Federal raised this past year. Collectively, Maine Credit Unions raised $513,309.19 in 2013--a record breaking number since the campaign began in 1990. Bangor Federal placed 4th in the state, ...

Oomph, Inc. today announced its Catholic Television Network website redesign has been selected as a finalist in the 'Nonprofit & Government 2014' category for the MITX What's Next Awards. This year MITX combined its annual Innovation and Interactive Awards into a single show recognizing Boston's entire digital ecosystem. Since 1996 the MITX Award shows have grown to become the largest and most prestigious awards competitions in the country for marketing innovations, celebrating the best creative and technological accomplishments emerging from New England. "The ...

ESP/SurgeX, the leader in energy intelligence and power protection, announces the acquisition of SurgeX International, which had been operating as its own entity since Electronic Systems Protection, Inc acquired SurgeX North America in 2008. The move unifies all SurgeX operations under a single management team located in Knightdale, NC, that will allow the company to streamline international expansion and better serve their customers. Global demand for smart energy and power management products is growing and the acquisition allows SurgeX to better serve the needs of ...

Jobs2Careers unveils the future of talent acquisition at upcoming conference. WHO: Jobs2Careers, leading job aggregator and fastest growing site for talent WHAT: Will exhibit as a platinum sponsor of the 14th Annual Spring ERE Recruiting Conference & Expo and share innovations for the future of recruitment WHEN: The conference will take place from Tuesday, April 22 - Thursday, April 24, 2014. Exhibit hall hours will be from 7:30AM to 6:30PM on Wednesday, April 23 and from 8:00AM to 2:00PM on Thursday, April 24. WHERE: San Diego Convention Center ...

The team behind Amazing Pet Expos has reason to celebrate today since they just found out that they've set a new industry standard for national pet expos. In just five years, Amazing Pet Expos has welcomed more than 700,000 guests - and their pets - to their 72 consecutive pet expos in more than 40 states across the country. "We're delighted to learn that we've produced the most-attended public pet expo series ever," says the Vice-President of Amazing Pet Expos, Patricia Welch. She adds, "It really is amazing how the pet community has responded to our events over the ...

Whether you attended NAB this year, or couldn't make it, you won't want to miss this month's Editors' Lounge where industry professionals will have the chance to get an up-close look at all the new features and latest gear from Avid. Product designers and managers are coming from the Massachusetts office to give demonstrations throughout the evening and will be available to answer questions and discuss Avid's strategy and vision for the future. Special date for the event will be Friday, April 25th at AlphaDogs Post Production 1612 W. Olive Ave, Suite 200, Burbank, CA 91506 ...

Ricky Villa Real joined the Classic Escapes membership program late last year to take his teenage son to Spain to meet international soccer superstar Cristiano Ronaldo and the entire Real Madrid team. With only weeks to plan the trip following a letter from the Real Madrid club inviting Mr Villa Real and his son to meet the stars, Classic Holidays' dedicated Member Services team pulled out every stop to ensure the opportunity would not be missed. "At short notice, Classic Holidays staff helped us organise the trip and before we knew it we were shaking hands with ...