CAMBRIDGE, Mass. (July 31, 2014) – Long associated with enabling the proliferation of cancer cells, the ancient cellular survival response regulated by Heat-Shock Factor 1 (HSF1) can also turn neighboring cells in their environment into co-conspirators that support malignant progression and metastasis. The finding, reported by Whitehead Institute scientists this week in the journal Cell, lends new insights into tumor biology with significant implications for the diagnosis, prognosis, and management of cancer patients. Over the past several years, researchers in the ...

This news release is available in German. The insular cortex is an integral "hub", combining sensory, emotional and cognitive content. Not surprisingly, alterations in insular structure and function have been reported in many psychiatric disorders, such as anxiety disorders, depression, addiction and autism spectrum disorders (ASD). Scientists from Harvard University and the Max-Planck Institute of Neurobiology in Martinsried now describe consistent alterations in integrative processing of the insular cortex across autism mouse models of diverse etiologies. In particular, ...

An experimental vaccine protected 100 percent of animal models against the highly infectious and virulent bacterium, Clostridium difficile, which causes an intestinal disease that kills approximately 30,000 Americans annually. The research is published ahead of print in Infection and Immunity. In the study, the vaccine protected the mice and non-human primates against the purified toxins produced by C. difficile, as well as from an orogastric spore infection, a laboratory model that mimics the human disease, after only two immunizations. "Animals that received two ...

Lincoln, Neb., July 31, 2014 -- Do people make a rational choice to be liberal or conservative? Do their mothers raise them that way? Is it a matter of genetics? Two political scientists from the University of Nebraska-Lincoln and a colleague from Rice University say that neither conscious decision-making nor parental upbringing fully explain why some people lean left while others lean right. A growing body of evidence shows that physiological responses and deep-seated psychology are at the core of political differences, the researchers say in the latest issue of the ...

Irvine, Calif., July 31, 2014 — Much of the liver's metabolic function is governed by circadian rhythms – our own body clock – and UC Irvine researchers have now found two independent mechanisms by which this occurs. The study, published online today in Cell, reveals new information about the body clock's sway over metabolism and points the way to more focused drug treatments for liver disease and such metabolic disorders as obesity and diabetes. Paolo Sassone-Corsi, UCI's Donald Bren Professor of Biological Chemistry, and postdoctoral scholar Selma Masri report that ...

There's sad news in the study of happiness. Rest assured, there is a happy ending, though. University of Cincinnati research on perceived happiness shows that many college students are stressed out and aren't coping. This is despite the fact that there are simple ways for students to relieve stress and feel happier, says Keith King, professor and coordinator of UC's Health Promotion and Education Program. The trouble is, they don't use them enough. "We have a whole array of different stress-management techniques college students can use and that we teach, but they're ...

WASHINGTON -- Everyone involved in the academic chemical research enterprise -- from researchers and principal investigators to university leadership -- has an important role to play in establishing and promoting a strong, positive safety culture, says a new report from the National Research Council. This requires a constant commitment to safety organization-wide and emphasis on identifying and solving problems, rather than merely adhering to a set of rules and assigning blame when those rules are not followed. Chemical hazards can be found in many academic fields ...

Magnetic resonance imaging (MRI), which is the medical application of nuclear magnetic resonance spectroscopy, is a powerful diagnostic tool. MRI works by resonantly exciting hydrogen atoms and measuring the relaxation time -- different materials return to equilibrium at different rates; this is how contrast develops (i.e. between soft and hard tissue). By comparing the measurements to a known spectrum of relaxation times, medical professionals can determine whether the imaged tissue is muscle, bone, or even a cancerous growth. At its heart, MRI operates by quantum principles, ...

Washington, D.C.— Molybdenum disulfide is a compound often used in dry lubricants and in petroleum refining. Its semiconducting ability and similarity to the carbon-based graphene makes molybdenum disulfide of interest to scientists as a possible candidate for use in the manufacture of electronics, particularly photoelectronics. New work from a team including several Carnegie scientists reveals that molybdenum disulfide becomes metallic under intense pressure. It is published in Physical Review Letters. Molybdenum disulfide crystalizes in a layered structure, with ...

An international team of scientists from Spain, France, and the U.S. has discovered and described a rove beetle that is the oldest definitive member of the tribe Omaliini that has ever been found in amber. The discovery and description were made possible through the use of the propagation phase-contrast X-ray synchrotron imaging technique, which allows the detailed study of otherwise invisible specimens in opaque amber. The new species is described in the journal Annals of the Entomological Society of America in an article called "Oldest Omaliini (Coleoptera: Staphylinidae: ...

This news release is available in German. Metal-organic frameworks (MOFs) can take up gases similar to a sponge that soaks up liquids. Hence, these highly porous materials are suited for storing hydrogen or greenhouse gases. However, loading of many MOFs is inhibited by barriers. Scien-tists of Karlsruhe Institute of Technology (KIT) now report in Nature Communications that the barriers are caused by cor-rosion of the MOF surface. This can be prevented by water-free synthesis and storing strategies. MOFs are crystalline materials consisting of metallic nodes ...

Since Alexandre Edmond Becquerel first discovered the photovoltaic effect in 1839, humankind has sought to further understand and harness the power of sunlight for its own purposes. In a new research report published in the August 2014 issue of the FASEB Journal, scientists may have uncovered a new method of exploiting the power of sunlight by focusing on a naturally occurring combination of lipids that have been strikingly conserved throughout evolution. This conservation—or persistence over time and across species—suggests that this specific natural combination of lipids ...

The spread of misinformation through online social networks is becoming an increasingly worrying problem. Researchers in India have now modeled how such fictions and diffuse through those networks. They described details of their research and the taxonomy that could help those who run, regulate and use online social networks better understand how to slow or even prevent the spread of misinformation to the wider public. Krishna Kumar and G. Geethakumari of the Department of Computer Science and Information Systems, at BITS-Pilani, Hyderabad Campus, in Andhra Pradesh, India, ...

GAINESVILLE, Fla. – Your teeth can tell stories about you, and not just that you always forget to floss. A study led by University of Florida geology researcher George D. Kamenov showed that trace amounts of lead in modern and historical human teeth can give clues about where they came from. The paper will be published in the August issue of Science of The Total Environment. The discovery could help police solve cold cases, Kamenov said. For instance, if an unidentified decomposed body is found, testing the lead in the teeth could immediately help focus the investigation ...

An important step has been made to help better identify and treat those with fibromuscular dysplasia (FMD). FMD causes both an abnormal narrowing and enlarging of medium sized arteries in the body, which can restrict blood flow to the kidneys and other organs causing damage. In a new report appearing in August 2014 issue of The FASEB Journal, scientists provide evidence that that FMD may not be limited to the arteries as currently believed. In addition, they show a connection to abnormalities of bones and joints, as well as evidence that inflammation may be driving the ...

BOZEMAN, Mont. – In the same week that the U.S. surgeon general issued a 101-page report about the dangers of skin cancer, researchers at Montana State University published a paper breaking new ground on how DNA – the genetic code in every cell – responds when exposed to ultraviolet (UV) light. The findings advance fundamental understanding of DNA damage by the UV rays found in sunlight. This damage can lead to skin cancer, aging and some degenerative eye diseases. "Our paper advances foundational knowledge about how DNA responds to UV radiation. In our experiments, ...

Transient ischemic attack (TIA) is a temporary event, which portends a higher risk of a disabling stroke following the TIA. However, the evaluation and management of TIA vary worldwide and is debated and controversial. Dr. Mohamed Al-Khaled from University of Lübeck in Germany considered With the development of brain imaging, particularly diffusion weighted imaging-magnetic resonance imaging (DWI-MRI), the diagnosis of TIA changed from time-based definition to a tissue-based one. DWI-MRI became a mandatory tool in the TIA workup. The DWI-MRI provides not only the evidence ...

Worldwide prevalence of Spinal Cord Injury (SCI) is ranging from 233 to 755 per million inhabitants, whereas reported incidence lies between 10.4 and 83 per million inhabitants per year. Thus, the socioeconomic impact of SCI associated with cervical trauma is high enough to be encountered within one of the most important worries in vast majority of developed countries. The ability to predict recovery following SCI is of paramount importance to the physician's role in providing the best care and guidance to patients and families during the illness. Diagnosis of cervical ...

Most people are familiar with Hibiscus flowers- they are an iconic symbol of tropical resorts worldwide where they are commonly planted in the landscape. Some, like Hawaii's State Flower- Hibiscus brackenridgei- are endangered species. Only a relatively few botanists and Hawaiian conservation workers, however, are aware of an equally beautiful and intriguing related group of plants known as Hibiscadelphus- literally "brother of Hibiscus". Brother of Hibiscus species are in fact highly endangered. Until recently only one of the seven previously known species remained ...

Researchers at the University of California, Los Angeles and the Chinese Academy of Sciences have pioneered a new study that could greatly improve current methods of localising birdsong data. Their findings, which ascertain the validity of using statistical algorithms to detect multiple-source signals in real time and in three-dimensional space, are of especial significance to modern warfare. Recently published in the journal Unmanned Systems, the study demonstrates the validity of using approximate maximum likelihood (AML) algorithms to determine the direction of arrival ...

TALLAHASSEE, Fla. — A Florida State University researcher found that bacteria in the Gulf of Mexico consumed many of the toxic components of the oil released during the Deepwater Horizon spill in the months after the spill, but not the most toxic contaminants. In two new studies conducted in a deep sea plume, Assistant Professor Olivia Mason found a species of bacteria called Colwellia likely consumed gaseous hydrocarbons and perhaps benzene, toluene, ethylbenzene and xylene compounds that were released as part of the oil spill. But, her research also showed that bacteria ...

White, brown and beige adipocytes, or fat cells, are inherently different. Each of these cell types has different functions and each plays its own role in metabolism. In the human body, white adipose tissue is by far the most prevalent. Its primary function is energy storage. On the other hand, brown adipocytes utilize available energy to generate heat but are only found in a few places in the adult human body. Beige adipocytes, which represent a special type of brown adipocytes, appear mixed with brown adipocytes in human brown adipose tissue or develop within the white ...

Functional group transformations are central to organic synthesis. Traditionally, the functionalities used in such transformations are highly active organic groups such as halogens, ester groups and hydroxyl groups. Carbon–hydrogen bonds are ubiquitous structural motifs in organic compounds, but they are not considered to be functional groups because (1) in general, the bond dissociation energy of a C–H bond is high, and therefore, such bonds are thermodynamically hard to break; and (2) the selective activation of one C–H bond among many similar and different C–H bonds ...

The method overcomes limitations of existing techniques which are limited to the surface or small-sized specimens, and allows a 3-D representation of the phase fractions within the sample volume. The work has just been published in the journal "Advanced Materials". "For many engineering applications it is of major importance to characterize the bulk of materials spatially, instead of only probing selected locations. The new method provides exactly that capability, and the HZB-UTK team has demonstrated it by using samples made from stainless steel that undergo a phase ...

Researchers at the MIT Media Laboratory and the University of California at Berkeley have developed a new display technology that automatically corrects for vision defects — no glasses (or contact lenses) required. The technique could lead to dashboard-mounted GPS displays that farsighted drivers can consult without putting their glasses on, or electronic readers that eliminate the need for reading glasses, among other applications. "The first spectacles were invented in the 13th century," says Gordon Wetzstein, a research scientist at the Media Lab and one of the display's ...