(WASHINGTON, March 10, 2014) – A pill that suppresses a key regulator of cancer growth may provide hope to relapsed leukemia and lymphoma patients running out of treatment options for their aggressive, treatment-resistant disease, according to three reports* published online today in Blood, the journal of the American Society of Hematology. Patients with blood cancer are typically administered a combination of chemotherapy and immunotherapy, the latter using the body's own immune system to help fight disease, as a first line of treatment. While chemotherapy has traditionally ...

Moffitt Cancer Center researchers have been instrumental in making significant improvements to the diagnostic procedure called sentinel node biopsy for melanoma patients and teaching this procedure to physicians from around the world. Sentinel nodes are the first lymph nodes to which cancer cells from a primary tumor like melanoma will spread. In the sentinel node biopsy procedure, a radioactive tracer and a blue-colored dye are injected at or near the melanoma site on the skin and tracked to the first lymph node(s). These sentinel nodes are then surgically removed and ...

New Rochelle, NY, March 10, 2014–Nearly $7 billion is spent each year in the U.S. on diagnostic testing of the estimated three million people with symptoms of obstructive coronary artery disease (CAD). A new blood test that detects specific genes activated in individuals with obstructive CAD could exclude the diagnosis without the need for imaging studies or more invasive tests, reducing health care costs, as described in an article in Population Health Management, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Population ...

The Orion Nebula is home to hundreds of young stars and even younger protostars known as proplyds. Many of these nascent systems will go on to develop planets, while others will have their planet-forming dust and gas blasted away by the fierce ultraviolet radiation emitted by massive O-type stars that lurk nearby. A team of astronomers from Canada and the United States has used the Atacama Large Millimeter/submillimeter Array (ALMA) to study the often deadly relationship between highly luminous O-type stars and nearby protostars in the Orion Nebula. Their data reveal ...

On Friday, March 7 there were two tropical lows located east and west of Queensland, Australia. Those lows organized and intensified into Tropical Cyclone Gillian and Hadi and were caught together in one amazing image from NASA's Aqua satellite. While Gillian has already made one landfall and is expected to make another, Hadi is turning tail and running from the mainland. NASA's Aqua satellite passed over Queensland on March 10 at 04:00 UTC and the Moderate Resolution Imaging Spectroradiometer instrument known as MODIS captured Tropical Cyclones Gillian in the Gulf of ...

Plants that live in unusual soils, such as those that are extremely low in essential nutrients, provide insight into the mechanisms of adaptation, natural selection, and endemism. A seminal paper by Arthur Kruckeberg from 1951 on serpentine plant endemism has served as a solid bedrock foundation for future research on the link between natural selection and speciation. A recent article in the American Journal of Botany focuses on how this paper has influenced subsequent research on local adaptation, evolutionary pathways, and the relationship between climate, soils, and ...

Older people globally are being denied proper access to cancer care, according to an editorial by Queen's University Belfast academic, Professor Mark Lawler of the Centre for Cancer Research and Cell Biology. In an editorial in the BMJ (British Medical Journal) Professor Lawler said: "there is increasing evidence from around the world that elderly patients are being 'undertreated', leading to a 'survival gap' between older and younger patients. "We need a fundamental change in cancer policy for the elderly patient. Our current practices are essentially ageist, as we ...

Smartphones are capable of giving us directions when we're lost, sending photos and videos to our friends in mere seconds, and even helping us find the best burger joint in a three-mile radius. But University of Houston researchers are using smartphones for another very important function: diagnosing diseases in real time. The researchers are developing a disease diagnostic system that offers results that could be read using only a smartphone and a $20 lens attachment. The system is the brainchild of Jiming Bao, assistant professor of electrical and computer engineering, ...

(SALT LAKE CITY)—Good news for lifelong exercisers: Along with its salutary effects on the heart, weight, and other facets of health, physical activity also helps to regenerate muscle mass, which tends to diminish as people age. In a study published in the journal Free Radical Biology and Medicine, researchers from the University of Utah and other institutions found that aged mice lacking Nrf2 that underwent two weeks of endurance exercise stress on treadmills showed poor stem cell regeneration, which is likely to hinder the recovery of lost muscle mass. Nrf2 is protein ...

Fresh banana, a waft of flowers, blueberry: the scents in Shota Atsumi's laboratory in the UC Davis Department of Chemistry are a little sweeter than most. That's because Atsumi and his team are engineering bacteria to make esters -- molecules widely used as scents and flavorings, and also as basic feedstock for chemical processes from paints to fuels. Their latest work is published March 9 in the journal Nature Chemical Biology. Nearly all industrial chemicals, from artificial flavorings to paint, are derived from oil or gas, Atsumi said. "Our motivation is to ...

Jerusalem, March 9, 2014 -- What if you could "hear" colors? Or shapes? These features are normally perceived visually, but using sensory substitution devices (SSDs) they can now be conveyed to the brain noninvasively through other senses. At the Center for Human Perception and Cognition, headed by Prof. Amir Amedi of the Edmond and Lily Safra Center for Brain Sciences and the Institute for Medical Research Israel-Canada at the Hebrew University of Jerusalem Faculty of Medicine, the blind and visually impaired are being offered tools, via training with SSDs, to receive ...

A new type of biomolecular tweezers could help researchers study how mechanical forces affect the biochemical activity of cells and proteins. The devices – too small to see without a microscope – use opposing magnetic and electrophoretic forces to precisely stretch the cells and molecules, holding them in position so that the activity of receptors and other biochemical activity can be studied. Arrays of the tweezers could be combined to study multiple molecules and cells simultaneously, providing a high-throughput capability for assessing the effects of mechanical forces ...

Australian astronomers have shown galaxies in the vast empty regions of the Universe are actually aligned into delicate strings in research published today in the Monthly Notices of the Royal Astronomical Society. A team of astronomers based at The University of Western Australia node of the International Centre for Radio Astronomy Research (ICRAR) has found short strings of faint galaxies in what were previously thought to be extremely empty parts of space. The Universe is full of vast collections of galaxies that are arranged into an intricate web of clusters and ...

(March 10, 2014) Antibiotics are valuable, potentially life-saving tools that have significantly reduced human morbidity and mortality. Unfortunately, antibiotics may also have unintended consequences from their off-target effects that may increase the risk of many long-term conditions. Recent epidemiologic studies have detected a possible link between antibiotic use in childhood and weight gain1 — with disruption to the normal gut microbiota considered the most likely cause. "Infancy is an important time in the development of the human microbiota and these studies provide ...

(March 10, 2014) A healthy and balanced diet, as well as probiotics, have been known to be helpful in preserving gastrointestinal health for quite a long time. But it is only recently that the underlying mechanisms have become somewhat clearer. A rapidly increasing body of knowledge promises to further clarify the effects of our daily food on the gut microbiota and to indicate more targeted applications of probiotics in the near future. This was one of the topics presented at the Gut Microbiota for Health World Summit in Miami, FL, USA. On March 8-9, 2014, internationally ...

Men who at the age of 18 years have poorer cardiovascular fitness and/or a lower IQ more often suffer from dementia before the age of 60. This is shown in a recent study encompassing more than one million Swedish men. In several extensive studies, researchers at the Sahlgrenska Academy of Gothenburg University have previously analyzed Swedish men's conscription results and were able to show a correlation between cardiovascular fitness as a teenager and health problems in later life. Increased risk for early-onset dementia In their latest study, based on data from 1.1 ...

In the study, which was conducted by researchers from the University of Gothenburg, Sahlgrenska University Hospital and the Norwegian Institute of Public Health, the participants completed a scientifically evaluated questionnaire about what they had been eating and drinking since becoming pregnant. The researchers also had access to information about the women's general lifestyle e.g. level of education, living conditions, income, weight, physical activity, smoking habits, alcohol consumption, number of children and medical factors such as history of preterm delivery. 15 ...

Tax fraud is a very serious problem for society, especially in Spain, where tax evasion represents almost one-fourth of its Gross Domestic Product. On the one hand, evasion is a problem because it produces a loss in public resources, something which is especially difficult in a time of economic crisis with cutbacks in public funding; on the other hand, tax fraud damages the effectiveness of justice within the tax system, since not everyone is able to evade taxes equally, thus leading to injustices between small and large companies and between the self-employed and employees. ...

The world's most widespread test for ovarian cancer reports false-positives in 94 of 100 diagnosed cases. Now, chemists at the University of Copenhagen working with clinical researchers at University College London have developed a method able to halve the number of false-positives. When fully developed, the new test will spare a significant number of women from unnecessary worry and further testing. Furthermore, global health care providers stand to save substantial sums – just by including a test on a certain sugar molecule in tandem with the currently prevailing diagnostic ...

WASHINGTON, March 10, 2014 — If you're having some drinks this St. Patrick's Day weekend, remember to have a designated driver, otherwise you may end up on the business end of a breathalyzer on the side of the road. If you think you can beat it, think again; chemistry will land you in cuffs. In the American Chemical Society's (ACS') latest Reactions video, we examine how your breath can get you busted when you've had too much to drink. The video is available here: http://youtu.be/rvVzlg26bCM Subscribe to the series at Reactions YouTube, and follow us on Twitter @ACSreactions ...

Potentially devastating plant pests and diseases are highlighted in a new report from EASAC, the European Academies' Science Advisory Council, the leading provider of independent scientific advice to Europe's policy-makers. In the detailed EU-wide study of emerging plant pests and diseases, EASAC describes their combined threat to crops and forests and wider ecosystems, with implications for human health. In economic terms, as admitted by the EU Commission, billions of euros could be at stake and the environmental impact may be irreversible. Prof. Anne Glover, Chief Scientific ...

Australian author on the paper, Professor Rodney Sinclair, Professor of Medicine at the University of Melbourne and Director of Dermatology at Epworth HealthCare said that the risk decreased significantly with increasing age, but it remains higher compared with individuals who have never had NMSC. "The risk for developing any cancer subsequent to NMSC decreases significantly with increasing age: 23 times higher risk for those under 25 years of age; 3.52 for those 25-44 years of age; 1.74 for those 45- 59 years of age; and 1.32 for those older than 60 years. Published ...

In a significant advance for the growing field of synthetic biology, Rice University bioengineers have created a toolkit of genes and hardware that uses colored lights and engineered bacteria to bring both mathematical predictability and cut-and-paste simplicity to the world of genetic circuit design. "Life is controlled by DNA-based circuits, and these are similar to the circuits found in electronic devices like smartphones and computers," said Rice bioengineer Jeffrey Tabor, the lead researcher on the project. "A major difference is that electrical engineers measure ...

A team of scientists at Washington University School of Medicine in St. Louis (WUSTL) and the University of Arizona (UA) in Tucson led by Samuel Achilefu have created a pair of high-tech glasses that help surgeons visualize cancer cells during surgeries, which glow blue when viewed through the glasses. Achilefu published the 2013 article he coauthored as part of a special section in the SPIE Journal of Biomedical Optics on fluorescence molecular imaging that details the development of the high-tech glasses (available via open access in the SPIE Digital Library). Achilefu, ...

Jena (Germany) Vast fields of sunflowers, sprawling pine trees and slim cypresses, as well as vineyards as far as the eye can see – these are typical memories of Tuscany for all those who have been there. By contrast, Professor Dr. Beate Michalzik from the Friedrich Schiller University of Jena and her colleagues are interested in the more barren aspects of the region in Central Italy: In a study the Jena geographers analyzed the condition of the soil in the region known as 'Crete Senesi' between Florence and Grosseto, whose hills are typically characterized by erosion – ...