Researchers at the Institute for Comprehensive Medical Science, Fujita Health University and the National Institute for Physiological Sciences, Japan, along with colleagues from 9 other institutions, have identified an exceptional mouse model of schizophrenia. After screening over 160 mutant mouse strains with a systematic battery of behavioral tests, they identified a mutant mouse lacking the Schnurri-2 protein (Shn-2 KO) that exhibits behavioral deficits and other brain features consistent with schizophrenia. Shn-2 is an NF-B site-binding protein that binds enhancers ...

Running along the border between the constellations of Canis Major (The Great Dog) and Monoceros (The Unicorn) in the southern sky, the Seagull Nebula is a huge cloud mostly made of hydrogen gas. It's an example of what astronomers refer to as an HII region. Hot new stars form within these clouds and their intense ultraviolet radiation causes the surrounding gas to glow brightly. The reddish hue in this image is a telltale sign of the presence of ionised hydrogen [1]. The Seagull Nebula, known more formally as IC 2177, is a complex object with a bird-like shape that is ...

New York, NY (February 6, 2013) — Columbia University Medical Center (CUMC) researchers have identified a protein trafficking defect within brain cells that may underlie common non-familial forms of Parkinson's disease. The defect is at a point of convergence for the action of at least three different genes that had been implicated in prior studies of Parkinson's disease. Whereas most molecular studies focus on mutations associated with rare familial forms of the disease, these findings relate directly to the common non-familial form of Parkinson's. The study was published ...

Scientists have, for the first time, traced the nanoparticles taken up from the soil by crop plants and analysed the chemical states of their metallic elements. Zinc was shown to dissolve and accumulate throughout the plants, whereas the element cerium did not dissolve into plant tissue. The results contribute to the controversial debate on plant toxicity of nanoparticles and whether engineered nanoparticles can enter into the food chain. The study was published on 6 February 2013 in the journal ACS Nano. The international research team was led by Jorge Gardea-Torresdey ...

Using publicly available data from NASA's Kepler space telescope, astronomers at the Harvard-Smithsonian Center for Astrophysics (CfA) have found that six percent of red dwarf stars have habitable, Earth-sized planets. Since red dwarfs are the most common stars in our galaxy, the closest Earth-like planet could be just 13 light-years away. "We thought we would have to search vast distances to find an Earth-like planet. Now we realize another Earth is probably in our own backyard, waiting to be spotted," said Harvard astronomer and lead author Courtney Dressing (CfA). Dressing ...

CHAMPAIGN, Ill. — Ever wonder why CEOs at poorly performing companies continue to receive exorbitant pay packages? According to a study from a University of Illinois labor professor, firms that trumpet how much they value shareholders actually pay their CEOs more, regardless of the quality of their performance as executives. Using compensation data from 290 chief executives at large U.S. firms over an 11-year period, Taekjin Shin, a professor of labor and employment relations at Illinois, shows that CEOs at firms with the appearance of a "shareholder-value orientation" ...

Cichlid fish are more likely to accept immigrants into their group when they are under threat from predators and need reinforcements, new research shows. The researcher suggests that there are parallels between cooperatively breeding fish's and humans' regulation of immigrants. The research was published today, 6 February 2013, in the journal Proceedings of the Royal Society B. The Princess of Lake Tanganyika (Neolamprologus pulcher), a cichlid fish which is popular in home aquariums, are cooperatively breeding fish with a dominant breeding pair and several 'helper' ...

Have you ever wondered why, and how, shoals of fish are comprised of fish of the same size? According to new research by Ashley Ward, from the University of Sydney in Australia, and Suzanne Currie, from Mount Allison University in Canada, fish can use a variety of different sensory cues to locate shoal-mates, but they are able to use chemical cues to find other fish of the same size as themselves. Using these cues, they can form a group with strength in numbers. The work is published online in Springer's journal, Behavioral Ecology and Sociobiology. Forming groups is ...

Dr Michael Pogue, a Research Entomologist in the ARS Systematic Entomology Laboratory, at the Smithsonian Institution, Washington, DC, was sent a series of moth specimens from Bahia, Brazil, for identification. The insects were under consideration as a possible biocontrol agent for the invasive Brazilian peppertree in Florida. 'The species was initially identified as a common species, but when comparisons were made, it became evident that there were multiple species involved' said Dr. Pogue. Using characters from the moths' male and female genitalia, Dr. Pogue determined ...

Two of the most widely used nanoparticles (NPs) accumulate in soybeans — second only to corn as a key food crop in the United States — in ways previously shown to have the potential to adversely affect the crop yields and nutritional quality, a new study has found. It appears in the journal ACS Nano. Jorge L. Gardea-Torresdey and colleagues cite rapid increases in commercial and industrial uses of NPs, the building blocks of a nanotechnology industry projected to put $1 trillion worth of products on the market by 2015. Zinc oxide and cerium dioxide are among today's most ...

University of Granada researchers have designed a guideline for physicians and patients on the Androgen Insensitivity Syndrome (AIS), a rare disease that makes the subject develop reverse sex, which occurs when a subject looks like a woman but has male genes. AIS has low prevalence (it only affects one in 2000 people), and it is characterized by the inability of tissues to respond to the action of male hormones. This prevents individuals with XY sex hormones (i.e. 46,XY) to develop male genitalia. This disorder is caused by a mutation in the gene that codifies the receptor ...

CHICAGO (Feb. 6, 2013)—Impacting approximately one-third of the U.S. population, obesity is a significant health concern for Americans. It's a risk factor for developing type 2 diabetes, heart disease, and certain forms of cancer, and now, according to an article published in the January/February 2013 issue of General Dentistry, the peer-reviewed clinical journal of the Academy of General Dentistry (AGD), it also may be a risk factor for gum disease. "We know that being overweight can affect many aspects of a person's health," says Charlene Krejci, DDS, MSD, lead author ...

European Science Foundation's ESSC comments the decisions taken (or not) at ESA's council meeting at ministerial level. Strasbourg – 6, February, 2013 - The European Space Sciences Committee (ESSC) today released its position on the perspectives for the European Space Agency's (ESA) scientific programmes. The position statement provides recommendations on the outcomes of the ESA council meeting at ministerial level, which took place on 26-27 November 2012 in Naples. The statement comments on the impact for science-relevant ESA's programmes resulting from the decisions ...

Mature cells can be reprogrammed to pluripotency and thus regain the ability to divide and differentiate into specialized cell types. Although these so-called induced pluripotent stem cells (iPS cells) represent a milestone in stem cell research, many of the biochemical processes that underlie reprogramming are still not understood. Scientists from the EMBL Hamburg and from the Max Planck Institute for Molecular Biomedicine in Münster, Germany now shed new light on this process. In a study published today in Nature Cell Biology, the scientists describe important details ...

The location of an underwater volcanic vent, marked by a low-lying plume of shimmering water, has been revealed by scientists at the National Oceanography Centre, Southampton. Writing in the journal PLOS ONE the researchers describe how the vent, discovered in a remote region of the Southern Ocean, differs from what we have come to recognise as "classic" hydrothermal vents. Using SHRIMP, the National Oceanography Centre's high resolution deep-towed camera platform, scientists imaged the seafloor at Hook Ridge, more than 1,000 metres deep. The study, funded by the ...

DURHAM, N.H. – Abusive bosses who target employees with ridicule, public criticism, and the silent treatment not only have a detrimental effect on the employees they bully, but they negatively impact the work environment for the co-workers of those employees who suffer from "second-hand" or vicarious abusive supervision, according to new research from the University of New Hampshire. In the first ever study to investigate vicarious supervisory abuse, Paul Harvey, associate professor of organizational behavior at UNH, and his research colleagues Kenneth Harris and Raina ...

Since its inception in 2009, the "Contributions to the systematics of New World macro- moths" series in ZooKeys has been playing an important role in publishing taxonomic changes and new discoveries concerning moth diversity in North America. With a total of 49 publications by 38 authors, this well-established series is among the topic leaders, alongside publications such as Canadian Staphylinidae. Geographic coverage in Zookeys has previously focused primarily on the North American fauna (Canada, United States and Mexico). This issue marks a rapid acceleration in contributions ...

Roughly a quarter of recreational skiers who tear their anterior cruciate ligament (ACL) while hitting the slopes can be successfully treated without surgery, according to a new study. The study, conducted by researchers at Hospital for Special Surgery in New York City, appears online ahead of print in the journal Knee Surgery Sports Traumatology Arthroscopy. "Some patients who tear their ACL while skiing can get away without surgery. Their ligament heals by itself, they will have stable knees, and they will be able to do whatever they want, including skiing," said Robert ...

Engineered to produce the bacterial toxin, Bt, "Bt corn" resists attack by corn rootworm, a pest that feeds on roots and can cause annual losses of up to $1 billion. But besides merely protecting against these losses, the Bt trait has also boosted corn yields, in some cases beyond normal expectations. So what makes it so successful? Fred Below and Jason Haegele of the University of Illinois at Urbana-Champaign set out to answer that question by determining how Bt corn uses nitrogen in the soil. Nitrogen is an important nutrient for corn, and with better root systems, ...

Chemists at the University of Burgos (Spain) have manufactured a sheet that changes colour in the presence of water contaminated with mercury. The results can be seen with the naked eye but when photographing the membrane with a mobile phone the concentration of this extremely toxic metal can be quantified. Mercury contamination is a problem that is particularly affecting developing countries. It poses a risk to public health since it accumulates in the brain and the kidneys causing long term neurological illnesses. It is emitted from industrial and mining waste, especially ...

The preservation of immovable historic relics displayed in large open spaces like China's world-renowned Museum of Qin Terracotta Warriors and Horses requires air curtains and other modifications to recreate the primitive environment from which archaeologists excavated the relics. That's the conclusion of a study of environmental control measures for archaeology museums in the People's Republic of China. Their study appears in ACS' journal Environmental Science & Technology. ZhaoLin Gu and colleagues point out that environmental factors have deteriorated many of the ...

NEW YORK February 6, 2012 From banks to telecom providers, various industries are moving to pricing plans that offer a certain amount of "free" service. Bank customers are allowed a certain number of free ATM withdrawals each month, and cell phone users receive free minutes. These three-part plans — which also include a regular (usually monthly) access fee as well as a usage fee if the customer exceeds the free allotment — are replacing older two-part plans that charged an access fee and a usage price for every unit of consumption. Recent studies show that consumers ...

The semi-aquatic earthworms in the genus Glyphidrilus are somewhat unfamiliar species that live between the terrestrial and freshwater ecosystems of rivers, streams, canals, ponds, swamps and paddy systems. Remarkably, each species is endemic to a single water basin, carrying its own signature of evolution from their common origin. A study describing ten newly discovered species of the genus has been published in the open access journal ZooKeys. In Thailand, the species demonstrate astonishing biodiversity due to the monsoon climate contributing to drastic river system ...

February 6, 2013 (Ottawa, ON) - Cities are major players in the climate change game. More than half of the world's population lives in urban areas and over 70% of global GHG (greenhouse gas) emissions can be attributed to cities. A case study of Toronto demonstrates alternative strategies for how the city can implement a low carbon urban infrastructure plan by 2031. Two scenarios are described: one based on Toronto's current policies was found to reduce GHG emissions by 31%; and another suggests aggressive alternatives that could reduce GHG emissions by 71%. Strategies ...

Laboratory experiments conducted by scientists at Virginia Commonwealth University Massey Cancer Center suggest that a novel combination of the drugs ibrutinib and bortezomib could potentially be an effective new therapy for several forms of blood cancer, including diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL). The study, published in the British Journal of Hematology, showed that the experimental drug combination killed cancer cells through a form of cell suicide known as apoptosis, but was relatively non-toxic to normal, healthy cells. Ibrutinib ...