A new paper in Genome Biology and Evolution, published by Oxford University Press, finds that the link between paternal age and rare congenital disorders is more complex than scientists had previously thought. While researchers have long realized that older fathers are more likely to have children with bone and heart malformations, such as Achondroplasia, Apert, or Noonan syndrome or neurodevelopmental disorders, schizophrenia, and autism, new examination indicates that while the link between some pathogenic mutations increases with paternal age, others do not and may even occur in the father’s testis before sexual maturity. Delayed fatherhood results in a higher ...

A study into parental smoking and childhood obesity has challenged previous notions by revealing that the links between the two are not confined to a specific socio-economic group.  The data shows a strong correlation between parents who smoke and their children’s consumption of high calorie unhealthy foods and drinks, across social classes.  Using longitudinal data on 5,000 Australian children collected over a 10-year period, the research found those living with parents who smoke, on average, eat less healthy, higher calorie food such as fruit juice, sausages, fries, snacks, full fat milk products, ...

Professor Jian HE, from the Department of Chemistry at The University of Hong Kong (HKU), has spearheaded a research endeavour aimed at revolutionising organic synthesis. His research team has successfully developed a novel heterogeneous copper photocatalyst that enables the efficient formation of cyclobutane rings, a crucial structural element in a vast array of bioactive molecules. Cyclobutane rings are prominently featured in pharmaceuticals, natural products, and various biologically active compounds. By enabling researchers to construct these rings easily and selectively, ...

The success of a deep learning-based network intrusion detection systems (NIDS) relies on large-scale, labeled, realistic traffic. However, automated labeling of realistic traffic, such as by sand-box and rule-based approaches, is prone to errors, which in turn affects deep learning-based NIDS. To solve the problems, a research team led by Yuefei ZHU published their new research on 15 Feb 2024 in Frontiers of Computer Science co-published by Higher Education Press and Springer Nature. The team ...

Researchers at the Centre for Genomic Regulation (CRG) reveal that the Snhg11 gene is critical for the function and formation of neurons in the hippocampus. Experiments with mice and human tissues revealed the gene is less active in brains with Down syndrome, potentially contributing to the memory deficits observed in people living with the condition. The findings are published today in the journal Molecular Psychiatry.   Traditionally, much of the focus in genomics has been on protein-coding genes, which in humans constitutes around just 2% of the entire genome. The rest is "dark ...

In The BMJ today, Keisha Bentley-Edwards at Duke University, North Carolina, and colleagues argue that systemic racism and economic inequality are at the root of disparity in covid-19 outcomes and suggest how to distribute resources more equitably.  The article is part of a series that highlights the lessons that can be learned from the US’s covid-19 experience and the actions that are needed to prevent the loss of another million citizens in the next pandemic and improve and protect population health. "Rather than waiting for the next pandemic to address systemic failures, the ...

A group led by researchers at Nagoya University and Meijo University in Japan has developed a disinfection technology that uses low-temperature plasma generated by electricity to cultivate environmentally friendly hydroponically grown crops. This innovative technology sterilizes the crops, promoting plant growth without the use of chemical fertilizers. Their findings appeared in Environmental Technology & Innovations. In hydroponic agriculture, farmers cultivate plants by providing their roots with a nutrient solution. However, the nutrient solution can become infected with pathogenic E. coli strains, contaminating the crop and leading to foodborne illnesses. To avoid ...

Two major studies part-funded by Cancer Research UK reveal that the use of chemotherapy and radiotherapy in the UK has lagged behind comparable countries in the past decade  Patients faced longer waits to begin key cancer treatment, which could be impacting people’s chances of survival in the UK  With an upcoming UK general election, Cancer Research UK is calling on political leaders to step up and ensure patients get the level of care that they deserve     People in the UK were treated with chemotherapy ...

The mechanisms by which antidepressants and other emotion-focused medications work could be reconsidered due to an important new breakthrough in the understanding of how the gut communicates with the brain. New research led by Flinders University has uncovered major developments in understanding how the gut communicates with the brain, which could have a profound impact on the make-up and use of medications such as antidepressants. “The gut-brain axis consists of complex bidirectional neural communication pathway between the brain and the gut, which links emotional and cognitive ...

In response to the rapidly evolving landscape of data collection and analysis driven by advances in artificial intelligence, the U.S. National Science Foundation (NSF) and the U.S. Department of Energy (DOE) have established a Research Coordination Network (RCN) dedicated to advancing privacy research and the development, deployment and scaling of privacy enhancing technologies (PETs). Fulfilling a mandate from the "Executive Order on the Safe, Secure, and Trustworthy Development and Use of Artificial Intelligence," the initiative advances the recommendations in the National Strategy to Advance ...

Allyship — the practice of relatively advantaged group members acting with the intention to support, advocate and improve circumstances for relatively disadvantaged groups — is critical to promoting more inclusive and equitable organizations. Not only are advantaged group members typically received more favorably within an organization than disadvantaged group members would be when they speak out against injustice, their allyship can improve disadvantaged group members’ psychological experience in the organization. For instance, men are more likely to believe other men, compared with women, when they confront sexism. And Black Americans report higher levels of self-esteem ...

University of Maryland School of Medicine (UMSOM) Dean Mark T. Gladwin, MD, announced  today that UMSOM  faculty scientists have been selected as key contractors by the Biomedical Advanced Research and Development Authority (BARDA), for the federal agency’s Radiation Nuclear Animal Model Development program. The $3.5 million award that Erika Davies, PhD, Assistant Professor of Radiation Oncology, received to develop Acute Radiation Syndrome Animal Models, has a $16 million potential total. The Division of Translational Radiation Sciences (DTRS), within the Department of Radiation Oncology, will support this project. Dr. Davies and her colleagues ...

Researchers at the University of Illinois at Urbana-Champaign have shown for the first time that expensive aberration-corrected microscopes are no longer required to achieve record-breaking microscopic resolution. The field of microscopy is in the middle of a great revolution. Since the 1800s and the invention of the compound light microscope, there have only been a few major jumps in resolution to see different length scales: from bacteria and cells, to viruses and proteins, and even down to single atoms. Generally, ...

 @Annalsofim    Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization they represent.    ----------------------------    1. ACP Recommends Ways to Better Meet the Health Care ...

Figshare, a leading provider of institutional repository infrastructure that supports open research, is pleased to announce that the University of Technology Sydney (UTS) has chosen Figshare to support them in sharing, showcasing and managing their research reports and non-traditional research outputs. UTS – Australia’s leading technology university – will use its Figshare repository and its integration with the Australian Research Data Commons Datacite DOI minting service to drive the discoverability and increase the impact of their research reports and non-traditional research outputs, ...

BIRMINGHAM, Ala. – Just imagine this, the creation of: An artificially intelligent machine that acts as a human exocortex, a system that will interface with and make an old brain tick normally. Human cells that can sense metastatic cancer or the boundaries of solid tumors and respond with killing of tumor cells, release of inflammatory payloads or bioluminescence to help guide surgical removal. Manufactured vaccines that prevent or impede a cancer, block opioid action or reverse autoimmune diseases like multiple sclerosis. These are a few of the far-reaching ideas put forward by 50 international biomedical engineering ...

Dr Weliton Menário Costa, a PhD graduate from The Australian National University (ANU), has been announced the overall winner of the 2024 global Dance Your PhD contest after wowing judges with his wickedly creative and quirky dance submission, ‘Kangaroo Time (Club Edit)’. One of the world's leading researchers in kangaroo behaviour, he is the first person from ANU to win the Dance Your PhD competition, and just the fourth person from an Australian institution to do so since its inception in 2008. Better known as ‘WELI’, the singer-songwriter, creator and biologist weaves together a funky beat, original songwriting, drag queens and Brazilian funk dancers ...

Black carbon is the most dangerous air pollutant you’ve never heard of. Its two main sources, diesel exhaust and wood smoke from wildfires and household heating, produce ultrafine air particles that are up to 25 times more of a health hazard per unit compared to other types of particulate matter. Despite its danger, black carbon is understudied due to a lack of monitoring equipment. Regulatory-standard sensors are wildly expensive to deploy and maintain, resulting in sparse coverage in regions infamous for poor air quality, such as the greater Salt Lake City metropolitan area in Utah. A University of Utah-led study found that the AethLabs ...

Irvine, Calif., Feb. 26, 2024 — The University of California, Irvine has received a five-year, $4 million grant from the California Institute for Regenerative Medicine to establish a shared resources lab in the Sue & Bill Gross Stem Cell Research Center. The facility will offer essential technologies and training for the development of novel in vitro stem cell-based modeling that will serve researchers across the campus and the state.   “Stem cells possess the potential to transform into particular cell types, offering promising avenues for rejuvenating and restoring tissues harmed by injury or affected ...

Among the vast expanse of Antarctica lies the Thwaites Glacier, the world’s widest glacier measuring about 80 miles on the western edge of the continent. Despite its size, the massive landform is losing about 50 billion tons of ice more than it is receiving in snowfall, which places it in a precarious position in respect to its stability. Accelerating ice loss has been observed since the 1970s, but it is unclear when this significant melting initiated – until now. A new study published in the journal PNAS, led by researchers ...

Researchers have shown that inedible species of butterfly that mimic each others’ colour patterns have also evolved similar flight behaviours to warn predators and avoid being eaten. It is well known that many inedible species of butterfly have evolved near identical colour patterns, which act as warning signals to predators so the butterflies avoid being eaten.  Researchers have now shown that these butterflies have not only evolved similar colour patterns, but that they have also evolved similar ...

Human coexistence depends on cooperation. Individuals have different motivations and reasons to collaborate, resulting in social dilemmas, such as the well-known prisoner's dilemma. Scientists from the Chatterjee group at the Institute of Science and Technology Austria (ISTA) now present a new mathematical principle that helps to understand the cooperation of individuals with different characteristics. The results, published in PNAS, can be applied to economics or behavioral studies. A group of neighbors shares a driveway. Following a heavy snowstorm, the entire driveway is covered in snow, requiring clearance for daily activities. ...

BEAUFORT, N.C. –With fish stocks declining globally, more than 190 countries recently made a commitment to protect about a third of the world’s oceans within “Marine Protected Areas,” or MPAs by the year 2030. But these designated areas of the ocean where fishing is either regulated or outright banned can come at a huge cost to some coastal communities, according to a new analysis. To help prepare for the expansion of MPAs, an international team of researchers from Duke University, Florida State ...

To become carbon neutral by 2060, as mandated by President Xi Jinping, China will have to build eight to 10 times more wind and solar power installations than existed in 2022. Reaching carbon neutrality will also require major construction of transmission lines.  China land use policies will also have to be more coordinated and focused on a nation-wide scale rather than be left to ad hoc decisions by local governments. That’s because 80% of solar power and 55% of wind power will have to be built within 100 miles of major population centers.  These are the conclusions of a new study from ...

There is no doubt that water is significant. Without it, life would never have begun, let alone continue today – not to mention its role in the environment itself, with oceans covering over 70% of Earth.  But despite its ubiquity, liquid water features some electronic intricacies that have long puzzled scientists in chemistry, physics, and technology. For example, the electron affinity, i.e. the energy stabilization undergone by a free electron when captured by water, has remained poorly characterized from an experimental ...